This page shows what was measured, who it was measured in, and what that does not settle.
What Compound solution of sodium chloride does in the body
Potassium chloride extended-release tablets are indicated for the treatment and prophylaxis of hypokalemia with or without metabolic alkalosis, in patients for whom dietary management with potassium-rich foods or diuretic dose reduction is insufficient.
The potassium ion is the principal intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes including the maintenance of intracellular tonicity, the transmission of nerve impulses, the contraction of cardiac, skeletal and smooth muscle and the maintenance of normal renal function. The intracellular concentration of potassium is approximately 150 to 160 mEq per liter. The normal adult plasma concentration is 3.5 to 5 mEq per liter.
Why people take it. Potassium chloride extended-release tablets are indicated for the treatment and prophylaxis of hypokalemia with or without metabolic alkalosis, in patients for whom dietary management with potassium-rich foods or diuretic dose reduction is insufficient.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
What the registries record it as
The supplement label database classes it as mineral, under the name Calcium.
7 registered substances share the start of this name, which is why a search for it can return more than one thing.
FDA substance registry · 0TJ29D9S34 · read 2026-08-29
Where each sentence above came from
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 151 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer3 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Focus
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer1 registered performance measure of this kind.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Energy
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
average pain scores in 1st 4 days post op; vas pain scoring; duration of analgesia; visual analog scale of pain
Focus
cognitive function
Energy
total energy expenditure
Blood sugar
glucose metabolism
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
3 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
△ Only a number moved
1 registered test measure.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Number of individuals vaccinated with two dose of oral cholera vaccine.
✗ The study did not show it
Who was studied
NCT01339845
How many people
240000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Radiologically confirmed all-cause pneumonia
✗ The study did not show it
Who was studied
NCT02079701
How many people
152723
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Total effect
✗ The study did not show it
Who was studied
NCT05500482
How many people
72400
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Community-acquired pneumonia: All-cause mortality (with subsidiary analyses of cause of death and of death at various timepoints following discharge)
✗ The study did not show it
Who was studied
NCT04381936
How many people
70000
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Targeted fruit and vegetable (TFV) intake
✗ The study did not show it
Who was studied
NCT02651064
How many people
55095
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Possible serious bacterial infection in neonate
✗ The study did not show it
Who was studied
NCT06824350
How many people
45450
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.1 registered measure of this kind. 1 written-up study measured this and did not show a benefit.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.1 registered measure of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.1 registered measure of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.3 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.5 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Mouse, Rat, Dog. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
average pain scores in 1st 4 days post op
vas pain scoring
visual analog scale of pain
Measured
Things only a test, a scale or a device shows.
creatinine clearance
high sensitivity c reactive protein
diastolic blood pressure by cuff 8 10 weeks minus baseline
c reactive protein
glucose metabolism
Meaningful
Things that change how a life goes, not only a number.
death or moderate to severe bronchopulmonary dysplasia
cognitive function
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (30)
forced vital capacity
forced expiratory volume
length of stay
occurrence of at least one adverse event
tolerability
average change in oral temperature from baseline to week 52
average change in respiration rate from baseline to week 52
average change in pulse comparing baseline to week 52
peak walking time
prevention of pulmonary mucus obstruction
forearm blood flow after tetraethylammonium administration
morphine consumption
total energy expenditure
lung function
albumin
palmoplantar pustulosis severity index before crossover
biochemical markers of bone turnover
primary end will be hospital admission rate
total amount of narcotic used in 1st 4 days post op
auc0 t
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
No description of who was studied is recorded.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Safety and effectiveness in the pediatric population have not been established.”
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
On older people, the label states: “Clinical studies of potassium chloride extended-release tablets did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.”
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary There are no human data related to use of potassium chloride extended-release tablets during pregnancy, and animal reproduction studies have not been conducted.”
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary The normal potassium ion content of human milk is about 13 mEq per liter.”
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
On people with reduced kidney function, the label states: “Patients with renal impairment have reduced urinary excretion of potassium and are at substantially increased risk of hyperkalemia.”
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No form or route is recorded.
No source is stored against this line.
Who oversees it
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Suppression classes recorded: S4.
No source is stored against this line.
