Sotatercept-Csrk
- Biologic
- Prescription only
- Identity checked
- Sources last checked 2026-09-04
This page shows what was measured, who it was measured in, and what that does not settle.
What Sotatercept-Csrk does in the body
Pulmonary arterial hypertension (PAH, Group 1 pulmonary hypertension) to improve exercise capacity and World Health Organization
From the FDA-approved label: Sotatercept-csrk, a recombinant activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein, is an activin signaling inhibitor that binds to activin A and other TGF- β superfamily ligands. As a result, sotatercept-csrk improves the balance between the pro-proliferative (ActRIIA/Smad2/3-mediated) and anti-proliferative (BMPRII/Smad1/5/8-mediated) signaling to modulate vascular proliferation. In rat models of PAH, a sotatercept-csrk analog reduced inflammation and inhibited proliferation of endothelial and smooth muscle cells in diseased vasculature. These cellular changes were associated with thinner vessel walls, partial reversal of right ventricular remodeling, and improved hemodynamics.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
- Where it acts
- Not recorded.
- Kind of result
- No result is published, so no kind of result applies yet
- Supervision
- Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
Where each sentence above came from
No recorded sentence describes the change this makes in a way that stands on its own. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 123 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Biomarker
A biomarker is a number from a test that stands in for something about health.
A picture of it, and where the picture fails
A biomarker is like a fuel gauge.
Where that stops being true. A gauge is wired to the tank. Many biomarkers are only loosely tied to health.
What people get wrong. A better number is read as a better life. Several medicines improved a number and helped nobody.
A measurable indicator used as a substitute for a clinical outcome of interest.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Formulation
A formulation is the exact made-up form a substance comes in.
A picture of it, and where the picture fails
It is like the difference between a whole bean and instant coffee.
Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.
What people get wrong. Two products with the same name are assumed to behave the same. They often do not.
The specific composition and physical form of a product, including salt, excipients and release profile.
What happened in peopleRead from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 24 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
| Goal | Life outcome | What a body can do | How a person feels | A test result | A step in the body | Harms | How long | Who was studied |
|---|---|---|---|---|---|---|---|---|
| Endurance | Nothing in the sources checkedNo registered study lists a life outcome for this goal. | Waiting for a reviewer1 registered performance measure of this kind. | Nothing in the sources checkedNo registered study lists a symptom measure for this goal. | Nothing in the sources checkedNo registered study lists a test result for this goal. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
| Body weight | Nothing in the sources checkedNo registered study lists a life outcome for this goal. | Nothing in the sources checkedNo registered study lists a performance measure for this goal. | Nothing in the sources checkedNo registered study lists a symptom measure for this goal. | Only a number moved1 registered test measure. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
Which registered measures put each goal on this table
- Endurance
- 6 minute walk distance at week 24
- Body weight
- body weight
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
- Nothing in the sources checked
- No registered study lists a life outcome for this goal.
- Waiting for a reviewer
- 1 registered performance measure of this kind.
- Not recorded
- Harms were not a registered measure for this goal.
- Only a number moved
- 1 registered test measure.
What happened in peopleRead from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
- Living longer, or avoiding a major event No evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
- What a body can do day to day Evidence recorded. Walking, dressing, breathing, recovering.1 registered measure of this kind.
- Measured performance Evidence recorded. How much was lifted, how far was run, how fast.1 registered measure of this kind.
- Symptoms and quality of life No evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.No registered study measures this.
- A number that stands in for health Evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.6 registered measures of this kind.
- A step measured inside a person Evidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
- Animals No evidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.No animal record is stored.
- Cells in a dish No evidence recorded. Cells or chemistry on a bench, far from a whole body.No cell or bench record is stored.
- A guess from software No evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to takeRead from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
No registered study measured anything of this kind.
Measured
Things only a test, a scale or a device shows.
- hemoglobin
- observed maximum concentration
- time to maximum concentration
- time to reach maximum observed serum concentration
- body weight
- blood pressure
Meaningful
Things that change how a life goes, not only a number.
