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Sodium Iodide

  • Prescription medicine
  • Prescription only
  • Identity checked
  • Sources last checked 2026-09-04

This page shows what was measured, who it was measured in, and what that does not settle.

What Sodium Iodide does in the body

Potassium iodide oral solution, USP is for use as an expectorant in the symptomatic treatment of chronic pulmonary diseases where tenacious mucus complicates the problem, including bronchial asthma, bronchitis and pulmonary emphysema.

Iodine is actively transported by the sodium-iodide symporter (NIS) protein, in thyroid follicular cells. Iodide is concentrated in follicular cells up to 50 times higher than in the plasma. Iodide is metabolically oxidized by thyroid peroxidase to iodinium (I + ) which in turn iodinates tyrosine residues of thyroglobulin (tri or tetra-iodinated tyrosine). The gamma emission of Iodine I 131 is imaged or counted.

Why people take it. Potassium iodide oral solution, USP is for use as an expectorant in the symptomatic treatment of chronic pulmonary diseases where tenacious mucus complicates the problem, including bronchial asthma, bronchitis and pulmonary emphysema.

What happened in people

RNAWiki has not yet published a reviewed conclusion for this use.

A fixed RNAWiki sentence

Where this came from

Wording RNAWiki always uses, not a finding about this substance.

No reviewed claim names a result for any goal on this record.

No source is stored against this line.

The limit that matters most

Not recorded.

Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.

What the registries record it as

  • The supplement label database classes it as mineral, under the name Potassium.

    NIH Dietary Supplement Label Database · 106 · read 2026-08-29

  • 8 registered substances share the start of this name, which is why a search for it can return more than one thing.

    FDA substance registry · 29UKX3A616 · read 2026-08-29

Where each sentence above came from

The use the label states, quoted from it. No plain-language version of this sentence has been written.

The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.

No statement of the main limit is recorded.

The four opening statements run to 137 words.

Words this page uses

Four words worth knowing first

Chosen from what this page shows, with each one explained before the word it depends on.

Formulation

A formulation is the exact made-up form a substance comes in.

A picture of it, and where the picture fails

It is like the difference between a whole bean and instant coffee.

Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.

What people get wrong. Two products with the same name are assumed to behave the same. They often do not.

The specific composition and physical form of a product, including salt, excipients and release profile.

What happened in peopleRead from sources, not yet reviewed

What happened in people

Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.

The number of reoperations due to infection

The study did not show it

Who was studied
NCT06126614
How many people
21006
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route.

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • Europe PMC · a recorded source, not a stored snapshot
  • CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot

Blood Culture Contamination

The study did not show it

Who was studied
NCT01216761
How many people
3879
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route.

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • Europe PMC · a recorded source, not a stored snapshot
  • CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot

Incidence of incisional surgical site infection (SSI)

The study did not show it

Who was studied
NCT04548661
How many people
2701
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route.

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • Europe PMC · a recorded source, not a stored snapshot
  • CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot

Change in vitamin A status among non-pregnant, non-lactating women

The study did not show it

Who was studied
NCT05178407
How many people
2372
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route.

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • Europe PMC · a recorded source, not a stored snapshot
  • CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot

Rate of Periprosthetic Infection (PJI) After Elective Total Joint Arthroplasty.

The study did not show it

Who was studied
NCT04075526
How many people
2129
Study design
Phase 1
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route.

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • Europe PMC · a recorded source, not a stored snapshot
  • CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot

Cancer Detection Rate Per 1000 Women Screened, by Breast Density

The study did not show it

Who was studied
NCT01925170
How many people
1638
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route.

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • Europe PMC · a recorded source, not a stored snapshot
  • CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.

What is missing or unclearRead from sources, not yet reviewed

Were people like you studied?

RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.

Who was studied

No description of who was studied is recorded.

Who is missing from the studies

  • Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

What the label states about particular groups

  • On pediatric, the label states: “Safety and effectiveness in children have not been established.”

