Its recorded molecular formula is C8H14O2S2, weighing 206.3.
PubChem record · 864 · read 2026-08-29
Where each sentence above came from
No plain explanation of what this changes is stored.
No recorded use is stored in reader language.
No statement of the main limit is recorded.
The four opening statements run to 26 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Formulation
A formulation is the exact made-up form a substance comes in.
A picture of it, and where the picture fails
It is like the difference between a whole bean and instant coffee.
Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.
What people get wrong. Two products with the same name are assumed to behave the same. They often do not.
The specific composition and physical form of a product, including salt, excipients and release profile.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 32 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Strength
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer1 registered performance measure of this kind.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Healthy ageing
…Waiting for a reviewer1 registered study measure of this kind. No reviewed result yet.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Strength
muscle strength
Blood sugar
insulin sensitivity
Healthy ageing
mortality
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
1 registered performance measure of this kind.
— Not recorded
Harms were not a registered measure for this goal.
△ Only a number moved
1 registered test measure.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Major Adverse Cardiovascular Events (MACE)
✗ The study did not show it
Who was studied
NCT07725484
How many people
1526
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Arm Vascular Function at Rest (Flow Mediated Dilation Test)
✗ The study did not show it
Who was studied
NCT04916327
How many people
720
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
What a body can do day to day
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
occurrence of clinically significant macular edema (CSME) within a follow-up period of 2 years
✗ The study did not show it
Who was studied
NCT01208948
How many people
520
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Primary efficacy variable: Absolute change in the neuropathy impairment score lower limbs enlarged by 7 objective items (NISLL+7) between baseline (mean of Visit 0.3 and 0.4 or last available value before randomisation, respectively) and endpoint
✗ The study did not show it
Who was studied
NCT00977483
How many people
460
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
To compare the relative change in NCS parameters between the study arms
✗ The study did not show it
Who was studied
NCT05813496
How many people
430
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Change in Limb Blood Flow
✗ The study did not show it
Who was studied
NCT02966665
How many people
420
Study design
Phase 1
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.1 registered measure of this kind. No reviewed result.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.2 registered measures of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.2 registered measures of this kind.
□Symptoms and quality of lifeNo evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.No registered study measures this.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.5 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Drosophila (fruit fly), Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
No registered study measured anything of this kind.
Measured
Things only a test, a scale or a device shows.
f2 isoprostane level urine f2 isoprostanes
muscle strength
insulin sensitivity
plasma oxyphytosterol concentrations
changes in urinary albumin excretion rate
serum level of e selectin
Meaningful
Things that change how a life goes, not only a number.
mortality
mobility timed 25 foot walk
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (24)
mini mental state exam from baseline to 12 months
ototoxicity measurement
biomarkers of oxidative stress
endothelial function
brain atrophy by mri
spirometric fvc values at baseline
spirometric fvc values at endpoint
spirometric fev1 values at baseline
spirometric fev1 values at endpoint
spirometric fef values at baseline
spirometric fef values at endpoint
histological evaluation
oxidative lesion biomarkers
trails making test part b
total symptoms
phase i percentage of adverse events
implants per cycle
comparison of oral tolerance between r la and racemic la
carotid artery intima media thickness
changes in total antioxidant capacity and malondialdehyde
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
HOMEOPATHIC INDICATIONS: For temporary relief of symptoms related to high blood sugar including dry mouth, thirst, night sweats, sugar and carb cravings. **These statements are based upon traditional homeopathic principles. They have not been reviewed by the Food and Drug Administration.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
A different form was studied
The studied form is not the form on the shelf.
On this record: This record is linked to 1 related forms. Evidence does not carry across all of them.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (9)
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Varies by country
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Sold as liquid, given by the oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
7 products list this as an active ingredient in the United States drug directory. 1 of them contain it and nothing else.
FDA National Drug Code directory · 43742-1554 · read 2026-08-29
They are sold as liquid and powder, taken oral.
FDA National Drug Code directory · 43742-1554 · read 2026-08-29
6 published labels name it as an active ingredient. None of them describes this substance alone, so no label text on this page can be attributed to it rather than to a combination.
US prescribing information · ca632470-6cbc-4994-a7f0-95b6ad9aa44f · read 2026-08-29
Those labels are classed as human otc drug.
US prescribing information · ca632470-6cbc-4994-a7f0-95b6ad9aa44f · read 2026-08-29
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (12)
Q1
What did Thioctic ACID, (-)-'s largest trial (460 people) and its longest (9.9 years) measure?
460 people in Thioctic ACID, (-)-'s largest registered study, 9.9 years in its longest registered window, measuring Mortality. ClinicalTrials.gov · 2026-09-01
18 phase2, 10 phase3, 9 phase1, 7 na, 6 phase4; NCT01406704; 2013-12. Last human test completed 2025, NCT06703593.
