Its recorded molecular formula is C42H60O4, weighing 628.9.
PubChem record · 9852188 · read 2026-08-29
Where each sentence above came from
No plain explanation of what this changes is stored.
No recorded use is stored in reader language.
No statement of the main limit is recorded.
The four opening statements run to 26 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Formulation
A formulation is the exact made-up form a substance comes in.
A picture of it, and where the picture fails
It is like the difference between a whole bean and instant coffee.
Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.
What people get wrong. Two products with the same name are assumed to behave the same. They often do not.
The specific composition and physical form of a product, including salt, excipients and release profile.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 20 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer1 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
pain as measured by the visual analog scale
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
1 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Prevention of COVID-19
✗ The study did not show it
Who was studied
NCT03944447
How many people
200000
Study design
Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Change in sleep disturbance
✗ The study did not show it
Who was studied
NCT05511818
How many people
2679
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Change in sleep disturbance
✗ The study did not show it
Who was studied
NCT05552898
How many people
1750
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Change in energy
✗ The study did not show it
Who was studied
NCT05502328
How many people
1427
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Self-reported cannabis and tobacco smoking abstinence in the 7 days prior to the 6-months follow-up visit, validated by carbon monoxide (CO) in exhaled air
✗ The study did not show it
Who was studied
NCT06120855
How many people
1177
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Change from baseline in the MATRICS Cognitive Battery composite standardized score
✗ The study did not show it
Who was studied
NCT00439634
How many people
873
Study design
Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.1 registered measure of this kind. No reviewed result.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.1 registered measure of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.1 registered measure of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.2 registered measures of this kind.
□A number that stands in for healthNo evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.No registered study measures this.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Drosophila (fruit fly), Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
physician global impression of change questionnaire
pain as measured by the visual analog scale
Measured
Things only a test, a scale or a device shows.
No registered study measured anything of this kind.
Meaningful
Things that change how a life goes, not only a number.
functional independence measure
overall survival time
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (16)
incidence of adverse events as a measure of safety
pharmacokinetics/pharmacodynamics
primary pk endpoints
treatment emergent adverse events
tolerability
feasibility
incidence rates of adverse events
pharmacokinetic parameters of thc cmax auc and auc
pharmacokinetic parameters of cbd cmax auc and auc
pharmacokinetic parameters of cannabidiol cmax auc and auc
pharmacokinetic parameters of 7 hydroxy cbd cmax auc and auc
pharmacokinetic endpoints of the analyte thc
pharmacokinetic endpoints of the analyte 11 oh thc
pharmacokinetic endpoints of the analyte 11 cooh thc
pharmacokinetic endpoints of the analyte cannabidiol
incidence of treatment emergent adverse events
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
No description of who was studied is recorded.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
A different form was studied
The studied form is not the form on the shelf.
On this record: This record is linked to 2 related forms. Evidence does not carry across all of them.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (9)
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Varies by country
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No form or route is recorded.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing is recorded about product quality.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
NABIXIMOLS appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 4924 reaction mentions were counted. One report can name several reactions.
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
The exact form studied is not recorded.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
270 marketed supplement labels list this ingredient, classed as non-nutrient/non-botanical.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
7 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
How this medicine reached us — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (13)
Q1
What did NABIXIMOLS's largest trial (978 people) and its longest (5 years) measure?
978 people in NABIXIMOLS's largest registered study, 5 years in its longest registered window, measuring Overall survival time (OS). ClinicalTrials.gov · 2026-09-01
35 phase3, 15 phase1, 10 phase2, 4 na, 1 na or unstated, 1 phase4; NCT01337089; 2016-01-27. Last human test completed 2022, NCT04298554.
Interpretation These counts include studies where NABIXIMOLS was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase3
35
phase1
15
phase2
10
na
4
na or unstated
1
phase4
1
1 more recorded row
Last recorded human testNCT04298554
2022-05-29
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has NABIXIMOLS shown lifespan?
terminated; "This study was terminated based on a business decision by the Sponsor."
NCT04592159
withdrawn; "The decision to suspend this study was based upon evaluation of pandemic-related challenges impacting both clinical trial sites and potential participants. This suspension was initiated prior to site activation and participant recruitment."
NCT04984278
terminated; "The study was terminated based on a business decision by the Sponsor."
NCT05974293
withdrawn; "Funding was withdrawn."
recorded 2026-09-01 · last checked 2026-09-04
Q4
More NABIXIMOLS was worse in human: at what point?
U-shaped in human: "CBD diverged from other minor cannabinoids in directing a linear dose-response profile, whereas CBG and CBC directed sigmoidal profiles and CBN activated DRG neurons with an inverted U-shaped dose-response relationship." Europe PMC · dose-response search · 2026-04-24
5 recorded sentences naming NABIXIMOLS; U-shaped, dose-response
Show the evidence
U-shaped
PMID 42139799
"CBD diverged from other minor cannabinoids in directing a linear dose-response profile, whereas CBG and CBC directed sigmoidal profiles and CBN activated DRG neurons with an inverted U-shaped dose-response relationship."
