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Public dataset

Recorded enzyme and transporter findings by polarity

Inspect every admitted source sentence for an exact medicine, enzyme or transporter, and recorded role, with assertions, denials, and unresolved polarity counted separately.

What this does not mean: This is not a drug interaction checker. A denial applies only to the named medicine, role, counterparty, conditions, and source sentence; it is not proof of no interaction and is not dosing or treatment advice.
Public rows
8,404
Generated
Schema version
1.3.0

Coverage

What this run contains

Medicine–counterparty–role groups
8,404
Source sentence records
20,358
Asserted sentences
4,700
Denied sentences
7,494
Polarity not recorded
8,164
Medicines represented
755
Counterparties represented
36
Corpus records considered
9,855
All corpus records were checked; a record without a documented counterparty cannot produce a row in this projection.
inducer groups
617
inhibitor groups
3,131
not_recorded groups
3,074
substrate groups
1,582

Method

How the rows were made

  1. A deterministic parser reads recorded FDA-label excerpts for named enzymes and transporters.
  2. A mention is admitted only when the stored excerpt contains the recorded counterparty, allowing letter-case differences only.
  3. Every admitted mention is grouped by exact medicine slug, recorded counterparty spelling, and exact role. A missing role remains NOT_RECORDED rather than being assigned to another group.
  4. Each sentence carries the exact source version and effective date when recorded; the API serializes null and the page says not recorded when either is absent.
  5. The API paginates groups. Within each returned group, sentences is the complete untruncated list used by the three polarity counts.

Limits

Read these before using a row

  • A recorded role is a mechanistic statement copied from a descriptive label section. It is not a clinical interaction, and nothing in this dataset describes what happens when a person is exposed to two medicines at once.
  • This dataset holds no relation between one medicine and another. Counts are per counterparty; the medicines naming a counterparty are listed with their sentences and are never paired, ranked against each other or compared.
  • ICH M12 states that no potency classification system exists for transporters or for non-CYP enzymes, so no strong, moderate or weak vocabulary is applied to any counterparty here. The tallies count records, not strength.
  • A counterparty with a high count is one that labels document often. Documentation frequency is not importance: US labelling asks for some enzymes to be characterised far more routinely than others, and that requirement is part of what these counts measure.
  • 40.1% of admitted mentions carry no role. The sentence named more than one role and the parser left the question open rather than attaching a guess, so a role tally is a count of sentences that settled the question, not of medicines for which it is settled.
  • Recorded spellings are counted separately and never merged. P-GP, PGP and P-GLYCOPROTEIN are three entries in this dataset because they are three strings in the corpus; whether they name one thing is a question for a person, and prefix relationships are reported as questions rather than resolved.
  • 9088 of 9855 records name no enzyme or transporter at all. That is an absence of recorded text in the sources fetched for those records. It is neither reassurance nor alarm about the medicines concerned.
  • 20358 of 20358 admitted mentions come from records the deterministic label parser produced, where no person chose the value or wrote its measurement context. The sentence is stored with each one so a reader can check it.
  • The uniform reference for concentration allocates the same 20358 mentions over the same 36 counterparties by chance. Labels are not written that way, so the reference shows only that the observed spread is not a consequence of how many mentions there are.
  • The public rows enumerate documentation about one medicine and one named counterparty. They never create medicine-to-medicine pairs and cannot answer whether two medicines interact.
  • A NOT_RECORDED role or polarity remains unresolved. It is never folded into an assertion or a denial.
  • Each returned group includes every admitted source sentence for checking, but the full source document remains authoritative.

Provenance

Source examples

Abacavir · CYP3A4 inhibitor

2 asserted · 2 denied · 0 polarity not recorded

FDA_LABEL:5676d391-f9a4-44be-9604-954b3d8d0e2b (opens source in a new tab)
In vitro experiments reveal that abacavir does not inhibit human CYP3A4, CYP2D6, or CYP2C9 activity at clinically relevant concentrations.

