This page shows what was measured, who it was measured in, and what that does not settle.
What Zinc Gluconate does in the body
▪ may help reduce duration of cold symptoms: ▪ sore throat ▪ stuffy nose ▪ sneezing ▪ coughing This product was formulated to help reduce the duration and severity of cold symptoms and was not formulated to be effective for flu or allergies.
Why people take it. ▪ may help reduce duration of cold symptoms: ▪ sore throat ▪ stuffy nose ▪ sneezing ▪ coughing This product was formulated to help reduce the duration and severity of cold symptoms and was not formulated to be effective for flu or allergies.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · U6WSN5SQ1Z · read 2026-08-29
The supplement label database classes it as mineral, under the name Zinc.
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 89 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Focus
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Focus
cognitive development
Blood sugar
acute insulin response from ivgtt
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
— Not recorded
Harms were not a registered measure for this goal.
… Waiting for a reviewer
Who was studied is listed further down the page.
△ Only a number moved
1 registered test measure.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Number of home fortification sachets consumed
✗ The study did not show it
Who was studied
NCT02593136
How many people
11861
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
ClinicalTrials.gov · a recorded source, not a stored snapshot
- To measure the impact of zinc and vitamin A on the duration of diarrheal illness
✗ The study did not show it
Who was studied
NCT00272116
How many people
2482
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
ClinicalTrials.gov · a recorded source, not a stored snapshot
a) All cause mortality during zinc supplementation over 4 weeks to 6 months of age b) Rate of severe illness requiring hospitalization
✗ The study did not show it
Who was studied
NCT00495690
How many people
2012
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
ClinicalTrials.gov · a recorded source, not a stored snapshot
Morbidity
✗ The study did not show it
Who was studied
NCT00980733
How many people
1325
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
ClinicalTrials.gov · a recorded source, not a stored snapshot
Serum ceruloplasmin
✗ The study did not show it
Who was studied
NCT03957720
How many people
400
Study design
Early phase 1
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
ClinicalTrials.gov · a recorded source, not a stored snapshot
Stool output (g/kg/24h)
✗ The study did not show it
Who was studied
NCT00370968
How many people
352
Study design
Phase 2/Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
ClinicalTrials.gov · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
□Symptoms and quality of lifeNo evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.No registered study measures this.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.2 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Yeast, C. elegans (roundworm), Drosophila (fruit fly), Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
No registered study measured anything of this kind.
Measured
Things only a test, a scale or a device shows.
lumbar spine bone mineral density by dxa
acute insulin response from ivgtt
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (38)
progression of age related macular degeneration
progression of lens opacity
infant maize/zn supplementation trial
linear growth velocity
zn homeostasis studies
m at 1 5 months
duration of illness
treatment failure
risk of treatment failure
adverse effects
immune failure
duration of severe symptoms
adverse events and serious adverse events
reduction in duration of diarrhoea
reeudction in total stool volume
incidence of acute lower respiratory infection
growth
time to cessation of severe pneumonia
illnesses requiring visits to healthcare providers
stool output
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
No description of who was studied is recorded.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Varies by country
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No form or route is recorded.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing is recorded about product quality.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Zinc Gluconate appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 192 reaction mentions were counted. One report can name several reactions.
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
The exact form studied is not recorded.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
87 products list this as an active ingredient in the United States drug directory. 30 of them contain it and nothing else.
FDA National Drug Code directory · 17312-431 · read 2026-08-29
They are sold as bar, chewable, granule, liquid, lozenge, spray and tablet, taken oral.
FDA National Drug Code directory · 17312-431 · read 2026-08-29
The regulator's established pharmacologic class for it is copper absorption inhibitor [epc] and decreased copper ion absorption [pe].
FDA National Drug Code directory · 17312-431 · read 2026-08-29
79 published labels name it as an active ingredient. 29 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · d3f89e4d-c3a0-4481-bf0e-0413993a8bc5 · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · d3f89e4d-c3a0-4481-bf0e-0413993a8bc5 · read 2026-08-29
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
Watching one thing carefully can tell you whether it moved. It cannot tell you what moved it.