    US prescribing information · 0bdf305f-ed4a-49d1-8901-edaed8d67850 · read 2026-08-30

  • On people who are breastfeeding, the label states: “Potassium iodide is excreted in breast milk.”

    US prescribing information · 0bdf305f-ed4a-49d1-8901-edaed8d67850 · read 2026-08-30

Where the result stopped carrying

  • This is a scope explorer, not a diagnosis engine.
  • It shows who was studied so you can see whether people similar to you were included.

RNAWiki cannot tell whether a study fits you. It can show who was in it.

What it would be like to takeRead from sources, not yet reviewed

Why it might seem to do nothing

A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.

It was studied in different people

The people in the studies were not much like the reader.

On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

A different form was studied

The studied form is not the form on the shelf.

On this record: This record is linked to 1 related forms. Evidence does not carry across all of them.

The evidence may simply be wrong

Small early studies often do not hold up.

On this record: RNAWiki has not yet published a reviewed conclusion for this use.

Other reasons RNAWiki checked and found nothing for (10)
It was studied for a different goal
The studies measured something else entirely. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.

None of these is a reason to take more. Taking more is not a step this page ever suggests.

What it would be like to takeRead from sources, not yet reviewed

What taking it involves

The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.

How it is supplied

Prescription only

Quoted from a source

Where this came from

Copied from a source RNAWiki stored, with the source named.

Read from the recorded approval status.

No source is stored against this line.

Form and route

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

No form or route is recorded.

No source is stored against this line.

Who oversees it

RNAWiki has not recorded a supervision or regulatory status for this substance.

Quoted from a source

Where this came from

Copied from a source RNAWiki stored, with the source named.

No register row and no identity class settled the question.

No source is stored against this line.

What is in the pack

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

Nothing is recorded about product quality.

No source is stored against this line.

Where it is registered

Regulatory records are listed in the technical disclosure at the foot of this page.

Counted from records

Where this came from

A count of rows RNAWiki holds. It describes our records, not your body.

Register entries are stored per jurisdiction and shown with their dates.

No source is stored against this line.

Why people stop

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

No record of why people stopped taking it is stored for this substance.

No source is stored against this line.

What it would be like to takeNothing found in the sources checked

What can go wrong

Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.

Nothing found in the sources checked

No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.

The sources listed were searched and held nothing. That is not the same as nothing existing.

Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.

Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

What is missing or unclearRead from sources, not yet reviewed

Does the exact form matter?

Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.

The form that was studied

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

The exact form studied is not recorded.

No source is stored against this line.

What is sold

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

Nothing further is recorded about which forms are sold.

No source is stored against this line.

What is recorded as being sold

  • 227 published labels name it as an active ingredient. 28 of them describe this substance alone, which is where its own label text on this page comes from.

    US prescribing information · 8e03667e-ae6a-4930-b117-3b14d5d26cb2 · read 2026-08-29

  • Those labels are classed as human otc drug and human prescription drug.

    US prescribing information · 8e03667e-ae6a-4930-b117-3b14d5d26cb2 · read 2026-08-29

  • Potassium Iodide (Saturated) is oral at How Supplied Potassium iodide oral solution, USP is supplied in 1 fluid ounce (30 mL) bottles (NDC 72919-728-30) with a calibrated dropper marked to deliver 0.3 mL (300 mg)., recorded as fda label in effect 2026-08-25 in the United States.

    US prescribing information · 0bdf305f-ed4a-49d1-8901-edaed8d67850 · read 2026-08-30

Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.

Names and forms linked to this record

  • Isotopologue of

    Sodium Iodide I-123

    Evidence on this page does not automatically apply to this one.

What it would be like to takeRead from sources, not yet reviewed

What you could measure

This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.

RNAWiki could not confidently classify this substance, so no self-experiment plan is offered.

