This page shows what was measured, who it was measured in, and what that does not settle.
What Nicotinic acid does in the body
Elevated TC, LDL-C, Apo B and TG levels, and to increase HDL-C
From the FDA-approved label: The mechanism by which niacin alters lipid profiles has not been well defined. It may involve several actions including partial inhibition of release of free fatty acids from adipose tissue, and increased lipoprotein lipase activity, which may increase the rate of chylomicron triglyceride removal from plasma. Niacin decreases the rate of hepatic synthesis of VLDL and LDL, and does not appear to affect fecal excretion of fats, sterols, or bile acids.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · 2679MF687A · read 2026-08-29
The supplement label database classes it as vitamin, under the name Niacin (Vitamin B3).
No recorded sentence describes the change this makes in a way that stands on its own. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 100 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Formulation
A formulation is the exact made-up form a substance comes in.
A picture of it, and where the picture fails
It is like the difference between a whole bean and instant coffee.
Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.
What people get wrong. Two products with the same name are assumed to behave the same. They often do not.
The specific composition and physical form of a product, including salt, excipients and release profile.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Cholesterol
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved10 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved3 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Mood
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer3 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Cholesterol
ldl c from baseline to week 12; ldl goal attainment; triglycerides; non hdl c; hdl c; total cholesterol; total cholesterol hdl c; effect of treatment on peak ldl particle size
anxiety; hads anxiety; state trait anxiety inventory state
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
△ Only a number moved
10 registered test measure.
— Not recorded
Harms were not a registered measure for this goal.
… Waiting for a reviewer
Who was studied is listed further down the page.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Infant Mortality Through 6 mo of Age
✗ The study did not show it
Who was studied
NCT00860470
How many people
44567
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Major Vascular Event
✗ The study did not show it
Who was studied
NCT00461630
How many people
25673
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Anemia status
✗ The study did not show it
Who was studied
NCT03287882
How many people
25447
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Perinatal mortality, i.e., the number of stillbirths (fetal deaths of 28 weeks or more of gestation) and the number of deaths within the first 0-6 days of life per 1000 births (live births and stillbirths)
✗ The study did not show it
Who was studied
NCT00133744
How many people
18962
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Fetal loss, low birth weight and pre-term birth.
✗ The study did not show it
Who was studied
NCT00197548
How many people
8468
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Composite of CV Death, Nonfatal MI (Including Silent MI), Nonfatal Stroke, Coronary Revascularization, or Unstable Angina Determined to be Caused by Myocardial Ischemia by Invasive / Non-invasive Testing and Requiring Emergent Hospitalization.
✗ The study did not show it
Who was studied
NCT01492361
How many people
8179
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.0 registered measures of this kind. 2 written-up studies measured this and did not show a benefit.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.3 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.16 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Yeast, C. elegans (roundworm), Mouse. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
anxiety
hads anxiety
state trait anxiety inventory state
Measured
Things only a test, a scale or a device shows.
ldl c from baseline to week 12
ldl goal attainment
triglycerides
non hdl c
hdl c
total cholesterol
total cholesterol hdl c
hepatic insulin sensitivity index
adipose tissue insulin sensitivity
skeletal muscle insulin sensitivity
and 6 more.
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (21)
severity of proximal stenosis
proteinuria
hepatic fat content for fenofibrate and niacin groups
relative effect on flow mediated dilatation of radial artery
adiponectin
hscrp
fast test retest reliability maximum flushing severity
fast longitudinal construct validity mean flushing severity
fast responsiveness mean flushing severity
fast responsiveness maximum flushing severity
apolipoprotein a i fractional catabolic rate
apo a1 production rate
serious adverse events
stai state
flow mediated vasodilation
plaque lipid composition in carotid arteries assessed by mr
relative fmd
endothelial function
evolution of metabolic parameters in postprandial state
pharmacokinetic of niacin and its metabolites
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hyperlipidemia. Niacin therapy is indicated as an adjunct to diet when the response to a diet restricted in saturated fat and cholesterol and other nonpharmacologic measures alone has been inadequate.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Safety and effectiveness of niacin therapy in pediatric patients (≤16 years) have not been established.”
