This page shows what was measured, who it was measured in, and what that does not settle.
What ISOMENTHOL, (+)- does in the body
Localized pain, itching, or discomfort from minor skin irritations
From the FDA-approved label: Sumatriptan is an agonist for a vascular 5-hydroxytryptamine 1 receptor subtype (probably a member of the 5-HT 1D family) having only a weak affinity for 5-HT 1A , 5-HT 5A , and 5-HT 7 receptors and no significant affinity (as measured using standard radioligand binding assays) or pharmacological activity at 5-HT 2 , 5-HT 3 , or 5-HT 4 receptor subtypes or at alpha 1- , alpha 2- , or beta-adrenergic; dopamine 1 ; dopamine 2 ; muscarinic; or benzodiazepine receptors. The vascular 5-HT 1 receptor subtype that sumatriptan activates is present on cranial arteries in both dog and primate, on the human basilar artery, and in the vasculature of human dura mater and mediates vasoconstriction.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The supplement label database classes it as non-nutrient/non-botanical, under the name Menthol.
19 registered substances share the start of this name, which is why a search for it can return more than one thing.
FDA substance registry · BZ1R15MTK7 · read 2026-08-29
Where each sentence above came from
No recorded sentence describes the change this makes in a way that stands on its own. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 134 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Formulation
A formulation is the exact made-up form a substance comes in.
A picture of it, and where the picture fails
It is like the difference between a whole bean and instant coffee.
Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.
What people get wrong. Two products with the same name are assumed to behave the same. They often do not.
The specific composition and physical form of a product, including salt, excipients and release profile.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer11 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
neck pain intensity; arm/hand pain intensity during work; numeric pain rating scale at 2 weeks; numeric pain rating scale at 4 weeks; spontaneous pain intensity; bpi pain interference improvement 3 months; pain immediately after pdt assessed by vas; pain over 5 time
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
11 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Electronic cigarette (EC) use among adolescent and young adult (AYA) current/susceptible users (Aim 1)
✗ The study did not show it
Who was studied
NCT07581041
How many people
3400
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Number and proportion of subjects who reduce their cigarettes per day (CPD).
✗ The study did not show it
Who was studied
NCT05960305
How many people
1845
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Average Total Number of Cigarillos Purchased
✗ The study did not show it
Who was studied
NCT05434013
How many people
1578
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Treatment success resolution of pain with decrease of VAS more than 50% comparing to initial value at 30 minutes following analgesia administration
✗ The study did not show it
Who was studied
NCT05054023
How many people
1525
Study design
Phase 2/Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Reported condom use in the last 2 months
✗ The study did not show it
Who was studied
NCT02765659
How many people
1353
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Past 7-day abstinence from combustible cigarette smoking for the final 7 days of the 13-week study period
✗ The study did not show it
Who was studied
NCT07598136
How many people
1280
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.3 registered measures of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.3 registered measures of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.14 registered measures of this kind.
□A number that stands in for healthNo evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.No registered study measures this.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Drosophila (fruit fly), Mouse, Rat, Dog, Non-human primate. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
neck pain intensity
arm/hand pain intensity during work
numeric pain rating scale at 2 weeks
numeric pain rating scale at 4 weeks
drug effects questionnaire good drug effects
spontaneous pain intensity
bpi pain interference improvement 3 months
pain immediately after pdt assessed by vas
pain over 5 time
numeric pain rating scale at 1 week
and 4 more.
Measured
Things only a test, a scale or a device shows.
No registered study measured anything of this kind.
Meaningful
Things that change how a life goes, not only a number.
neck disability index at 1 week
functional status
neck disability index
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (23)
onset time of brachial plexus anesthesia
onset time of brachial plexus sensory block
improvement in behaviour
had no or mild peristalsis during the therapeutic procedures
womac
cmax of diclofenac gel in tube/cmax of oral diclofenac
laryngeal vestibule closure time
change cervical range of motion at 1 week
lumbar range of motion over one week
underglove failure rate compared between all competitors
erectile function
joint angles
joint velocity
joint acceleration
temporal measures
visual analogue scale
knee flexion
change inhip flexion
step length
hip flexion
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
■ For the temporary relief of localized pain, itching, or discomfort from minor skin irritations. When using this product ■ Avoid contact with eyes ■ Do not exceed the recommended daily dosage unless directed by a doctor. ■ Do not put this product into the rectum by using fingers or any mechanical device or applicator. Stop use and ask a doctor if ■ Condition worsens or does not improve within 7 days.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
A different form was studied
The studied form is not the form on the shelf.
