This page shows what was measured, who it was measured in, and what that does not settle.
What MENTHOL, Unspecified Form does in the body
Temporarily relieves minor aches and pains of muscles and joints associated with: simple backache arthritis strains bruises sprains
Why people take it. Temporarily relieves minor aches and pains of muscles and joints associated with: simple backache arthritis strains bruises sprains
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
What the registries record it as
The substance registry classes this as mixture.
FDA substance registry · L7T10EIP3A · read 2026-08-29
Where each sentence above came from
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 49 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Protein
A protein is a folded chain your body builds to do a specific job.
A picture of it, and where the picture fails
A protein is like a tool bent into one shape for one task.
Where that stops being true. A tool keeps its shape. A protein can change shape and stop working.
What people get wrong. Protein in food and a protein in the body are related but not the same thing.
A polymer of amino acids folded into a defined structure that determines its function.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer11 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
neck pain intensity; arm/hand pain intensity during work; numeric pain rating scale at 2 weeks; numeric pain rating scale at 4 weeks; spontaneous pain intensity; bpi pain interference improvement 3 months; pain immediately after pdt assessed by vas; pain over 5 time
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
11 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Electronic cigarette (EC) use among adolescent and young adult (AYA) current/susceptible users (Aim 1)
✗ The study did not show it
Who was studied
NCT07581041
How many people
3400
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Number and proportion of subjects who reduce their cigarettes per day (CPD).
✗ The study did not show it
Who was studied
NCT05960305
How many people
1845
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Average Total Number of Cigarillos Purchased
✗ The study did not show it
Who was studied
NCT05434013
How many people
1578
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Treatment success resolution of pain with decrease of VAS more than 50% comparing to initial value at 30 minutes following analgesia administration
✗ The study did not show it
Who was studied
NCT05054023
How many people
1525
Study design
Phase 2/Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Past 7-day abstinence from combustible cigarette smoking for the final 7 days of the 13-week study period
✗ The study did not show it
Who was studied
NCT07598136
How many people
1280
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Validated 7-day point prevalence abstinence (1)
✗ The study did not show it
Who was studied
NCT04236791
How many people
1246
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.2 registered measures of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.2 registered measures of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.13 registered measures of this kind.
□A number that stands in for healthNo evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.No registered study measures this.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm). A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
neck pain intensity
arm/hand pain intensity during work
numeric pain rating scale at 2 weeks
numeric pain rating scale at 4 weeks
drug effects questionnaire good drug effects
spontaneous pain intensity
bpi pain interference improvement 3 months
pain immediately after pdt assessed by vas
pain over 5 time
numeric pain rating scale at 1 week
and 3 more.
Measured
Things only a test, a scale or a device shows.
No registered study measured anything of this kind.
Meaningful
Things that change how a life goes, not only a number.
neck disability index at 1 week
neck disability index
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (25)
onset time of brachial plexus anesthesia
onset time of brachial plexus sensory block
had no or mild peristalsis during the therapeutic procedures
womac
cmax of diclofenac gel in tube/cmax of oral diclofenac
laryngeal vestibule closure time
change cervical range of motion at 1 week
lumbar range of motion over one week
erectile function
joint angles
joint velocity
joint acceleration
temporal measures
knee flexion
change inhip flexion
step length
hip flexion
subjective drug ratings
e cigarette use
pharmacokinetics of peppermint oil
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
No description of who was studied is recorded.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No form or route is recorded.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing is recorded about product quality.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
The exact form studied is not recorded.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
417 products list this as an active ingredient in the United States drug directory. 169 of them contain it and nothing else.
FDA National Drug Code directory · 71574-600 · read 2026-08-29
They are sold as aerosol, spray, cream, crystal, gel, liniment and liquid, taken cutaneous, oral, topical and transdermal.
FDA National Drug Code directory · 71574-600 · read 2026-08-29
407 published labels name it as an active ingredient. 162 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 48836a5b-0baa-b7ee-e063-6294a90ac12b · read 2026-08-29
Those labels are classed as human otc drug.
US prescribing information · 48836a5b-0baa-b7ee-e063-6294a90ac12b · read 2026-08-29
34037 marketed supplement labels list this ingredient, classed as botanical with nutrients, mineral, non-nutrient/non-botanical and other combinations.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
Biofreeze Professional Colorless Roll-On is topical at HOW SUPPLIED Product: 50090-6360 NDC: 50090-6360-0 89 mL in a BOTTLE, recorded as fda label in effect 2025-01-09 in the United States.
