This page shows what was measured, who it was measured in, and what that does not settle.
What Olive Oil does in the body
helps reduce bacteria that potentially can cause disease for use when soap and water are not available
From the FDA-approved label: SMOFlipid provides a biologically utilizable source of calories and essential fatty acids. Fatty acids serve as an important substrate for energy production. The most common mechanism of action for energy production derived from fatty acid metabolism is beta oxidation. Fatty acids are also important for membrane structure and function, as precursors for bioactive molecules (such as prostaglandins), and as regulators of gene expression.
Why people take it. helps reduce bacteria that potentially can cause disease for use when soap and water are not available
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
What the registries record it as
The substance registry classes this as structurallydiverse.
FDA substance registry · 6UYK2W1W1E · read 2026-08-29
It is recorded as coming from OLEA EUROPAEA WHOLE. The part recorded is fruit.
FDA substance registry · 6UYK2W1W1E · read 2026-08-29
The supplement label database classes it as fat, under the name Olive Oil.
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 112 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Cholesterol
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved8 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Mood
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer1 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer1 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Body weight
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Cholesterol
serum non hdl cholesterol; triglycerides from baseline; low density lipoprotein cholesterol; triglyceride for all; total cholesterol; ldl cholesterol; hdl cholesterol; triglycerides
Mood
depression symptom severity at 12 weeks
Pain
pain
Body weight
body composition
Blood sugar
glucose
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
△ Only a number moved
8 registered test measure.
— Not recorded
Harms were not a registered measure for this goal.
… Waiting for a reviewer
Who was studied is listed further down the page.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Composite of the First Occurrence of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI) or Nonfatal Stroke
✗ The study did not show it
Who was studied
NCT00069784
How many people
12537
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
cardiovascular deaths and hospitalization for cardiovascular causes
✗ The study did not show it
Who was studied
NCT00317707
How many people
12513
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Glucose - Diet Specific mixed meal tolerance test (MMTT) Diet A
✗ The study did not show it
Who was studied
NCT05701657
How many people
8000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Premature birth
✗ The study did not show it
Who was studied
NCT02770456
How many people
5531
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Sudden cardiac death
✗ The study did not show it
Who was studied
NCT00251134
How many people
3800
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Composite maternal outcomes: pre-eclampsia or gestational diabetes
✗ The study did not show it
Who was studied
NCT02218931
How many people
3442
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.0 registered measures of this kind. 3 written-up studies measured this and did not show a benefit.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.3 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.17 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
depression symptom severity at 12 weeks
irritable bowel syndrome symptom severity
pain
Measured
Things only a test, a scale or a device shows.
24 hour ambulatory systolic blood pressure
serum conjugated bilirubin
serum non hdl cholesterol
heart rate variability changes
plasma glp 1
triglycerides from baseline
changes in bone mineral density
low density lipoprotein cholesterol
triglyceride for all
evolution of inflammatory markers in postprandial state
and 7 more.
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (20)
microvolt t wave alternans status
pc20 methacholine sensitivity
omega 3
yale global tic severity scale
gestation length
pulmonary function
incidence of parenteral nutrition associated cholestasis
25 hydroxyvitamin d levels at 12 weeks
ocular surface disease index
glomerular filtration rate
reactive hyperemia index
time to flatus
retinopathy of prematurity
sarcopenic index
maximum voluntary contraction force
metabolomic profile
evolution of metabolic parameters in postprandial state
pharmacokinetic of niacin and its metabolites
total bilirubin
cigarettes per day from baseline to 4 weeks
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
CLINOLIPID is indicated in adults and pediatric patients, including term and preterm neonates, as a source of calories and essential fatty acids for parenteral nutrition (PN) when oral or enteral nutrition is not possible, insufficient, or contraindicated.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Given by a clinician
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Intravenous
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Sold as emulsion, liquid, injection, emulsion, cream, given by the intravenous, oral, topical route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Olive Oil appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 238 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
macular degeneration — 45 reaction mentions
malaise — 39 reaction mentions
fatty acid deficiency — 26 reaction mentions
pain — 25 reaction mentions
pyrexia — 25 reaction mentions
constipation — 17 reaction mentions
infusion related reaction — 17 reaction mentions
weight decreased — 16 reaction mentions
cholestasis — 14 reaction mentions
chronic sinusitis — 14 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Intravenous
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
9 products list this as an active ingredient in the United States drug directory. 2 of them contain it and nothing else.
