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Daxibotulinumtoxina-Lanm

  • Biologic
  • Prescription only
  • Identity checked
  • Sources last checked 2026-09-04

This page shows what was measured, who it was measured in, and what that does not settle.

What Daxibotulinumtoxina-Lanm does in the body

DAXXIFY is an acetylcholine release inhibitor and neuromuscular-blocking agent indicated for: Temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/ or procerus muscle activity in adult patients.

DAXXIFY blocks neuromuscular transmission at the neuromuscular junction by inhibiting the release of acetylcholine. This inhibition occurs as the neurotoxin cleaves SNAP-25, a protein necessary for the successful docking and release of acetylcholine vesicles within nerve endings. Recovery of neurotransmission occurs gradually as the neuromuscular junction recovers from SNAP-25 cleavage and as new nerve endings are formed.

Why people take it. DAXXIFY is an acetylcholine release inhibitor and neuromuscular-blocking agent indicated for: Temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/ or procerus muscle activity in adult patients.

What happened in people

RNAWiki has not yet published a reviewed conclusion for this use.

A fixed RNAWiki sentence

Where this came from

Wording RNAWiki always uses, not a finding about this substance.

No reviewed claim names a result for any goal on this record.

No source is stored against this line.

The limit that matters most

Not recorded.

Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
Where each sentence above came from

The use the label states, quoted from it. No plain-language version of this sentence has been written.

The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.

No statement of the main limit is recorded.

The four opening statements run to 134 words.

Words this page uses

Four words worth knowing first

Chosen from what this page shows, with each one explained before the word it depends on.

Stand-in result

A stand-in result is a number measured because the real result takes too long.

A picture of it, and where the picture fails

It is like judging a journey by the speedometer rather than by arriving.

Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.

What people get wrong. A stand-in result is often reported as the result itself.

A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.

Formulation

A formulation is the exact made-up form a substance comes in.

A picture of it, and where the picture fails

It is like the difference between a whole bean and instant coffee.

Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.

What people get wrong. Two products with the same name are assumed to behave the same. They often do not.

The specific composition and physical form of a product, including salt, excipients and release profile.

Receptor

A receptor is a part of a cell that a signal fits into.

A picture of it, and where the picture fails

A receptor is like a lock waiting for one key.

Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.

What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.

A protein that binds a specific ligand and converts that binding into a cellular response.

Pathway

A pathway is a chain of steps inside a cell, each one setting off the next.

A picture of it, and where the picture fails

A pathway is like a row of dominoes.

Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.

What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.

An ordered series of molecular interactions producing a defined cellular change.

What happened in peopleRead from sources, not yet reviewed

What was measured, goal by goal

One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.

Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.

There is no single score. A strong test result and a weak life result are different facts.

Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
GoalLife outcomeWhat a body can doHow a person feelsA test resultA step in the bodyHarmsHow longWho was studied
PainNothing in the sources checkedNo registered study lists a life outcome for this goal.Nothing in the sources checkedNo registered study lists a performance measure for this goal.Waiting for a reviewer5 registered symptom measure.Nothing in the sources checkedNo registered study lists a test result for this goal.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
StrengthNothing in the sources checkedNo registered study lists a life outcome for this goal.Waiting for a reviewer2 registered performance measure of this kind.Nothing in the sources checkedNo registered study lists a symptom measure for this goal.Nothing in the sources checkedNo registered study lists a test result for this goal.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
Fertility and sexual healthNothing in the sources checkedNo registered study lists a life outcome for this goal.Nothing in the sources checkedNo registered study lists a performance measure for this goal.Nothing in the sources checkedNo registered study lists a symptom measure for this goal.Nothing in the sources checkedNo registered study lists a test result for this goal.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
MoodNothing in the sources checkedNo registered study lists a life outcome for this goal.Nothing in the sources checkedNo registered study lists a performance measure for this goal.Waiting for a reviewer1 registered symptom measure.Nothing in the sources checkedNo registered study lists a test result for this goal.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
decrease in pain at 8 weeks post injection; visual analogue scale for pain; average pain scores in 1st 4 days post op; days of decrease in pain level using vas; pain
Strength
grip strength; plantar flexor muscle strength
Fertility and sexual health
total sperm count per ejaculate
Mood
beck depression inventory

Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.

