Sus Scrofa Ovary
- Hormone
- Varies by country
- Identity checked
- Sources last checked 2026-09-04
This page shows what was measured, who it was measured in, and what that does not settle.
RNAWiki holds very little about this substance. The page shows what there is.
What Sus Scrofa Ovary does in the body
RNAWiki has not recorded what this substance changes in the body.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
- Where it acts
- Not recorded.
- Kind of result
- No result is published, so no kind of result applies yet
- Supervision
- Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
What the registries record it as
The substance registry classes this as structurallydiverse.
FDA substance registry · S7YTV04R8O · read 2026-08-29
It is recorded as coming from SUS SCROFA WHOLE. The part recorded is ovary.
FDA substance registry · S7YTV04R8O · read 2026-08-29
Where each sentence above came from
No plain explanation of what this changes is stored.
No recorded use is stored in reader language.
No statement of the main limit is recorded.
The four opening statements run to 26 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in peopleRead from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 36 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
| Goal | Life outcome | What a body can do | How a person feels | A test result | A step in the body | Harms | How long | Who was studied |
|---|---|---|---|---|---|---|---|---|
| Focus | Nothing in the sources checkedNo registered study lists a life outcome for this goal. | Waiting for a reviewer1 registered performance measure of this kind. | Nothing in the sources checkedNo registered study lists a symptom measure for this goal. | Nothing in the sources checkedNo registered study lists a test result for this goal. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
| Mood | Nothing in the sources checkedNo registered study lists a life outcome for this goal. | Nothing in the sources checkedNo registered study lists a performance measure for this goal. | Waiting for a reviewer1 registered symptom measure. | Nothing in the sources checkedNo registered study lists a test result for this goal. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
| Blood sugar | Nothing in the sources checkedNo registered study lists a life outcome for this goal. | Nothing in the sources checkedNo registered study lists a performance measure for this goal. | Nothing in the sources checkedNo registered study lists a symptom measure for this goal. | Only a number moved1 registered test measure. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
| Cholesterol | Nothing in the sources checkedNo registered study lists a life outcome for this goal. | Nothing in the sources checkedNo registered study lists a performance measure for this goal. | Nothing in the sources checkedNo registered study lists a symptom measure for this goal. | Only a number moved1 registered test measure. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
Which registered measures put each goal on this table
- Focus
- cognitive function in girls turner syndrome; neural responses to an emotional subsequent memory task
- Mood
- mood
- Blood sugar
- insulin sensitivity
- Cholesterol
- very low density lipoprotein triglyceride secretion rate
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
- Nothing in the sources checked
- No registered study lists a life outcome for this goal.
- Waiting for a reviewer
- 1 registered performance measure of this kind.
- Not recorded
- Harms were not a registered measure for this goal.
- Only a number moved
- 1 registered test measure.
What happened in peopleRead from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
- Living longer, or avoiding a major event Evidence recorded. Death, a heart attack, a stroke, a hospital stay.1 registered measure of this kind. No reviewed result.
- What a body can do day to day Evidence recorded. Walking, dressing, breathing, recovering.1 registered measure of this kind.
- Measured performance Evidence recorded. How much was lifted, how far was run, how fast.1 registered measure of this kind.
- Symptoms and quality of life Evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.3 registered measures of this kind.
- A number that stands in for health Evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.2 registered measures of this kind.
- A step measured inside a person Evidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
- Animals Evidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Mouse, Rat, Dog, Non-human primate. A result in animals says what to test next. It does not say what happens in people.
- Cells in a dish Evidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
- A guess from software No evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to takeRead from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
- mood
- vulvovaginal symptom questionnaire
- oab q short form symptom bother scores
Measured
Things only a test, a scale or a device shows.
- insulin sensitivity
- very low density lipoprotein triglyceride secretion rate
Meaningful
Things that change how a life goes, not only a number.
- cognitive function in girls turner syndrome
- confirmed relapse annualized relapse rate
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (29)
- progression of subclinical atherosclerosis
- efficacy of estraderm treatment on osteoporotic women
- that had an increase in myocardial fatty acid utilization
- bone density
- functional capillary density by videocapillaroscopy
- frequency of epistaxis
- badds
- improving of sleeping quality
- relative abundance of lactobacillus
- clinical pregnancy rate
- amh of ibd is lower than that of healthy women
- e2 of ibd is lower than that of healthy women
- fsh of ibd is lower than that of healthy women
- afc of ibd is lower than that of healthy women
- endometrial thickness
- ongoing pregnancy rate
- electrodermal responses to fear conditioned stimuli
- emotion recognition thresholds
- resting state functional connectivity
- neural responses to emotional faces
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclearRead from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
- Temporarily supports female reproductive health and relieves discomfort due to frequently increased menstruation, bleeding between periods, painful coitus, increased vaginal discharge, and swelling (without pain) in the lower abdomen.
