This page shows what was measured, who it was measured in, and what that does not settle.
What Nifedipine does in the body
Vasospastic angina confirmed by any of the following criteria
From the FDA-approved label: A) Angina The precise mechanisms by which inhibition of calcium influx relieves angina has not been fully determined, but includes at least the following two mechanisms: 1) Relaxation and Prevention of Coronary Artery Spasm Nifedipine dilates the main coronary arteries and coronary arterioles, both in normal and ischemic regions, and is a potent inhibitor of coronary artery spasm, whether spontaneous or ergonovine-induced. This property increases myocardial oxygen delivery in patients with coronary artery spasm, and is responsible for the effectiveness of nifedipine in vasospastic (Prinzmetal's or variant) angina.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · I9ZF7L6G2L · read 2026-08-29
Where each sentence above came from
No recorded sentence describes the change this makes in a way that stands on its own. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 114 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Focus
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Focus
cognitive assessment trail making test part b; cognitive assessment forward digit span test
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
— Not recorded
Harms were not a registered measure for this goal.
… Waiting for a reviewer
Who was studied is listed further down the page.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Number of participants with the adverse pregnancy composite
✗ The study did not show it
Who was studied
NCT07746271
How many people
4120
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Success Rate of standard medical management
✗ The study did not show it
Who was studied
NCT00664846
How many people
4000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
HAPE：Recovery
✗ The study did not show it
Who was studied
NCT07639931
How many people
3035
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Number of Covid-19 positive participants who die, require intubation in ICU, or require hospitalization for non-invasive ventilation (NIV)
✗ The study did not show it
Who was studied
NCT04330300
How many people
2414
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Composite Adverse Perinatal Outcome
✗ The study did not show it
Who was studied
NCT02299414
How many people
2408
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Patient experience - Respect
✗ The study did not show it
Who was studied
NCT04879797
How many people
1538
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.1 registered measure of this kind. No reviewed result.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.1 registered measure of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.10 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Mouse, Rat, Dog. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
improvement in quality of life
Measured
Things only a test, a scale or a device shows.
decrease in supine systolic blood pressure
blood pressure
central systolic blood pressure
area under the concentration time curve
24 hour ambulatory blood pressure monitoring
nighttime systolic blood pressure reduction
serum zinc
serum 25 d
serum vitamin a
maximum plasma concentration
Meaningful
Things that change how a life goes, not only a number.
prolonged hospitalization
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (28)
drug discrimination measure
cognitive assessment trail making test part b
cognitive assessment forward digit span test
prolongation of pregnancy
proteinuria
rate and extend of absorption
systemic vascular resistance
reduction of preterm birth
recurrence of atrial fibrillation
treatment cost for 16 week of double blind treatment period
genotyping
preterm birth
maternal who achieve 48 hours of pregnancy prolongation
preeclampsia
time of delivery
vascular function
medication recommended by acog for severe hypertension
placenta myd88
placenta trif
placenta nfkb
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
I. Vasospastic Angina Nifedipine is indicated for the management of vasospastic angina confirmed by any of the following criteria: 1) classical pattern of angina at rest accompanied by ST segment elevation, 2) angina or coronary artery spasm provoked by ergonovine, or 3) angiographically demonstrated coronary artery spasm.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “The safety and effectiveness of Nifedipine Extended-Release tablets, USP in pediatric patients have not been established.”
US prescribing information · ca5b0178-4e5f-4077-ada5-7058b0a03858 · read 2026-08-30
On older people, the label states: “Although small pharmacokinetic studies have identified an increased half-life and increased C max and AUC (See CLINICAL PHARMACOLOGY: Pharmacokinetics and Metabolism ), clinical studies of nifedipine did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.”
US prescribing information · ca5b0178-4e5f-4077-ada5-7058b0a03858 · read 2026-08-30
On people who are pregnant, the label states: “On a mg/kg or mg/m 2 basis, some of the doses associated with these various effects are higher than the maximum recommended human dose and some are lower, but all are within an order of magnitude of it.”
US prescribing information · ca5b0178-4e5f-4077-ada5-7058b0a03858 · read 2026-08-30
On people who are breastfeeding, the label states: “Nursing mothers are advised not to breastfeed their babies when taking the drug.”