FDA National Drug Code directory · 43857-0486 · read 2026-08-29
They are sold as cream, injection, emulsion, liquid and oil, taken intravenous, oral and topical.
FDA National Drug Code directory · 43857-0486 · read 2026-08-29
7 published labels name it as an active ingredient. None of them describes this substance alone, so no label text on this page can be attributed to it rather than to a combination.
US prescribing information · e95845f0-26d1-4190-bb45-e5f276a2bba4 · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · e95845f0-26d1-4190-bb45-e5f276a2bba4 · read 2026-08-29
10131 marketed supplement labels list this ingredient, classed as botanical, fat/fatty acid and fat.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
Clinolipid is intravenous at 3 DOSAGE FORMS AND STRENGTHS CLINOLIPID is a sterile, homogenous, white, milky, lipid injectable emulsion supplied as: • 20% (20 g/100 mL)(0.2g/mL) of lipid in 100 mL single-dose Flexible Container • 20% (50 g/250 mL)(0…, recorded as fda label in effect 2025-07-24 in the United States.
US prescribing information · ae98eb03-c0e7-49d1-b024-77968e3d9d6e · read 2026-08-30
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
A single-person plan is offered only as a structure for observing yourself. It never calculates an amount to take, and it cannot prove cause.
Questions worth asking
Which of the trials of Olive Oil studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
How fast does the body clear it?
The sources RNAWiki checked hold nothing for this field.
Why it matters. Without this, nothing on this page can say how long anything lasts.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Olive Oil are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
Where else this substance is registered
FDA substance identifier (UNII)
6UYK2W1W1E
CAS registry number
8001-25-0
RxNorm concept
1309250
EMA substance identifier
100000080054
European Chemicals Agency number
232-277-0
DrugBank
DB09567
Checks this page had to pass
✓ Passed
Identity resolved
no open identity hold
✓ Passed
No unresolved merge across substance families
no quarantine open
✓ Passed
Every public sentence names a source
The opening statement carries the origin: Quoted from a stored source.
✗ Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
✓ Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
✓ Passed
Safety mode resolved
The identity record classes it as a supplement ingredient; no medicines register records an approval.
✓ Passed
Canonical metadata present
slug and display name present
What is missing or unclear◇Read from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
2 approved applications cover products containing this substance. The earliest was NDA204508, approved 20131003 to BAXTER HLTHCARE CORP.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (12)
Q1
What did Olive Oil's largest trial (5531 people) and its longest (21 years) measure?
5531 people in Olive Oil's largest registered study, 21 years in its longest registered window, measuring The primary outcome measures is defined as the change from baseline to final assessment of the study knee in the 3 core continuous variables pain and physical function, assessing using the WOMAC… ClinicalTrials.gov · 2026-09-01
74 na, 23 phase4, 20 phase2, 18 phase3, 11 phase1, 3 na or unstated, 1 early phase1; NCT01353807; 2011-05. Last human test completed 2025, NCT03018041.
Interpretation These counts include studies where Olive Oil was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
74
phase4
23
phase2
20
phase3
18
phase1
11
na or unstated
3
2 more recorded rows
early phase1
1
Last recorded human testNCT03018041
2025-03-22
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has Olive Oil shown lifespan?
The primary outcome measures is defined as the change from baseline to final assessment of the study knee in the 3 core continuous variables pain and physical… — the recorded outcome words.