- 6 minute walk distance at week 24
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (17)
- treatment emergent adverse events
- treatment emergent adverse events related to study drug
- serious adverse events
- electrocardiogram abnormalities
- apparent total clearance
- terminal half life
- anemia response
- duration of response
- extension period change from baseline in pvr
- who experienced an adverse event
- who discontinued study treatment due to an ae
- who experience an adverse event
- who discontinue study treatment due to an ae
- who experience one or more adverse events
- who discontinue study intervention due to an ae
- electrocardiogram
- one or more adverse events
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclearRead from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
- WINREVAIR™ is indicated for the treatment of adults with pulmonary arterial hypertension (PAH, Group 1 pulmonary hypertension) to improve exercise capacity and World Health Organization (WHO) functional class (FC), and reduce the risk of clinical worsening events including hospitalization for PAH, lung transplantation and death [see Clinical Studies (14.1) ].
Who is missing from the studies
- Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “The safety and effectiveness of WINREVAIR have not been established in patients less than 18 years of age.”
US prescribing information · 21693ee2-cd23-4137-ac67-066bb3a4a9b7 · read 2026-08-30
On older people, the label states: “Clinical studies of WINREVAIR did not include sufficient numbers of patients aged 75 and older to determine whether they respond differently from younger patients.”
US prescribing information · 21693ee2-cd23-4137-ac67-066bb3a4a9b7 · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary Based on findings in animal reproduction studies, WINREVAIR may cause fetal harm when administered to a pregnant woman.”
US prescribing information · 21693ee2-cd23-4137-ac67-066bb3a4a9b7 · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary There are no data on the presence of sotatercept-csrk in human milk, the effects on the breastfed infant, or the effects on milk production.”
US prescribing information · 21693ee2-cd23-4137-ac67-066bb3a4a9b7 · read 2026-08-30
Where the result stopped carrying
- This is a scope explorer, not a diagnosis engine.
- It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to takeRead from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The studied form is not the form on the shelf.
On this record: This record is linked to 1 related forms. Evidence does not carry across all of them.
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (9)
- There was nothing to correct
- Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
- Something else had to happen too
- In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
- The change is too small to feel
- A real change can still sit below what a person notices. Nothing in this record points to this reason.
- Day-to-day swing hides it
- Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
- Not enough time yet
- The studies ran longer than the person has waited. Nothing in this record points to this reason.
- It was not taken as studied
- Missed days change the result, and studies count them. Nothing in this record points to this reason.
- Something else changed at the same time
- Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
- The product may not be what it says
- Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
- No recorded reason
- RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to takeRead from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Injection
Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Suppression classes recorded: S3.
No source is stored against this line.
What is in the pack
Sold as injectable, given by the injection route.
Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to takeNothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclearRead from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Injection
Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
1 product lists this as an active ingredient in the United States drug directory. 1 of them contain it and nothing else.
FDA National Drug Code directory · 71124-0061 · read 2026-08-29
They are sold as liquid.
FDA National Drug Code directory · 71124-0061 · read 2026-08-29
1 published label names it as an active ingredient. 1 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 21693ee2-cd23-4137-ac67-066bb3a4a9b7 · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · 21693ee2-cd23-4137-ac67-066bb3a4a9b7 · read 2026-08-29
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
Names and forms linked to this record
Biosimilar of
Evidence on this page does not automatically apply to this one.
What it would be like to takeRead from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
Self-experiment planning is not offered for a prescription or clinician-supervised medicine. The questions below are for a clinician or pharmacist.
Questions worth asking
- Which of the trials of Sotatercept-Csrk studied people like me?
- What was measured, and for how long?
- Was the result a laboratory value or a health outcome?
- What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclearRead from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
How much did people take in the studies?
The sources RNAWiki checked hold nothing for this field.
Why it matters. A result belongs to an amount. Without the amount the result floats free.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Sotatercept-Csrk are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in peopleNothing found in the sources checked
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
Nothing found in the sources checked
No traced study record is stored for this substance.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Checks this page had to pass
Passed
Identity resolved
no open identity hold
Passed
No unresolved merge across substance families
no quarantine open
Passed
Every public sentence names a source
The opening statement carries the origin: Written into the record, not signed off.
Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
Passed
Safety mode resolved
Suppression classes recorded: S3.
Passed
Canonical metadata present
slug and display name present
What is missing or unclearRead from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
1 approved application covers products containing this substance. The earliest was BLA761363, approved 20240326 to MERCK SHARP DOHME.
Drugs@FDA application register · BLA761363 · read 2026-08-29
Marketing status on the register: prescription.