Abacavir · BCRP substrate

0 asserted · 4 denied · 0 polarity not recorded

FDA_LABEL:5676d391-f9a4-44be-9604-954b3d8d0e2b (opens source in a new tab)
Based on in vitro study results, abacavir at therapeutic drug exposures is not expected to affect the pharmacokinetics of drugs that are substrates of the following transporters: organic anion transporter polypeptide (OATP)1B1/3, breast cancer resistance protein (BCRP) or P-glycoprotein (P-gp), organic cation transporter (OCT)1, OCT2, or multidrug and toxic extrusion protein (MATE)1 and MATE2-K.

Abacavir · CYP2C9 not_recorded

0 asserted · 0 denied · 2 polarity not recorded

FDA_LABEL:5676d391-f9a4-44be-9604-954b3d8d0e2b (opens source in a new tab)
Abacavir did not inhibit or induce other CYP enzymes (such as CYP2C9, or CYP2D6).

Artifact used for this view: data/agents/current/enzyme-and-transporter-documentation.json. The reader resolves the current run first and uses the checked-in compatibility run only when a current artifact is absent.

Schema

Fields in the public projection

FieldTypeMeaning
medicineSlugstringStable RNAWiki medicine route key.
medicineNamestringRecorded medicine name; not normalized for display style.
counterpartystringThe exact recorded counterparty spelling.
rolestringSUBSTRATE, INHIBITOR, INDUCER, or NOT_RECORDED when the sentence did not settle one role.
assertedCountnumberSentence records whose polarity is ASSERTED.
deniedCountnumberSentence records whose polarity is NEGATED.
polarityNotRecordedCountnumberSentence records for which the parser did not settle assertion or denial.
sentencessentence[]Every admitted sentence for this group, with polarity, section, source identity, source version/effective date or explicit absence, retrieval date, and exact excerpt. The list is not truncated.

Reader

Search and filter the rows

Case-insensitive text search over the public fields named for this dataset.

Exact recorded role.

Exact recorded counterparty spelling.

Clear

Showing 2,021–2,030 of 8,404 matching rows. Filters and search terms remain attached when you move between pages or open the API view.

  1. Projected row 2021

    Medicine slug
    deutetrabenazine
    Medicine name
    Deutetrabenazine
    Enzyme or transporter
    CYP2D6
    Role
    INHIBITOR
    Asserted sentences
    2
    Denied sentences
    2
    Polarity not recorded
    0
    Complete sentence records
    1. ASSERTEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      The effect of CYP2D6 inhibition on the pharmacokinetics of deutetrabenazine and its metabolites was studied in 24 healthy subjects following a single 22.5 mg dose of deutetrabenazine given after 8 days of administration of the strong CYP2D6 inhibitor paroxetine 20 mg daily.
    2. ASSERTEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      The effect of CYP2D6 inhibition on the pharmacokinetics of deutetrabenazine and its metabolites was studied in 24 healthy subjects following a single 22.5 mg dose of deutetrabenazine given after 8 days of administration of the strong CYP2D6 inhibitor paroxetine 20 mg daily.
    3. NEGATEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      The effect of moderate or weak CYP2D6 inhibitors such as duloxetine, terbinafine, amiodarone, or sertraline on the exposure of deutetrabenazine and its metabolites has not been evaluated.
    4. NEGATEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      The effect of moderate or weak CYP2D6 inhibitors such as duloxetine, terbinafine, amiodarone, or sertraline on the exposure of deutetrabenazine and its metabolites has not been evaluated.

