This page shows what was measured, who it was measured in, and what that does not settle.
What Remifentanil does in the body
Intravenous (IV) administration
From the FDA-approved label: Remifentanil Hydrochloride for injection is a μ-opioid agonist with rapid onset and peak effect, and short duration of action. The μ- opioid activity of Remifentanil Hydrochloride for injection is antagonized by opioid antagonists such as naloxone. Unlike other opioids, Remifentanil Hydrochloride for injection is rapidly metabolized by hydrolysis of the propanoic acid-methyl ester linkage by nonspecific blood and tissue esterases. Remifentanil Hydrochloride for injection is not a substrate for plasma cholinesterase (pseudocholinesterase) and, therefore, patients with atypical cholinesterase are expected to have a normal duration of action.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · P10582JYYK · read 2026-08-29
Its recorded molecular formula is C20H28N2O5•HCl, weighing 412.91.
US prescribing information · d2374b84-81c9-44f9-a4a9-1071281b2531 · read 2026-08-30
Where each sentence above came from
No recorded sentence describes the change this makes in a way that stands on its own. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 107 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Biomarker
A biomarker is a number from a test that stands in for something about health.
A picture of it, and where the picture fails
A biomarker is like a fuel gauge.
Where that stops being true. A gauge is wired to the tank. Many biomarkers are only loosely tied to health.
What people get wrong. A better number is read as a better life. Several medicines improved a number and helped nobody.
A measurable indicator used as a substitute for a clinical outcome of interest.
Placebo
A placebo is a dummy treatment given so the real one can be compared with it.
A picture of it, and where the picture fails
A placebo is like a blank control in an experiment.
Where that stops being true. A blank does nothing. People given a placebo often do get better.
What people get wrong. A placebo effect is read as imaginary. The improvement is measured and real.
An inactive intervention matched in appearance to the test intervention, used to control for non-specific effects.
Comparator
A comparator is whatever the treatment was measured against.
A picture of it, and where the picture fails
It is like the other runner in a race.
Where that stops being true. A race has one winner. A study can show both arms improved.
What people get wrong. Results are read without asking what the other group got. Beating nothing is not beating a treatment.
The control condition against which the experimental intervention is assessed.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Adherence to PONV Guidelines
✗ The study did not show it
Who was studied
NCT02625181
How many people
27034
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Mortality
✗ The study did not show it
Who was studied
NCT01728558
How many people
4000
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
The number of operative interventions during labor
✗ The study did not show it
Who was studied
NCT06135961
How many people
3471
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
The dose of propofol required to maintain BIS (bispectral index) between 40 and 60 during maintenance of anesthesia
✗ The study did not show it
Who was studied
NCT00896714
How many people
3278
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Proportion of participants with one or more intubation or anaesthesia related adverse events
✗ The study did not show it
Who was studied
NCT06564857
How many people
2648
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Mortality rate during the first year following anesthesia
✗ The study did not show it
Who was studied
NCT01198639
How many people
2044
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Remifentanil hydrochloride (HCl) for injection is indicated for intravenous (IV) administration: • As an analgesic agent for use during the induction and maintenance of general anesthesia for inpatient and outpatient procedures.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “The efficacy and safety of remifentanil HCl as an analgesic agent for use in the maintenance of general anesthesia in outpatient and inpatient pediatric surgery have been established in controlled clinical studies in pediatric patients from birth to 12 years [see Clinical Studies ( 14.4 )] .”
US prescribing information · d2374b84-81c9-44f9-a4a9-1071281b2531 · read 2026-08-30
On older people, the label states: “Of the total number of subjects in clinical studies of remifentanil HCl, 486 were 65 and over (age range 66 to 90 years).”
US prescribing information · d2374b84-81c9-44f9-a4a9-1071281b2531 · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary Prolonged use of opioid analgesics during pregnancy may cause neonatal opioid withdrawal syndrome.”
US prescribing information · d2374b84-81c9-44f9-a4a9-1071281b2531 · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary It is not known whether remifentanil is excreted in human milk.”
US prescribing information · d2374b84-81c9-44f9-a4a9-1071281b2531 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (11)
It was studied for a different goal
The studies measured something else entirely. Nothing in this record points to this reason.
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Injection
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Suppression classes recorded: S1, S2, S6.
No source is stored against this line.
What is in the pack
Sold as injectable, injection, powder, lyophilized, for solution, given by the injection, intravenous route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Injection
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
19 products list this as an active ingredient in the United States drug directory. 19 of them contain it and nothing else.
FDA National Drug Code directory · 72078-035 · read 2026-08-29
They are sold as injection, powder, lyophilized, for solution and powder, taken intravenous.