US prescribing information · 52ad4a6a-81cc-4b03-b8b1-3bd9a1d4064e · read 2026-08-30
On older people, the label states: “Of 979 patients in clinical studies of niacin extended-release tablets, 21% of the patients were age 65 and over.”
US prescribing information · 52ad4a6a-81cc-4b03-b8b1-3bd9a1d4064e · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary Discontinue niacin extended-release tablets when pregnancy is recognized in patients receiving the drug for the treatment of hyperlipidemia.”
US prescribing information · 52ad4a6a-81cc-4b03-b8b1-3bd9a1d4064e · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary Niacin is present in human milk and the amount of niacin increases with maternal supplementation.”
US prescribing information · 52ad4a6a-81cc-4b03-b8b1-3bd9a1d4064e · read 2026-08-30
On people with reduced liver function, the label states: “No studies have been performed in this population.”
US prescribing information · 52ad4a6a-81cc-4b03-b8b1-3bd9a1d4064e · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
A different form was studied
The studied form is not the form on the shelf.
On this record: This record is linked to 1 related forms. Evidence does not carry across all of them.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (9)
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Sold as tablet, tablet, extended release, capsule, pellet, given by the oral, sublingual route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
70 products list this as an active ingredient in the United States drug directory. 28 of them contain it and nothing else.
FDA National Drug Code directory · 47335-613 · read 2026-08-29
They are sold as capsule, capsule, gelatin coated, capsule, liquid filled, liquid, pellet and powder, taken oral and sublingual.
FDA National Drug Code directory · 47335-613 · read 2026-08-29
The regulator's established pharmacologic class for it is nicotinic acid [epc] and nicotinic acids [cs].
FDA National Drug Code directory · 47335-613 · read 2026-08-29
56 published labels name it as an active ingredient. 14 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 377f4a5b-bcbb-47b7-b4f4-d198b98c8427 · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · 377f4a5b-bcbb-47b7-b4f4-d198b98c8427 · read 2026-08-29
12906 marketed supplement labels list this ingredient, classed as other combinations, single vitamin and mineral and vitamin.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
Niacin is oral at 3 DOSAGE FORMS & STRENGTHS • 500 mg Orange, oval shaped, biconvex, film-coated tablets debossed with “L 55” on one side and plain on the other side • 1000 mg Orange, oval shaped, biconvex, film-coated tablets debossed w…, recorded as fda label in effect 2025-01-10 in the United States.
US prescribing information · 52ad4a6a-81cc-4b03-b8b1-3bd9a1d4064e · read 2026-08-30
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (11)
Q1
What did Nicotinic acid's largest trial (3414 people) and its longest (20 years) measure?
3414 people in Nicotinic acid's largest registered study, 20 years in its longest registered window, measuring The GSK256073 Area Under Concentration-time Curve (AUC) and High Density Lipoprotein Cholesterol (HDLc) Data to Evolve the Exposure-response Pharmacokinetic/Pharmacodynamic (PK/PD) Relationship for… ClinicalTrials.gov · 2026-09-01
35 phase2, 24 na, 22 phase3, 18 phase4, 13 phase1, 9 early phase1, 6 na or unstated; NCT00000482; 1985-03; no ageing endpoint recorded. Last human test completed 2025, NCT05092945.
Interpretation These counts include studies where Nicotinic acid was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase2
35
na
24
phase3
22
phase4
18
phase1
13
early phase1
9
2 more recorded rows
na or unstated
6
Last recorded human testNCT05092945
2025-08-18
recorded 2026-09-01 · last checked 2026-09-04
Q2
From yeast to human: where has Nicotinic acid shown lifespan?
The GSK256073 Area Under Concentration-time Curve (AUC) and High Density Lipoprotein Cholesterol (HDLc) Data to Evolve the Exposure-response… — the recorded outcome words.
