This page shows what was measured, who it was measured in, and what that does not settle.
What Norethisterone does in the body
Pregnancy
From the FDA-approved label: Mode of Action Norethindrone progestin-only oral contraceptives prevent conception by suppressing ovulation in approximately half of users, thickening the cervical mucus to inhibit sperm penetration, lowering the midcycle LH and FSH peaks, slowing the movement of the ovum through the fallopian tubes and altering the endometrium.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · T18F433X4S · read 2026-08-29
Where each sentence above came from
No recorded sentence describes the change this makes in a way that stands on its own. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 64 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Biomarker
A biomarker is a number from a test that stands in for something about health.
A picture of it, and where the picture fails
A biomarker is like a fuel gauge.
Where that stops being true. A gauge is wired to the tank. Many biomarkers are only loosely tied to health.
What people get wrong. A better number is read as a better life. Several medicines improved a number and helped nobody.
A measurable indicator used as a substitute for a clinical outcome of interest.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Formulation
A formulation is the exact made-up form a substance comes in.
A picture of it, and where the picture fails
It is like the difference between a whole bean and instant coffee.
Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.
What people get wrong. Two products with the same name are assumed to behave the same. They often do not.
The specific composition and physical form of a product, including salt, excipients and release profile.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 16 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer2 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Focus
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer1 registered performance measure of this kind.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Fertility and sexual health
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
worst pain over the last month; pain area under the curve
Focus
cognitive function assessed by paced serial addition test
Fertility and sexual health
sperm penetration scores
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
2 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Antimicrobial utilization at the ICU level
✗ The study did not show it
Who was studied
NCT07093450
How many people
9000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral-28
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Number of In-Treatment Pregnancies Per 100 Woman Years of Exposure (Pearl Index)
✗ The study did not show it
Who was studied
NCT01656434
How many people
3173
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral-28
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Composity of Major Cardiovascular Events
✗ The study did not show it
Who was studied
NCT01620398
How many people
2534
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral-28
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Pearl Index, 18-35 Years, MITT Population
✗ The study did not show it
Who was studied
NCT00477633
How many people
1700
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral-28
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Pregnancy Rate (Expressed as Pearl Index) in Women Aged 18 to 35, MITT Population,
✗ The study did not show it
Who was studied
NCT00391807
How many people
1683
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral-28
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Pregnancy Rate
✗ The study did not show it
Who was studied
NCT01140217
How many people
1659
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral-28
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.1 registered measure of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.1 registered measure of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.2 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.4 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
□AnimalsNo evidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.No animal record is stored.
□Cells in a dishNo evidence recorded. Cells or chemistry on a bench, far from a whole body.No cell or bench record is stored.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
worst pain over the last month
pain area under the curve
Measured
Things only a test, a scale or a device shows.
minimum observed analyte concentration of jnj 63623872
maximum observed analyte concentration of jnj 63623872
average steady state plasma concentration of jnj 63623872
blood pressure
Meaningful
Things that change how a life goes, not only a number.
cognitive function assessed by paced serial addition test
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (9)
pregnancy rate
premature ovarian failure rate
cervical mucus baseline
sperm penetration scores
cervical mucus 2 hour
cervical mucus 6 hour
cervical mucus 24 hour
ovulation
treatment success rate
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Progestin-only oral contraceptives are indicated for the prevention of pregnancy. 2. Efficacy If used perfectly, the first-year failure rate for progestin-only oral contraceptives is 0.3%. However, the typical failure rate is estimated to be closer to 9%, due to late or omitted pills. Table 1 lists the pregnancy rates for users of all major methods of contraception.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Pediatric Use Safety and efficacy of Errin ® Tablets have been established in women of reproductive age.”
US prescribing information · df29577b-c2f0-bea8-b048-7719972707aa · read 2026-08-30
On people who are pregnant, the label states: “Pregnancy Many studies have found no effects on fetal development associated with long-term use of contraceptive doses of oral progestins.”
US prescribing information · df29577b-c2f0-bea8-b048-7719972707aa · read 2026-08-30
On people who are breastfeeding, the label states: “Nursing Mothers In general, no adverse effects have been found on breastfeeding performance or on the health, growth, or development of the infant.”
US prescribing information · df29577b-c2f0-bea8-b048-7719972707aa · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
A different form was studied
The studied form is not the form on the shelf.
On this record: This record is linked to 1 related forms. Evidence does not carry across all of them.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (9)
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral-28
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as tablet, film, extended release, injectable, tablet, capsule, given by the oral-28, oral, oral-21 route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Norethisterone appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 4435 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
pulmonary embolism — 1004 reaction mentions
hot flush — 653 reaction mentions
deep vein thrombosis — 574 reaction mentions
metrorrhagia — 416 reaction mentions
vaginal haemorrhage — 341 reaction mentions
wrong technique in product usage process — 339 reaction mentions
unintended pregnancy — 331 reaction mentions
application site rash — 286 reaction mentions
migraine — 257 reaction mentions
application site erythema — 234 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral-28
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
88 products list this as an active ingredient in the United States drug directory. 39 of them contain it and nothing else.