On this record: This record is linked to 1 related forms. Evidence does not carry across all of them.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (9)
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as patch, cream, liquid, solution, given by the topical, oral, nasal route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
1963 products list this as an active ingredient in the United States drug directory. 1004 of them contain it and nothing else.
FDA National Drug Code directory · 71399-4458 · read 2026-08-29
They are sold as aerosol, spray, chewable gel, cloth, cream, cream, augmented and crystal, taken cutaneous, dental, extracorporeal and nasal.
FDA National Drug Code directory · 71399-4458 · read 2026-08-29
2023 published labels name it as an active ingredient. 1079 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 12652c98-e2a8-21fc-e063-6394a90a94cb · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · 12652c98-e2a8-21fc-e063-6394a90a94cb · read 2026-08-29
713 marketed supplement labels list this ingredient, classed as botanical, other combinations and non-nutrient/non-botanical.
Those labels carry all other, no claim and nutrient claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (13)
Q1
What did ISOMENTHOL, (+)-'s largest trial (3507 people) and its longest (7.5 years) measure?
3507 people in ISOMENTHOL, (+)-'s largest registered study, 7.5 years in its longest registered window, measuring Sweat Potassium Concentration. ClinicalTrials.gov · 2026-09-01
41 na, 9 phase2, 8 phase4, 5 na or unstated, 5 phase1, 5 phase3, 2 early phase1; NCT03169140; 2024-07-31. Last human test completed 2025, NCT07573878.
Interpretation These counts include studies where ISOMENTHOL, (+)- was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
41
phase2
9
phase4
8
na or unstated
5
phase1
5
phase3
5
2 more recorded rows
early phase1
2
Last recorded human testNCT07573878
2025-10-01
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has ISOMENTHOL, (+)- shown lifespan?
C. elegans: lifespan, Drosophila: lifespan, NHP: lifespan, mouse: lifespan, rat: mechanism-only, dog: lifespan and human: biomarker (71): the rungs where ISOMENTHOL, (+)- has a recorded finding. Europe PMC and ClinicalTrials.gov · organism ladder · 2026-09-01
Interpretation Sweat Potassium Concentration — the recorded outcome words.
Show the evidence
C. elegans
lifespan
Drosophila
lifespan
NHP
lifespan
mouse
lifespan
rat
mechanism-only
dog
lifespan
1 more recorded row
humanNCT05302804
biomarker; Sweat Potassium Concentration; 71
recorded 2026-09-01 · last checked 2026-09-04
Q3
6 of ISOMENTHOL, (+)-'s trials stopped: accrual/recruitment, funding/business, other?
accrual/recruitment (1), funding/business (2) and other (3): ISOMENTHOL, (+)-'s stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"Lack of resources to perform the study"; 6 of 71 registered studies
Show the evidence
Trial
NCT01542827
terminated; "Lack of resources to perform the study"
NCT01565070
withdrawn; "The local authorities did not authorize the use of biofreeze in Chile."
NCT03169140
terminated; "Decided not to proceed"
NCT03888807
terminated; "Decided not go move forward with this population as recruitment was difficult"
NCT04484428
terminated; "Internal business decision"
NCT04497870
withdrawn; "This study was superseded by NCT03295747"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of ISOMENTHOL, (+)- used Menthol, NF 5.00 % — over how long?
3 recorded entries; human; also "Topical L-menthol 40%", "5% menthol in aqueous cream"
Show the evidence
human
NCT02403687
Menthol, NF 5.00 %
NCT02653703
Topical L-menthol 40%
NCT02984072
5% menthol in aqueous cream
recorded 2026-09-01 · last checked 2026-09-04
Q5
Did ISOMENTHOL, (+)- move GrimAge, and by how much?
GrimAge: "After adjusting for chronological age and race, intrinsic epigenetic age acceleration (<i>p</i> = 0.041), extrinsic epigenetic age acceleration (<i>p</i> = 0.050), PhenoAge acceleration (<i>p</i> = 0.001), GrimAge acceleration (<i>p</i> < 0.001), and DunedinPACE (<i>p</i> = 0.006) were significantly higher and…" Europe PMC · epigenetic clock search · 2024-05-31
2 recorded sentences; 2024, 2022; biomarker
Show the evidence
GrimAge
PMID 38820227
2024; "After adjusting for chronological age and race, intrinsic epigenetic age acceleration (<i>p</i> = 0.041), extrinsic epigenetic age acceleration (<i>p</i> = 0.050), PhenoAge acceleration (<i>p</i> = 0.001), GrimAge acceleration (<i>p</i> < 0.001), and DunedinPACE (<i>p</i> = 0.006) were significantly higher and telomere length (<i>p</i> = 0.027) was significantly lower following the first cycle of…"
PMID 35944168
2022; "GrimAge most strongly predicted chronological age, and GrimAge acceleration was associated with baseline and cycle characteristics as well as cycle outcomes, which indicates its potential clinical relevance in evaluating both oocyte quantity and quality."
recorded 2024-05-31 · last checked 2026-09-04
Q6
More ISOMENTHOL, (+)- was worse in human: at what point?
