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Public dataset

Recorded enzyme and transporter findings by polarity

Inspect every admitted source sentence for an exact medicine, enzyme or transporter, and recorded role, with assertions, denials, and unresolved polarity counted separately.

What this does not mean: This is not a drug interaction checker. A denial applies only to the named medicine, role, counterparty, conditions, and source sentence; it is not proof of no interaction and is not dosing or treatment advice.
Public rows
8,404
Generated
Schema version
1.3.0

Coverage

What this run contains

Medicine–counterparty–role groups
8,404
Source sentence records
20,358
Asserted sentences
4,700
Denied sentences
7,494
Polarity not recorded
8,164
Medicines represented
755
Counterparties represented
36
Corpus records considered
9,855
All corpus records were checked; a record without a documented counterparty cannot produce a row in this projection.
inducer groups
617
inhibitor groups
3,131
not_recorded groups
3,074
substrate groups
1,582

Method

How the rows were made

  1. A deterministic parser reads recorded FDA-label excerpts for named enzymes and transporters.
  2. A mention is admitted only when the stored excerpt contains the recorded counterparty, allowing letter-case differences only.
  3. Every admitted mention is grouped by exact medicine slug, recorded counterparty spelling, and exact role. A missing role remains NOT_RECORDED rather than being assigned to another group.
  4. Each sentence carries the exact source version and effective date when recorded; the API serializes null and the page says not recorded when either is absent.
  5. The API paginates groups. Within each returned group, sentences is the complete untruncated list used by the three polarity counts.

Limits

Read these before using a row

  • A recorded role is a mechanistic statement copied from a descriptive label section. It is not a clinical interaction, and nothing in this dataset describes what happens when a person is exposed to two medicines at once.
  • This dataset holds no relation between one medicine and another. Counts are per counterparty; the medicines naming a counterparty are listed with their sentences and are never paired, ranked against each other or compared.
  • ICH M12 states that no potency classification system exists for transporters or for non-CYP enzymes, so no strong, moderate or weak vocabulary is applied to any counterparty here. The tallies count records, not strength.
  • A counterparty with a high count is one that labels document often. Documentation frequency is not importance: US labelling asks for some enzymes to be characterised far more routinely than others, and that requirement is part of what these counts measure.
  • 40.1% of admitted mentions carry no role. The sentence named more than one role and the parser left the question open rather than attaching a guess, so a role tally is a count of sentences that settled the question, not of medicines for which it is settled.
  • Recorded spellings are counted separately and never merged. P-GP, PGP and P-GLYCOPROTEIN are three entries in this dataset because they are three strings in the corpus; whether they name one thing is a question for a person, and prefix relationships are reported as questions rather than resolved.
  • 9088 of 9855 records name no enzyme or transporter at all. That is an absence of recorded text in the sources fetched for those records. It is neither reassurance nor alarm about the medicines concerned.
  • 20358 of 20358 admitted mentions come from records the deterministic label parser produced, where no person chose the value or wrote its measurement context. The sentence is stored with each one so a reader can check it.
  • The uniform reference for concentration allocates the same 20358 mentions over the same 36 counterparties by chance. Labels are not written that way, so the reference shows only that the observed spread is not a consequence of how many mentions there are.
  • The public rows enumerate documentation about one medicine and one named counterparty. They never create medicine-to-medicine pairs and cannot answer whether two medicines interact.
  • A NOT_RECORDED role or polarity remains unresolved. It is never folded into an assertion or a denial.
  • Each returned group includes every admitted source sentence for checking, but the full source document remains authoritative.

Provenance

Source examples

Abacavir · CYP3A4 inhibitor

2 asserted · 2 denied · 0 polarity not recorded

FDA_LABEL:5676d391-f9a4-44be-9604-954b3d8d0e2b (opens source in a new tab)
In vitro experiments reveal that abacavir does not inhibit human CYP3A4, CYP2D6, or CYP2C9 activity at clinically relevant concentrations.

Abacavir · BCRP substrate

0 asserted · 4 denied · 0 polarity not recorded

FDA_LABEL:5676d391-f9a4-44be-9604-954b3d8d0e2b (opens source in a new tab)
Based on in vitro study results, abacavir at therapeutic drug exposures is not expected to affect the pharmacokinetics of drugs that are substrates of the following transporters: organic anion transporter polypeptide (OATP)1B1/3, breast cancer resistance protein (BCRP) or P-glycoprotein (P-gp), organic cation transporter (OCT)1, OCT2, or multidrug and toxic extrusion protein (MATE)1 and MATE2-K.