Show the evidence
C. elegans
lifespan
mouse
lifespan
rat
lifespan
humanNCT00670475
healthspan; The primary outcome measures is defined as the change from baseline to final assessment of the study knee in the 3 core continuous variables pain and physical function, assessing using the WOMAC subscales, and patient global assessment…; 141
recorded 2026-09-01 · last checked 2026-09-04
Q3
9 of Olive Oil's trials stopped: futility/efficacy, accrual/recruitment, funding/business, other?
futility/efficacy (1), accrual/recruitment (2), funding/business (1) and other (5): Olive Oil's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"funding not secured"; 9 of 141 registered studies
Show the evidence
Trial
NCT00507390
withdrawn; "funding not secured"
NCT01630551
withdrawn; "No participants enrolled"
NCT02070042
terminated; "Lack of participation"
NCT02579265
terminated; "Outcome of a planned interim analysis was that the sample size required to show superiority was too high to be feasible. Fresenius Kabi requested termination to the FDA on 17 Jan 2020. FDA accepted termination by written response on 16 Apr…"
NCT02633384
terminated; "One of the intravenous lipid emulsions was retired from the market"
NCT02853253
withdrawn; "scientific question reconsidered"
3 further recorded trials
NCT03054948
withdrawn; "Redesign of study protocol."
NCT03563222
terminated; "Prematurely stopped in agreement with authorities (FDA)"
NCT03708354
withdrawn; "Difficulties in Recruiting"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Olive Oil used SMOFlipid 20%® (Fresenius Kabi Deutschland GmbH,Bad Homburg, Germany) — over how long?
Human studies of Olive Oil used "SMOFlipid 20%® (Fresenius Kabi Deutschland GmbH,Bad Homburg, Germany)". ClinicalTrials.gov · 2026-09-01
11 recorded entries; human; also "SMOFlipid 20%", "Olive oil, 4g", "2880mg olive oil daily"
Show the evidence
human
NCT00600912
SMOFlipid 20%® (Fresenius Kabi Deutschland GmbH,Bad Homburg, Germany)
NCT00793195
SMOFlipid 20%
NCT01408303
Olive oil, 4g
NCT02166424
2880mg olive oil daily
NCT02579265
Smoflipid 20% (investigational lipid for parenteral nutrition)
NCT02579265
Smoflipid 20% (lipid injectable emulsion)
5 more recorded rows
humanNCT03149653
SMOFlipid 20% Fresenius Kabi
humanNCT03149653
SMOFlipid 20% Fresenius Kabi + Omegaven 10% Fresenius Kabi
humanNCT03563222
Smoflipid® Lipid Injectible Emulsion, USP 20%
humanNCT04951791
smoflipid 20% lipid emulsion
humanNCT06065202
CLINOLIPID 20%
recorded 2026-09-01 · last checked 2026-09-04
Q5
Could one person measure Olive Oil's effect on microvolt t wave alternans status?
Microvolt t wave alternans status: measured in Olive Oil's trials.
Interpretation microvolt t wave alternans status is the recorded endpoint.
incidence of parenteral nutrition associated cholestasis; 2026-09-01
biomarkers
25 hydroxyvitamin d levels at 12 weeks; 2026-09-01
biomarkers
ocular surface disease index; 2026-09-01
biomarkers
triglycerides from baseline; 2026-09-01
biomarkers
glomerular filtration rate; 2026-09-01
biomarkers
pain; 2026-09-01
biomarkers
reactive hyperemia index; 2026-09-01
human trials at or under30
41
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT00507390; PHASE4; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q6
Which of 24 hour ambulatory systolic blood pressure, 25 hydroxyvitamin d levels at 12 weeks and body composition did Olive Oil's trials measure?
24 hour ambulatory systolic blood pressure, 25 hydroxyvitamin d levels at 12 weeks and body composition lead 40 outcome terms across Olive Oil's trials. ClinicalTrials.gov · 2026-09-01
pc20 methacholine sensitivity, depression symptom severity at 12 weeks, omega 3, yale global tic severity scale, gestation length and serum non hdl cholesterol follow.