What is in the pack
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing is recorded about product quality.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Compound solution of sodium chloride appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 5042 reaction mentions were counted. One report can name several reactions.
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
The exact form studied is not recorded.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
1270 published labels name it as an active ingredient. 506 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 37c111ec-5b62-42b9-bbb2-3b0c530e34c9 · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · 37c111ec-5b62-42b9-bbb2-3b0c530e34c9 · read 2026-08-29
Potassium Chloride is oral at 3 DOSAGE FORMS AND STRENGTHS Potassium chloride extended-release tablets USP are supplied as: 600 mg (8 mEq) are pink, circular, film-coated biconvex tablet debossed with “N 31” on one side and plain on other side. 750…, recorded as fda label in effect 2026-03-30 in the United States.
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
Self-experiment planning is not offered for a prescription or clinician-supervised medicine. The questions below are for a clinician or pharmacist.
Questions worth asking
Which of the trials of Compound solution of sodium chloride studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
How fast does the body clear it?
The sources RNAWiki checked hold nothing for this field.
Why it matters. Without this, nothing on this page can say how long anything lasts.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Compound solution of sodium chloride are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people∅Nothing found in the sources checked
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
∅Nothing found in the sources checked
No traced study record is stored for this substance.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Checks this page had to pass
✓ Passed
Identity resolved
no open identity hold
✓ Passed
No unresolved merge across substance families
no quarantine open
✓ Passed
Every public sentence names a source
The opening statement carries the origin: Quoted from a stored source.
✗ Not passed
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How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
20 approved applications cover products containing this substance. The earliest was ANDA071320, approved 19780208 to DYNAPHARM.
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What is not here
6 questions this page could not answer
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Recorded evidence blocks (12)
Q2
What did Compound solution of sodium chloride's largest trial (43626 people) and its longest (31 years) measure?
43626 people in Compound solution of sodium chloride's largest registered study, 31 years in its longest registered window, measuring Mortality, any cause, during the 28 day period after randomization. ClinicalTrials.gov · 2026-09-01
700 na, 675 phase2, 602 phase4, 455 phase3, 350 phase1, 69 early phase1, 15 na or unstated; NCT03705234; 2049-12. Last human test completed 2026, NCT06634030.
Interpretation These counts include studies where Compound solution of sodium chloride was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
700
phase2
675
phase4
602
phase3
455
phase1
350
early phase1
69
2 more recorded rows
na or unstated
15
Last recorded human testNCT06634030
2026-07-15
recorded 2026-09-01 · last checked 2026-09-04
Q3
From C. elegans to human: where has Compound solution of sodium chloride shown lifespan?
Mortality, any cause, during the 28 day period after randomization — the recorded outcome words.
Show the evidence
C. elegans
mechanism-only
mouse
lifespan
rat
lifespan
dog
mechanism-only
humanNCT00327704
lifespan; Mortality, any cause, during the 28 day period after randomization; 2635
recorded 2026-09-01 · last checked 2026-09-04
Q4
340 of Compound solution of sodium chloride's trials stopped: safety, futility/efficacy, accrual/recruitment, funding/business, sponsor decision unspecified, other?
safety (11), futility/efficacy (18), accrual/recruitment (110), funding/business (48), sponsor decision unspecified (1) and other (152): Compound solution of sodium chloride's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"The trial was halted because of unanticipated nonrespiratory adverse events related to dexamethasone therapy."; 340 of 2635 registered studies
Show the evidence
Trial
NCT00005777
terminated; "The trial was halted because of unanticipated nonrespiratory adverse events related to dexamethasone therapy."
NCT00125229
terminated; "Dr. Hladky died Sept 2006 prior to study completion"
NCT00166166
terminated; "Limited clinical staff"
NCT00224939
terminated; "Only apx 1/3 of enrolled subjects (signed consent) participated. Futility analysis to show primary endpoint"
NCT00235495
terminated; "Recruitment halted by DSMB following interim analysis."
NCT00265980
terminated; "Closed by sponsor. Lack of funding."