PMID 42139799
"In contrast, CBN activated predominantly larger sensory neurons in an inverted U-shaped dose-response profile and was independent of TRPV1 and CB<sub>1</sub>R. A combination of minor cannabinoids is hypothesized to direct complementary antinociceptive activity."
"CBD diverged from other minor cannabinoids in directing a linear dose-response profile whereas CBG and CBC directed sigmoidal dose-response profiles and CBN activated DRG neurons with an inverted U-shaped dose-response relationship."
dose-response
PMID 42139799
"We queried whether calcium responses induced by the 4 cannabinoids differed in potency of activation, neuronal size preference, and dose-response relationships."
"We queried if calcium responses induced by the four cannabinoids differed in potency of activation, neuronal size preference, and dose-response relationships."
recorded 2026-04-24 · last checked 2026-09-04
Q5
Could one person measure NABIXIMOLS's effect on incidence of adverse events as a measure of safety?
Incidence of adverse events as a measure of safety: measured in NABIXIMOLS's trials.
Interpretation incidence of adverse events as a measure of safety is the recorded endpoint.
Show the evidence
biomarkers
incidence of adverse events as a measure of safety; 2026-09-01
pharmacokinetics/pharmacodynamics; 2026-09-01
primary pk endpoints; 2026-09-01
treatment emergent adverse events; 2026-09-01
tolerability; 2026-09-01
feasibility; 2026-09-01
14 more recorded rows
biomarkers
physician global impression of change questionnaire; 2026-09-01
biomarkers
incidence rates of adverse events; 2026-09-01
biomarkers
pharmacokinetic parameters of thc cmax auc and auc; 2026-09-01
biomarkers
pharmacokinetic parameters of cbd cmax auc and auc; 2026-09-01
biomarkers
pharmacokinetic parameters of cannabidiol cmax auc and auc; 2026-09-01
biomarkers
pharmacokinetic parameters of 7 hydroxy cbd cmax auc and auc; 2026-09-01
biomarkers
pharmacokinetic endpoints of the analyte thc; 2026-09-01
biomarkers
pharmacokinetic endpoints of the analyte 11 oh thc; 2026-09-01
biomarkers
pharmacokinetic endpoints of the analyte 11 cooh thc; 2026-09-01
biomarkers
pharmacokinetic endpoints of the analyte cannabidiol; 2026-09-01
biomarkers
functional independence measure; 2026-09-01
biomarkers
incidence of treatment emergent adverse events; 2026-09-01
biomarkers
pain as measured by the visual analog scale; 2026-09-01
biomarkers
overall survival time; 2026-09-01
human trials at or under30
21
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT01868048; PHASE3; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q6
Which of feasibility, functional independence measure and incidence of adverse events as a measure of safety did NABIXIMOLS's trials measure?
feasibility, functional independence measure and incidence of adverse events as a measure of safety lead 20 outcome terms across NABIXIMOLS's trials. ClinicalTrials.gov · 2026-09-01
Interpretation treatment emergent adverse events, tolerability, feasibility, physician global impression of change questionnaire, incidence rates of adverse events and pharmacokinetic parameters of thc cmax auc and auc follow.
Show the evidence
incidence of adverse events as a measure of safety
1
pharmacokinetics/pharmacodynamics
1
primary pk endpoints
1
treatment emergent adverse events
1
tolerability
1
feasibility
1
14 more recorded rows
physician global impression of change questionnaire
1
incidence rates of adverse events
1
pharmacokinetic parameters of thc cmax auc and auc
1
pharmacokinetic parameters of cbd cmax auc and auc
1
pharmacokinetic parameters of cannabidiol cmax auc and auc
1
pharmacokinetic parameters of 7 hydroxy cbd cmax auc and auc
1
pharmacokinetic endpoints of the analyte thc
1
pharmacokinetic endpoints of the analyte 11 oh thc
1
pharmacokinetic endpoints of the analyte 11 cooh thc
1
pharmacokinetic endpoints of the analyte cannabidiol
1
functional independence measure
1
incidence of treatment emergent adverse events
1
pain as measured by the visual analog scale
1
overall survival time
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
What will the one ongoing trial of NABIXIMOLS report, and when?
"ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids"; n 120; "Overall survival time (OS)"; 2027-04
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which running trial of NABIXIMOLS could settle lifespan?
NCT05629702 measures Overall survival time (OS), reading out 2027-04.
1 open trial; n 120; "ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids"
Show the evidence
TrialNCT05629702
"ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids"; n 120; "Overall survival time (OS)"; 2027-04
Q9
Which 19 trials of NABIXIMOLS posted no result?