U-shaped in human: "No significant associations were found between Asian BMI categories and ectopic pregnancy, miscarriage, or preterm birth. <bold>Conclusion</bold> : The relationship between female BMI and LBR after the first IUI cycle presents an inverted U-shaped curve, with an optimal BMI around 27.18 kg/m²." Europe PMC · dose-response search · 2026-08-26
5 recorded sentences naming ISOMENTHOL, (+)-; U-shaped, Hormesis, biphasic
Show the evidence
U-shaped
"No significant associations were found between Asian BMI categories and ectopic pregnancy, miscarriage, or preterm birth. <bold>Conclusion</bold> : The relationship between female BMI and LBR after the first IUI cycle presents an inverted U-shaped curve, with an optimal BMI around 27.18 kg/m²."
HormesisPMID 37709054
"Hormesis is active throughout the life-cycle and can be diminished by aging processes affecting the onset and severity of debilitating conditions/diseases, especially in elderly subjects."
biphasic
PMID 42642038
"An alternation between diploid and haploid phases is universal among sexual eukaryotes, with three kinds of biphasic life cycle distinguished by the presence or absence of mitosis in each phase."
PMID 42642038
"Within a biphasic cycle, selection opportunities are modified by within-phase two-way interactions, and across-phase one-way bridges where selection in one phase is tethered to a given genotype's phenotypic experience in the previous phase."
PMID 41671740
"The results of apoptosis assay and cell cycle analysis showed that the effects of compound 1 on MV4-11 may be biphasic, with an immediate cell cycle stabilizing effect at low picomolar concentrations, and a stronger effect to arrest cell cycle and induce apoptosis at low nanomolar concentrations."
recorded 2026-08-26 · last checked 2026-09-04
Q7
Could one person measure ISOMENTHOL, (+)-'s effect on onset time of brachial plexus anesthesia?
Onset time of brachial plexus anesthesia: measured in ISOMENTHOL, (+)-'s trials.
Interpretation onset time of brachial plexus anesthesia is the recorded endpoint.
Show the evidence
biomarkers
onset time of brachial plexus anesthesia; 2026-09-01
onset time of brachial plexus sensory block; 2026-09-01
improvement in behaviour; 2026-09-01
had no or mild peristalsis during the therapeutic procedures; 2026-09-01
neck pain intensity; 2026-09-01
womac; 2026-09-01
14 more recorded rows
biomarkers
arm/hand pain intensity during work; 2026-09-01
biomarkers
numeric pain rating scale at 2 weeks; 2026-09-01
biomarkers
numeric pain rating scale at 4 weeks; 2026-09-01
biomarkers
drug effects questionnaire good drug effects; 2026-09-01
biomarkers
cmax of diclofenac gel in tube/cmax of oral diclofenac; 2026-09-01
pain immediately after pdt assessed by vas; 2026-09-01
biomarkers
pain over 5 time; 2026-09-01
biomarkers
laryngeal vestibule closure time; 2026-09-01
biomarkers
numeric pain rating scale at 1 week; 2026-09-01
biomarkers
neck disability index at 1 week; 2026-09-01
biomarkers
change cervical range of motion at 1 week; 2026-09-01
biomarkers
functional status; 2026-09-01
human trials at or under30
22
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT01395563; NA; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q8
Which of arm/hand pain intensity during work, bpi pain interference improvement 3 months and change cervical range of motion at 1 week did ISOMENTHOL, (+)-'s trials measure?
arm/hand pain intensity during work, bpi pain interference improvement 3 months and change cervical range of motion at 1 week lead 40 outcome terms across ISOMENTHOL, (+)-'s trials. ClinicalTrials.gov · 2026-09-01
had no or mild peristalsis during the therapeutic procedures, neck pain intensity, womac, arm/hand pain intensity during work, numeric pain rating scale at 2 weeks and numeric pain rating scale at 4 weeks follow.