  2. Projected row 2022

    Medicine slug
    deutetrabenazine
    Medicine name
    Deutetrabenazine
    Enzyme or transporter
    CYP2D6
    Role
    NOT_RECORDED
    Asserted sentences
    0
    Denied sentences
    0
    Polarity not recorded
    9
    Complete sentence records
    1. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      The clearance values (CL/F) of the α-HTBZ, and β-HTBZ metabolites of AUSTEDO are approximately 65 L/hour and 200 L/hour, respectively, for a 70 kg HD or TD patient with functional CYP2D6 metabolism in the fed state.
    2. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Metabolism In vitro experiments in human liver microsomes demonstrate that deutetrabenazine is extensively biotransformed, mainly by carbonyl reductase, to its major active metabolites, α-HTBZ and β-HTBZ, which are subsequently metabolized primarily by CYP2D6, with minor contributions of CYP1A2 and CYP3A4/5, to form several minor metabolites.
    3. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Drug Interaction Studies Effect of Other Drugs on AUSTEDO/AUSTEDO XR CYP2D6 Inhibitors In vitro studies indicate that the α-HTBZ and β-HTBZ metabolites of deutetrabenazine are substrates for CYP2D6.
    4. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Effect of AUSTEDO/AUSTEDO XR on Other Drugs CYP Enzymes In vitro studies showed that at clinically relevant concentrations, deutetrabenazine, and its active metabolites did not inhibit CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 enzymes, and did not induce CYP1A2, CYP2B6, and CYP3A4 enzymes.
    5. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      An exposure-response analysis on QTc prolongation from a study in extensive or intermediate (EM) and poor CYP2D6 metabolizers (PM) showed that a clinically-relevant effect can be excluded at exposures following single doses of 24 and 48 mg of AUSTEDO.
    6. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      The clearance values (CL/F) of the α-HTBZ, and β-HTBZ metabolites of AUSTEDO are approximately 65 L/hour and 200 L/hour, respectively, for a 70 kg HD or TD patient with functional CYP2D6 metabolism in the fed state.
    7. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Metabolism In vitro experiments in human liver microsomes demonstrate that deutetrabenazine is extensively biotransformed, mainly by carbonyl reductase, to its major active metabolites, α-HTBZ and β-HTBZ, which are subsequently metabolized primarily by CYP2D6, with minor contributions of CYP1A2 and CYP3A4/5, to form several minor metabolites.
    8. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Drug Interaction Studies Effect of Other Drugs on AUSTEDO/AUSTEDO XR CYP2D6 Inhibitors In vitro studies indicate that the α-HTBZ and β-HTBZ metabolites of deutetrabenazine are substrates for CYP2D6.
    9. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Effect of AUSTEDO/AUSTEDO XR on Other Drugs CYP Enzymes In vitro studies showed that at clinically relevant concentrations, deutetrabenazine, and its active metabolites did not inhibit CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 enzymes, and did not induce CYP1A2, CYP2B6, and CYP3A4 enzymes.

  3. Projected row 2023

    Medicine slug
    deutetrabenazine
    Medicine name
    Deutetrabenazine
    Enzyme or transporter
    CYP3A4
    Role
    NOT_RECORDED
    Asserted sentences
    0
    Denied sentences
    0
    Polarity not recorded
    4
    Complete sentence records
    1. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Metabolism In vitro experiments in human liver microsomes demonstrate that deutetrabenazine is extensively biotransformed, mainly by carbonyl reductase, to its major active metabolites, α-HTBZ and β-HTBZ, which are subsequently metabolized primarily by CYP2D6, with minor contributions of CYP1A2 and CYP3A4/5, to form several minor metabolites.
    2. NOT_RECORDEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Effect of AUSTEDO/AUSTEDO XR on Other Drugs CYP Enzymes In vitro studies showed that at clinically relevant concentrations, deutetrabenazine, and its active metabolites did not inhibit CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 enzymes, and did not induce CYP1A2, CYP2B6, and CYP3A4 enzymes.
    3. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Metabolism In vitro experiments in human liver microsomes demonstrate that deutetrabenazine is extensively biotransformed, mainly by carbonyl reductase, to its major active metabolites, α-HTBZ and β-HTBZ, which are subsequently metabolized primarily by CYP2D6, with minor contributions of CYP1A2 and CYP3A4/5, to form several minor metabolites.
    4. NOT_RECORDEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Effect of AUSTEDO/AUSTEDO XR on Other Drugs CYP Enzymes In vitro studies showed that at clinically relevant concentrations, deutetrabenazine, and its active metabolites did not inhibit CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 enzymes, and did not induce CYP1A2, CYP2B6, and CYP3A4 enzymes.