Show the evidence
microvolt t wave alternans status
1
24 hour ambulatory systolic blood pressure
1
serum conjugated bilirubin
1
pc20 methacholine sensitivity
1
depression symptom severity at 12 weeks
1
omega 3
1
14 more recorded rows
yale global tic severity scale
1
gestation length
1
serum non hdl cholesterol
1
irritable bowel syndrome symptom severity
1
heart rate variability changes
1
plasma glp 1
1
pulmonary function
1
incidence of parenteral nutrition associated cholestasis
1
25 hydroxyvitamin d levels at 12 weeks
1
ocular surface disease index
1
triglycerides from baseline
1
glomerular filtration rate
1
pain
1
reactive hyperemia index
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of Olive Oil's 11 ongoing trials reports first?
Persistent wheeze 0 to 3 years of age; Fat mass; latest 2033-03
Show the evidence
Trial
NCT00798226
"Fish Oil Supplementation During Pregnancy for Prevention of Asthma, Eczema and Allergies in Childhood"; n 800; "Persistent wheeze 0 to 3 years of age"; 2027-07
NCT03705845
"Tocotrienols for Obesity of Postmenopausal Women"; n 60; "Fat mass"; 2025-12-30
NCT04031508
"Effect of a Parenteral Emulsion With Omega3 on Neonates With PPHN and CDH"; n 40; "Change on systolic pressure of pulmonary artery"; 2026-12
NCT05465252
"Effect of Omega-3 Fatty Acid Supplementation on Dry-AMD Progression"; n 24; "Change in Macular Drusen Volume"; 2026-05
NCT06049680
"Safety Study of SMOFlipid to Evaluate the Risk of Developing EFAD and/or PNAC in Pediatric and Adult Patients"; n 100; "Incidence of PNAC"; 2026-09
NCT06065202
"Personalized Nutrition to Improve Recovery in Trauma"; n 150; "Change in six-minute walk distance (6 MWD)"; 2027-06-30
5 further recorded trials
NCT06570889
"VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma"; n 2000; "Early childhood asthma/persistent wheeze age 0-3 years"; 2033-03
NCT06880926
"Antarctic Krill Oil for Knee Osteoarthritis Pain"; n 116; "Visual Analogue Pain Scale"; 2026-02-28
NCT06880939
"Antarctic Krill Oil Functional Food Mitigates Bladder Cancer Treatment Side Effects"; n 210; "The degree of relief from bladder irritation symptoms."; 2028-05-30
NCT06971445
"Effect of Omega-3 Supplementation on Pregnant Outcomes and Inflammation Markers of Women Infected With HIV Using Antiretroviral Therapy"; n 92; "Birth weigth"; 2029-12
NCT07038252
"The Effect of Oral SPM Supplementation on INflammation-induced Vascular Ageing in Obese Hypertensive Patients"; n 60; "Flow-mediated dilation (FMD)"; 2027-02-26
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which running trial of Olive Oil could settle function?
NCT06065202 measures Change in six-minute walk distance (6 MWD), reading out 2027-06-30.
1 open trial; n 150; "Personalized Nutrition to Improve Recovery in Trauma"
Show the evidence
TrialNCT06065202
"Personalized Nutrition to Improve Recovery in Trauma"; n 150; "Change in six-minute walk distance (6 MWD)"; 2027-06-30
Q9
Which 76 trials of Olive Oil posted no result?
Posted no result
76 of 76 completed trials
Registrations
NCT00876356, NCT00728338, NCT00600912, NCT00251134, NCT00620529 and NCT01888211, and 70 more
Completion dates
oldest 2004-09; newest 2024-07-31
Show the evidence
Trial
NCT00876356
2004-09
NCT00728338
2005-11
NCT00600912
2007-12
NCT00251134
2008-09
NCT00620529
2009-02
NCT01888211
2009-06
14 further recorded trials
NCT00585390
2009-11
NCT00885053
2009-12
NCT00988585
2009-12
NCT00670475
2010-04
NCT00925795
2010-10
NCT01258335
2010-11
NCT00885781
2010-12
NCT01067898
2011-05
NCT01353807
2011-05
NCT01510223
2011-07
NCT01850979
2011-11
NCT01453842
2012-03
NCT01315327
2012-05
NCT01193543
2012-08
Q10
At the median, Olive Oil's trials enrolled 53 people — anything larger?