Drugs@FDA application register · BLA761363 · read 2026-08-29
The earliest marketing start date recorded for a listed product is 20260304.
FDA National Drug Code directory · 71124-0061 · read 2026-08-29
What is missing or unclearRead from sources, not yet reviewed
What to learn next
Ordered by what would most change how you read this page, starting with what is easiest to misunderstand.
- Were people like me actually studied?
- How close is this evidence to something I would notice?
- What does nobody know about this yet?
- What is a biomarker?
This order is fixed in code and does not count clicks or time on the page.
What is not here
7 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
- What happened in people — found nothing in the sources checked.
- The path through the body — found nothing in the sources checked.
- How long anything takes — found nothing in the sources checked.
- What it may clash with — found nothing in the sources checked.
- Other ways to the same goal — found nothing in the sources checked.
- Claims that go past the evidence — found nothing in the sources checked.
- What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (7)
What did Sotatercept-Csrk's largest trial (815 people) and its longest (16 years) measure?
815 people in Sotatercept-Csrk's largest registered study, 16 years in its longest registered window, measuring Time to First Confirmed Morbidity or Mortality Event. ClinicalTrials.gov · 2026-09-01
16 phase2, 5 phase3, 4 phase1, 2 phase4, 1 na or unstated; NCT01562405; 2027-12; no ageing endpoint recorded. Last human test completed 2026, NCT04945460.
Interpretation These counts include studies where Sotatercept-Csrk was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
- phase216
- phase35
- phase14
- phase42
- na or unstated1
- Last recorded human test NCT049454602026-04-09
recorded 2026-09-01 · last checked 2026-09-04
Sotatercept-Csrk was tested only in human — what did it show?
human: lifespan (27): the rungs where Sotatercept-Csrk has a recorded finding. Europe PMC and ClinicalTrials.gov · organism ladder · 2026-09-01
Interpretation Time to First Confirmed Morbidity or Mortality Event — the recorded outcome words.
Show the evidence
- human NCT04896008lifespan; Time to First Confirmed Morbidity or Mortality Event; 27
recorded 2026-09-01 · last checked 2026-09-04
5 of Sotatercept-Csrk's trials stopped: accrual/recruitment, other?
accrual/recruitment (2) and other (3): Sotatercept-Csrk's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"administrative reasons (slow patient enrollment)"; 5 of 27 registered studies
Show the evidence
Trial
- NCT00931606terminated; "administrative reasons (slow patient enrollment)"
- NCT01190644terminated; "Isotope needed to conduct RBC/PV analysis (primary endpoint) no longer available from manufacturer. No alternatives available for use."
- NCT01284348terminated; "Persistent low enrollment made study continuation no longer feasible"
- NCT01464164terminated; "Supporter terminated the study due to no active patients (secondary to travel restrictions due to COVID)."
- NCT04811092terminated; "Study was stopped early due to loss of clinical equipoise based on robust evidence of clinical benefit of sotatercept demonstrated in previous studies."
recorded 2026-09-01 · last checked 2026-09-04
Which of 6 minute walk distance at week 24, anemia response and apparent total clearance did Sotatercept-Csrk's trials measure?
6 minute walk distance at week 24, anemia response and apparent total clearance lead 24 outcome terms across Sotatercept-Csrk's trials. ClinicalTrials.gov · 2026-09-01
Interpretation hemoglobin, electrocardiogram abnormalities, observed maximum concentration, time to maximum concentration, apparent total clearance and terminal half life follow.
Show the evidence
- treatment emergent adverse events1
- treatment emergent adverse events related to study drug1
- serious adverse events1
- hemoglobin1
- electrocardiogram abnormalities1
- observed maximum concentration1
14 more recorded rows
- time to maximum concentration1
- apparent total clearance1
- terminal half life1
- anemia response1
- duration of response1
- time to reach maximum observed serum concentration1
- extension period change from baseline in pvr1
- 6 minute walk distance at week 241
- who experienced an adverse event1
- who discontinued study treatment due to an ae1
- who experience an adverse event1
- who discontinue study treatment due to an ae1
- who experience one or more adverse events1
- who discontinue study intervention due to an ae1
recorded 2026-09-01 · last checked 2026-09-04
Which of Sotatercept-Csrk's 7 ongoing trials reports first?