Who is missing from the studies
- Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
- This is a scope explorer, not a diagnosis engine.
- It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to takeRead from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
- A different form was studied
- The studied form is not the form on the shelf. Nothing in this record points to this reason.
- There was nothing to correct
- Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
- Something else had to happen too
- In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
- The change is too small to feel
- A real change can still sit below what a person notices. Nothing in this record points to this reason.
- Day-to-day swing hides it
- Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
- Not enough time yet
- The studies ran longer than the person has waited. Nothing in this record points to this reason.
- It was not taken as studied
- Missed days change the result, and studies count them. Nothing in this record points to this reason.
- Something else changed at the same time
- Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
- The product may not be what it says
- Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
- No recorded reason
- RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to takeRead from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Varies by country
Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Sold as liquid, tablet, soluble, solution/ drops, tablet, given by the oral, topical route.
Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to takeNothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclearRead from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
58 products list this as an active ingredient in the United States drug directory. None of them contains it on its own, so nothing on this page can separate it from what it is combined with.
FDA National Drug Code directory · 71742-0004 · read 2026-08-29
They are sold as gel, globule, liquid, solution/ drops, spray and tablet, taken oral and topical.
FDA National Drug Code directory · 71742-0004 · read 2026-08-29
58 published labels name it as an active ingredient. None of them describes this substance alone, so no label text on this page can be attributed to it rather than to a combination.
US prescribing information · 8b6077c2-ecab-441a-8196-fcf736643fc6 · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · 8b6077c2-ecab-441a-8196-fcf736643fc6 · read 2026-08-29
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to takeRead from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
A single-person plan is offered only as a structure for observing yourself. It never calculates an amount to take, and it cannot prove cause.
Questions worth asking
- Which of the trials of Sus Scrofa Ovary studied people like me?
- What was measured, and for how long?
- Was the result a laboratory value or a health outcome?
- What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclearRead from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
How much did people take in the studies?
The sources RNAWiki checked hold nothing for this field.
Why it matters. A result belongs to an amount. Without the amount the result floats free.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
How fast does the body clear it?
The sources RNAWiki checked hold nothing for this field.
Why it matters. Without this, nothing on this page can say how long anything lasts.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Sus Scrofa Ovary are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in peopleRead from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
Where else this substance is registered
- FDA substance identifier (UNII)
- S7YTV04R8O
- RxNorm concept
- 1311336
- EMA substance identifier
- 100000151684
Checks this page had to pass
Passed
Identity resolved
no open identity hold
Passed
No unresolved merge across substance families
no quarantine open
Not passed
Every public sentence names a source
The opening statement carries no source: the record holds neither an explanation nor a recorded use.
Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
Passed
Safety mode resolved
The identity record classes it as a supplement ingredient; no medicines register records an approval.
Passed
Canonical metadata present
slug and display name present
What is missing or unclearRead from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
The earliest marketing start date recorded for a listed product is 20060523.
FDA National Drug Code directory · 71742-0004 · read 2026-08-29
What is missing or unclearRead from sources, not yet reviewed
What to learn next
Ordered by what would most change how you read this page, starting with what is easiest to misunderstand.
- Were people like me actually studied?
- How close is this evidence to something I would notice?
- What does nobody know about this yet?
- What is a stand-in result?
This order is fixed in code and does not count clicks or time on the page.
What is not here
7 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
- What happened in people — found nothing in the sources checked.
- The path through the body — found nothing in the sources checked.
- How long anything takes — found nothing in the sources checked.
- What it may clash with — found nothing in the sources checked.
- Other ways to the same goal — found nothing in the sources checked.
- Claims that go past the evidence — found nothing in the sources checked.
- What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (11)
What did Sus Scrofa Ovary's largest trial (643 people) and its longest (25 years) measure?
643 people in Sus Scrofa Ovary's largest registered study, 25 years in its longest registered window, measuring Change in sex steroid hormone concentrations in a time frame of 12 weeks. ClinicalTrials.gov · 2026-09-01
16 na, 10 phase2, 8 phase4, 7 phase3, 2 phase1, 1 early phase1, 1 na or unstated; NCT01425541; 2025-08. Last human test completed 2026, NCT05562518.