Show the evidence
C. elegans
lifespan
yeast
lifespan
mouse
lifespan
humanNCT00903617
biomarker; The GSK256073 Area Under Concentration-time Curve (AUC) and High Density Lipoprotein Cholesterol (HDLc) Data to Evolve the Exposure-response Pharmacokinetic/Pharmacodynamic (PK/PD) Relationship for Changes in HDLc Levels; 120
recorded 2026-09-01 · last checked 2026-09-04
Q3
11 of Nicotinic acid's trials stopped: safety, accrual/recruitment, funding/business, other?
safety (1), accrual/recruitment (3), funding/business (4) and other (3): Nicotinic acid's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"Unable to recruit sufficient study subjects"; 11 of 120 registered studies
Show the evidence
Trial
NCT00108485
terminated; "Unable to recruit sufficient study subjects"
NCT00120289
terminated; "AIM-HIGH was stopped on the recommendation of the DSMB because of lack of efficacy of niacin in preventing primary outcome events."
NCT00500045
terminated; "The PI retired/left the institution. Efforts were made to contact the PI but were unsuccessful."
NCT00796887
terminated; "Study was stopped early due to limitations in funding. As a result, the sample size was insufficient for meaningful exploration of functional outcomes"
NCT01159054
terminated; "The funding source is not going to fund this anymore. Only two subjects completed the study therefore meaningful analysis not possible."
NCT01450410
terminated; "Study terminated (halted prematurely) as recomended by the drug supplier and medical agencies"
5 further recorded trials
NCT03685773
withdrawn; "Permanently terminated due to COVID-19 given the poor vaccine penetrance in liver transplant recipients. This is not a suspension of IRB approval."
NCT03752918
withdrawn; "Funding ended."
NCT03808961
terminated; "Not enough recruitment"
NCT04424225
terminated; "Could not secure additional funding to continue the study. Pilot phase of study completed."
NCT04677049
suspended; "Recruitment has been placed on hold to determine evaluability of currently enrolled patients. Recruitment will remain on hold until evaluability is confirmed. If fewer than 48 evaluable patients are achieved, the study will be re-opened to…"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Nicotinic acid used Niacin 600 mg — over how long?
Change in Endogenous glucose production (EGP) rate; Plasma norepinephrine levels; latest 2030-07
Show the evidence
Trial
NCT03540758
"Regulation of Endogenous Glucose Production by Central KATP Channels"; n 100; "Change in Endogenous glucose production (EGP) rate"; 2027-04
NCT04234217
"Mechanisms of Prediabetic States in Sleep Apnea"; n 300; "Plasma norepinephrine levels"; 2026-07-15
NCT04464070
"Pathways of Eicosanoid Metabolism"; n 10; "prostaglandin metabolites"; 2027-08-31
NCT05119166
"International Milk Composition (IMiC) Consortium"; n 1000; "Create an international consortium of 4 birth cohorts in Tanzania, Pakistan, Burkina Faso and Canada (Field Site Partners), human milk scientists (Laboratory Partners), and data scientists and biostatisticians (Data Science Partners)."; 2026-10-30
NCT05398484
"Psilocybin Therapy in Advanced Cancer"; n 200; "Change in Structured Interview Guide for the Hamilton Anxiety Scale (HAM-A): SIGH-A Score"; 2027-01-01
NCT05452772
"5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder"; n 66; "Potential Efficacy (Smoking Cessation)"; 2027-05
12 further recorded trials
NCT05702398
"Pilot Trial of Supplemental Vitamin A and Nicotinamide"; n 30; "Change of Blood Vitamin A and Nicotinamide Levels"; 2028-03-01
NCT05934409
"Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery"; n 40; "Change in white adipose tissue dietary fatty acid (DFA) trapping and partitioning"; 2028-05-01
NCT06175403
"A Study of Niacin Regulation"; n 32; "Change in plasma free fatty acid (FFA) concentrations"; 2027-05-31
NCT06200155
"Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy"; n 48; "Safety and adverse events (AEs)"; 2026-12-31
NCT06760533
"Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)"; n 10; "Change in Abdominal Pain Severity Numeric Rating Scale (APS-NRS) Score"; 2026-12
NCT06843148
"Stimulating Fat Tissue Storage With Niacin to Reduce Fat Accumulation in the Liver."; n 36; "Prolonged small-dose niacin treatment does not lead to desensitization of the niacin-induced reduction in hepatic total fatty acids flux."; 2030-07
NCT06858332
"Lipoprotein(a) Levels in Patients With Atherosclerotic Cardiovascular Diseases in Russia"; n 2382; "Percentage of patients (%) with Lp(a) ≥125 nmol/L"; 2027-09-30
NCT06983730
"The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response"; n 28; "Urinary neutrophil gelatinase-associated lipocalin"; 2028-06
NCT06991712
"Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients"; n 138; "Change in visual field sensitivity"; 2026-12-31
NCT07119996
"Clinical Trial on the Protective Role of Vitamin B3 in Enhancing Immunotherapy for Bladder Cancer Patients"; n 12; "Phase I: The DLT dose of the Vitamin B3"; 2027-02-01
NCT07306364
"Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain"; n 45; "Change in interoceptive awareness as measured by the Multidimensional Assessment of Interoceptive Awareness-2 from 4 weeks post-dose to 8 weeks post dose"; 2029-06
NCT07732166
"Changes in Self-awareness Induced by Psychoactive Substances: an Experimental Study With Psilocybin."; n 100; "Changes in global metacognitive judgment using the Computerized Success-Failure Manipulation Paradigm."; 2027-12-01
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which 42 trials of Nicotinic acid posted no result?