  4. Projected row 2024

    Medicine slug
    deutetrabenazine
    Medicine name
    Deutetrabenazine
    Enzyme or transporter
    MATE1
    Role
    INHIBITOR
    Asserted sentences
    0
    Denied sentences
    2
    Polarity not recorded
    0
    Complete sentence records
    1. NEGATEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.
    2. NEGATEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.

  5. Projected row 2025

    Medicine slug
    deutetrabenazine
    Medicine name
    Deutetrabenazine
    Enzyme or transporter
    MATE2
    Role
    INHIBITOR
    Asserted sentences
    0
    Denied sentences
    2
    Polarity not recorded
    0
    Complete sentence records
    1. NEGATEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.
    2. NEGATEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.

  6. Projected row 2026

    Medicine slug
    deutetrabenazine
    Medicine name
    Deutetrabenazine
    Enzyme or transporter
    OAT1
    Role
    INHIBITOR
    Asserted sentences
    0
    Denied sentences
    2
    Polarity not recorded
    0
    Complete sentence records
    1. NEGATEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.
    2. NEGATEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.

  7. Projected row 2027

    Medicine slug
    deutetrabenazine
    Medicine name
    Deutetrabenazine
    Enzyme or transporter
    OAT3
    Role
    INHIBITOR
    Asserted sentences
    0
    Denied sentences
    2
    Polarity not recorded
    0
    Complete sentence records
    1. NEGATEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.
    2. NEGATEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.

  8. Projected row 2028

    Medicine slug
    deutetrabenazine
    Medicine name
    Deutetrabenazine
    Enzyme or transporter
    OATP1B1
    Role
    INHIBITOR
    Asserted sentences
    0
    Denied sentences
    2
    Polarity not recorded
    0
    Complete sentence records
    1. NEGATEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.
    2. NEGATEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.

  9. Projected row 2029

    Medicine slug
    deutetrabenazine
    Medicine name
    Deutetrabenazine
    Enzyme or transporter
    OATP1B1
    Role
    SUBSTRATE
    Asserted sentences
    2
    Denied sentences
    0
    Polarity not recorded
    0
    Complete sentence records
    1. ASSERTEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Deutetrabenazine and its active metabolites are unlikely substrates of OATP1B1, OATP1B3, and OCT1.
    2. ASSERTEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Deutetrabenazine and its active metabolites are unlikely substrates of OATP1B1, OATP1B3, and OCT1.

  10. Projected row 2030

    Medicine slug
    deutetrabenazine
    Medicine name
    Deutetrabenazine
    Enzyme or transporter
    OATP1B3
    Role
    INHIBITOR
    Asserted sentences
    0
    Denied sentences
    2
    Polarity not recorded
    0
    Complete sentence records
    1. NEGATEDpharmacokineticsRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.
    2. NEGATEDclinical_pharmacologyRetrieved 2026-08-30
      FDA_LABEL:7ea3c60a-45c7-44cc-afc2-d87fa53993c0 (opens source in a new tab)

      Deutetrabenazine label

      Version not recorded · Effective date not recorded

      Transporters In vitro studies demonstrated that at clinically relevant concentrations, deutetrabenazine and its active metabolites did not inhibit the following transporters: P-gp, BCRP, BSEP, MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, and OCT2.

Access

Query or download the projection

View this filtered page as JSONDownload up to 200 filtered CSV rows
GET /api/datasets/enzyme-transporter-negatives?limit=10&offset=2020

Allowed query parameters

q
Case-insensitive text search over the public fields named for this dataset.
role
Exact recorded role.Values: INDUCER, INHIBITOR, NOT_RECORDED, SUBSTRATE
counterparty
Exact recorded counterparty spelling.
limit / offset
Pagination is required. limit is at most 200; offset is bounded. Set format=csv for the same projected page as a download.

Reuse and corrections

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CC BY 4.0 applies to RNAWiki licenses its selection, schema, structure, and derived projection. Quoted source passages and third-party records retain their original rights.

Cite RNAWiki, this dataset identifier, and the generated date. Keep the “does not mean” statement with any downstream display so a corpus measurement is not mistaken for medical advice.

Read the correction policy