14 further recorded trials
NCT00293202
terminated; "We were unable to recruit sufficient patients within the confines of our budget considering the restrains on our recruitment criteria"
NCT00384995
terminated; "Lack of funding"
NCT00395161
terminated; "Terminated for futility on 11/30/09 based on the recommendation of the DSMB"
NCT00403806
terminated; "drug-related harm"
NCT00508118
terminated; "3/7 subjects experienced hypotension. Study was terminated."
NCT00515099
terminated; "Slow accrual"
NCT00519584
terminated; "Collected study data was not usable due to process miscommunications"
NCT00528502
withdrawn; "Terminated due to no patient enrollment."
NCT00541671
terminated; "Terminated: recruiting or enrolling participants has halted prematurely and will not resume; participants are no longer being examined or treated"
NCT00556387
withdrawn; "This study has been withdraw from the IRB. The PI has transferred to another university. The IND was transferred."
NCT00557843
withdrawn; "No patients enrolled"
NCT00566111
terminated; "Early indication of an unfavorable risk/benefit ratio."
NCT00624299
withdrawn; "A similar study had already been conducted, therefore pursuing this trial would have been unethical"
NCT00626574
terminated; "This study is terminated as a result of data from a study that showed increased mortality in stroke patients."
recorded 2026-09-01 · last checked 2026-09-04
Q5
Human studies of Compound solution of sodium chloride used 0.9% saline — over how long?
20 recorded entries; human; injection, IV, intravenous; also "0.9% saline", "Sodium chloride injection (0.9%)", "Sodium chloride injection USP (0.9%)"
Show the evidence
human
NCT00041392
0.9% saline
NCT00111605
injection; Sodium chloride injection (0.9%)
NCT00195312
injection; Sodium chloride injection USP (0.9%)
NCT00314132
0.9% Saline
NCT00375258
Sodium Chloride 0.9%
NCT00377403
Saline spray (0.65%)
14 more recorded rows
humanNCT00384995
IV; 0.9% (154 mEq/L) IV Sodium Chloride
humanNCT00421148
sodium chloride 0.9% solution
humanNCT00442169
0.9% Saline solution
humanNCT00457873
intravenous; 0.9% saline in 5% dextrose (intravenous)
humanNCT00457873
intravenous; 0.45% saline in 5% dextrose (intravenous)
humanNCT00552643
Saline (0.9% NaCl)
humanNCT00619918
Nebulized 3% saline
humanNCT00619918
3% saline
humanNCT00619918
Nebulized 0.9% saline
humanNCT00639912
Normal saline. Isotonic saline. Sodium chloride 0.9% .
humanNCT00639912
Normal saline. Isotonic saline. Sodium Chloride 0.9% .
humanNCT00650143
Sodium Chloride (NaCl) 0.9 %
humanNCT00708266
0.9% Saline Solution
humanNCT00722215
0.9 % saline
recorded 2026-09-01 · last checked 2026-09-04
Q6
Which of albumin, arterial stiffness and auc0 inf did Compound solution of sodium chloride's trials measure?
albumin, arterial stiffness and auc0 inf lead 40 outcome terms across Compound solution of sodium chloride's trials. ClinicalTrials.gov · 2026-09-01
forced expiratory volume, length of stay, occurrence of at least one adverse event, tolerability, average change in oral temperature from baseline to week 52 and average change in respiration rate from baseline to week 52 follow.
Show the evidence
death or moderate to severe bronchopulmonary dysplasia
1
cognitive function
1
forced vital capacity
1
forced expiratory volume
1
length of stay
1
occurrence of at least one adverse event
1
14 more recorded rows
tolerability
1
average change in oral temperature from baseline to week 52
1
average change in respiration rate from baseline to week 52
1
average change in pulse comparing baseline to week 52
1
peak walking time
1
prevention of pulmonary mucus obstruction
1
creatinine clearance
1
forearm blood flow after tetraethylammonium administration
1
high sensitivity c reactive protein
1
morphine consumption
1
diastolic blood pressure by cuff 8 10 weeks minus baseline
1
total energy expenditure
1
lung function
1
albumin
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of Compound solution of sodium chloride's 371 ongoing trials reports first?