FDA National Drug Code directory · 72078-035 · read 2026-08-29
The regulator's established pharmacologic class for it is full opioid agonists [moa] and opioid agonist [epc].
FDA National Drug Code directory · 72078-035 · read 2026-08-29
5 published labels name it as an active ingredient. 5 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · d2374b84-81c9-44f9-a4a9-1071281b2531 · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · d2374b84-81c9-44f9-a4a9-1071281b2531 · read 2026-08-29
Remifentanil Hydrochloride is intravenous at 3 DOSAGE FORMS AND STRENGTHS For injection: 1 mg, 2 mg, and 5 mg: 3 mL Vial 1 mg lyophilized powder 5 mL Vial 2 mg lyophilized powder 10 mL Vial 5 mg lyophilized powder For injection: 1 mg, 2 mg, and 5 mg for intravenou…, recorded as fda label in effect 2024-09-15 in the United States.
US prescribing information · d2374b84-81c9-44f9-a4a9-1071281b2531 · read 2026-08-30
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
Self-experiment planning is not offered for a prescription or clinician-supervised medicine. The questions below are for a clinician or pharmacist.
Questions worth asking
Which of the trials of Remifentanil studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Remifentanil are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
How many documents were read
5 documents were read for this substance.
RNAWiki source record
5 of them state the same halfLife, and they agree.
RNAWiki source record
Where else this substance is registered
FDA substance identifier (UNII)
P10582JYYK
CAS registry number
132875-61-7
PubChem compound
60815
ChEMBL
CHEMBL1005
ChEBI
8802
WHO international nonproprietary name list entry
6924
RxNorm concept
73032
EMA substance identifier
100000089165
DrugBank
DB00899
Checks this page had to pass
✓ Passed
Identity resolved
no open identity hold
✓ Passed
No unresolved merge across substance families
no quarantine open
✓ Passed
Every public sentence names a source
The opening statement carries the origin: Written into the record, not signed off.
✗ Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
✓ Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
✓ Passed
Safety mode resolved
Suppression classes recorded: S1, S2, S6.
✓ Passed
Canonical metadata present
slug and display name present
What is missing or unclear◇Read from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
4 approved applications cover products containing this substance. The earliest was NDA020630, approved 19960712 to MYLAN INSTITUTIONAL.
This order is fixed in code and does not count clicks or time on the page.
What is not here
9 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
What was measured, goal by goal — found nothing in the sources checked.
How close this is to real life — found nothing in the sources checked.
The path through the body — found nothing in the sources checked.
Felt, measured, or meaningful — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (10)
Q2
On the Remifentanil label: indicated for what?
"ULTIVA is indicated for intravenous (IV) administration: • As an analgesic agent for use during the induction and maintenance of general anesthesia for inpatient and outpatient procedures. • For continuation as an analgesic into the immediate postoperative period in adult patients under the direct supervision of an…": indications and usage on Remifentanil's label. DailyMed label · 4dbcb8f9-1987-4b66-bd2f-d251fda0be10 · 2025-12-15
Q3
354 registered trials of Remifentanil — at which phases?
Registered studies posting no result
311 of 354
354 registered studies of Remifentanil: 146 na, 140 phase4, 20 na or unstated, 20 phase3, 19 phase2, 9 phase1, 6 early phase1. CLINICALTRIALS_SNAPSHOT · 2026-09-01
futility/efficacy (1), accrual/recruitment (10), funding/business (3), sponsor decision unspecified (2) and other (14): Remifentanil's stop wording, clustered. CLINICALTRIALS_SNAPSHOT · 2026-09-01
"Closed due to lack of enrollment"; 30 of 354 registered studies
Show the evidence
Trial
NCT00335972
terminated; "Closed due to lack of enrollment"
NCT00436345
terminated; "recruitment issues"
NCT00615472
terminated; "Lack of funding"
NCT00681174
terminated; "Failure to enroll sufficient patients by expected deadline."
NCT00693160
terminated; "the manufacturing of preservative free ketorolac (Acular-PF) was discontinued"
NCT00778505
terminated; "difficulty in recruiting"
14 further recorded trials
NCT01043952
terminated; "Poor enrollment."
NCT01563939
terminated; "Difficult recruitment."
NCT01746641
terminated; "Occurrence of severe respiratory depression in the remifentanil group."
NCT02164734
terminated; "Slow to impossible recruitment during COVID-19 pandemic"
NCT02430389
terminated; "A priori hypothesis confirmed with interim analysis."
NCT02488486
terminated; "Intermediate analysis"
NCT02664922
terminated; "Poor study design and too many study groups."
NCT02683837
withdrawn; "Principal investigator left the institution"
NCT02799589
withdrawn; "Difficulty in recruitment"
NCT02989597
terminated; "Due to personnel loss and logistical issues the study was unable to be completed as planned."