Abacavir · CYP2C9 not_recorded

0 asserted · 0 denied · 2 polarity not recorded

FDA_LABEL:5676d391-f9a4-44be-9604-954b3d8d0e2b (opens source in a new tab)
Abacavir did not inhibit or induce other CYP enzymes (such as CYP2C9, or CYP2D6).

Artifact used for this view: data/agents/current/enzyme-and-transporter-documentation.json. The reader resolves the current run first and uses the checked-in compatibility run only when a current artifact is absent.

Schema

Fields in the public projection

FieldTypeMeaning
medicineSlugstringStable RNAWiki medicine route key.
medicineNamestringRecorded medicine name; not normalized for display style.
counterpartystringThe exact recorded counterparty spelling.
rolestringSUBSTRATE, INHIBITOR, INDUCER, or NOT_RECORDED when the sentence did not settle one role.
assertedCountnumberSentence records whose polarity is ASSERTED.
deniedCountnumberSentence records whose polarity is NEGATED.
polarityNotRecordedCountnumberSentence records for which the parser did not settle assertion or denial.
sentencessentence[]Every admitted sentence for this group, with polarity, section, source identity, source version/effective date or explicit absence, retrieval date, and exact excerpt. The list is not truncated.

Reader

Search and filter the rows

Case-insensitive text search over the public fields named for this dataset.

Exact recorded role.

Exact recorded counterparty spelling.

Clear

Showing 251–260 of 8,404 matching rows. Filters and search terms remain attached when you move between pages or open the API view.

  1. Projected row 251

    Medicine slug
    ambrisentan
    Medicine name
    Ambrisentan
    Enzyme or transporter
    P-GP
    Role
    NOT_RECORDED
    Asserted sentences
    0
    Denied sentences
    0
    Polarity not recorded
    2
    Complete sentence records
    1. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:32549c43-f8ff-422c-b42d-ca0877e661cf (opens source in a new tab)

      Ambrisentan label

      Version not recorded · Effective date not recorded

      Ambrisentan demonstrated weak dose-dependent inhibition of OATP1B1, OATP1B3, and NTCP (IC 50 of 47 μM, 45 μM, and approximately 100 μM, respectively) and no transporter-specific inhibition of BSEP, BRCP, P-gp, or MRP2.
    2. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:32549c43-f8ff-422c-b42d-ca0877e661cf (opens source in a new tab)

      Ambrisentan label

      Version not recorded · Effective date not recorded

      Ambrisentan demonstrated weak dose-dependent inhibition of OATP1B1, OATP1B3, and NTCP (IC 50 of 47 μM, 45 μM, and approximately 100 μM, respectively) and no transporter-specific inhibition of BSEP, BRCP, P-gp, or MRP2.

  2. Projected row 252

    Medicine slug
    ambrisentan
    Medicine name
    Ambrisentan
    Enzyme or transporter
    P-GP
    Role
    SUBSTRATE
    Asserted sentences
    4
    Denied sentences
    0
    Polarity not recorded
    0
    Complete sentence records
    1. ASSERTEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:32549c43-f8ff-422c-b42d-ca0877e661cf (opens source in a new tab)

      Ambrisentan label

      Version not recorded · Effective date not recorded

      In vitro studies indicate that ambrisentan is a substrate of P-gp.
    2. ASSERTEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:32549c43-f8ff-422c-b42d-ca0877e661cf (opens source in a new tab)

      Ambrisentan label

      Version not recorded · Effective date not recorded

      In vitro studies suggest that ambrisentan is a substrate of the Organic Anion Transporting Polypeptides OATP1B1 and OATP1B3, and P-glycoprotein (P-gp).
    3. ASSERTEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:32549c43-f8ff-422c-b42d-ca0877e661cf (opens source in a new tab)

      Ambrisentan label

      Version not recorded · Effective date not recorded

      In vitro studies indicate that ambrisentan is a substrate of P-gp.
    4. ASSERTEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:32549c43-f8ff-422c-b42d-ca0877e661cf (opens source in a new tab)

      Ambrisentan label

      Version not recorded · Effective date not recorded

      In vitro studies suggest that ambrisentan is a substrate of the Organic Anion Transporting Polypeptides OATP1B1 and OATP1B3, and P-glycoprotein (P-gp).