Interpretation These counts include studies where Thioctic ACID, (-)- was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase2
18
phase3
10
phase1
9
na
7
phase4
6
Last recorded human testNCT06703593
2025-05-01
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has Thioctic ACID, (-)- shown lifespan?
More Thioctic ACID, (-)- was worse in human: at what point?
Hormetic in human: "The endogenous and dietary agent, alpha lipoic acid (ALA), is evaluated for its capacity to induce a broad spectrum of adaptive responses via hormetic dose responses and their underlying mechanisms." Europe PMC · dose-response search · 2023-05-10
5 recorded sentences naming Thioctic ACID, (-)-; hormetic, dose-response
Show the evidence
hormetic
PMID 37169059
"The endogenous and dietary agent, alpha lipoic acid (ALA), is evaluated for its capacity to induce a broad spectrum of adaptive responses via hormetic dose responses and their underlying mechanisms."
PMID 34227035
"We treated the flies with sesamol-conjugated lipoic acid derivative (a phenolic compound) at hormetic doses to evaluate its effect on the memory of flies."
"We treated the flies with sesamol conjugated lipoic acid derivative (a phenolic compound) at hormetic doses to evaluate its effect on the memory of flies.</p>"
PMID 30096293
"The electrophilic nature of oxidized nucleophilic molecules, including α-lipoic acid, renders more plausible a mechanism based on the ability to activate Nrf2/EpRE mediated hormetic response."
dose-responsePMID 33199187
"This systematic review and dose-response meta-analysis was conducted to summarize data from available clinical trials on the effects of α-lipoic acid (ALA) supplementation on glycemic markers including glucose, hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>), insulin, homeostatic model assessment of insulin resistance (HOMA-IR), HOMA-β, and quantitative insulin check index in adults."
recorded 2023-05-10 · last checked 2026-09-04
Q6
Could one person measure Thioctic ACID, (-)-'s effect on f2 isoprostane level urine f2 isoprostanes?
mini mental state exam from baseline to 12 months; 2026-09-01
ototoxicity measurement; 2026-09-01
muscle strength; 2026-09-01
biomarkers of oxidative stress; 2026-09-01
insulin sensitivity; 2026-09-01
14 more recorded rows
biomarkers
endothelial function; 2026-09-01
biomarkers
brain atrophy by mri; 2026-09-01
biomarkers
spirometric fvc values at baseline; 2026-09-01
biomarkers
spirometric fvc values at endpoint; 2026-09-01
biomarkers
spirometric fev1 values at baseline; 2026-09-01
biomarkers
spirometric fev1 values at endpoint; 2026-09-01
biomarkers
spirometric fef values at baseline; 2026-09-01
biomarkers
spirometric fef values at endpoint; 2026-09-01
biomarkers
histological evaluation; 2026-09-01
biomarkers
oxidative lesion biomarkers; 2026-09-01
biomarkers
trails making test part b; 2026-09-01
biomarkers
plasma oxyphytosterol concentrations; 2026-09-01
biomarkers
total symptoms; 2026-09-01
biomarkers
phase i percentage of adverse events; 2026-09-01
human trials at or under30
14
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT00398892; PHASE2; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q7
Which of biomarkers of oxidative stress, brain atrophy by mri and carotid artery intima media thickness did Thioctic ACID, (-)-'s trials measure?
biomarkers of oxidative stress, brain atrophy by mri and carotid artery intima media thickness lead 32 outcome terms across Thioctic ACID, (-)-'s trials. ClinicalTrials.gov · 2026-09-01
Interpretation muscle strength, biomarkers of oxidative stress, insulin sensitivity, endothelial function, brain atrophy by mri and spirometric fvc values at baseline follow.
Show the evidence
f2 isoprostane level urine f2 isoprostanes
1
mini mental state exam from baseline to 12 months
1
ototoxicity measurement
1
muscle strength
1
biomarkers of oxidative stress
1
insulin sensitivity
1
14 more recorded rows
endothelial function
1
brain atrophy by mri
1
spirometric fvc values at baseline
1
spirometric fvc values at endpoint
1
spirometric fev1 values at baseline
1
spirometric fev1 values at endpoint
1
spirometric fef values at baseline
1
spirometric fef values at endpoint
1
histological evaluation
1
oxidative lesion biomarkers
1
trails making test part b
1
plasma oxyphytosterol concentrations
1
total symptoms
1
phase i percentage of adverse events
1
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which of Thioctic ACID, (-)-'s 2 ongoing trials reports first?