This is sold without a prescription, so a person can sensibly watch one thing and see whether it moves.
Pick one goal. One goal only. Two at once cannot be told apart afterwards.
Pick one thing to watch. Registered studies measured things like: lumbar spine bone mineral density by dxa; acute insulin response from ivgtt.
Measure before you start. Take the same measurement several times first. One reading is not a starting point.
Know the swing. Write down how much it moves on its own across a normal week.
Change one thing. Change nothing else at the same time, including training and sleep.
Give it the study length. No finished study window is recorded, so no length is suggested here.
Track whether you took it. Missed days are the most common reason a home test shows nothing.
Read the trend. Look at the line across weeks. A single reading tells you almost nothing.
What not to measure
Anything that swings more day to day than the change you are looking for.
A wearable estimate of sleep stages, which is an estimate and not a measurement.
Weight on one morning, which mostly records water.
A feeling you did not write down before starting.
When to stop
Stop if something new and unpleasant starts, and ask a pharmacist or doctor.
Stop if you cannot keep everything else steady, because the result will not mean anything.
Stop at the end of the window you set, and read the trend then.
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki does not work out an amount for anyone.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
How fast does the body clear it?
The sources RNAWiki checked hold nothing for this field.
Why it matters. Without this, nothing on this page can say how long anything lasts.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Zinc Gluconate are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
Where else this substance is registered
FDA substance identifier (UNII)
U6WSN5SQ1Z
Checks this page had to pass
✓ Passed
Identity resolved
no open identity hold
✓ Passed
No unresolved merge across substance families
no quarantine open
✓ Passed
Every public sentence names a source
The opening statement carries the origin: Quoted from a stored source.
✗ Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
✓ Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
✓ Passed
Safety mode resolved
The identity record classes it as a supplement ingredient; no medicines register records an approval.
✓ Passed
Canonical metadata present
slug and display name present
What is missing or unclear◇Read from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
The earliest marketing start date recorded for a listed product is 19840815.
FDA National Drug Code directory · 17312-431 · read 2026-08-29
What is missing or unclear◇Read from sources, not yet reviewed
What to learn next
Ordered by what would most change how you read this page, starting with what is easiest to misunderstand.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (15)
Q1
What did Zinc Gluconate's largest trial (8000 people) and its longest (16 years) measure?
8000 people in Zinc Gluconate's largest registered study, 16 years in its longest registered window, measuring Progression of age-related macular degeneration. ClinicalTrials.gov · 2026-09-01
63 na, 48 phase3, 44 phase2, 31 phase4, 13 phase1, 5 na or unstated, 4 early phase1; NCT00000145; 2006-12. Last human test completed 2026, NCT07383363.
Interpretation These counts include studies where Zinc Gluconate was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
63
phase3
48
phase2
44
phase4
31
phase1
13
na or unstated
5
2 more recorded rows
early phase1
4
Last recorded human testNCT07383363
2026-03-30
recorded 2026-09-01 · last checked 2026-09-04
Q2
From yeast to human: where has Zinc Gluconate shown lifespan?
C. elegans: lifespan, Drosophila: lifespan, yeast: mechanism-only, mouse: mechanism-only, rat: mechanism-only and human: mechanism-only (188): the rungs where Zinc Gluconate has a recorded finding. Europe PMC and ClinicalTrials.gov · organism ladder · 2026-09-01
Interpretation Progression of age-related macular degeneration — the recorded outcome words.
Show the evidence
C. elegans
lifespan
Drosophila
lifespan
yeast
mechanism-only
mouse
mechanism-only
rat
mechanism-only
humanNCT00000145
mechanism-only; Progression of age-related macular degeneration; 188
recorded 2026-09-01 · last checked 2026-09-04
Q3
12 of Zinc Gluconate's trials stopped: safety, accrual/recruitment, funding/business, other?
safety (1), accrual/recruitment (5), funding/business (1) and other (5): Zinc Gluconate's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"Terminated for futility on 11/30/09 based on the recommendation of the DSMB"; 12 of 188 registered studies
Show the evidence
Trial
NCT00395161
terminated; "Terminated for futility on 11/30/09 based on the recommendation of the DSMB"
NCT00395226
terminated; "Difficulty recruiting subjects"
NCT01468636
terminated; "There was no clear benefit but numerous side effects."