US prescribing information · ce392c4f-cc43-484d-9c49-18fa25e4e5e9 · read 2026-08-30
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
A single-person plan is offered only as a structure for observing yourself. It never calculates an amount to take, and it cannot prove cause.
Questions worth asking
Which of the trials of MENTHOL, Unspecified Form studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
How fast does the body clear it?
The sources RNAWiki checked hold nothing for this field.
Why it matters. Without this, nothing on this page can say how long anything lasts.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of MENTHOL, Unspecified Form are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
Where else this substance is registered
FDA substance identifier (UNII)
L7T10EIP3A
RxNorm concept
415975
Checks this page had to pass
✓ Passed
Identity resolved
no open identity hold
✓ Passed
No unresolved merge across substance families
no quarantine open
✓ Passed
Every public sentence names a source
The opening statement carries the origin: Quoted from a stored source.
✗ Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
✓ Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
✓ Passed
Safety mode resolved
The identity record classes it as a supplement ingredient; no medicines register records an approval.
✓ Passed
Canonical metadata present
slug and display name present
What is missing or unclear◇Read from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
The earliest marketing start date recorded for a listed product is 19841001.
FDA National Drug Code directory · 71574-600 · read 2026-08-29
What is missing or unclear◇Read from sources, not yet reviewed
What to learn next
Ordered by what would most change how you read this page, starting with what is easiest to misunderstand.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (10)
Q1
What did MENTHOL, Unspecified Form's largest trial (300 people) and its longest (7.5 years) measure?
300 people in MENTHOL, Unspecified Form's largest registered study, 7.5 years in its longest registered window, measuring Sweat Potassium Concentration. ClinicalTrials.gov · 2026-09-01
25 na, 8 phase4, 6 phase2, 4 na or unstated, 4 phase3, 3 early phase1, 3 phase1; NCT03169140; 2024-07-31. Last human test completed 2025, NCT06584981.
Interpretation These counts include studies where MENTHOL, Unspecified Form was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
25
phase4
8
phase2
6
na or unstated
4
phase3
4
early phase1
3
2 more recorded rows
phase1
3
Last recorded human testNCT06584981
2025-06-30
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has MENTHOL, Unspecified Form shown lifespan?
pain immediately after pdt assessed by vas; 2026-09-01
biomarkers
pain over 5 time; 2026-09-01
biomarkers
laryngeal vestibule closure time; 2026-09-01
biomarkers
numeric pain rating scale at 1 week; 2026-09-01
biomarkers
neck disability index at 1 week; 2026-09-01
biomarkers
change cervical range of motion at 1 week; 2026-09-01
biomarkers
numeric pain rating scale over one week; 2026-09-01
biomarkers
fear avoidance beliefs questionnaire over one week; 2026-09-01
human trials at or under30
17
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT01565070; PHASE3; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q6
Which of arm/hand pain intensity during work, bpi pain interference improvement 3 months and change cervical range of motion at 1 week did MENTHOL, Unspecified Form's trials measure?
arm/hand pain intensity during work, bpi pain interference improvement 3 months and change cervical range of motion at 1 week lead 40 outcome terms across MENTHOL, Unspecified Form's trials. ClinicalTrials.gov · 2026-09-01
neck pain intensity, womac, arm/hand pain intensity during work, numeric pain rating scale at 2 weeks, numeric pain rating scale at 4 weeks and drug effects questionnaire good drug effects follow.
Show the evidence
onset time of brachial plexus anesthesia
1
onset time of brachial plexus sensory block
1
had no or mild peristalsis during the therapeutic procedures
1
neck pain intensity
1
womac
1
arm/hand pain intensity during work
1
14 more recorded rows
numeric pain rating scale at 2 weeks
1
numeric pain rating scale at 4 weeks
1
drug effects questionnaire good drug effects
1
cmax of diclofenac gel in tube/cmax of oral diclofenac
1
spontaneous pain intensity
1
bpi pain interference improvement 3 months
1
pain immediately after pdt assessed by vas
1
pain over 5 time
1
laryngeal vestibule closure time
1
numeric pain rating scale at 1 week
1
neck disability index at 1 week
1
change cervical range of motion at 1 week
1
numeric pain rating scale over one week
1
fear avoidance beliefs questionnaire over one week
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of MENTHOL, Unspecified Form's 8 ongoing trials reports first?