Interpretation These counts include studies where Sus Scrofa Ovary was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
- na16
- phase210
- phase48
- phase37
- phase12
- early phase11
2 more recorded rows
- na or unstated1
- Last recorded human test NCT055625182026-03-02
recorded 2026-09-01 · last checked 2026-09-04
From C. elegans to human: where has Sus Scrofa Ovary shown lifespan?
C. elegans: healthspan, NHP: mechanism-only, mouse: lifespan, rat: mechanism-only, dog: mechanism-only and human: biomarker (44): the rungs where Sus Scrofa Ovary has a recorded finding. Europe PMC and ClinicalTrials.gov · organism ladder · 2026-09-01
Change in sex steroid hormone concentrations in a time frame of 12 weeks. — the recorded outcome words.
Show the evidence
- C. eleganshealthspan
- NHPmechanism-only
- mouselifespan
- ratmechanism-only
- dogmechanism-only
- human NCT05562518biomarker; Change in sex steroid hormone concentrations in a time frame of 12 weeks.; 44
recorded 2026-09-01 · last checked 2026-09-04
3 of Sus Scrofa Ovary's trials stopped: accrual/recruitment, other?
accrual/recruitment (1) and other (2): Sus Scrofa Ovary's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"Atypically high dropout rate."; 3 of 44 registered studies
Show the evidence
Trial
- NCT00565916terminated; "Atypically high dropout rate."
- NCT00827151withdrawn; "The study was not funded"
- NCT01986764withdrawn; "Funding was not obtained for this study and no participants were enrolled."
recorded 2026-09-01 · last checked 2026-09-04
Did Sus Scrofa Ovary move epigenetic age, and by how much?
epigenetic age: "Of note, in women with bilateral oophorectomy before natural menopause experiencing shorter lifetime estrogen exposure than those with natural menopause, epigenetic age accel substantially influenced BC development, independent of obesity status and exogeneous estrogen use." Europe PMC · epigenetic clock search · 2025-09-01
3 recorded sentences; 2024, 2021, 2025; biomarker
Show the evidence
- epigenetic age PMID 396428702024; "Of note, in women with bilateral oophorectomy before natural menopause experiencing shorter lifetime estrogen exposure than those with natural menopause, epigenetic age accel substantially influenced BC development, independent of obesity status and exogeneous estrogen use."
- Hannum PMID 337718492021; "Age-adjusted regression models were used to examine for associations between factors related to estrogen exposure and five DNA methylation-based estimates: Grim age, pan-tissue age, Hannum age, phenotypic age, and skin and blood clock age."
- epigenetic clock PMID 408908542025; "Considering estrogen replacement therapy in TS, some epigenetic clocks found that treatment reduced biological age in TS."
recorded 2025-09-01 · last checked 2026-09-04
More Sus Scrofa Ovary was worse in human: at what point?
Hormetic in human: "Hormetic dose responses were commonly reported, being induced by a broad range of chemicals, including pharmaceuticals (e.g., atorvastatin, isoproterenol, lithium, nicotine, ouabain), dietary supplements (e.g., curcumin, multiple ginsenosides, resveratrol), endogenous agents (e.g., estrogen, hydrogen peroxide,…" Europe PMC · dose-response search · 2026-05-15
4 recorded sentences naming Sus Scrofa Ovary; Hormetic, biphasic, dose-response
Show the evidence
- Hormetic PMID 34932953"Hormetic dose responses were commonly reported, being induced by a broad range of chemicals, including pharmaceuticals (e.g., atorvastatin, isoproterenol, lithium, nicotine, ouabain), dietary supplements (e.g., curcumin, multiple ginsenosides, resveratrol), endogenous agents (e.g., estrogen, hydrogen peroxide, melatonin), and physical stressor agents (e.g., hypoxia, ionizing radiation)."
biphasic
- PMID 42142547"Estrogen receptor expression in ovarian tissue was dynamically regulated, where Esr1 increased significantly after 2-weeks and returned toward baseline by 5-weeks, while Esr2 showed a biphasic response with initial downregulation followed by upregulation at 5-weeks."
- PMID 41137378"The influence of estrogen on arrhythmias may occur via a biphasic effect that potentially provides antiarrhythmic benefits during phases of low estrogen and increases the risk of arrhythmia during peak estrogen phases."