What each mark on this table means
Nothing in the sources checked
No registered study lists a life outcome for this goal.
Waiting for a reviewer
5 registered symptom measure.
Not recorded
Harms were not a registered measure for this goal.

What happened in peopleRead from sources, not yet reviewed

What happened in people

Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.

Therapeutic Response based on the modified Jankovic Rating Scale

The study did not show it

Who was studied
NCT06195241
How many people
40
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route.

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • Europe PMC · a recorded source, not a stored snapshot

IGA-FWS

The study did not show it

Who was studied
NCT06411002
How many people
27
Study design
Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route.

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • Europe PMC · a recorded source, not a stored snapshot
What we know
RNAWiki holds 2 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.

What happened in peopleRead from sources, not yet reviewed

How close this is to real life

The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.

  1. Living longer, or avoiding a major event No evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
  2. What a body can do day to day Evidence recorded. Walking, dressing, breathing, recovering.2 registered measures of this kind.
  3. Measured performance Evidence recorded. How much was lifted, how far was run, how fast.2 registered measures of this kind.
  4. Symptoms and quality of life Evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.8 registered measures of this kind.
  5. A number that stands in for health Evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.4 registered measures of this kind.
  6. A step measured inside a person Evidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
  7. Animals Evidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
  8. Cells in a dish No evidence recorded. Cells or chemistry on a bench, far from a whole body.No cell or bench record is stored.
  9. A guess from software No evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.

Higher on these steps means closer to something a person would feel. It does not mean better done.

What it would be like to takeRead from sources, not yet reviewed

Felt, measured, or meaningful

Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.

Felt

Things a person could notice without a test.

  • decrease in pain at 8 weeks post injection
  • international prostate symptom at week 12
  • visual analogue scale for pain
  • average pain scores in 1st 4 days post op
  • days of decrease in pain level using vas
  • beck depression inventory
  • pain
  • total international prostate symptom at week 12

Measured

Things only a test, a scale or a device shows.

  • urinary urge incontinence episodes
  • weekly episodes of urinary incontinence
  • grip strength
  • urinary symptoms
  • plantar flexor muscle strength
  • daily episodes of urinary incontinence

Meaningful

Things that change how a life goes, not only a number.

No registered study measured anything of this kind.

A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.

Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.

Measured, but not felt. A number moves. The person notices nothing. Both can be true.

Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.

Matters, but takes years. The result that counts may take longer than anyone would keep watching.

Names that fit none of the three (26)
  • forced vital capacity
  • forced expiratory volume
  • frequency of headache episodes
  • frequency of headache days
  • assessment of axillary sweat production
  • total amount of narcotic used in 1st 4 days post op
  • duration of treatment benefit
  • forced expiratory volume in one second
  • fev1/fvc
  • nih cpsi total
  • dysphagia incidence over 10 weeks
  • seven functional tasks
  • adverse events
  • sino nasal outcome test 22
  • first visit onset of efficacy as measured by assessment
  • total sperm count per ejaculate
  • a positive response on the 4 treatment benefit scale
  • a positive response on the 4 tbs
  • response rate
  • clinical

These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.

What is missing or unclearRead from sources, not yet reviewed

Were people like you studied?

RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.

Who was studied

No description of who was studied is recorded.

Who is missing from the studies

  • Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

What the label states about particular groups

  • On pediatric, the label states: “Safety and effectiveness of DAXXIFY in patients less than 18 years of age have not been established.”

    US prescribing information · 3aaa6e14-a3f7-4fb2-b9f9-d3a9c3ae1f74 · read 2026-08-30

  • On older people, the label states: “Clinical studies of DAXXIFY did not include sufficient numbers of subjects aged 65 and older to determine whether they responded differently from younger subjects [see Clinical Studies (14) ].”