Questions worth asking

  • Which of the trials of Sodium Iodide studied people like me?
  • What was measured, and for how long?
  • Was the result a laboratory value or a health outcome?
  • What would we watch for, and when would we stop?

Tracking can show whether something changed for you. It cannot show what caused it.

RNAWiki records evidence. It does not say whether this substance is right for you.

What is missing or unclearRead from sources, not yet reviewed

What nobody knows yet

Open questions, each with why it is open and what would close it.

Missing populations

Which groups were under-represented in the studies has not been recorded.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Missing long-term data

No completed tested study window is recorded.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

No reviewed conclusion

RNAWiki has not yet published a reviewed conclusion for this use.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Missing interaction studies

No interaction was found in the registers checked. Not finding one is not the same as showing there is none.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Formulation uncertainty

Several salts, forms or products of Sodium Iodide are recorded. Results from one form may not transfer to another.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Mechanism not reviewed

No reviewed mechanism story exists for this substance.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

What happened in peopleNothing found in the sources checked

Check any of this yourself

Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.

Nothing found in the sources checked

No traced study record is stored for this substance.

The sources listed were searched and held nothing. That is not the same as nothing existing.

Checks this page had to pass

  • Passed

    Identity resolved

    no open identity hold

  • Passed

    No unresolved merge across substance families

    no quarantine open

  • Passed

    Every public sentence names a source

    The opening statement carries the origin: Quoted from a stored source.

  • Not passed

    Trial roles classified for highlighted evidence

    No registered study is classified as testing this substance.

  • Passed

    No internal keys in reader text

    enforced by the copy-contract test over the rendered page

  • Not passed

    Safety mode resolved

    No register row and no identity class settled the question.

  • Passed

    Canonical metadata present

    slug and display name present

What is missing or unclearRead from sources, not yet reviewed

What to learn next

Ordered by what would most change how you read this page, starting with what is easiest to misunderstand.

This order is fixed in code and does not count clicks or time on the page.

What is not here

10 questions this page could not answer

These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.

  • What was measured, goal by goal — found nothing in the sources checked.
  • How close this is to real life — found nothing in the sources checked.
  • The path through the body — found nothing in the sources checked.
  • Felt, measured, or meaningful — found nothing in the sources checked.
  • How long anything takes — found nothing in the sources checked.
  • What it may clash with — found nothing in the sources checked.
  • Other ways to the same goal — found nothing in the sources checked.
  • Claims that go past the evidence — found nothing in the sources checked.
  • How this medicine reached us — found nothing in the sources checked.
  • What changed on this page — found nothing in the sources checked.

The record as stored

The full record, for auditing

Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.

Recorded evidence blocks (7)

On the Sodium Iodide label: indicated for what?

"Potassium iodide oral solution, USP is for use as an expectorant in the symptomatic treatment of chronic pulmonary diseases where tenacious mucus complicates the problem, including bronchial asthma, bronchitis and pulmonary emphysema.": indications and usage on Sodium Iodide's label. DailyMed label · 0bdf305f-ed4a-49d1-8901-edaed8d67850 · 2026-08-30

18 registered trials of Sodium Iodide — at which phases?

Registered studies posting no result
13 of 18

18 registered studies of Sodium Iodide: 6 na, 4 phase2, 3 phase3, 3 phase4, 2 na or unstated, 1 phase1. CLINICALTRIALS_SNAPSHOT · 2026-09-01

34 with a PubMed record

Show the evidence
  • na
    6
  • phase2
    4
  • phase3
    3
  • phase4
    3
  • na or unstated
    2
  • phase1
    1
5 more recorded rows
  • completed
    10
  • terminated
    3
  • active not recruiting
    2
  • unknown
    2
  • no longer available
    1

recorded 2026-09-01 · last checked 2026-09-04

2 of Sodium Iodide's trials stopped: accrual/recruitment?

accrual/recruitment (2): Sodium Iodide's stop wording, clustered. CLINICALTRIALS_SNAPSHOT · 2026-09-01

"Low Accrual"; 2 of 18 registered studies

Show the evidence

Trial

  • NCT00490490
    terminated; "Low Accrual"
  • NCT02656329
    terminated; "Sponsor discretion (low recruitment rate)"

recorded 2026-09-01 · last checked 2026-09-04

Human studies of Sodium Iodide used Iodide (150 μg/day) — over how long?