- dose-response PMID 40436023"The meta-analysis model indicated that LC supplementation did not change the serum levels of estrogen and testosterone; however, the dose-response meta-analysis indicated that prolonged LC intake significantly increased estrogen levels."
recorded 2026-05-15 · last checked 2026-09-04
Could one person measure Sus Scrofa Ovary's effect on cognitive function in girls turner syndrome?
Cognitive function in girls turner syndrome: measured in Sus Scrofa Ovary's trials.
Interpretation cognitive function in girls turner syndrome is the recorded endpoint.
Show the evidence
biomarkers
- cognitive function in girls turner syndrome; 2026-09-01
- progression of subclinical atherosclerosis; 2026-09-01
- mood; 2026-09-01
- efficacy of estraderm treatment on osteoporotic women; 2026-09-01
- confirmed relapse annualized relapse rate; 2026-09-01
- that had an increase in myocardial fatty acid utilization; 2026-09-01
14 more recorded rows
- biomarkersinsulin sensitivity; 2026-09-01
- biomarkersvery low density lipoprotein triglyceride secretion rate; 2026-09-01
- biomarkersbone density; 2026-09-01
- biomarkersfunctional capillary density by videocapillaroscopy; 2026-09-01
- biomarkersfrequency of epistaxis; 2026-09-01
- biomarkersbadds; 2026-09-01
- biomarkersimproving of sleeping quality; 2026-09-01
- biomarkersvulvovaginal symptom questionnaire; 2026-09-01
- biomarkersrelative abundance of lactobacillus; 2026-09-01
- biomarkersclinical pregnancy rate; 2026-09-01
- biomarkersamh of ibd is lower than that of healthy women; 2026-09-01
- biomarkerse2 of ibd is lower than that of healthy women; 2026-09-01
- biomarkersfsh of ibd is lower than that of healthy women; 2026-09-01
- biomarkersafc of ibd is lower than that of healthy women; 2026-09-01
- human trials at or under309
- Not recorded for this substancea recorded half-life
- smallest human trial0; NCT00827151; PHASE3; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Which of afc of ibd is lower than that of healthy women, amh of ibd is lower than that of healthy women and badds did Sus Scrofa Ovary's trials measure?
afc of ibd is lower than that of healthy women, amh of ibd is lower than that of healthy women and badds lead 36 outcome terms across Sus Scrofa Ovary's trials. ClinicalTrials.gov · 2026-09-01
Interpretation efficacy of estraderm treatment on osteoporotic women, confirmed relapse annualized relapse rate, that had an increase in myocardial fatty acid utilization, insulin sensitivity, very low density lipoprotein triglyceride secretion rate and bone density follow.
Show the evidence
- cognitive function in girls turner syndrome1
- progression of subclinical atherosclerosis1
- mood1
- efficacy of estraderm treatment on osteoporotic women1
- confirmed relapse annualized relapse rate1
- that had an increase in myocardial fatty acid utilization1
14 more recorded rows
- insulin sensitivity1
- very low density lipoprotein triglyceride secretion rate1
- bone density1
- functional capillary density by videocapillaroscopy1
- frequency of epistaxis1
- badds1
- improving of sleeping quality1
- vulvovaginal symptom questionnaire1
- relative abundance of lactobacillus1
- clinical pregnancy rate1
- amh of ibd is lower than that of healthy women1
- e2 of ibd is lower than that of healthy women1
- fsh of ibd is lower than that of healthy women1
- afc of ibd is lower than that of healthy women1
recorded 2026-09-01 · last checked 2026-09-04
Which of Sus Scrofa Ovary's 5 ongoing trials reports first?
5 registered trials of Sus Scrofa Ovary are open; earliest completion 2026-08-16. ClinicalTrials.gov · 2026-09-01
To assess changes in breast cancer proliferation after a 7-14 day trial of estradiol in newly diagnosed estrogen receptor positive post-menopausal breast cancer patients prior to…; OAB-q short form (SF) symptom bother scores; latest 2030-12-31
Show the evidence
Trial
- NCT02238808"A Study to See Whether Estrogen Can Slow the Growth of Some ER Positive Breast Cancers"; n 19; "To assess changes in breast cancer proliferation after a 7-14 day trial of estradiol in newly diagnosed estrogen receptor positive post-menopausal breast cancer patients prior to surgery."; 2028-06
- NCT05221021"Vaginal Estradiol vs Oral Beta-3 Agonist for Overactive Bladder Syndrome"; n 152; "OAB-q short form (SF) symptom bother scores"; 2027-01-30
- NCT05283421"Improving Diagnostics in Cervical Dysplasia"; n 150; "Scoring of the visibility of the Squamous columnar junction (SCJ)"; 2026-08-16
- NCT06520982"Early Neurovascular Adaptations in Aging Women"; n 64; "Magnitude of forearm blood flow"; 2028-06-30
- NCT07420218"Menopausal Hormones and Sympathetic Activation"; n 80; "sympathetic nerve activity"; 2030-12-31
recorded 2026-09-01 · last checked 2026-09-04
Which 17 trials of Sus Scrofa Ovary posted no result?