    US prescribing information · 3aaa6e14-a3f7-4fb2-b9f9-d3a9c3ae1f74 · read 2026-08-30

  • On people who are pregnant, the label states: “Risk Summary There are no available data on DAXXIFY use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.”

    US prescribing information · 3aaa6e14-a3f7-4fb2-b9f9-d3a9c3ae1f74 · read 2026-08-30

  • On people who are breastfeeding, the label states: “Risk Summary There are no data on the presence of DAXXIFY in human or animal milk, the effects on the breastfed infant, or the effects on milk production.”

    US prescribing information · 3aaa6e14-a3f7-4fb2-b9f9-d3a9c3ae1f74 · read 2026-08-30

Where the result stopped carrying

  • This is a scope explorer, not a diagnosis engine.
  • It shows who was studied so you can see whether people similar to you were included.

RNAWiki cannot tell whether a study fits you. It can show who was in it.

What it would be like to takeRead from sources, not yet reviewed

Why it might seem to do nothing

A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.

It was studied for a different goal

The studies measured something else entirely.

On this record: Some registered studies measured things that match no goal on this page.

It was studied in different people

The people in the studies were not much like the reader.

On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

A different form was studied

The studied form is not the form on the shelf.

On this record: This record is linked to 1 related forms. Evidence does not carry across all of them.

The evidence may simply be wrong

Small early studies often do not hold up.

On this record: RNAWiki has not yet published a reviewed conclusion for this use.

Other reasons RNAWiki checked and found nothing for (9)
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.

None of these is a reason to take more. Taking more is not a step this page ever suggests.

What it would be like to takeRead from sources, not yet reviewed

What taking it involves

The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.

How it is supplied

Prescription only

Quoted from a source

Where this came from

Copied from a source RNAWiki stored, with the source named.

Read from the recorded approval status.

No source is stored against this line.

Form and route

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

No form or route is recorded.

No source is stored against this line.

Who oversees it

Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.

Quoted from a source

Where this came from

Copied from a source RNAWiki stored, with the source named.

Suppression classes recorded: S6.

No source is stored against this line.

What is in the pack

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

Nothing is recorded about product quality.

No source is stored against this line.

Where it is registered

Regulatory records are listed in the technical disclosure at the foot of this page.

Counted from records

Where this came from

A count of rows RNAWiki holds. It describes our records, not your body.

Register entries are stored per jurisdiction and shown with their dates.

No source is stored against this line.

Why people stop

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

No record of why people stopped taking it is stored for this substance.

No source is stored against this line.

What it would be like to takeNothing found in the sources checked

What can go wrong

Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.

Nothing found in the sources checked

No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.

The sources listed were searched and held nothing. That is not the same as nothing existing.

Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.

Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

What is missing or unclearRead from sources, not yet reviewed

Does the exact form matter?

Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.

The form that was studied

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

The exact form studied is not recorded.

No source is stored against this line.

What is sold

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

Nothing further is recorded about which forms are sold.

No source is stored against this line.

What is recorded as being sold

  • DAXXIFY is intramuscular at 3 DOSAGE FORMS AND STRENGTHS For injection: 50 Units or 100 Units of white to off-white lyophilized powder in single-dose vial for reconstitution with sterile preservative-free 0.9% Sodium Chloride Injection, USP., recorded as fda label in effect 2026-01-07 in the United States.

    US prescribing information · 3aaa6e14-a3f7-4fb2-b9f9-d3a9c3ae1f74 · read 2026-08-30

Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.

Names and forms linked to this record

  • Biosimilar of

    Abobotulinumtoxina

    Evidence on this page does not automatically apply to this one.

What it would be like to takeRead from sources, not yet reviewed

What you could measure

This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.

Self-experiment planning is not offered for a prescription or clinician-supervised medicine. The questions below are for a clinician or pharmacist.

Questions worth asking

  • Which of the trials of Daxibotulinumtoxina-Lanm studied people like me?
  • What was measured, and for how long?
  • Was the result a laboratory value or a health outcome?
  • What would we watch for, and when would we stop?