  3. Projected row 253

    Medicine slug
    amiodarone
    Medicine name
    Amiodarone
    Enzyme or transporter
    CYP2C8
    Role
    NOT_RECORDED
    Asserted sentences
    0
    Denied sentences
    0
    Polarity not recorded
    2
    Complete sentence records
    1. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:e9108958-b8d7-4fba-87c3-9a32990de551 (opens source in a new tab)

      Amiodarone label

      Version not recorded · Effective date not recorded

      Amiodarone is metabolized to DEA by the cytochrome P450 (CYP450) enzyme group, specifically cytochrome P4503A (CYP3A) and CYP2C8.
    2. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:e9108958-b8d7-4fba-87c3-9a32990de551 (opens source in a new tab)

      Amiodarone label

      Version not recorded · Effective date not recorded

      Amiodarone is metabolized to DEA by the cytochrome P450 (CYP450) enzyme group, specifically cytochrome P4503A (CYP3A) and CYP2C8.

  4. Projected row 254

    Medicine slug
    amiodarone
    Medicine name
    Amiodarone
    Enzyme or transporter
    CYP2D6
    Role
    INHIBITOR
    Asserted sentences
    2
    Denied sentences
    0
    Polarity not recorded
    0
    Complete sentence records
    1. ASSERTEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:e9108958-b8d7-4fba-87c3-9a32990de551 (opens source in a new tab)

      Amiodarone label

      Version not recorded · Effective date not recorded

      Amiodarone inhibits CYP2D6.Chronic (> 2 weeks) oral amiodarone administration impairs metabolism of dextromethorphan can lead to increased serum concentrations.
    2. ASSERTEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:e9108958-b8d7-4fba-87c3-9a32990de551 (opens source in a new tab)

      Amiodarone label

      Version not recorded · Effective date not recorded

      Amiodarone inhibits CYP2D6.Chronic (> 2 weeks) oral amiodarone administration impairs metabolism of dextromethorphan can lead to increased serum concentrations.

  5. Projected row 255

    Medicine slug
    amiodarone
    Medicine name
    Amiodarone
    Enzyme or transporter
    CYP2D6
    Role
    SUBSTRATE
    Asserted sentences
    2
    Denied sentences
    0
    Polarity not recorded
    0
    Complete sentence records
    1. ASSERTEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:e9108958-b8d7-4fba-87c3-9a32990de551 (opens source in a new tab)

      Amiodarone label

      Version not recorded · Effective date not recorded

      Dextromethorphan is a substrate for both CYP2D6 and CYP3A.
    2. ASSERTEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:e9108958-b8d7-4fba-87c3-9a32990de551 (opens source in a new tab)

      Amiodarone label

      Version not recorded · Effective date not recorded

      Dextromethorphan is a substrate for both CYP2D6 and CYP3A.

  6. Projected row 256

    Medicine slug
    amisulpride
    Medicine name
    Amisulpride
    Enzyme or transporter
    BCRP
    Role
    INHIBITOR
    Asserted sentences
    0
    Denied sentences
    2
    Polarity not recorded
    0
    Complete sentence records
    1. NEGATEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:ab23bc6e-b6a8-165f-e053-2a95a90ab144 (opens source in a new tab)

      Amisulpride label

      Version not recorded · Effective date not recorded

      Amisulpride does not inhibit P-gp, BCRP, OCT1, OCT2, OAT1, OAT3, OATP1B1, OATP1B3 at therapeutic concentrations.
    2. NEGATEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:ab23bc6e-b6a8-165f-e053-2a95a90ab144 (opens source in a new tab)

      Amisulpride label

      Version not recorded · Effective date not recorded

      Amisulpride does not inhibit P-gp, BCRP, OCT1, OCT2, OAT1, OAT3, OATP1B1, OATP1B3 at therapeutic concentrations.