NCT02130388
terminated; "Slow Recruitment and funds no longer available."
NCT03404310
terminated; "Lack of recruitment"
NCT03532555
terminated; "Slow enrollment"
6 further recorded trials
NCT04321850
terminated; "Health restrictions due to the COVID-19 pandemic"
NCT04351490
withdrawn; "change study design and funding"
NCT04528927
withdrawn; "\- Interest in the use of HCQ is controversial."
NCT04621149
terminated; "Unable to recruit participants due to decline in COVID-19."
NCT05000762
withdrawn; "Sponsor no longer has support available."
NCT05894109
withdrawn; "Per the PI, the project is not IRB approved yet and will likely not be completed."
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Zinc Gluconate used Zinc acetate (20mg/d) — over how long?
19 recorded entries; human; tablet; also "Zinc sulphate (20 mg)", "Zinc (12.5 mg/day)", "Zinc sulphate 20 mg"
Show the evidence
human
NCT00104494
Zinc acetate (20mg/d)
NCT00142285
Zinc sulphate (20 mg)
NCT00228254
Zinc (12.5 mg/day)
NCT00355043
Zinc sulphate 20 mg
NCT00495690
Oral zinc gluconate (5 mg elemental)
NCT02072746
Zinc sulfate 220 mg
13 more recorded rows
humanNCT03005496
Zinc Picolinate 50 mg
humanNCT03135522
Zinc Acetate 50 Mg Oral Capsule
humanNCT03824925
Zinc Sulfate 220 MG
humanNCT04321850
Zinc Sulfate 50 Mg Tab
humanNCT04899843
tablet; Zinc sulphate tablet 20 mg
humanNCT05178953
Zinc Sulfate 220 mg Capsules
humanNCT05190562
Zinc Sulfate 110 MG (Zinc 25 MG) Oral Tablet
humanNCT05835037
Zinc Gluconate 30 MG
humanNCT05892770
50 mg zinc gluconate (Puritan's Pride brand)
humanNCT05894109
zinc citrate 50 mg
humanNCT06290219
Zinc Gluconate 10 MG Oral Tablet
humanNCT06577285
zinc gluconate 50 mg with phytase supplement 176mg (800FTU)
humanNCT06577285
zinc gluconate 50 mg
recorded 2026-09-01 · last checked 2026-09-04
Q5
Did Zinc Gluconate move Horvath, and by how much?
Horvath: "A one standard deviation increase in individual essential metals (copper, manganese, and zinc) was associated with 0.94-1.2 weeks lower Horvath EAA at birth, and patterns of exposures identified by exploratory factor analysis suggested that a common source of essential metals was associated with Horvath EAA." Europe PMC · epigenetic clock search · 2026-06-01
3 recorded sentences; 2024, 2026; biomarker
Show the evidence
Horvath
PMID 38412256
2024; "A one standard deviation increase in individual essential metals (copper, manganese, and zinc) was associated with 0.94-1.2 weeks lower Horvath EAA at birth, and patterns of exposures identified by exploratory factor analysis suggested that a common source of essential metals was associated with Horvath EAA."
PMID 38412256
2024; "We also observed evidence nonlinear associations of zinc with Bohlin EGAA, magnesium and lead with Horvath EAA, and cesium with skin and blood EAA at birth."
epigenetic agePMID 41875434
2026; "We evaluated exposure to high ambient temperatures and sperm epigenetic age among 1,220 men residing along the Wasatch Front in Utah in an ancillary prospective cohort study set within the Folic Acid and Zinc Supplementation Trial (FAZST; 2013-2018)."
recorded 2026-06-01 · last checked 2026-09-04
Q6
More Zinc Gluconate was worse in human: at what point?