Tracking can show whether something changed for you. It cannot show what caused it.

RNAWiki records evidence. It does not say whether this substance is right for you.

What is missing or unclearRead from sources, not yet reviewed

What nobody knows yet

Open questions, each with why it is open and what would close it.

How fast does the body clear it?

The sources RNAWiki checked hold nothing for this field.

Why it matters. Without this, nothing on this page can say how long anything lasts.

What would answer it

A stored source that records it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Missing populations

Which groups were under-represented in the studies has not been recorded.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Missing long-term data

No completed tested study window is recorded.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

No reviewed conclusion

RNAWiki has not yet published a reviewed conclusion for this use.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Missing interaction studies

No interaction was found in the registers checked. Not finding one is not the same as showing there is none.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Formulation uncertainty

Several salts, forms or products of Daxibotulinumtoxina-Lanm are recorded. Results from one form may not transfer to another.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Mechanism not reviewed

No reviewed mechanism story exists for this substance.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

What happened in peopleNothing found in the sources checked

Check any of this yourself

Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.

Nothing found in the sources checked

No traced study record is stored for this substance.

The sources listed were searched and held nothing. That is not the same as nothing existing.

Checks this page had to pass

  • Passed

    Identity resolved

    no open identity hold

  • Passed

    No unresolved merge across substance families

    no quarantine open

  • Passed

    Every public sentence names a source

    The opening statement carries the origin: Quoted from a stored source.

  • Not passed

    Trial roles classified for highlighted evidence

    No registered study is classified as testing this substance.

  • Passed

    No internal keys in reader text

    enforced by the copy-contract test over the rendered page

  • Passed

    Safety mode resolved

    Suppression classes recorded: S6.

  • Passed

    Canonical metadata present

    slug and display name present

What is missing or unclearRead from sources, not yet reviewed

How this medicine reached us

Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.

What the approval register records

  • 1 approved application covers products containing this substance. The earliest was BLA761127, approved 20220907 to REVANCE THERAPEUTICS, INC..

    Drugs@FDA application register · BLA761127 · read 2026-08-29

  • Marketing status on the register: prescription.

    Drugs@FDA application register · BLA761127 · read 2026-08-29

What is missing or unclearRead from sources, not yet reviewed

What to learn next

Ordered by what would most change how you read this page, starting with what is easiest to misunderstand.

This order is fixed in code and does not count clicks or time on the page.

What is not here

6 questions this page could not answer

These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.

  • The path through the body — found nothing in the sources checked.
  • How long anything takes — found nothing in the sources checked.
  • What it may clash with — found nothing in the sources checked.
  • Other ways to the same goal — found nothing in the sources checked.
  • Claims that go past the evidence — found nothing in the sources checked.
  • What changed on this page — found nothing in the sources checked.

The record as stored

The full record, for auditing

Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.

Recorded evidence blocks (8)

What did Daxibotulinumtoxina-Lanm's largest trial (1168 people) and its longest (14 years) measure?


1168 people in Daxibotulinumtoxina-Lanm's largest registered study, 14 years in its longest registered window, measuring grip strength. ClinicalTrials.gov · 2026-09-01

119 phase2, 116 phase3, 91 phase4, 54 phase1, 48 na, 32 na or unstated, 12 early phase1; NCT02019004; 2027-12. Last human test completed 2026, NCT03654066.

Interpretation These counts include studies where Daxibotulinumtoxina-Lanm was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.

Show the evidence
  • phase2
    119
  • phase3
    116
  • phase4
    91
  • phase1
    54
  • na
    48
  • na or unstated
    32
2 more recorded rows
  • early phase1
    12
  • Last recorded human test NCT03654066
    2026-08-01

recorded 2026-09-01 · last checked 2026-09-04

From mouse to human: where has Daxibotulinumtoxina-Lanm shown healthspan?


mouse: mechanism-only, rat: mechanism-only and human: healthspan (431): the rungs where Daxibotulinumtoxina-Lanm has a recorded finding. Europe PMC and ClinicalTrials.gov · organism ladder · 2026-09-01

Interpretation grip strength — the recorded outcome words.