Show the evidence
onset time of brachial plexus anesthesia
1
onset time of brachial plexus sensory block
1
improvement in behaviour
1
had no or mild peristalsis during the therapeutic procedures
1
neck pain intensity
1
womac
1
14 more recorded rows
arm/hand pain intensity during work
1
numeric pain rating scale at 2 weeks
1
numeric pain rating scale at 4 weeks
1
drug effects questionnaire good drug effects
1
cmax of diclofenac gel in tube/cmax of oral diclofenac
1
spontaneous pain intensity
1
bpi pain interference improvement 3 months
1
pain immediately after pdt assessed by vas
1
pain over 5 time
1
laryngeal vestibule closure time
1
numeric pain rating scale at 1 week
1
neck disability index at 1 week
1
change cervical range of motion at 1 week
1
functional status
1
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which of ISOMENTHOL, (+)-'s 8 ongoing trials reports first?
Change in Numeric Pain Rating Scale; CTCM Coherence; latest 2028-12-31
Show the evidence
Trial
NCT03888820
"Biofreeze® vs. a Placebo on Chronic Low Back Pain Walking Gait Characteristics and Pain"; n 20; "Change in Numeric Pain Rating Scale"; 2019-04-30
NCT06293638
"Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor"; n 55; "CTCM Coherence"; 2028-12-31
NCT06344403
"Clinical Efficacy and Safety of Tender Point Infiltration (TPI) for Acute and Subacute Zoster Associated Pain"; n 136; "The presence of postherpetic neuralgia using VAS score"; 2027-12-01
NCT06444594
"Transient Receptor Potential Channels"; n 45; "Skin blood flow during slow local heating"; 2027-12-31
NCT06500910
"Exercise in Prematurely Born Preadolescents to Mitigate Cardiovascular Risk and Improve Cognitive Impairment"; n 50; "Central Retinal Arteriolar Equivalent (CRAE)"; 2025-08-12
NCT07268495
"The Impact of Intraperitoneal Spray Combined With Intravenous Lidocaine on Postoperative Pain After Myomectomy"; n 100; "The incidence rate of moderate to severe pain within 24 hours"; 2025-12-20
2 further recorded trials
NCT07630155
"Office-Based Ureteroscopy Utilizing a Single Use Digital, Flexible Ureteroscope for Upper Tract Urothelial Carcinoma"; n 10; "Success rate"; 2027-08
NCT07747350
"Comparison Between the Effectiveness of Low-Grade Laser Therapy vs. Conventional Analgesics for Pain Reduction During Orthodontic Treatment in Malay Female Population"; n 30; "Pain Intensity Score"; 2027-02-20
recorded 2026-09-01 · last checked 2026-09-04
Q10
Which 33 trials of ISOMENTHOL, (+)- posted no result?
Posted no result
33 of 33 completed trials
Registrations
NCT00724035, NCT00702416, NCT01411176, NCT01411189, NCT01716767 and NCT03012503, and 27 more
Completion dates
oldest 2009-07; newest 2024-06-06
Show the evidence
Trial
NCT00724035
2009-07
NCT00702416
2009-11
NCT01411176
2012-06
NCT01411189
2012-06
NCT01716767
2013-01
NCT03012503
2013-05
14 further recorded trials
NCT01408446
2013-08-30
NCT02201238
2014-11-21
NCT02653703
2014-12
NCT01363544
2015-01
NCT03050957
2015-01
NCT01955265
2015-02
NCT02403687
2017-02
NCT03161782
2017-07-25
NCT03449940
2017-12
NCT07370870
2017-12-20
NCT03157349
2019-02-01
NCT03582644
2019-06-01
NCT03542955
2019-07-30
NCT03516240
2019-09-01
Q11
At the median, ISOMENTHOL, (+)-'s trials enrolled 52 people — anything larger?
Median enrolment
52
Largest enrolment
3507
Registered trials counted
71
Q12
Was ISOMENTHOL, (+)- studied with exercise?
exercise is named in ISOMENTHOL, (+)-'s label sentences: "To determine the feasibility of conducting a randomised controlled trial and investigate the acceptability and credibility of comprehensive progressive foot exercise and education compared to brief advice for PHP." openfda-label+europepmc · 2026-08-10
1 recorded statement; exercise
Show the evidence
exercise
To determine the feasibility of conducting a randomised controlled trial and investigate the acceptability and credibility of comprehensive progressive foot exercise and education compared to brief advice for PHP.
recorded 2026-08-10 · last checked 2026-09-04
Q13
What is recorded about ISOMENTHOL, (+)- and autophagy?