Change in Numeric Pain Rating Scale; The presence of postherpetic neuralgia using VAS score; latest 2027-12-31
Show the evidence
Trial
NCT03888820
"Biofreeze® vs. a Placebo on Chronic Low Back Pain Walking Gait Characteristics and Pain"; n 20; "Change in Numeric Pain Rating Scale"; 2019-04-30
NCT06344403
"Clinical Efficacy and Safety of Tender Point Infiltration (TPI) for Acute and Subacute Zoster Associated Pain"; n 136; "The presence of postherpetic neuralgia using VAS score"; 2027-12-01
NCT06444594
"Transient Receptor Potential Channels"; n 45; "Skin blood flow during slow local heating"; 2027-12-31
NCT06857760
"Effects of Three Different Methods Applied to Patients After Spine Surgery on Nausea, Thirst and Comfort"; n 128; "Nausea"; 2026-06-30
NCT07080645
"BIOSILITACE AS A DESENSITIZING AGENTIN HMI"; n 42; "The Visual Analogue Scale (VAS)"; 2025-11-15
NCT07268495
"The Impact of Intraperitoneal Spray Combined With Intravenous Lidocaine on Postoperative Pain After Myomectomy"; n 100; "The incidence rate of moderate to severe pain within 24 hours"; 2025-12-20
2 further recorded trials
NCT07630155
"Office-Based Ureteroscopy Utilizing a Single Use Digital, Flexible Ureteroscope for Upper Tract Urothelial Carcinoma"; n 10; "Success rate"; 2027-08
NCT07747350
"Comparison Between the Effectiveness of Low-Grade Laser Therapy vs. Conventional Analgesics for Pain Reduction During Orthodontic Treatment in Malay Female Population"; n 30; "Pain Intensity Score"; 2027-02-20
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which 26 trials of MENTHOL, Unspecified Form posted no result?
Posted no result
26 of 26 completed trials
Registrations
NCT00724035, NCT00702416, NCT01411176, NCT01411189, NCT01716767 and NCT03012503, and 20 more
Completion dates
oldest 2009-07; newest 2024-06-06
Show the evidence
Trial
NCT00724035
2009-07
NCT00702416
2009-11
NCT01411176
2012-06
NCT01411189
2012-06
NCT01716767
2013-01
NCT03012503
2013-05
14 further recorded trials
NCT01408446
2013-08-30
NCT02201238
2014-11-21
NCT02653703
2014-12
NCT03050957
2015-01
NCT02403687
2017-02
NCT03449940
2017-12
NCT03157349
2019-02-01
NCT03542955
2019-07-30
NCT03516240
2019-09-01
NCT02984072
2019-10-10
NCT02728687
2020-12-18
NCT04989127
2021-02-21
NCT04994262
2021-05-01
NCT05678296
2022-04-23
Q9
At the median, MENTHOL, Unspecified Form's trials enrolled 50 people — anything larger?
Median enrolment
50
Largest enrolment
300
Registered trials counted
51
Q10
What is recorded about MENTHOL, Unspecified Form and mTOR?
"Taken together, these findings indicate that SVA antagonizes the antiviral function of RETREG1-mediated ER-phagy via its 3C[pro], highlighting RETREG1 as a potential therapeutic target for combating SVA infection.<b>Abbreviations:</b> 2-APB: 2-aminoethyl diphenylborinate; PRKAA2/AMPK: protein kinase AMP-activated catalytic subunit alpha…" — where MENTHOL, Unspecified Form and mTOR appear together. Europe PMC · pathway abstract search · 2026-08-11
mTOR, AMPK; PMID 42576627
Show the evidence
mTORPMID 42576627
"Taken together, these findings indicate that SVA antagonizes the antiviral function of RETREG1-mediated ER-phagy via its 3C[pro], highlighting RETREG1 as a potential therapeutic target for combating SVA infection.<b>Abbreviations:</b> 2-APB: 2-aminoethyl diphenylborinate; PRKAA2/AMPK: protein kinase AMP-activated catalytic subunit alpha 2; ATL3: atlastin GTPase 3; BHK-21: baby hamster kidney-21;…"
AMPKPMID 42576627
"Taken together, these findings indicate that SVA antagonizes the antiviral function of RETREG1-mediated ER-phagy via its 3C[pro], highlighting RETREG1 as a potential therapeutic target for combating SVA infection.<b>Abbreviations:</b> 2-APB: 2-aminoethyl diphenylborinate; PRKAA2/AMPK: protein kinase AMP-activated catalytic subunit alpha 2; ATL3: atlastin GTPase 3; BHK-21: baby hamster kidney-21;…"
recorded 2026-08-11 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md
✗ required summary fields resolved: 3 required field(s) not terminal: Best-supported result, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 7 source rows
✓ no critical contamination: no quarantine open
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✓ no raw internal fields: enforced by the copy-contract test over the rendered page
This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.