Yeast C. elegans Drosophila Mouse mechanism-onlyRat mechanism-onlyDog Non-human primate Human healthspan
Show the evidence
  • mouse
    mechanism-only
  • rat
    mechanism-only
  • human NCT00395616
    healthspan; grip strength; 431

recorded 2026-09-01 · last checked 2026-09-04

54 of Daxibotulinumtoxina-Lanm's trials stopped: safety, futility/efficacy, accrual/recruitment, funding/business, sponsor decision unspecified, other?


safety (1), futility/efficacy (2), accrual/recruitment (24), funding/business (8), sponsor decision unspecified (2) and other (17): Daxibotulinumtoxina-Lanm's stop wording, clustered. ClinicalTrials.gov · 2026-09-01

"Not able to recruit any subjects for the study and was closed in February 2008"; 54 of 431 registered studies

Show the evidence

Trial

  • NCT00175604
    withdrawn; "Not able to recruit any subjects for the study and was closed in February 2008"
  • NCT00373789
    terminated; "higher than anticipated rate of increased post-void residual in subjects who received botulinum toxin A injection"
  • NCT00384371
    terminated; "Funding was unable to be secured for this study"
  • NCT00432341
    terminated; "Study was terminated early due to difficulties with patient recruitment"
  • NCT00439140
    terminated; "In agreement with FDA the study was terminated based on data available."
  • NCT00464373
    terminated; "Slow accrual."
14 further recorded trials
  • NCT00496964
    terminated; "Insufficient recruitment in a reasonable time + expiration of study medication"
  • NCT00575016
    terminated; "The study was terminated early due to enrollment challenges."
  • NCT00624299
    withdrawn; "A similar study had already been conducted, therefore pursuing this trial would have been unethical"
  • NCT00651339
    terminated; "recruiting or enrolling participants has halted prematurely and will not resume"
  • NCT00667095
    terminated; "Study terminated early due to PI's extended medical leave."
  • NCT00681148
    withdrawn; "No funding"
  • NCT00732680
    terminated; "Lead investigator moved to a new medical center; study was stopped when he left."
  • NCT00765375
    terminated; "Investigator decision"
  • NCT00850421
    terminated; "Recently published BOTOX efficacy data and study design deficits."
  • NCT01045694
    terminated; "Unable to acquire additional funding needed to continue this study."
  • NCT01225341
    terminated; "Too many patients withdrew/lost to follow up"
  • NCT01272414
    withdrawn; "lack of funding"
  • NCT01483209
    terminated; "Low accrual"
  • NCT01678053
    withdrawn; "Was not able to recruit patients for randomization."

recorded 2026-09-01 · last checked 2026-09-04

Human studies of Daxibotulinumtoxina-Lanm used botox 100 IU — over how long?


studies of Daxibotulinumtoxina-Lanm used the recorded amount. ClinicalTrials.gov · 2026-09-01

8 recorded entries; human; also "botox 100 IU", "Botox® 100 units", "Botox 50 Unit Injection"

Show the evidence

human

  • NCT04467450
    botox 100 IU
  • NCT05463822
    Botox® 100 units
  • NCT05512039
    Botox 50 Unit Injection
  • NCT05512039
    Botox 100 Unit Injection
  • NCT06851598
    25 units botox
  • NCT06851598
    50 units Botox
2 more recorded rows
  • human NCT06851598
    75 units Botox
  • human NCT07013279
    Botox® 100 Units

recorded 2026-09-01 · last checked 2026-09-04

Which of a positive response on the 4 tbs, a positive response on the 4 treatment benefit scale and adverse events did Daxibotulinumtoxina-Lanm's trials measure?


a positive response on the 4 tbs, a positive response on the 4 treatment benefit scale and adverse events lead 40 outcome terms across Daxibotulinumtoxina-Lanm's trials. ClinicalTrials.gov · 2026-09-01

frequency of headache days, urinary urge incontinence episodes, assessment of axillary sweat production, decrease in pain at 8 weeks post injection, international prostate symptom at week 12 and weekly episodes of urinary incontinence follow.