Posted no result
42 of 42 completed trials
Registrations
NCT00000482, NCT00000483, NCT00000512, NCT00000461, NCT00000599 and NCT00000539, and 36 more
Completion dates
oldest 1985-03; newest 2024-07-25
Show the evidence
Trial
NCT00000482
1985-03
NCT00000483
1985-03
NCT00000512
1989-08
NCT00000461
1992-11
NCT00000599
1994-11
NCT00000539
1999-03
14 further recorded trials
NCT00000553
2001-02
NCT00304993
2005-02
NCT00079638
2005-05
NCT01921010
2005-06
NCT00590629
2005-11
NCT00378833
2007-03
NCT00652431
2007-07
NCT00152893
2008-02
NCT01104519
2008-07
NCT00302744
2008-12
NCT00298909
2009-06
NCT00930839
2010-02
NCT01071291
2010-09
NCT01083329
2012-06
Q9
At the median, Nicotinic acid's trials enrolled 40 people — anything larger?
Median enrolment
40
Largest enrolment
3414
Registered trials counted
114
Q10
Was Nicotinic acid studied with fasting and exercise?
fasting and exercise are named in Nicotinic acid's label sentences: "Studies were done under normal, fasting conditions (control trial: CON) and following administration of a nicotinic acid analogue (low plasma non-esterified fatty acid trial: LFA)." openfda-label+europepmc · 2018-06-23
2 recorded statements; fasting, exercise
Show the evidence
fasting
Studies were done under normal, fasting conditions (control trial: CON) and following administration of a nicotinic acid analogue (low plasma non-esterified fatty acid trial: LFA).
exercise
Fourteen male type 2 diabetes patients (age 65 ± 2 years, HbA<sub>1c</sub> 6.7 ± 0.1% (50 ± 2 mmol/mol)) participated in a double-blind placebo-controlled randomized cross-over study in which subjects performed endurance-type exercise after being administered 250 mg of a nicotinic acid analogue (acipimox; ACP) or a placebo (PLA).
recorded 2018-06-23 · last checked 2026-09-04
Q11
What is recorded about Nicotinic acid and NAD+?
"We previously showed that nicotinic acid riboside (NAR) sustains NAD biosynthesis in vivo and compensates for NAMPT inhibition in SCLC models." — where Nicotinic acid and NAD+ appear together. Europe PMC · pathway abstract search · 2026-07-28
"We previously showed that nicotinic acid riboside (NAR) sustains NAD biosynthesis in vivo and compensates for NAMPT inhibition in SCLC models."
PMID 42521252
"Here, we evaluated combining NAMPT inhibition with dietary nicotinic acid (NA) restriction to suppress NAR-dependent NAD biosynthesis."
PMID 41592801
"Loss of nicotinic acid phosphoribosyltransferase (NAPRT) has been associated with an increased vulnerability to NAMPT inhibition in specific metabolic contexts."
sirtuin
PMID 38946587
"Nicotinic acid (NA) is a precursor to nicotinamide dinucleotide (NAD+) which is exhausted in cachectic muscle and is a direct activator of sirt1."
PMID 41409579
"In the current study, we report the identification and characterization of a SIRT5 modulator, reduced nicotinic acid riboside (NARH)."
recorded 2026-07-28 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
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