Posted no result
19 of 19 completed trials
Registrations
NCT01322464, NCT01323569, NCT01037608, NCT00872144, NCT01538225 and NCT01887301, and 13 more
Completion dates
oldest 2008-02; newest 2022-05-29
Show the evidence
Trial
NCT01322464
2008-02
NCT01323569
2008-06
NCT01037608
2011-12-12
NCT00872144
2013-03
NCT01538225
2013-11
NCT01887301
2014-05
13 further recorded trials
NCT01893424
2015-01
NCT02073474
2015-01
NCT02325011
2015-02
NCT01776970
2015-12
NCT02249299
2015-12
NCT01812603
2016-06
NCT01812616
2016-06
NCT03201835
2016-06-06
NCT01898520
2017-03
NCT03186664
2018-06
NCT03936907
2019-07-18
NCT03087201
2020-11-20
NCT04298554
2022-05-29
Q10
At the median, NABIXIMOLS's trials enrolled 59.5 people — anything larger?
Median enrolment
59.5
Largest enrolment
978
Registered trials counted
62
Q11
What do 4924 spontaneous reports say about NABIXIMOLS — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
NABIXIMOLS appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 4924 reaction mentions were counted: seizure 1992; diarrhoea 622; somnolence 592; drug abuse 471. open-targets-adr · CHEMBL3833333 · 2026-06-24
Show the evidence
seizure
1992
diarrhoea
622
somnolence
592
drug abuse
471
product dose omission issue
254
drug dependence
208
4 more recorded rows
aggression
207
decreased appetite
207
weight increased
195
agitation
176
recorded 2026-06-24 · last checked 2026-09-04
Q12
Was NABIXIMOLS studied with exercise?
exercise is named in NABIXIMOLS's label sentences: "Published randomized controlled trials (RCTs) that reported a responder analysis of adults with chronic low back pain treated with any of the following 15 interventions: oral or topical nonsteroidal anti-inflammatory drugs (NSAIDs), exercise, acupuncture, spinal manipulation therapy, corticosteroid…" openfda-label+europepmc · 2021-01-01
1 recorded statement; exercise
Show the evidence
exercise
Published randomized controlled trials (RCTs) that reported a responder analysis of adults with chronic low back pain treated with any of the following 15 interventions: oral or topical nonsteroidal anti-inflammatory drugs (NSAIDs), exercise, acupuncture, spinal manipulation therapy, corticosteroid injections, acetaminophen, oral opioids, anticonvulsants, tricyclic antidepressants,…
recorded 2021-01-01 · last checked 2026-09-04
Q13
What is recorded about NABIXIMOLS and mTOR?
"Cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinol (THC), modulate key regulators like mTOR, AMPK, and Beclin-1, thereby influencing autophagic flux, inflammation, and apoptosis." — where NABIXIMOLS and mTOR appear together. Europe PMC · pathway abstract search · 2026-02-10
"Cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinol (THC), modulate key regulators like mTOR, AMPK, and Beclin-1, thereby influencing autophagic flux, inflammation, and apoptosis."
AMPKPMID 41516397
"Cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinol (THC), modulate key regulators like mTOR, AMPK, and Beclin-1, thereby influencing autophagic flux, inflammation, and apoptosis."
autophagyPMID 41516397
"Cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinol (THC), modulate key regulators like mTOR, AMPK, and Beclin-1, thereby influencing autophagic flux, inflammation, and apoptosis."
mTORPMID 41516397
"Experimental studies indicate that cannabinoids inhibit the PI3K/AKT/mTOR pathway, promote reactive oxygen species (ROS)-induced autophagy, and modulate cytokine secretion, mechanisms that underline their dual anti-inflammatory and anti-cancer capabilities."
autophagy
PMID 41516397
"Experimental studies indicate that cannabinoids inhibit the PI3K/AKT/mTOR pathway, promote reactive oxygen species (ROS)-induced autophagy, and modulate cytokine secretion, mechanisms that underline their dual anti-inflammatory and anti-cancer capabilities."
PMID 41679657
"Engagement of these receptors by cannabinoids can suppress proliferation, invasion, and induce morphological changes in GBM cells, also activating intrinsic autophagy pathways."
mTORPMID 34548620
"Mechanistically, cannabinoids imprint tolerogenicity in human DCs by inhibiting NF-κB, MAPK and mTOR signalling pathways while inducing AMPK and functional autophagy flux via CB1- and PPARα-mediated activation, which drives metabolic rewiring towards increased mitochondrial activity and oxidative phosphorylation."
AMPK
PMID 34548620
"Mechanistically, cannabinoids imprint tolerogenicity in human DCs by inhibiting NF-κB, MAPK and mTOR signalling pathways while inducing AMPK and functional autophagy flux via CB1- and PPARα-mediated activation, which drives metabolic rewiring towards increased mitochondrial activity and oxidative phosphorylation."
PMID 30610735
"In turn, emerging evidence suggests that the activation of AMPK by cannabinoids may mediate an anti-inflammatory effect through a range of processes."
recorded 2026-02-10 · last checked 2026-09-04
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