U-shaped in human: "Dose-response analysis based on restricted cubic splines revealed nonlinear patterns: blood cadmium exhibited a U-shaped dose-response relationship (P non-linear = 0.005) with risk rising markedly above 3.5 µg/L, and dietary zinc showed a J-shaped curve (P non-linear = 0.004) peaking around 22 mg/day." Europe PMC · dose-response search · 2026-08-07
6 recorded sentences naming Zinc Gluconate; U-shaped, hormesis, hormetic
Show the evidence
U-shaped
PMID 42566870
"Dose-response analysis based on restricted cubic splines revealed nonlinear patterns: blood cadmium exhibited a U-shaped dose-response relationship (P non-linear = 0.005) with risk rising markedly above 3.5 µg/L, and dietary zinc showed a J-shaped curve (P non-linear = 0.004) peaking around 22 mg/day."
PMID 42524553
"RCS analysis demonstrated linear protective trends for calcium, phosphorus, zinc, potassium, and selenium, while magnesium, iron, and copper exhibited U-shaped dose-response patterns."
PMID 42126678
"Selenium showed a protective effect (Q4 vs. Q1: OR = 0.49, 95% CI: 0.32-0.73), while zinc displayed a non-linear, U-shaped relationship."
hormesisPMID 41343535
"Our results indicate that foliar application of zinc oxide nanoparticles is a viable strategy for reducing Cd accumulation in lettuce and other leafy vegetables under Cd-induced hormesis, thereby ensuring food safety."
hormetic
PMID 41166048
"All fungi exhibited a hormetic response to zinc, evidenced by increased biomass and stimulated sporulation."
PMID 41166048
"These collective findings suggest a predominantly hormetic, rather than a stress-induced, response to zinc exposure."
recorded 2026-08-07 · last checked 2026-09-04
Q7
Could one person measure Zinc Gluconate's effect on progression of age related macular degeneration?
Progression of age related macular degeneration: measured in Zinc Gluconate's trials.
Interpretation progression of age related macular degeneration is the recorded endpoint.
Show the evidence
biomarkers
progression of age related macular degeneration; 2026-09-01
progression of lens opacity; 2026-09-01
infant maize/zn supplementation trial; 2026-09-01
linear growth velocity; 2026-09-01
zn homeostasis studies; 2026-09-01
m at 1 5 months; 2026-09-01
14 more recorded rows
biomarkers
duration of illness; 2026-09-01
biomarkers
treatment failure; 2026-09-01
biomarkers
risk of treatment failure; 2026-09-01
biomarkers
adverse effects; 2026-09-01
biomarkers
immune failure; 2026-09-01
biomarkers
duration of severe symptoms; 2026-09-01
biomarkers
adverse events and serious adverse events; 2026-09-01
biomarkers
reduction in duration of diarrhoea; 2026-09-01
biomarkers
reeudction in total stool volume; 2026-09-01
biomarkers
incidence of acute lower respiratory infection; 2026-09-01
biomarkers
growth; 2026-09-01
biomarkers
time to cessation of severe pneumonia; 2026-09-01
biomarkers
illnesses requiring visits to healthcare providers; 2026-09-01
biomarkers
stool output; 2026-09-01
human trials at or under30
27
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT04351490; NA; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q8
Which of acute insulin response from ivgtt, adverse effects and adverse events and serious adverse events did Zinc Gluconate's trials measure?
acute insulin response from ivgtt, adverse effects and adverse events and serious adverse events lead 40 outcome terms across Zinc Gluconate's trials. ClinicalTrials.gov · 2026-09-01
linear growth velocity, zn homeostasis studies, m at 1 5 months, duration of illness, treatment failure and risk of treatment failure follow.
Show the evidence
progression of age related macular degeneration
1
progression of lens opacity
1
infant maize/zn supplementation trial
1
linear growth velocity
1
zn homeostasis studies
1
m at 1 5 months
1
14 more recorded rows
duration of illness
1
treatment failure
1
risk of treatment failure
1
adverse effects
1
immune failure
1
duration of severe symptoms
1
adverse events and serious adverse events
1
reduction in duration of diarrhoea
1
reeudction in total stool volume
1
incidence of acute lower respiratory infection
1
growth
1
time to cessation of severe pneumonia
1
illnesses requiring visits to healthcare providers
1
stool output
1
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which of Zinc Gluconate's 17 ongoing trials reports first?