Serum level of E-Selectin; Consent Rate; latest 2028-03-01
Show the evidence
Trial
NCT06286098
"Alpha Lipoic Acid in Pediatrics on Hemodialysis"; n 50; "Serum level of E-Selectin"; 2028-03-01
NCT07501663
"Optimizing Integrative Oncology Approaches to Address Chemotherapy-induced Peripheral Neuropathy in Gastrointestinal (GI) Cancer Patients: A SMART Pilot Study"; n 60; "Consent Rate"; 2027-04
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which 12 trials of Thioctic ACID, (-)- posted no result?
Posted no result
12 of 12 completed trials
Registrations
NCT00977483, NCT00328601, NCT00065624, NCT00703989, NCT00676156 and NCT00795262, and 6 more
Completion dates
oldest 2005-01; newest 2019-01-25
Show the evidence
Trial
NCT00977483
2005-01
NCT00328601
2005-06
NCT00065624
2007-07
NCT00703989
2008-02
NCT00676156
2008-11
NCT00795262
2009-07
6 further recorded trials
NCT00994513
2010-05
NCT01056497
2011-06
NCT02056366
2013-09
NCT01495260
2013-11
NCT01294176
2016-11
NCT03493841
2019-01-25
Q10
At the median, Thioctic ACID, (-)-'s trials enrolled 42 people — anything larger?
Median enrolment
42
Largest enrolment
460
Registered trials counted
40
Q11
Was Thioctic ACID, (-)- studied with fasting and exercise?
fasting and exercise are named in Thioctic ACID, (-)-'s label sentences: "Although no change (p < 0.05) in serum glucose was observed, α-lipoic acid-supplemented subjects demonstrated reduced fasting serum insulin (p = 0.04) and HOMA-IR (p = 0.07) compared with the placebo group." openfda-label+europepmc · 2024-12-01
2 recorded statements; fasting, exercise
Show the evidence
fasting
Although no change (p < 0.05) in serum glucose was observed, α-lipoic acid-supplemented subjects demonstrated reduced fasting serum insulin (p = 0.04) and HOMA-IR (p = 0.07) compared with the placebo group.
exercise
The study included 82 participants allocated into the intervention group (alpha-lipoic acid and exercise on 15 consecutive therapeutic days, <i>n</i> = 42) and control group (alpha lipoic acid only, <i>n</i> = 40).
recorded 2024-12-01 · last checked 2026-09-04
Q12
What is recorded about Thioctic ACID, (-)- and AMPK?
"Treatment with α-lipoic acid (ALA) rescued soma growth, normalize ATP levels and reduce AMPK activation." — where Thioctic ACID, (-)- and AMPK appear together. Europe PMC · pathway abstract search · 2025-10-17
"Treatment with α-lipoic acid (ALA) rescued soma growth, normalize ATP levels and reduce AMPK activation."
mTORPMID 40922217
"Metabolomic analysis identified 150 different metabolites between DN and RMP groups, of which 85 were up-regulated and 65 were down-regulated, including folate biosynthesis, pyrimidine metabolism, arginine biosynthesis, tyrosine metabolism, lipoic acid metabolism, and mTOR signaling pathway as a potential target."
autophagyPMID 40429916
"Excessive iron accumulation poses a significant threat to liver health, primarily through oxidative stress and autophagy dysregulation. α-Lipoic acid (ALA), a natural antioxidant with hepatoprotective properties, may alleviate iron-induced liver damage, but its underlying mechanisms are not fully understood."
mTORPMID 37088764
"To investigate the effect of α-lipoic acid in ameliorating liver injury in rats with type 2 diabetes mellitus <i>via</i> activating adenosine 5'-monophosphate-activate protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway."
AMPK
PMID 37088764
"To investigate the effect of α-lipoic acid in ameliorating liver injury in rats with type 2 diabetes mellitus <i>via</i> activating adenosine 5'-monophosphate-activate protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway."
PMID 37088764
"The 32 rats with T2DM were randomly divided into 4 groups: T2DM group, α-lipoic acid group (LA), Compound C group (Comp C, an inhibitor of AMPK) and LA+Comp C group, with 8 rats in each group."
mTORPMID 37088764
"The expression of p-AMPK was decreased (<i>P</i>＜0.05) and the expression of p-mTOR was increased significantly(<i>P</i>＜0.05). α-lipoic acid could reverse the above-mentioned changes, ameliorate insulin resistance (all <i>P</i>＜0.05), protect the structure and function of liver, and activate the AMPK/mTOR pathway (<i>P</i>＜0.05)."
sirtuinPMID 41110565
"Therapeutic strategies have evolved from traditional antioxidants (e.g., α-lipoic acid) to novel approaches, including targeting the Nrf2/HO-1 pathway (e.g., using saffron-rich GJ-4 extract), regulating mitochondrial function, utilizing natural compounds (e.g., resveratrol acting via SIRT1 activation), and non-pharmacological interventions such as acupuncture."
recorded 2025-10-17 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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