- Posted no result
- 17 of 17 completed trials
- Registrations
- NCT00000482, NCT00000483, NCT00443716, NCT00000177, NCT00001752 and NCT00018343, and 11 more
- Completion dates
- oldest 1985-03; newest 2024-04-04
Show the evidence
Trial
- NCT000004821985-03
- NCT000004831985-03
- NCT004437161989-04
- NCT000001771999-01
- NCT000017522000-07
- NCT000183432001-03
11 further recorded trials
- NCT000063992004-03
- NCT003325532004-05
- NCT002294502004-08
- NCT000001762007-09
- NCT000291592012-06
- NCT012958922013-04
- NCT018336632013-10
- NCT020860322015-07
- NCT024197292015-11
- NCT043306772020-01-25
- NCT045319432024-04-04
At the median, Sus Scrofa Ovary's trials enrolled 64 people — anything larger?
- Median enrolment
- 64
- Largest enrolment
- 643
- Registered trials counted
- 37
What is recorded about Sus Scrofa Ovary and mTOR?
"This review synthesizes molecular evidence linking adipose-derived estrogen excess, insulin/IGF-1 activation of PI3K/AKT/mTOR and RAS/MAPK pathways, adipokine imbalance, and NF-κB-dependent inflammation to EC initiation and progression." — where Sus Scrofa Ovary and mTOR appear together. Europe PMC · pathway abstract search · 2026-06-12
mTOR, IGF-1, sirtuin, autophagy, AMPK, NAD+; PMID 41895370, 41300302, 41843303, 41648753
Show the evidence
- mTOR PMID 41895370"This review synthesizes molecular evidence linking adipose-derived estrogen excess, insulin/IGF-1 activation of PI3K/AKT/mTOR and RAS/MAPK pathways, adipokine imbalance, and NF-κB-dependent inflammation to EC initiation and progression."
IGF-1
- PMID 41895370"This review synthesizes molecular evidence linking adipose-derived estrogen excess, insulin/IGF-1 activation of PI3K/AKT/mTOR and RAS/MAPK pathways, adipokine imbalance, and NF-κB-dependent inflammation to EC initiation and progression."
- PMID 41895370"Dietary exposures modulate these biochemical networks bidirectionally: sucrose-rich ultra-processed foods intensify insulin resistance and inflammation, whereas Mediterranean and plant-forward dietary patterns attenuate insulin/IGF-1 activity, reduce systemic inflammation, improve estrogen metabolism, and enrich phytochemicals, such as glucosinolate-derived isothiocyanates, with detoxifying and…"
- sirtuin PMID 41300302"Similarly, in gynecological cancers, SIRT1 displays dual roles: promoting proliferation via estrogen signaling and p53/FOXO1 inhibition in Type I endometrial cancer yet potentially supporting DNA repair in high-grade Type II tumors."
- autophagy PMID 41843303"Estrogen signaling, pro-inflammatory mediators, and hormone resistance also modulate the autophagy–lysosome axis, further exacerbating disease pathogenesis."