Zinc-dependent effect on fasting glucose levels at 1 year; Oral Mucositis; latest 2030-06-30
Show the evidence
Trial
NCT05835037
"Effect of Zinc on Glucose Homeostasis"; n 200; "Zinc-dependent effect on fasting glucose levels at 1 year"; 2028-07
NCT05853692
"Prevention of Oral Mucositis in Head and Neck Cancer."; n 130; "Oral Mucositis"; 2028-06-10
NCT06120140
"Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib"; n 305; "Number of Participants With Grade Greater Than or Equal to (>=) 2 Dermatologic Adverse Events of Interest (DAEIs) Within 12 Weeks After Initiation of Anticancer Treatment"; 2030-06-30
NCT06151392
"Effect of Probiotic and Zinc Supplementations on the Clinical Outcome in Pediatric Patients with Ventriculitis"; n 140; "CSF culture"; 2025-12
NCT06517862
"Efficacy & Safety of Oral Adjuvants to Phototherapy in Neonatal Hyperbilirubinemia"; n 80; "serum bilirubin level."; 2026-06-30
NCT06567717
"Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis"; n 60; "Feasibility of Retention"; 2027-01
11 further recorded trials
NCT06577285
"The Effect Of Botox In Patients With Gummy Smile With And Without Zinc And Phytase Supplementation."; n 36; "Gingival display"; 2025-06-01
NCT06588036
"A Comprehensive Analysis of the Comparative Efficacy of Multimodal Diarrhea Therapies in the Paediatric Population"; n 100; "resolution of diarrhea"; 2024-12-30
NCT06612554
"Zn Supplementation in HIV Immunological Non Responders"; n 120; "CD4+ T-cell number change"; 2026-12
NCT06664008
"The Effect of Probiotic and Zinc Supplementation in Patients With Gastroesophageal Reflux Disease"; n 120; "Change in Gastrointestinal Symptom Rating Scale (GSRS)"; 2025-10-01
NCT06674564
"Effect of Zinc and Probiotics Supplementation on Laryngeal Cancer Patients Undergoing Laryngectomy Surgery to Improve Prognosis and Better Wound Healing"; n 140; "wound healing"; 2026-10
NCT07102836
"COMPARISON OF ZINC AND PROBIOTICS ON NEONATES WITH INDIRECT HYPERBILIRUBINEMIA UNDERGOING PHOTOTHERAPY"; n 110; "Rate of decline in Bilirubin levels during phototherapy with this adjuvant therapy"; 2026-05-07
NCT07140874
"Zinc as an Adjunctive Therapy for Cervical Dystonia"; n 25; "Duration of Botox efficacy"; 2027-05-31
NCT07145268
"Zinc Sulphate in Treatment Fibrosis in HBV Patient Receiving Antiviral Therapy"; n 44; "Change in fibrosis scores."; 2026-09
NCT07275827
"Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori Infection"; n 88; "Serum interleukin-6 (IL-6) level: will be assessed by ELISA"; 2026-10
NCT07367412
"Zinc Supplementation and Infections in Older Medical Patients"; n 8000; "Days Alive and Out of Hospital"; 2028-03-15
NCT07405554
"Zinc Supplementation With Botulinum Toxin for Overactive Bladder"; n 72; "Number of patients needing repeat intradetrusor botulinum toxin injection at 6 months"; 2026-12
recorded 2026-09-01 · last checked 2026-09-04
Q10
Which running trial of Zinc Gluconate could settle inflammatory markers?
NCT07275827 measures Serum interleukin-6 (IL-6) level: will be assessed by ELISA, reading out 2026-10.
1 open trial; n 88; "Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori Infection"
Show the evidence
TrialNCT07275827
"Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori Infection"; n 88; "Serum interleukin-6 (IL-6) level: will be assessed by ELISA"; 2026-10
Q11
Which 105 trials of Zinc Gluconate posted no result?