371 registered trials of Compound solution of sodium chloride are open; earliest completion 2021-07-25. ClinicalTrials.gov · 2026-09-01
Difference in VO2max between saline day and placebo day; Major cardiac and cerebral events; latest 2049-12
Show the evidence
Trial
NCT01000350
"Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)"; n 40; "Difference in VO2max between saline day and placebo day"; 2028-06
NCT01878344
"Effects of N-acetyl Cysteine During Primary Percutaneous Coronary Intervention"; n 100; "Major cardiac and cerebral events"; 2026-12
NCT01878669
"Effects of N-acetyl Cysteine During Percutaneous Coronary Intervention"; n 390; "periprocedural myocardial infarction"; 2026-12
NCT01983241
"Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)"; n 345; "Change from Baseline in Whole lung PD15 (15th percentile point)"; 2027-01
NCT02081326
"Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes"; n 150; "Change in HbA1c values in juvenile onset type 1 diabetics"; 2031-07
NCT02081924
"Reproductive Hormones During Sustained Administration of Kisspeptin"; n 76; "Effect of Kisspeptin on hypothalamic reproductive function - LH levels"; 2027-11-30
14 further recorded trials
NCT02134925
"Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps"; n 110; "Change in Anti-MUC1 Immunoglobulin G (IgG) Levels as Determined by Enzyme-linked Immunosorbent Assay (ELISA)"; 2027-03-09
NCT02196155
"Botulinum Toxin A Versus Steroids for the Treatment of Chronic Plantar Fasciitis"; n 54; "Change from baseline in foot pain"; 2026-12
NCT02314988
"Tranexamic Acid to Reduce Blood Loss in Spine Surgery"; n 252; "Maximal drop in systemic hemoglobin concentration during the postoperative period"; 2027-07
NCT02392442
"Effects of Bronchial Segmental Endotoxin Instillation in Humans"; n 58; "Identification of cell-associated and secreted miRNA with specific types of resident and inflammatory cells in the lung."; 2027-06-30
NCT02608996
"Nesiritide in Hypertension"; n 15; "Changes in blood pressure (BP)"; 2030-12
NCT02646475
"Metabolic Effects of Angiotensin-(1-7)"; n 26; "Whole-Body Insulin Sensitivity"; 2029-12
NCT02726711
"Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic"; n 2; "The percentage of increase of the y intercept of the P-V relationship"; 2026-12
NCT03063892
"Effect of Tranexamic Acid (TXA) on Reduction of Postoperative Blood Transfusion"; n 200; "proportion of patients requiring packed Red Blood Cell transfusion"; 2027-09-01
NCT03142893
"Hormonal Mechanisms of Sleep Restriction - Axis Study"; n 80; "Average Blood Cortisol Concentration"; 2026-06-30
NCT03168958
"Methadone and Quality of Postoperative Recovery"; n 130; "Quality of recovery scores (QoR 40) on postoperative day 1"; 2021-07-25
NCT03194815
"IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2"; n 70; "Time to start of symptomatic recovery (symptomatic remission sustained for at least 6 months)"; 2027-04-30
NCT03241706
"Liver Glycogen and Hypoglycemia in Humans"; n 40; "Epinephrine"; 2028-05-31
NCT03318094
"Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity"; n 36; "Contrast Enhanced-Ultrasonography (CEU)"; 2027-11-30
NCT03332238
"Stromal Vascular Fraction Cell Therapy to Improve the Repair of Rotator Cuff Tears"; n 56; "Change in scapular plane abduction strength from baseline, and additional isometric, isokinetic strength measurements to assess supraspinatus function."; 2026-07-23
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which running trial of Compound solution of sodium chloride could settle lifespan?
NCT04821284 measures Progression-free survival, reading out 2026-02-28.