US prescribing information · ca5b0178-4e5f-4077-ada5-7058b0a03858 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as tablet, extended release, capsule, tablet, film coated, extended release, given by the oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Nifedipine appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 2349 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
premature baby — 426 reaction mentions
drug hypersensitivity — 359 reaction mentions
hypotension — 359 reaction mentions
premature delivery — 255 reaction mentions
low birth weight baby — 185 reaction mentions
hypertension — 173 reaction mentions
drug interaction — 159 reaction mentions
bradycardia — 157 reaction mentions
oedema peripheral — 143 reaction mentions
toxicity to various agents — 133 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
157 products list this as an active ingredient in the United States drug directory. 157 of them contain it and nothing else.
FDA National Drug Code directory · 71610-689 · read 2026-08-29
They are sold as capsule, capsule, liquid filled, powder, tablet, extended release and tablet, film coated, extended release, taken oral.
FDA National Drug Code directory · 71610-689 · read 2026-08-29
The regulator's established pharmacologic class for it is calcium channel antagonists [moa], dihydropyridine calcium channel blocker [epc] and dihydropyridines [cs].
FDA National Drug Code directory · 71610-689 · read 2026-08-29
89 published labels name it as an active ingredient. 89 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · bddfd658-ac61-4ba2-a3fa-07acc35d368a · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · bddfd658-ac61-4ba2-a3fa-07acc35d368a · read 2026-08-29
Nifedipine is oral at HOW SUPPLIED Nifedipine Extended-Release Tablets, USP, are supplied as 90 mg unscored, round, film-coated tablets as follows: Strength Color Markings 90 mg Yellow 90 mg unscored, round, film-coated tablets, engraved wit…, recorded as fda label in effect 2026-02-05 in the United States.
US prescribing information · ca5b0178-4e5f-4077-ada5-7058b0a03858 · read 2026-08-30
Recorded price in US: 0.25782–0.66772 USD per one unit as the pricing file counts it — a tablet, capsule, patch or single item, across 7 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
RNAWiki could not confidently classify this substance, so no self-experiment plan is offered.
Questions worth asking
Which of the trials of Nifedipine studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Nifedipine are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
How many documents were read
89 documents were read for this substance.
RNAWiki source record
56 of them state the same bioavailability, and they agree.
RNAWiki source record
Where else this substance is registered
FDA substance identifier (UNII)
I9ZF7L6G2L
RxNorm concept
198032
Checks this page had to pass
✓ Passed
Identity resolved
no open identity hold
✓ Passed
No unresolved merge across substance families
no quarantine open
✓ Passed
Every public sentence names a source
The opening statement carries the origin: Written into the record, not signed off.
✗ Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
✓ Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
✗ Not passed
Safety mode resolved
No register row and no identity class settled the question.
✓ Passed
Canonical metadata present
slug and display name present
What is missing or unclear◇Read from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
36 approved applications cover products containing this substance. The earliest was NDA018482, approved 19811231 to PFIZER.
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What is not here
6 questions this page could not answer
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Recorded evidence blocks (13)
Q1
What did Nifedipine's largest trial (22213 people) and its longest (16 years) measure?
22213 people in Nifedipine's largest registered study, 16 years in its longest registered window, measuring All-Cause-Hospitalization or All-Cause Mortality. ClinicalTrials.gov · 2026-09-01
36 phase4, 27 phase3, 20 na, 17 phase2, 13 phase1, 11 na or unstated, 2 early phase1; NCT00223717; 2017-01. Last human test completed 2026, NCT07649668.
Interpretation These counts include studies where Nifedipine was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase4
36
phase3
27
na
20
phase2
17
phase1
13
na or unstated
11
2 more recorded rows
early phase1
2
Last recorded human testNCT07649668
2026-05-29
recorded 2026-09-01 · last checked 2026-09-04
Q2
From mouse to human: where has Nifedipine shown lifespan?
0; NCT00194974; PHASE1/PHASE2; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q6
Which of 24 hour ambulatory blood pressure monitoring, area under the concentration time curve and blood pressure did Nifedipine's trials measure?
24 hour ambulatory blood pressure monitoring, area under the concentration time curve and blood pressure lead 40 outcome terms across Nifedipine's trials. ClinicalTrials.gov · 2026-09-01
Interpretation cognitive assessment forward digit span test, prolongation of pregnancy, proteinuria, blood pressure, rate and extend of absorption and central systolic blood pressure follow.