NCT03066739
terminated; "Study terminated early due to low enrollment. Only 8 participants enrolled out of the target 105."
NCT03283150
terminated; "Due to a decrease in scheduled study-eligible patients, we terminated the study prematurely"
NCT03316339
terminated; "Sponsor's decision"
NCT03401606
terminated; "a respiratory depression in remifentanyl group"
recorded 2026-09-01 · last checked 2026-09-04
Q5
Human studies of Remifentanil used Remifentanil 2 MG — over how long?
studies of Remifentanil used the recorded amount. ClinicalTrials.gov · 2026-09-01
4 recorded entries; human; also "Remifentanil 2 MG", "Remifentanil Injection plus 30%", "Remifentanil 1 MG Injection [Ultiva]"
Show the evidence
human
NCT04117009
Remifentanil 2 MG
NCT05026125
Remifentanil Injection plus 30%
NCT05115578
Remifentanil 1 MG Injection [Ultiva]
NCT06564857
Remifentanil 5 mg diluted in 100 ml saline, which corresponds to Remifentanil 50 micrograms/ml
recorded 2026-09-01 · last checked 2026-09-04
Q6
Remifentanil's half-life is 6 minutes — which schedules were studied?
6 minutes, the half-life Remifentanil's label states: "After IV doses administered over 60 seconds, the pharmacokinetics of remifentanil fit a three-compartment model with a rapid distribution half-life of one minute, a slower distribution half-life of 6 minutes, and a terminal elimination half-life of 10 to 20 minutes." DailyMed label · 4dbcb8f9-1987-4b66-bd2f-d251fda0be10 · 2025-12-15
Show the evidence
half lifepharmacokinetics
6 minutes; After IV doses administered over 60 seconds, the pharmacokinetics of remifentanil fit a three-compartment model with a rapid distribution half-life of one minute, a slower distribution half-life of 6 minutes, and a terminal elimination half-life of 10 to 20 minutes.
metabolismpharmacokinetics
Metabolism Remifentanil is an esterase-metabolized opioid.
recorded 2025-12-15 · last checked 2026-09-04
Q7
Which running trial of Remifentanil could settle inflammatory markers?
NCT07571473 measures Change in interleukin-6 (IL-6) levels, reading out 2026-05-30.
1 open trial; n 30; "CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy"
Show the evidence
TrialNCT07571473
"CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy"; n 30; "Change in interleukin-6 (IL-6) levels"; 2026-05-30
Q8
Which 185 trials of Remifentanil posted no result?
Posted no result
185 of 185 completed trials
Registrations
NCT00391105, NCT01947114, NCT02637726, NCT00534586, NCT00349245 and NCT00455026, and 179 more
Completion dates
oldest 2005-11; newest 2024-08-28
Show the evidence
Trial
NCT00391105
2005-11
NCT01947114
2006-08
NCT02637726
2007-03
NCT00534586
2007-05
NCT00349245
2007-08
NCT00455026
2007-10
14 further recorded trials
NCT01013558
2007-12
NCT00474071
2008-04
NCT02602002
2008-06
NCT00665119
2008-10
NCT00706277
2008-12
NCT00785863
2009-04
NCT01079312
2009-04
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2009-09
NCT01350037
2009-09
NCT02619032
2009-09
NCT01015651
2009-10
NCT01056224
2010-01
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2010-06
NCT01026129
2010-07
Q9
At the median, Remifentanil's trials enrolled 62 people — anything larger?
Median enrolment
62
Largest enrolment
27034
Registered trials counted
353
Q10
What do 583 spontaneous reports say about Remifentanil — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Remifentanil appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 583 reaction mentions were counted: hypotension 85; low birth weight baby 80; anaphylactic shock 72; anaphylactic reaction 66. FAERS via Open Targets · CHEMBL1005 · 2026-06-24
Show the evidence
hypotension
85
low birth weight baby
80
anaphylactic shock
72
anaphylactic reaction
66
bradycardia
62
cardiac arrest
57
4 more recorded rows
premature baby
47
drug interaction
46
respiratory depression
37
unwanted awareness during anaesthesia
31
recorded 2026-06-24 · last checked 2026-09-04
Q11
Which 10 reactions does Remifentanil's label not list?
ChEMBL 37 — CC BY-SA 3.0 Unported · ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Open Targets 26.06 — CC0 · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
✗ required summary fields resolved: 4 required field(s) not terminal: Why people use it, Best-supported result, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 6 source rows
✓ no critical contamination: no quarantine open
✓ canonical metadata passed: slug and display name present
✓ no raw internal fields: enforced by the copy-contract test over the rendered page
This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.