  7. Projected row 257

    Medicine slug
    amisulpride
    Medicine name
    Amisulpride
    Enzyme or transporter
    BCRP
    Role
    NOT_RECORDED
    Asserted sentences
    0
    Denied sentences
    0
    Polarity not recorded
    2
    Complete sentence records
    1. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:ab23bc6e-b6a8-165f-e053-2a95a90ab144 (opens source in a new tab)

      Amisulpride label

      Version not recorded · Effective date not recorded

      Amisulpride is a substrate for P-gp, BCRP, OCT1, MATE1 and MATE2-K, but not a substrate for OATP1B1, OATP1B3, OAT1, OAT3 and OCT2.
    2. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:ab23bc6e-b6a8-165f-e053-2a95a90ab144 (opens source in a new tab)

      Amisulpride label

      Version not recorded · Effective date not recorded

      Amisulpride is a substrate for P-gp, BCRP, OCT1, MATE1 and MATE2-K, but not a substrate for OATP1B1, OATP1B3, OAT1, OAT3 and OCT2.

  8. Projected row 258

    Medicine slug
    amisulpride
    Medicine name
    Amisulpride
    Enzyme or transporter
    CYP1A2
    Role
    NOT_RECORDED
    Asserted sentences
    0
    Denied sentences
    0
    Polarity not recorded
    2
    Complete sentence records
    1. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:ab23bc6e-b6a8-165f-e053-2a95a90ab144 (opens source in a new tab)

      Amisulpride label

      Version not recorded · Effective date not recorded

      In Vitro Studies Cytochrome P450-Related Metabolism In vitro , amisulpride did not inhibit CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, or CYP3A4, or induce CYP1A2, CYP2C9, CYP2C19, or CYP3A4.
    2. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:ab23bc6e-b6a8-165f-e053-2a95a90ab144 (opens source in a new tab)

      Amisulpride label

      Version not recorded · Effective date not recorded

      In Vitro Studies Cytochrome P450-Related Metabolism In vitro , amisulpride did not inhibit CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, or CYP3A4, or induce CYP1A2, CYP2C9, CYP2C19, or CYP3A4.

  9. Projected row 259

    Medicine slug
    amisulpride
    Medicine name
    Amisulpride
    Enzyme or transporter
    CYP1A2
    Role
    SUBSTRATE
    Asserted sentences
    0
    Denied sentences
    2
    Polarity not recorded
    0
    Complete sentence records
    1. NEGATEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:ab23bc6e-b6a8-165f-e053-2a95a90ab144 (opens source in a new tab)

      Amisulpride label

      Version not recorded · Effective date not recorded

      In vitro , amisulpride was not a substrate of CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4.
    2. NEGATEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:ab23bc6e-b6a8-165f-e053-2a95a90ab144 (opens source in a new tab)

      Amisulpride label

      Version not recorded · Effective date not recorded

      In vitro , amisulpride was not a substrate of CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4.

  10. Projected row 260

    Medicine slug
    amisulpride
    Medicine name
    Amisulpride
    Enzyme or transporter
    CYP2A6
    Role
    NOT_RECORDED
    Asserted sentences
    0
    Denied sentences
    0
    Polarity not recorded
    2
    Complete sentence records
    1. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:ab23bc6e-b6a8-165f-e053-2a95a90ab144 (opens source in a new tab)

      Amisulpride label

      Version not recorded · Effective date not recorded

      In Vitro Studies Cytochrome P450-Related Metabolism In vitro , amisulpride did not inhibit CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, or CYP3A4, or induce CYP1A2, CYP2C9, CYP2C19, or CYP3A4.
    2. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:ab23bc6e-b6a8-165f-e053-2a95a90ab144 (opens source in a new tab)

      Amisulpride label

      Version not recorded · Effective date not recorded

      In Vitro Studies Cytochrome P450-Related Metabolism In vitro , amisulpride did not inhibit CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, or CYP3A4, or induce CYP1A2, CYP2C9, CYP2C19, or CYP3A4.

Access

Query or download the projection

View this filtered page as JSONDownload up to 200 filtered CSV rows
GET /api/datasets/enzyme-transporter-negatives?limit=10&offset=250

Allowed query parameters

q
Case-insensitive text search over the public fields named for this dataset.
role
Exact recorded role.Values: INDUCER, INHIBITOR, NOT_RECORDED, SUBSTRATE
counterparty
Exact recorded counterparty spelling.
limit / offset
Pagination is required. limit is at most 200; offset is bounded. Set format=csv for the same projected page as a download.

Reuse and corrections

Keep the boundary attached

CC BY 4.0 applies to RNAWiki licenses its selection, schema, structure, and derived projection. Quoted source passages and third-party records retain their original rights.

Cite RNAWiki, this dataset identifier, and the generated date. Keep the “does not mean” statement with any downstream display so a corpus measurement is not mistaken for medical advice.

Read the correction policy