Human studies of Sodium Iodide used "Iodide (150 μg/day)". ClinicalTrials.gov · 2026-09-01

Show the evidence
  • human NCT05382793
    Iodide (150 μg/day)

recorded 2026-09-01 · last checked 2026-09-04

Which running trial of Sodium Iodide could settle lifespan?

NCT04743661 measures 2-year event free survival (EFS) in the Recurrent Medulloblastoma Cohort, reading out 2027-09-30.

1 open trial; n 62; "131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma"

Show the evidence
  • Trial NCT04743661
    "131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma"; n 62; "2-year event free survival (EFS) in the Recurrent Medulloblastoma Cohort"; 2027-09-30

Which 5 trials of Sodium Iodide posted no result?

Posted no result
5 of 5 completed trials
Registrations
NCT00277589, NCT00638092, NCT02771704, NCT02359279 and NCT05382793
Completion dates
oldest 2008-12; newest 2023-12-15
Show the evidence

Trial

  • NCT00277589
    2008-12
  • NCT00638092
    2015-05
  • NCT02771704
    2016-02
  • NCT02359279
    2016-06
  • NCT05382793
    2023-12-15

At the median, Sodium Iodide's trials enrolled 36 people — anything larger?

Median enrolment
36
Largest enrolment
1275
Registered trials counted
17
Where it is registered
Identifiers, relations and other names

The exact record

ChEMBL id
CHEMBL1644695
PubChem CID
5238
CAS number
7681-82-5
RxCUI
9884
InChIKey
FVAUCKIRQBBSSJ-UHFFFAOYSA-M

Relations

Also called
Fdy-5301, IODIDE (AS SODIUM IODIDE) [VANDF], SODIUM IODIDE [EP MONOGRAPH], SODIUM IODIDE [HSDB], SODIUM IODIDE [II], SODIUM IODIDE [JAN], SODIUM IODIDE [MART.], SODIUM IODIDE [MI], SODIUM IODIDE [USP MONOGRAPH], SODIUM IODIDE [VANDF]
Salt form
Iodide (as sodium iodide)
Development code
NSC-77388
Trade name
Mild Iodine Tincture, Iodine Tincture Mild, Cvs Iodine, Leader 2% Mild Iodine Tincture, Sunmark Iodine, Ddm Iodine Tincture Mild, Mild Iodine Tincture / Iodine Tincture Mild / Cvs Iodine / Leader 2% Mild Iodine Tincture / Sunmark Iodine / Ddm Iodine Tincture Mild
Sources (5)

Sources

  • ChEMBL 37 chembl ·
  • CLINICALTRIALS_SNAPSHOT K1:F5WR8N145C ·
  • ClinicalTrials.gov clinicaltrials.gov ·
  • DailyMed label 0bdf305f-ed4a-49d1-8901-edaed8d67850 ·
  • Drugs@FDA K1:F5WR8N145C ·

ChEMBL 37 — CC BY-SA 3.0 Unported · ClinicalTrials.gov — US Government work · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work

How these records are assembled · Which registers were checked

Index-quality checks
  • identity passed: no open identity hold
  • required summary fields resolved: 3 required field(s) not terminal: Best-supported result, Biggest unanswered question, Human evidence
  • public claims reviewed: 0 reviewed claim(s); drafts are never rendered
  • source coverage passed: 5 source rows
  • no critical contamination: no quarantine open
  • canonical metadata passed: slug and display name present
  • no raw internal fields: enforced by the copy-contract test over the rendered page

This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.