Posted no result
105 of 105 completed trials
Registrations
NCT00226616, NCT00228254, NCT00198666, NCT00212368, NCT00325247 and NCT00692224, and 99 more
Completion dates
oldest 2002-07; newest 2024-06-30
Show the evidence
Trial
NCT00226616
2002-07
NCT00228254
2004-06
NCT00198666
2004-08
NCT00212368
2005-12
NCT00325247
2006-05
NCT00692224
2006-10
14 further recorded trials
NCT00408356
2006-11
NCT00000145
2006-12
NCT00370968
2006-12
NCT00149552
2007-01
NCT00373100
2007-03
NCT00098202
2007-04
NCT00036881
2007-06
NCT00272142
2007-08
NCT00104494
2007-09
NCT00355043
2007-09
NCT00459485
2007-12
NCT01166815
2008-01
NCT00682955
2008-04
NCT00142285
2008-05
Q12
At the median, Zinc Gluconate's trials enrolled 100 people — anything larger?
Median enrolment
100
Largest enrolment
8000
Registered trials counted
185
Q13
What do 192 spontaneous reports say about Zinc Gluconate — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Zinc Gluconate appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 192 reaction mentions were counted: anosmia 41; condition aggravated 25; ageusia 21; loss of consciousness 18. open-targets-adr · CHEMBL3833377 · 2026-06-24
Show the evidence
anosmia
41
condition aggravated
25
ageusia
21
loss of consciousness
18
septic shock
17
beta haemolytic streptococcal infection
14
4 more recorded rows
copper deficiency
14
necrosis ischaemic
14
pneumonia streptococcal
14
weight increased
14
recorded 2026-06-24 · last checked 2026-09-04
Q14
Was Zinc Gluconate studied with exercise?
exercise is named in Zinc Gluconate's label sentences: "Healthy pregnant women were randomized to four groups: exercise (<i>n</i> = 19), AMS (zinc/magnesium/tocopherol/vitamin C/niacin) (<i>n</i> = 19), exercise plus AMS (<i>n</i> = 19), and controls (<i>n</i> = 20)." openfda-label+europepmc · 2025-07-09
1 recorded statement; exercise
Show the evidence
exercise
Healthy pregnant women were randomized to four groups: exercise (<i>n</i> = 19), AMS (zinc/magnesium/tocopherol/vitamin C/niacin) (<i>n</i> = 19), exercise plus AMS (<i>n</i> = 19), and controls (<i>n</i> = 20).
recorded 2025-07-09 · last checked 2026-09-04
Q15
What is recorded about Zinc Gluconate and mTOR?
"The included studies suggest that cardiomyocyte death induced by SIMD might be partially regulated by autophagy and its associated genes and pathways, including but not limited to Unc-51 like-autophagy-activating kinase 1 (ULK1), Zinc finger antisense 1 (ZFAS1), miR-590-3p, miR-214-3p, miR-21-3p, Silent information regulator 1 (SIRT1),…" — where Zinc Gluconate and mTOR appear together. Europe PMC · pathway abstract search · 2026-07-08
"The included studies suggest that cardiomyocyte death induced by SIMD might be partially regulated by autophagy and its associated genes and pathways, including but not limited to Unc-51 like-autophagy-activating kinase 1 (ULK1), Zinc finger antisense 1 (ZFAS1), miR-590-3p, miR-214-3p, miR-21-3p, Silent information regulator 1 (SIRT1), SH3 domain-containing protein 2 (SORBS2), AMP-activated…"
AMPKPMID 41676277
"The included studies suggest that cardiomyocyte death induced by SIMD might be partially regulated by autophagy and its associated genes and pathways, including but not limited to Unc-51 like-autophagy-activating kinase 1 (ULK1), Zinc finger antisense 1 (ZFAS1), miR-590-3p, miR-214-3p, miR-21-3p, Silent information regulator 1 (SIRT1), SH3 domain-containing protein 2 (SORBS2), AMP-activated…"
sirtuinPMID 41676277
"The included studies suggest that cardiomyocyte death induced by SIMD might be partially regulated by autophagy and its associated genes and pathways, including but not limited to Unc-51 like-autophagy-activating kinase 1 (ULK1), Zinc finger antisense 1 (ZFAS1), miR-590-3p, miR-214-3p, miR-21-3p, Silent information regulator 1 (SIRT1), SH3 domain-containing protein 2 (SORBS2), AMP-activated…"