7 registered trials of Sotatercept-Csrk are open; earliest completion 2027-12. ClinicalTrials.gov · 2026-09-01
Maximum Tolerated Dose of ACE-011; Number of Participants Who Experience an Adverse Event (AE); latest 2035-08-10
Show the evidence
Trial
- NCT01562405"Sotatercept (ACE-011) With Lenalidomide or Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma"; n 33; "Maximum Tolerated Dose of ACE-011"; 2027-12
- NCT06814145"Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)"; n 440; "Number of Participants Who Experience an Adverse Event (AE)"; 2035-08-10
- NCT06925750"A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)"; n 130; "Number of Participants Who Experience One or More Adverse Events (AEs)"; 2028-06-16
- NCT07140484"Sotatercept in Pulmonary Arterial Hypertension"; n 27; "Lung diffusing capacity"; 2030-01-01
- NCT07218029"A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)"; n 815; "Number of Participants Who Experience an Adverse Event (AE)"; 2028-12-07
- NCT07600723"A Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) in India (MK-7962-037)"; n 30; "Number of participants who experience an adverse event (AE)"; 2028-04-03
- 1 further recorded trial NCT07646860"A Study of Sotatercept (MK-7962) in Japanese Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-032)"; n 6; "Number of Participants With One or More Adverse Events"; 2031-05-16
recorded 2026-09-01 · last checked 2026-09-04
Which one trial of Sotatercept-Csrk posted no result?
- Posted no result
- 1 of 1 completed trials
- Registrations
- NCT06843460
- Completion dates
- oldest 2024-05-21
Show the evidence
- Trial NCT068434602024-05-21
At the median, Sotatercept-Csrk's trials enrolled 48 people — anything larger?
- Median enrolment
- 48
- Largest enrolment
- 815
- Registered trials counted
- 26
Where it is registered
Identifiers, relations and other names
The exact record
- UNII
- 0QI90BTJ37
- CAS number
- 1001080-50-7
Relations
- Biosimilar of Sotatercept
- Trade name
- Winrevair
- Also called
- (HUMAN ACTIVIN RECEPTOR TYPE-2A PRECURSOR-(21-135)-PEPTIDYL)-THREONYLTRIGLYCYL-(HUMAN IMMUNOGLOBULIN HEAVY CONSTANT .GAMMA.1 FC FRAGMENT: (8-15)-HINGE-(A-100>V)-CH2-CH3 OF HOMO SAPIENS IGHG1*03), (123-123':126-126')-BISDISULFIDE DIMER, (HUMAN ACTIVIN RECEPTOR TYPE-2A PRECURSOR-(21-135)-PEPTIDYL)-THREONYLTRIGLYCYL-(HUMAN IMMUNOGLOBULIN HEAVY CONSTANT .GAMMA.1 FC FRAGMENT: (8-15)-HINGE-(A-100>V)-CH2-CH3 OF HOMO SAPIENS IGHG1*03), (123-123':126-126')-BISDISULPHIDE DIMER, ACTIVIN RECEPTOR TYPE IIA (SYNTHETIC HUMAN EXTRACELLULAR DOMAIN-CONTAINING FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (SYNTHETIC HUMAN HEAVY CHAIN FC FRAGMENT), DIMER, SOTATERCEPT, SOTATERCEPT [USAN], Sotatercept [MI], Sotatercept [WHO-DD], Sotatercept csrk [WHO-DD]
- Development code
- ACE-011, ACE011
Sources (6)
Sources
- ClinicalTrials.gov ClinicalTrials.gov API v2 snapshot 2026-09-01T09:00:05 ·
- this record's own fields 2,3,5 ·
- Europe PMC dose-response search ·
- Europe PMC and ClinicalTrials.gov organism ladder ·
- openfda-label 21693ee2-cd23-4137-ac67-066bb3a4a9b7 ·
- national registers US ·
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
How these records are assembled · Which registers were checked
Index-quality checks
- identity passed: no open identity hold
- required summary fields resolved: 4 required field(s) not terminal: Why people use it, Best-supported result, Biggest unanswered question, Human evidence
- public claims reviewed: 0 reviewed claim(s); drafts are never rendered
- source coverage passed: 6 source rows
- no critical contamination: no quarantine open
- canonical metadata passed: slug and display name present
- no raw internal fields: enforced by the copy-contract test over the rendered page
This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.