23 open trials; n 120; "Sonoporation and Chemotherapy for the Treatment of Pancreatic Cancer"
Show the evidence
Trial
NCT04821284
"Sonoporation and Chemotherapy for the Treatment of Pancreatic Cancer"; n 120; "Progression-free survival"; 2026-02-28
NCT05324748
"Repeated GON Injections in CCH"; n 50; "mean number of days, from first injection until discontinuation, study participants remain using study medication (retention rate in survival curve)"; 2026-06
NCT03741478
"Intranasal Insulin and Olanzapine Study in Healthy Volunteers"; n 64; "Endogenous Glucose Production: Pancreatic Euglycemic Clamp Experiments"; 2026-07-30
NCT03818178
"Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids"; n 60; "Change in fatty acid enrichment of intramyocellular signaling molecules before and after a euglycemic, hyperinsulinemic clamp"; 2026-12
NCT04910464
"Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis"; n 80; "ICU mortality"; 2027-01-30
NCT07271771
"The Effect of Denosumab on Muscle and Strength and Insulin Sensitivity"; n 40; "Insulin sensitivity: HbA1c"; 2027-03-01
14 further recorded trials
NCT04220671
"Measles Vaccination at Health System Contacts"; n 5400; "Non-accident mortality or admission (Composite outcome)"; 2027-06
NCT06319274
"Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure"; n 450; "28-day mortality"; 2027-09-30
NCT06897384
"High-dose Intravenous Vitamin C for the Treatment of Severe Acute Pancreatitis"; n 388; "Mortality rate in ICU"; 2027-12-31
NCT07152600
"Adaptive RCT of Corticosteroids for Severe Adenovirus Pneumonia in Adults"; n 262; "28-day all cause mortality"; 2027-12-31
NCT07152613
"Corticosteroids for PJP in Non-HIV Immunocompromised Adults"; n 240; "28-days all cause mortality"; 2027-12-31
NCT06167057
"POST URS Chemotherapy Instillation"; n 264; "1 year IVR free survival"; 2028-01-30
NCT01000350
"Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)"; n 40; "Difference in VO2max between saline day and placebo day"; 2028-06
NCT04380740
"Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis"; n 160; "Severe AGVHD-free, severe CGVHD-free, relapse-free survival (SGRFS)"; 2028-06
NCT07426172
"Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism."; n 24; "Lipolysis rate at rest, exercise and OGTT when blood lactate is elevated in MH individuals"; 2028-09-30
NCT07351500
"Adaptive RCT of Corticosteroids for Severe Influenza Pneumonia in Adults"; n 496; "28-day all cause mortality"; 2028-11-30
NCT07352865
"Adaptive RCT of Corticosteroids for Severe Chlamydia Psittaci Pneumonia in Adults"; n 100; "28-day all cause mortality"; 2028-11-30
NCT06251609
"Naloxone for Opioid Associated Out of Hospital Cardiac Arrest"; n 98; "Survival to hospital discharge"; 2028-12-31
NCT07724834
"CD19-B Cell Depletion in PAIS-ME/CFS Patients"; n 38; "Improvement in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) comparing Inebilizumab with placebo"; 2029-03-01
NCT02646475
"Metabolic Effects of Angiotensin-(1-7)"; n 26; "Whole-Body Insulin Sensitivity"; 2029-12
Q9
Which 962 trials of Compound solution of sodium chloride posted no result?
Posted no result
962 of 962 completed trials
Registrations
NCT00009620, NCT01188733, NCT00845754, NCT03537989, NCT00198497 and NCT00271310, and 956 more
Completion dates
oldest 1997-02; newest 2024-09-01
Show the evidence
Trial
NCT00009620
1997-02
NCT01188733
2000-12
NCT00845754
2001-08
NCT03537989
2001-08-31
NCT00198497
2003-06
NCT00271310
2003-11
14 further recorded trials
NCT00069082
2004-01
NCT00612625
2004-12
NCT01115179
2005-12
NCT00717782
2006-01
NCT01095276
2006-01
NCT00354263
2006-02
NCT00430859
2006-03
NCT00606827
2006-03
NCT00318006
2006-08
NCT00346853
2006-09
NCT00639236
2006-11
NCT00239707
2006-12
NCT00772122
2007-01
NCT00527202
2007-03
Q10
At the median, Compound solution of sodium chloride's trials enrolled 60 people — anything larger?
