Caffeine (thermogenic)
Evidence: ★★★★☆ · Status: FDA Approved, OTC Supplement
In plain English
Nudges your body to release stored fat and burn slightly more energy. The base of nearly every fat-burner.
How it works
Adenosine antagonism raises catecholamines → cAMP → hormone-sensitive lipase, mobilising free fatty acids; modestly raises resting metabolic rate.
Molecular target & official sources
ADORA2A (NCBI Gene) · Caffeine (PubChem CID 2519)
Protocol
100–300 mg pre-training.
Bottom line
The only fat-burner ingredient that reliably works and is safe.
Helps with: Lose Fat · Hormones & Testosterone
Stacks with
Shares a pathway — often paired with: Caffeine, Semaglutide (Ozempic / Wegovy / Rybelsus), Tirzepatide (Mounjaro / Zepbound), PDE-5 Inhibitors (Sildenafil / Tadalafil).
Availability & where to buy
Available over the counter. Widely available OTC — e.g. iHerb (ships worldwide); in Singapore also Guardian, Watsons, GNC, Shopee / Lazada. Look for a third-party-tested / GMP mark and check the dose per serving.
How it works: the GPCR → cAMP pathway →
Compare Caffeine (thermogenic)
- Caffeine (thermogenic) vs Caffeine
- Caffeine (thermogenic) vs Semaglutide (Ozempic / Wegovy / Rybelsus)
- Caffeine (thermogenic) vs Tirzepatide (Mounjaro / Zepbound)
- Caffeine (thermogenic) vs Testosterone (TRT)
- Caffeine (thermogenic) vs Retatrutide
- Caffeine (thermogenic) vs Liraglutide (Saxenda / Victoza)
- Caffeine (thermogenic) vs Ephedrine (EC/ECA stack)
Common questions
Does Caffeine (thermogenic) actually work?
Human-evidence rating: 4 of 5. The only fat-burner ingredient that reliably works and is safe.
How do you take Caffeine (thermogenic)?
100–300 mg pre-training.
Is Caffeine (thermogenic) legal or approved?
Regulatory status: FDA Approved, OTC Supplement.