Show the evidence
decrease in supine systolic blood pressure
1
drug discrimination measure
1
cognitive assessment trail making test part b
1
cognitive assessment forward digit span test
1
prolongation of pregnancy
1
proteinuria
1
14 more recorded rows
blood pressure
1
rate and extend of absorption
1
central systolic blood pressure
1
systemic vascular resistance
1
reduction of preterm birth
1
recurrence of atrial fibrillation
1
treatment cost for 16 week of double blind treatment period
1
improvement in quality of life
1
genotyping
1
area under the concentration time curve
1
preterm birth
1
maternal who achieve 48 hours of pregnancy prolongation
1
24 hour ambulatory blood pressure monitoring
1
preeclampsia
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of Nifedipine's 13 ongoing trials reports first?
"Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants"; n 1600; "M/P ratio"; 2028-07-31
NCT03976063
"Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation"; n 857; "Perinatal morti-morbidity"; 2031-11
NCT04278404
"Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)"; n 5000; "Clearance (CL) or apparent oral clearance (CL/F) as measured by PK sampling"; 2026-12
NCT04298034
"Preeclampsia Postpartum Antihypertensive Treatment"; n 300; "Hospital Readmission"; 2026-09-30
NCT04755764
"Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy"; n 60; "Systolic blood pressure"; 2025-12
NCT05309460
"Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial"; n 600; "Readmission"; 2024-12-01
7 further recorded trials
NCT05551104
"Safest Choice of Antihypertensive Regimen for Postpartum Hypertension"; n 500; "Composite maternal morbidity"; 2027-12
NCT05687344
"Intensive Postpartum Antihypertensive Treatment"; n 60; "Feasibility in randomization"; 2026-08-30
NCT06220721
"Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia"; n 618; "Chronic hypertension"; 2029-06-30
NCT06915792
"PEACE Trial: Postpartum Evaluation of Antihypertensive Cessation and Efficacy"; n 110; "Continuation of antihypertensive medication"; 2027-10-31
NCT07023003
"Postpartum Evaluation of Nifedipine and Enalapril for Hypertension"; n 850; "Hospital Readmission"; 2028-12
NCT07659665
"Oral Nifedipine Versus Placebo for Pain and Healing After Hemorrhoidectomy"; n 100; "Visual Analogue Scale (VAS) Pain Score"; 2026-12-30
NCT07746271
"Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial"; n 4120; "Number of participants with the adverse pregnancy composite"; 2030-04-30
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which 47 trials of Nifedipine posted no result?
Posted no result
47 of 47 completed trials
Registrations
NCT00000478, NCT00000530, NCT00004266, NCT00672113, NCT01518855 and NCT00864617, and 41 more
Completion dates
oldest 1997-06; newest 2023-12-15
Show the evidence
Trial
NCT00000478
1997-06
NCT00000530
1998-06
NCT00004266
1999-07
NCT00672113
2004-08
NCT01518855
2005-04
NCT00864617
2005-05
14 further recorded trials
NCT00519870
2005-07
NCT00865891
2005-07
NCT00244530
2005-10
NCT00280462
2006-04
NCT00722215
2007-12
NCT00185952
2008-08
NCT02071589
2009-03
NCT00884442
2009-04
NCT00817037
2009-07-07
NCT00593463
2010-05
NCT00712738
2010-09-22
NCT00993109
2011-05
NCT01287260
2011-08
NCT01435161
2011-08
Q9
At the median, Nifedipine's trials enrolled 94 people — anything larger?
Median enrolment
94
Largest enrolment
22213
Registered trials counted
113
Q10
What do 2349 spontaneous reports say about Nifedipine — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Nifedipine appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 2349 reaction mentions were counted: premature baby 426; drug hypersensitivity 359; hypotension 359; premature delivery 255. open-targets-adr · CHEMBL193 · 2026-06-24
Show the evidence
premature baby
426
drug hypersensitivity
359
hypotension
359
premature delivery
255
low birth weight baby
185
hypertension
173
4 more recorded rows
drug interaction
159
bradycardia
157
oedema peripheral
143
toxicity to various agents
133
recorded 2026-06-24 · last checked 2026-09-04
Q11
Nifedipine and CYP3A4 and CYP3A: shared by which compounds?