Median enrolment
53
Largest enrolment
5531
Registered trials counted
140
Q11
What do 238 spontaneous reports say about Olive Oil — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Olive Oil appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 238 reaction mentions were counted: macular degeneration 45; malaise 39; fatty acid deficiency 26; pain 25. open-targets-adr · CHEMBL2107910 · 2026-06-24
Show the evidence
macular degeneration
45
malaise
39
fatty acid deficiency
26
pain
25
pyrexia
25
constipation
17
4 more recorded rows
infusion related reaction
17
weight decreased
16
cholestasis
14
chronic sinusitis
14
recorded 2026-06-24 · last checked 2026-09-04
Q12
What is recorded about Olive Oil and AMPK?
"Mechanistic studies indicate that olive polyphenols influence lipid metabolism and vascular function through AMPK activation, suppression of SREBP-1c, modulation of PPAR pathways, enhancement of antioxidant defences <i>via</i> Nrf2 signalling, and attenuation of inflammatory pathways including NF-κB and MAPK. <i>Conclusion</i>: overall,…" — where Olive Oil and AMPK appear together. Europe PMC · pathway abstract search · 2026-04-27
"Mechanistic studies indicate that olive polyphenols influence lipid metabolism and vascular function through AMPK activation, suppression of SREBP-1c, modulation of PPAR pathways, enhancement of antioxidant defences <i>via</i> Nrf2 signalling, and attenuation of inflammatory pathways including NF-κB and MAPK. <i>Conclusion</i>: overall, current evidence indicates that olive leaf and olive oil…"
mTORPMID 40979569
"Olive oil is involved in the management of these markers to prevent and/or treat all types of cancers by upregulating tumor suppressor genes, downregulating oncogenes, and modulating different pathways (PI3K/AKT/mTOR, Wnt/β-catenin, and MAPK)."
autophagy
PMID 41123491
"Collectively, our data demonstrated that dietary MUFA exhibits a distinctive tumor-promoting effect on HCC through HSP90A-mediated LD mobilization and suggested that targeting HSP90A-regulated autophagy may serve as a therapeutic strategy for the treatment of HCC.<b>Abbreviation</b>: Apo: apoptozole; Baf A1: bafilomycin A<sub>1</sub>; CMA: chaperone-mediated autophagy; CQ: chloroquine; DGAT:…"
PMID 39595648
"EOO antifungal activity was also observed in the case of <i>Candida glabrata.</i> In conclusion, ozonated olive oil demonstrates potent antifungal activity against <i>C. albicans</i> by reducing cell viability, inhibiting hyphal and biofilm formation, and triggering oxidative stress and autophagy pathways."
AMPKPMID 32723184
"The objective of this review was to provide an update of scientific knowledge on the relationship between EVOO phenolic compounds and brown adipose tissue.According to this review, it has been demonstrated that extra virgin olive oil phenolic compounds can have beneficial effects on obesity by activating brown adipose tissue and enhance thermogenesis through different signaling pathways mediated…"
sirtuinPMID 32723184
"The objective of this review was to provide an update of scientific knowledge on the relationship between EVOO phenolic compounds and brown adipose tissue.According to this review, it has been demonstrated that extra virgin olive oil phenolic compounds can have beneficial effects on obesity by activating brown adipose tissue and enhance thermogenesis through different signaling pathways mediated…"
recorded 2026-04-27 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence
✗ required summary fields resolved: 5 required field(s) not terminal: Why people use it, Best-supported result, Most important common problem, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 8 source rows
✓ no critical contamination: no quarantine open
✓ canonical metadata passed: slug and display name present
✓ no raw internal fields: enforced by the copy-contract test over the rendered page
This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.