Median enrolment
60
Largest enrolment
43626
Registered trials counted
2633
Q11
What do 5042 spontaneous reports say about Compound solution of sodium chloride — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Compound solution of sodium chloride appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 5042 reaction mentions were counted: peritonitis 1434; peritonitis bacterial 1266; fluid overload 442; abdominal distension 416. open-targets-adr · CHEMBL1200574 · 2026-06-24
Show the evidence
peritonitis
1434
peritonitis bacterial
1266
fluid overload
442
abdominal distension
416
peritoneal dialysis complication
401
toxic anterior segment syndrome
394
4 more recorded rows
fungal peritonitis
186
bloody peritoneal effluent
183
endophthalmitis
179
hypervolaemia
141
recorded 2026-06-24 · last checked 2026-09-04
Q12
Was Compound solution of sodium chloride studied with fasting and exercise?
fasting and exercise are named in Compound solution of sodium chloride's label sentences: "They underwent five testing sessions, separated by a one-week washout period: a baseline trial in the fed state, followed by four trials after 14 h of fasting with either CHO, NaHCO<sub>3</sub>, or a placebo (sodium chloride) ingestion." openfda-label+europepmc · 2025-08-29
2 recorded statements; fasting, exercise
Show the evidence
fasting
They underwent five testing sessions, separated by a one-week washout period: a baseline trial in the fed state, followed by four trials after 14 h of fasting with either CHO, NaHCO<sub>3</sub>, or a placebo (sodium chloride) ingestion.
exercise
After one familiarisation trial, this was repeated on two separate occasions whereby participants ingested either 0.3 g.kg<sup>-1</sup> BM NaHCO<sub>3</sub> or 0.05 g.kg<sup>-1</sup> BM sodium chloride (placebo) in solution 60 min prior to exercise.
recorded 2025-08-29 · last checked 2026-09-04
Q13
What is recorded about Compound solution of sodium chloride and mTOR?
"Overall, these findings suggest that the autolysosomal compartment is a novel target of Na<sup>+</sup>-modulated cell autonomous innate immunity. <b>Abbreviations</b>: ACT: actins; AKT: AKT serine/threonine kinase 1; ATG2A: autophagy related 2A; ATG4C: autophagy related 4C, cysteine peptidase; ATG7: autophagy related 7; ATG12: autophagy…" — where Compound solution of sodium chloride and mTOR appear together. Europe PMC · pathway abstract search · 2020-03-19
"Overall, these findings suggest that the autolysosomal compartment is a novel target of Na<sup>+</sup>-modulated cell autonomous innate immunity. <b>Abbreviations</b>: ACT: actins; AKT: AKT serine/threonine kinase 1; ATG2A: autophagy related 2A; ATG4C: autophagy related 4C, cysteine peptidase; ATG7: autophagy related 7; ATG12: autophagy related 12; BECN1: beclin 1; BMDM: bone marrow-derived…"
autophagyPMID 30982460
"Overall, these findings suggest that the autolysosomal compartment is a novel target of Na<sup>+</sup>-modulated cell autonomous innate immunity. <b>Abbreviations</b>: ACT: actins; AKT: AKT serine/threonine kinase 1; ATG2A: autophagy related 2A; ATG4C: autophagy related 4C, cysteine peptidase; ATG7: autophagy related 7; ATG12: autophagy related 12; BECN1: beclin 1; BMDM: bone marrow-derived…"
mTORPMID 25057011
"Here we show that treatment with sodium chloride (NaCl), which activates NFAT5 signaling, increased mTORC1 repressor regulated in development and DNA damage response 1 (REDD1) protein expression and inhibited mTOR signaling; these alterations were attenuated by knockdown of NFAT5."
autophagyPMID 32160108
"The findings of our study reveal a novel role for NRBF2 in regulating apoptotic cell clearance to restrict intestinal inflammation.<b>Abbreviation:</b> ANOVA: analysis of variance; ATG14: autophagy related 14; ATG16L1: autophagy related 16-like 1 (S. cerevisiae); BMDM: bone marrow-derived macrophage; BSA: bovine serum albumin; CD: Crohn disease; CD68: CD68 molecule; CFP: cyan fluorescent protein;…"
recorded 2020-03-19 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
✗ required summary fields resolved: 4 required field(s) not terminal: Best-supported result, Most important common problem, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 10 source rows
✓ no critical contamination: no quarantine open
✓ canonical metadata passed: slug and display name present
✓ no raw internal fields: enforced by the copy-contract test over the rendered page
This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.