Show the evidence
  • forced vital capacity
    1
  • forced expiratory volume
    1
  • frequency of headache episodes
    1
  • frequency of headache days
    1
  • urinary urge incontinence episodes
    1
  • assessment of axillary sweat production
    1
14 more recorded rows
  • decrease in pain at 8 weeks post injection
    1
  • international prostate symptom at week 12
    1
  • weekly episodes of urinary incontinence
    1
  • visual analogue scale for pain
    1
  • grip strength
    1
  • average pain scores in 1st 4 days post op
    1
  • total amount of narcotic used in 1st 4 days post op
    1
  • duration of treatment benefit
    1
  • forced expiratory volume in one second
    1
  • fev1/fvc
    1
  • nih cpsi total
    1
  • dysphagia incidence over 10 weeks
    1
  • seven functional tasks
    1
  • adverse events
    1

recorded 2026-09-01 · last checked 2026-09-04

Which of Daxibotulinumtoxina-Lanm's 36 ongoing trials reports first?


36 registered trials of Daxibotulinumtoxina-Lanm are open; earliest completion 2021-06-01. ClinicalTrials.gov · 2026-09-01

Change in glabellar wrinkle score from baseline to 6 months for botox vs. xeomin; Spectrophotometer measurement; latest 2030-08-01

Show the evidence

Trial

  • NCT02019004
    "A Pilot Study Testing Onabotulinum Toxin A Versus Incobotulinum Toxin A Injections for Facial Wrinkles"; n 20; "Change in glabellar wrinkle score from baseline to 6 months for botox vs. xeomin"; 2027-12
  • NCT02216838
    "Treatment of Facial Flushing With Botulinum Toxin A Injections"; n 16; "Spectrophotometer measurement"; 2027-12
  • NCT03944876
    "Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache"; n 112; "Difference in change from baseline week 5-8 in mean number of cluster headache attacks per week at weeks 5-8 post-intervention in the treatment group versus the placebo group"; 2025-09
  • NCT04020510
    "Standard Injections Versus Reduced Injections for Intravesical onabotulinumtoxinA Treatment of Overactive Bladder"; n 184; "Mean change from baseline in overactive bladder symptom severity and health related quality of life scores on the overactive bladder questionnaire short form"; 2021-12-31
  • NCT04305743
    "Post-procedural Pain Associated With 5 Versus 20 Intravesical Injections of Onabotulinumtoxin A"; n 60; "Pain from procedure: score"; 2021-06-01
  • NCT05218785
    "Treatment of Gastrocnemius Tightness and Subsequent Chronic Plantar Fasciitis with Botulinum Toxin a"; n 40; "Manchester Oxford Foot Questionnaire"; 2026-01
14 further recorded trials
  • NCT05403710
    "Botulinum Toxin Therapy in Hidradenitis Suppurativa"; n 20; "Quantification and phenotyping of skin resident dendritic cell, macrophage, and T cell populations in patients before and after intralesional Botox treatment."; 2028-04-30
  • NCT05512039
    "Reduced-dose Botox for Urgency Incontinence Among Elder Females"; n 376; "Change in symptom specific quality of life and bother over time."; 2027-01-01
  • NCT05598723
    "BOTOX® vs. XEOMIN® for Chronic Migraine"; n 128; "Headache days per month"; 2027-08-24
  • NCT05698979
    "Evaluation of Botulinum TOXin Type A in the Treatment of Buerger's Disease"; n 8; "Feasibility in Number of patients"; 2028-02
  • NCT05720065
    "Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A"; n 100; "Change of gene expression measured with bulk RNA-seq"; 2027-08-31
  • NCT05765071
    "Treatment of Lower Leg Anterolateral Chronic Exertional Compartment Syndrome With Intra-muscular Botulinum Injections."; n 50; "Change in maximum level of pain at time of painful sport activity from Baseline to 2, 4, 6, 8, 12, 16 and 24-weeks post-injection"; 2028-06-30
  • NCT05806164
    "Beta-Agonist Versus OnabotulinumtoxinA Trial for Urgency Urinary Incontinence"; n 432; "Change in score Overactive Bladder Questionnaire-Symptom Bother Scale (OAB-q-SS) at 3 months"; 2030-08-01
  • NCT05878951
    "Examining the Effects of Intra-detrusor Botox at Time of HoLEP in Men With Overactive Bladder Symptoms"; n 66; "Improve Overactive Bladder Symptoms (OAB) utilizing botox injections into the bladder."; 2026-12-31
  • NCT05990881
    "Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis"; n 50; "Thumb Pain"; 2026-07
  • NCT06075134
    "EMG-guided Botox Injection Versus Conventional Botox Injection in Gummy Smile Patients"; n 32; "Change in amount of gingival display"; 2026-08
  • NCT06195241
    "Effects of DaxibotulinumtoxinA for Blepharospasm and Hemifacial Spasm"; n 40; "Therapeutic Response based on the modified Jankovic Rating Scale"; 2027-03
  • NCT06212661
    "Migraine Medication Effects on Urinary Symptoms"; n 200; "changes in OAB symptoms"; 2026-12
  • NCT06216886
    "OnabotulinumtoxinA for Trigeminal Neuralgia"; n 20; "Change in Number of TN Attacks per week"; 2027-09-01
  • NCT06543979
    "Anorectal Manometery in Pediatric Chronic Refractory Constipation"; n 60; "To evaluate the manometric parameters in children with chronic refractory constipation"; 2025-10-01