- mTOR PMID 41648753"In this review, we have focused on the intervention of MFH species and active ingredients on ovarian aging, with an emphasis on the molecular mechanisms involved in antioxidant, anti-inflammatory, apoptosis inhibitory, balance of autophagy, maintenance of genome stability, mitochondrial function protective and estrogen-like effects through multiple signaling pathways (e.g., PI3K/Akt, Nrf2/HO-1,…"
- sirtuin PMID 41648753"In this review, we have focused on the intervention of MFH species and active ingredients on ovarian aging, with an emphasis on the molecular mechanisms involved in antioxidant, anti-inflammatory, apoptosis inhibitory, balance of autophagy, maintenance of genome stability, mitochondrial function protective and estrogen-like effects through multiple signaling pathways (e.g., PI3K/Akt, Nrf2/HO-1,…"
- autophagy PMID 41648753"In this review, we have focused on the intervention of MFH species and active ingredients on ovarian aging, with an emphasis on the molecular mechanisms involved in antioxidant, anti-inflammatory, apoptosis inhibitory, balance of autophagy, maintenance of genome stability, mitochondrial function protective and estrogen-like effects through multiple signaling pathways (e.g., PI3K/Akt, Nrf2/HO-1,…"
- AMPK PMID 41306723"IND exposure showed a notable reduction in the gene expression of Estrogen-Related Receptor Alpha (ERRα), nuclear respiratory factor-1 (NRF-1), mitochondrial transcription factor-A (TFAM), peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC-1α), nuclear respiratory factor-2 (Nrf-2), and silent information regulator sirtuin-1 (SIRT1) while increasing the expression of adenosine…"
7 more recorded rows
- sirtuin PMID 41306723"IND exposure showed a notable reduction in the gene expression of Estrogen-Related Receptor Alpha (ERRα), nuclear respiratory factor-1 (NRF-1), mitochondrial transcription factor-A (TFAM), peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC-1α), nuclear respiratory factor-2 (Nrf-2), and silent information regulator sirtuin-1 (SIRT1) while increasing the expression of adenosine…"
- mTOR PMID 41217893"Estrogen deficiency synergizes with metabolic dysfunction to aggravate metabolic dysfunction-associated steatotic liver disease progression through AMPK/mTOR pathway dysregulation."
- AMPK PMID 41217893"Estrogen deficiency synergizes with metabolic dysfunction to aggravate metabolic dysfunction-associated steatotic liver disease progression through AMPK/mTOR pathway dysregulation."
- autophagy PMID 42186781"Rapamycin (Rapa), an mTOR inhibitor, enhances autophagy to alleviate bone loss in senile and estrogen-deficient osteoporosis by restoring the biological properties of bone marrow stromal cells (BMSCs)."
- NAD+ PMID 36463943"We demonstrated that the activation of estrogen receptor β-Forkhead box O1-Nicotinamide phosphoribosyl transferase (ERβ-FOXO1-Nampt) signaling pathway upregulated the NAD<sup>+</sup> concentration in hepatocytes, and activated SIRT1 ultimately."
- AMPK PMID 42368952"The biological pathways linking nutritional status to cancer progression, treatment tolerance, and survivorship are discussed across four interconnected domains: insulin-IGF-1 and AMPK-mTOR signaling, adiposity-related inflammation and tumor microenvironment remodeling, gut microbiome-diet-metabolite interactions affecting estrogen metabolism, and micronutrient-dependent epigenetic regulation."
- IGF-1 PMID 42368952"The biological pathways linking nutritional status to cancer progression, treatment tolerance, and survivorship are discussed across four interconnected domains: insulin-IGF-1 and AMPK-mTOR signaling, adiposity-related inflammation and tumor microenvironment remodeling, gut microbiome-diet-metabolite interactions affecting estrogen metabolism, and micronutrient-dependent epigenetic regulation."
recorded 2026-06-12 · last checked 2026-09-04
Where it is registered
Identifiers, relations and other names
The exact record
- UNII
- S7YTV04R8O
- RxCUI
- 1311336
- Trade name
- Estrogen, Female Stimulant, Dairy Allergen Mix, High Vitality Tab, Pms, Vital Female Sexual Energy, Estrogen / Female Stimulant / Dairy Allergen Mix / High Vitality Tab / Pms / Vital Female Sexual Energy
- Also called
- OOPHORINUM SHEEP/COW/PIG [HPUS], OOPHORINUM [HPUS], OVARY, PORCINE, PORK OVARY, SUS SCROFA OVARY PREPARATION
Sources (7)
Sources
- ClinicalTrials.gov ClinicalTrials.gov API v2 snapshot 2026-09-01T09:00:05 ·
- this record's own fields 2,3,5 ·
- Europe PMC dose-response search ·
- Europe PMC epigenetic clock search ·
- Europe PMC pathway abstract search ·
- Europe PMC search ·
1 more source
- Europe PMC and ClinicalTrials.gov organism ladder ·
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence
How these records are assembled · Which registers were checked
Index-quality checks
- identity passed: no open identity hold
- required summary fields resolved: 4 required field(s) not terminal: Why people use it, Best-supported result, Biggest unanswered question, Human evidence
- public claims reviewed: 0 reviewed claim(s); drafts are never rendered
- source coverage passed: 7 source rows
- no critical contamination: no quarantine open
- canonical metadata passed: slug and display name present
- no raw internal fields: enforced by the copy-contract test over the rendered page
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