autophagy
PMID 41676277
"The included studies suggest that cardiomyocyte death induced by SIMD might be partially regulated by autophagy and its associated genes and pathways, including but not limited to Unc-51 like-autophagy-activating kinase 1 (ULK1), Zinc finger antisense 1 (ZFAS1), miR-590-3p, miR-214-3p, miR-21-3p, Silent information regulator 1 (SIRT1), SH3 domain-containing protein 2 (SORBS2), AMP-activated…"
PMID 42301500
"Mice were administered with varying doses (low, medium, and high) of zinc gluconate via gavage, subjected to MTF1 knockdown or overexpression, or treated with the PINK1 activator PARL-IN-2, the autophagy inhibitor chloroquine, or the ferroptosis inhibitor Ferrostatin-1."
AMPKPMID 42415176
"We previously identified 1H10 as an AMP-activated protein kinase (AMPK) inhibitor and subsequently demonstrated its zinc-binding capacity and ability to regulate intracellular zinc homeostasis."
autophagyPMID 42415176
"Building on our prior findings that intra-lysosomal zinc promotes acidification and activates transcription factor EB (TFEB), we investigated whether 1H10 enhances lysosomal function through zinc mobilization in neurons, thereby improving autophagy and reducing pathological protein accumulation."
AMPKPMID 42260976
"Collectively, these findings revealed that viruses weaponized the moonlighting function of a metabolic enzyme to dismantle autophagic flux, highlighting PHGDH as a broad-spectrum antiviral target that bridged metabolism and membrane trafficking.<b>Abbreviation:</b> AMPK: AMP-activated protein kinase; BECN1: beclin 1; CQ: chloroquine; MAP1LC3/LC3: microtubule associated protein 1 light chain 3;…"
sirtuinPMID 41454179
"The latter may be mediated by inhibition of SIRT1/SIRT3 activity, as well as modulation of PINK1/ zinc finger protein 746 (ZNF746)/PGC-1α axis."
mTORPMID 42047332
"Exploring the intricate molecular interplay between natural products and autophagy in limiting infections may provide valuable insights that could inform the development of innovative host-directed antimicrobial treatments based on autophagy regulation.<b>Abbreviations:</b> 3-MA: 3-methyladenine; AM: alveolar macrophages; AMP: antimicrobial peptides; AMPK: 5' adenosine monophosphate-activated…"
sirtuinPMID 42047332
"Exploring the intricate molecular interplay between natural products and autophagy in limiting infections may provide valuable insights that could inform the development of innovative host-directed antimicrobial treatments based on autophagy regulation.<b>Abbreviations:</b> 3-MA: 3-methyladenine; AM: alveolar macrophages; AMP: antimicrobial peptides; AMPK: 5' adenosine monophosphate-activated…"
2 more recorded rows
NAD+PMID 42209503
"Finally, we evaluate emerging mitochondria-targeted rejuvenation strategies, NAD⁺ repletion, mitophagy enhancers, mitochondrial transplantation/engineering, and precision elimination of mutant mtDNA using mitochondria-targeted transcription activator-like effector nucleases (mitoTALENs) or zinc-finger nucleases (mitoZFNs), emphasizing tissue-specific thresholds and context dependence for…"
mTORPMID 40873286
"Zinc acts via various signaling pathways, such as AMPK and mTOR, and influences lipid and glucose metabolism."
recorded 2026-07-08 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
✗ required summary fields resolved: 4 required field(s) not terminal: Best-supported result, Most important common problem, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 11 source rows
✓ no critical contamination: no quarantine open
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This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.