recorded 2026-09-01 · last checked 2026-09-04

Which 137 trials of Daxibotulinumtoxina-Lanm posted no result?


Posted no result
137 of 137 completed trials
Registrations
NCT00651729, NCT00651690, NCT03181802, NCT00717782, NCT00827736 and NCT00430196, and 131 more
Completion dates
oldest 2004-12; newest 2024-07-10
Show the evidence

Trial

  • NCT00651729
    2004-12
  • NCT00651690
    2005-05
  • NCT03181802
    2005-05-08
  • NCT00717782
    2006-01
  • NCT00827736
    2006-03
  • NCT00430196
    2006-09
14 further recorded trials
  • NCT00989209
    2006-12
  • NCT00168480
    2007-04
  • NCT00628472
    2007-05
  • NCT00168415
    2007-06
  • NCT00435682
    2008-01
  • NCT00467207
    2008-03
  • NCT00279903
    2008-08
  • NCT01091727
    2009-04
  • NCT01018485
    2010-06
  • NCT01332474
    2010-08
  • NCT00934687
    2010-10
  • NCT01088230
    2010-11
  • NCT00997815
    2011-06
  • NCT00976443
    2011-09

At the median, Daxibotulinumtoxina-Lanm's trials enrolled 48 people — anything larger?


Median enrolment
48
Largest enrolment
1168
Registered trials counted
430
Where it is registered
Identifiers, relations and other names

The exact record

CAS number
93384-43-1
RxCUI
1712

Relations

Trade name
Daxxify, BOCOUTURE, BOTOX
Also called
ABOBOTULINUMTOXIN A, ABOBOTULINUMTOXINA, ABOBOTULINUMTOXINA [PURPLE BOOK CDER], ABOBOTULINUMTOXINA [USAN], ABOBOTULINUMTOXINA [VANDF]
Development code
AGN-151607, ANT-1207, ANT-1401, ANT-1403
Sources (6)

Sources

ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md

How these records are assembled · Which registers were checked

Index-quality checks
  • identity passed: no open identity hold
  • required summary fields resolved: 3 required field(s) not terminal: Best-supported result, Biggest unanswered question, Human evidence
  • public claims reviewed: 0 reviewed claim(s); drafts are never rendered
  • source coverage passed: 6 source rows
  • no critical contamination: no quarantine open
  • canonical metadata passed: slug and display name present
  • no raw internal fields: enforced by the copy-contract test over the rendered page

This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.