FDA National Drug Code directory · 24823-908 · read 2026-08-29
They are sold as capsule, capsule, liquid filled, patch, extended release, powder, tablet and tablet, film coated, taken oral and transdermal.
FDA National Drug Code directory · 24823-908 · read 2026-08-29
The regulator's established pharmacologic class for it is progesterone congeners [cs] and progestin [epc].
FDA National Drug Code directory · 24823-908 · read 2026-08-29
60 published labels name it as an active ingredient. 30 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · e166bdf6-eb60-49b8-9747-2a33c3e3461b · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · e166bdf6-eb60-49b8-9747-2a33c3e3461b · read 2026-08-29
ERRIN is oral at HOW SUPPLIED Errin ® (norethindrone tablets USP, 0.35 mg) are packaged in cartons of three blister cards each containing 28 tablets (NDC 75907-075-32)., recorded as fda label in effect 2024-03-01 in the United States.
US prescribing information · df29577b-c2f0-bea8-b048-7719972707aa · read 2026-08-30
Recorded price in US: 0.09065–0.29484 USD per one unit as the pricing file counts it — a tablet, capsule, patch or single item, across 11 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (12)
Q1
What did Norethisterone's largest trial (1659 people) and its longest (13 years) measure?
1659 people in Norethisterone's largest registered study, 13 years in its longest registered window, measuring Observed Analyte Concentration Just Prior to the Beginning or at the End of a Dosing Interval (Ctrough) of JNJ-63623872. ClinicalTrials.gov · 2026-09-01
8 phase3, 7 na, 7 phase4, 5 phase2, 2 na or unstated, 1 phase1; NCT01160315; 2015-10; no ageing endpoint recorded. Last human test completed 2024, NCT03106454.
Interpretation These counts include studies where Norethisterone was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase3
8
na
7
phase4
7
phase2
5
na or unstated
2
phase1
1
1 more recorded row
Last recorded human testNCT03106454
2024-01-01
recorded 2026-09-01 · last checked 2026-09-04
Q2
Norethisterone was tested only in human — what did it show?
Observed Analyte Concentration Just Prior to the Beginning or at the End of a Dosing Interval (Ctrough) of JNJ-63623872 — the recorded outcome words.
Show the evidence
humanNCT02652650
biomarker; Observed Analyte Concentration Just Prior to the Beginning or at the End of a Dosing Interval (Ctrough) of JNJ-63623872; 29
recorded 2026-09-01 · last checked 2026-09-04
Q3
4 of Norethisterone's trials stopped: accrual/recruitment, funding/business, other?
accrual/recruitment (1), funding/business (2) and other (1): Norethisterone's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"Original PI left institution, lack of funding to continue"; 4 of 29 registered studies
Show the evidence
Trial
NCT03970330
terminated; "Original PI left institution, lack of funding to continue"
NCT04527003
terminated; "Recruitment has been challenging due to the BMI cutoff, need to take oral progesterone and abstain from cannabis products prior to the study."
NCT04676061
terminated; "It was in the best interest of the investigator to terminate the study earlier than anticipated."
NCT04948489
withdrawn; "No funding"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Norethisterone used Norethisterone Acetate tablets - 5mg — over how long?
3 recorded entries; human; also "Norethindrone Acetate 5 MG", "Norethindrone 0.35 MG"
Show the evidence
human
NCT01266759
Norethisterone Acetate tablets - 5mg
NCT05294341
Norethindrone Acetate 5 MG
NCT05294341
Norethindrone 0.35 MG
recorded 2026-09-01 · last checked 2026-09-04
Q5
Could one person measure Norethisterone's effect on pregnancy rate?
Pregnancy rate: measured in Norethisterone's trials.
Interpretation pregnancy rate is the recorded endpoint.
Show the evidence
biomarkers
pregnancy rate; 2026-09-01
premature ovarian failure rate; 2026-09-01
cognitive function assessed by paced serial addition test; 2026-09-01
worst pain over the last month; 2026-09-01
minimum observed analyte concentration of jnj 63623872; 2026-09-01
maximum observed analyte concentration of jnj 63623872; 2026-09-01
10 more recorded rows
biomarkers
average steady state plasma concentration of jnj 63623872; 2026-09-01
biomarkers
cervical mucus baseline; 2026-09-01
biomarkers
sperm penetration scores; 2026-09-01
biomarkers
cervical mucus 2 hour; 2026-09-01
biomarkers
cervical mucus 6 hour; 2026-09-01
biomarkers
cervical mucus 24 hour; 2026-09-01
biomarkers
ovulation; 2026-09-01
biomarkers
pain area under the curve; 2026-09-01
biomarkers
treatment success rate; 2026-09-01
biomarkers
blood pressure; 2026-09-01
human trials at or under30
10
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT04948489; PHASE2; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q6
Which of average steady state plasma concentration of jnj 63623872, blood pressure and cervical mucus 2 hour did Norethisterone's trials measure?
average steady state plasma concentration of jnj 63623872, blood pressure and cervical mucus 2 hour lead 16 outcome terms across Norethisterone's trials. ClinicalTrials.gov · 2026-09-01
worst pain over the last month, minimum observed analyte concentration of jnj 63623872, maximum observed analyte concentration of jnj 63623872, average steady state plasma concentration of jnj 63623872, cervical mucus baseline and sperm penetration scores follow.