CYP3A4 and CYP3A appear in Nifedipine's recorded interaction sentences, 4 in all. openfda-label+europepmc · 2026-08-04
Interpretation drug_interactions
Show the evidence
CYP3A4
drug_interactions
Nifedipine is metabolized by CYP3A4.
drug_interactions
Co-administration of nifedipine with phenytoin, an inducer of CYP3A4, lowers the systemic exposure to nifedipine by approximately 70%.
drug_interactions
Avoid co-administration of nifedipine with phenytoin or any known CYP3A4 inducer or consider an alternative antihypertensive therapy.
CYP3Adrug_interactions
CYP3A inhibitors such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir may result in increased exposure to nifedipine when co-administered.
recorded 2026-08-04 · last checked 2026-09-04
Q12
Was Nifedipine studied with fasting and exercise?
fasting and exercise are named in Nifedipine's label sentences: "This study aimed to analyze the pharmacokinetic (PK) characteristics, safety, and bioequivalence (BE) of a test (T) preparation of a nifedipine controlled-release tablet and the reference (R) drug (Adalat GTIS) in Chinese study participants in the context of fasting and postprandial states." openfda-label+europepmc · 2026-08-04
2 recorded statements; fasting, exercise
Show the evidence
fasting
This study aimed to analyze the pharmacokinetic (PK) characteristics, safety, and bioequivalence (BE) of a test (T) preparation of a nifedipine controlled-release tablet and the reference (R) drug (Adalat GTIS) in Chinese study participants in the context of fasting and postprandial states.
exercise
Fifty-five subjects with mild hypertension, double-blindly randomized to placebo or to a fixed-dose combination of an angiotensin-receptor blocker (telmisartan 80 mg) and a calcium-channel blocker (nifedipine slow release 30 mg), performed a cardiopulmonary exercise test at sea level and after the first night's stay at 3260 m altitude.
recorded 2026-08-04 · last checked 2026-09-04
Q13
What is recorded about Nifedipine and AMPK?
"Contrary to the nifedipine, metformin activates AMPK, increases fatty acid oxidation, suppresses fatty acid synthesis and deposition, and thus alleviates lipotoxicity." — where Nifedipine and AMPK appear together. Europe PMC · pathway abstract search · 2024-01-01
"Contrary to the nifedipine, metformin activates AMPK, increases fatty acid oxidation, suppresses fatty acid synthesis and deposition, and thus alleviates lipotoxicity."
PMID 32679123
"AMPK inhibition or transfection with AMPK siRNA showed that the anti-senescence effect of nifedipine involved AMPK activation."
PMID 32679123
"These results suggest nifedipine-inducted AMPK activation suppresses VSMC senescence by regulating autophagic flux and Ca<sup>2+</sup> levels."
autophagy
PMID 32679123
"These results suggest nifedipine-inducted AMPK activation suppresses VSMC senescence by regulating autophagic flux and Ca<sup>2+</sup> levels."
PMID 37806540
"However, nifedipine, an inhibitor of L-type calcium ion channels, reversed TA-induced autophagy and Ca<sup>2+</sup> influx in MASMCs."
PMID 32214849
"Verapamil combined with DOC or VCR induces chemoresistant lung cancer cells to death through autophagy burst and apoptosis more strongly than Diltiazem and Nifedipine."
NAD+
PMID 23785817
"Nifedipine (7.5 mg/kg per os) activated NAD-depended site of respiratory chain and prevented hyperactivation of succunate-depended breath."
PMID 20795474
"Nifedipine 7.5 mg/kg orally activated NAD-dependent site of cell breath and reduced hyperactivation of succinate-dependent breath by means of down-up mechanism."
PMID 20726343
"Nifedipine (7.5 mg/kg per os) activated the NAD-dependent site of respiratory chain and prevented hyperactivation of the succinate-dependent breath."
mTORPMID 27114559
"Treatment with nifedipine, an inhibitor of L-type Ca(2+) channels, abrogated GDF-15-induced increases in [Ca(2+)]i and ICa The GDF-15-induced increase in ICa was mediated via up-regulation of the Cav1.3 α subunit, which was attenuated by inhibiting Akt/mTOR and ERK (extracellular-signal-regulated kinase) pathways and by pharmacological inhibition of Src-mediated TβRII phosphorylation."
IGF-1PMID 8614272
"Potentiation by IGF-1 was dependent on the presence of extracellular Ca2+ and was inhibited by verapamil or nifedipine."
recorded 2024-01-01 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 11 source rows
✓ no critical contamination: no quarantine open
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✓ no raw internal fields: enforced by the copy-contract test over the rendered page
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