Show the evidence
pregnancy rate
1
premature ovarian failure rate
1
cognitive function assessed by paced serial addition test
1
worst pain over the last month
1
minimum observed analyte concentration of jnj 63623872
1
maximum observed analyte concentration of jnj 63623872
1
10 more recorded rows
average steady state plasma concentration of jnj 63623872
1
cervical mucus baseline
1
sperm penetration scores
1
cervical mucus 2 hour
1
cervical mucus 6 hour
1
cervical mucus 24 hour
1
ovulation
1
pain area under the curve
1
treatment success rate
1
blood pressure
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of Norethisterone's 2 ongoing trials reports first?
"Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders Study"; n 300; "Treatment success rate"; 2029-06
NCT07293728
"A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in Preeclampsia"; n 50; "Blood Pressure"; 2026-12
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which 10 trials of Norethisterone posted no result?
Posted no result
10 of 10 completed trials
Registrations
NCT00003771, NCT03594604, NCT00453960, NCT01266759, NCT01499602 and NCT01140217, and 4 more
Completion dates
oldest 2004-02; newest 2024-01-01
Show the evidence
Trial
NCT00003771
2004-02
NCT03594604
2007-12-15
NCT00453960
2008-12
NCT01266759
2010-09
NCT01499602
2011-11
NCT01140217
2012-03
4 further recorded trials
NCT01160315
2015-10
NCT02652650
2016-06
NCT05476172
2023-06-30
NCT03106454
2024-01-01
Q9
At the median, Norethisterone's trials enrolled 59 people — anything larger?
Median enrolment
59
Largest enrolment
1659
Registered trials counted
29
Q10
What do 4435 spontaneous reports say about Norethisterone — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Norethisterone appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 4435 reaction mentions were counted: pulmonary embolism 1004; hot flush 653; deep vein thrombosis 574; metrorrhagia 416. open-targets-adr · CHEMBL1162 · 2026-06-24
Show the evidence
pulmonary embolism
1004
hot flush
653
deep vein thrombosis
574
metrorrhagia
416
vaginal haemorrhage
341
wrong technique in product usage process
339
4 more recorded rows
unintended pregnancy
331
application site rash
286
migraine
257
application site erythema
234
recorded 2026-06-24 · last checked 2026-09-04
Q11
Norethisterone and CYP3A4 and cytochrome P450: shared by which compounds?
CYP3A4 and cytochrome P450 appear in Norethisterone's recorded interaction sentences, 2 in all. openfda-label+europepmc · 2026-08-24
Interpretation drug_interactions
Show the evidence
cytochrome P450drug_interactions
Drug Interactions Consult the labeling of concurrently-used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations. • Effect of Other Drugs on Hormonal Contraceptives Substances decreasing the systemic concentrations of hormonal contraceptives (HCs) and potentially diminishing the efficacy of HCs Drugs or herbal products that…
CYP3A4drug_interactions
Substances increasing the systemic concentrations of HCs Co-administration of certain HCs and strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase the systemic concentrations of progestins, including norethindrone.
recorded 2026-08-24 · last checked 2026-09-04
Q12
Was Norethisterone studied with fasting and exercise?
fasting and exercise are named in Norethisterone's label sentences: "Thus, we aimed to examine the impact of the co-administration of 17β-estradiol and norethisterone acetate on glycated haemoglobin (HbA1c), fasting glucose, insulin and C-peptide concentrations in females by means of a systematic review and meta-analysis of randomized controlled trials (RCTs)." openfda-label+europepmc · 2026-08-24
2 recorded statements; fasting, exercise
Show the evidence
fasting
Thus, we aimed to examine the impact of the co-administration of 17β-estradiol and norethisterone acetate on glycated haemoglobin (HbA1c), fasting glucose, insulin and C-peptide concentrations in females by means of a systematic review and meta-analysis of randomized controlled trials (RCTs).
exercise
One hundred and sixteen post-menopausal women will be recruited and randomised to receive one of two exercise programs (sham or targeted intervention exercise) and transdermal creams (MHT cream containing oestradiol 50mcg and norethisterone acetate 140mcg or placebo cream).
recorded 2026-08-24 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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