"Pharmacological inhibition of the integrin/FAK axis and/or BRD4 induced cell cycle arrest, autophagy, and senescence in highly proliferative cells, consistent with a metabolic stress phenotype." — where ISOMENTHOL, (+)- and autophagy appear together. Europe PMC · pathway abstract search · 2026-09-01
"Pharmacological inhibition of the integrin/FAK axis and/or BRD4 induced cell cycle arrest, autophagy, and senescence in highly proliferative cells, consistent with a metabolic stress phenotype."
"Ultrastructural analysis demonstrated early podocyte foot process effacement, while autophagosomes were observed following autophagy modulation."
mTORPMID 42338171
"Overall, this study elucidates how FMDV modulates glycolysis through two different autophagic pathways, which would contribute to our understanding of how the autophagy-glycolysis axis regulates viral replication, providing new avenues for developing antiviral strategies targeting metabolism.<b>Abbreviations</b>: 3-MA: 3-methyladenine; ACTB: actin beta; ATG: autophagy related; CQ: chloroquine;…"
sirtuinPMID 42338171
"Overall, this study elucidates how FMDV modulates glycolysis through two different autophagic pathways, which would contribute to our understanding of how the autophagy-glycolysis axis regulates viral replication, providing new avenues for developing antiviral strategies targeting metabolism.<b>Abbreviations</b>: 3-MA: 3-methyladenine; ACTB: actin beta; ATG: autophagy related; CQ: chloroquine;…"
autophagyPMID 42338171
"Overall, this study elucidates how FMDV modulates glycolysis through two different autophagic pathways, which would contribute to our understanding of how the autophagy-glycolysis axis regulates viral replication, providing new avenues for developing antiviral strategies targeting metabolism.<b>Abbreviations</b>: 3-MA: 3-methyladenine; ACTB: actin beta; ATG: autophagy related; CQ: chloroquine;…"
NAD+PMID 42442093
"Aging-associated NAD<sup>+</sup> decline was modeled using FK866, a NAMPT inhibitor that depletes intracellular NAD<sup>+</sup>, which reduced rhythm amplitude, lengthened the period, and increased cycle-to-cycle variability."
sirtuinPMID 42325507
"In contrast, under pathological or aging conditions, excessive or dysregulated NAD+ signaling activates SIRT2 to deacetylate PAX7 and repress Myogenic Differentiation 1 (MyoD), leading to cell-cycle arrest and MuSC exhaustion."
NAD+PMID 42325507
"In contrast, under pathological or aging conditions, excessive or dysregulated NAD+ signaling activates SIRT2 to deacetylate PAX7 and repress Myogenic Differentiation 1 (MyoD), leading to cell-cycle arrest and MuSC exhaustion."
7 more recorded rows
AMPKPMID 41317217
"The molecules AMP-activated protein kinase (AMPK), Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), Irisin, and brain-derived neurotrophic factor (BDNF) are essential to this “anti-aging cycle” because they all support cellular function and maintenance in ways that may eventually delay or reverse the effects of aging even that partially or…"
sirtuinPMID 41317217
"The molecules AMP-activated protein kinase (AMPK), Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), Irisin, and brain-derived neurotrophic factor (BDNF) are essential to this “anti-aging cycle” because they all support cellular function and maintenance in ways that may eventually delay or reverse the effects of aging even that partially or…"
NAD+PMID 41901696
"Sirtuin 1 (SIRT1) is an NAD<sup>+</sup>-dependent deacetylase that plays a critical role in regulating cell cycle progression, DNA damage responses, and apoptosis."
mTORPMID 42467316
"Celastrol increases leptin sensitivity in cell-based and animal studies, inhibits phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin (PI3K/AKT/mTOR), signal transducer and activator of transcription 3 (STAT3), and nuclear factor kappa B (NF-κB) signaling, disrupts heat shock protein 90-cell division cycle 37 (Hsp90-Cdc37) client-protein stabilization, and induces adenosine…"
AMPKPMID 42467316
"Celastrol increases leptin sensitivity in cell-based and animal studies, inhibits phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin (PI3K/AKT/mTOR), signal transducer and activator of transcription 3 (STAT3), and nuclear factor kappa B (NF-κB) signaling, disrupts heat shock protein 90-cell division cycle 37 (Hsp90-Cdc37) client-protein stabilization, and induces adenosine…"
mTORPMID 42677956
"Sotagliflozin reduced cell viability, clonogenic survival, migration, and invasion, and these effects were accompanied by G2/M cell-cycle arrest, increased AMPK activation, and changes in PTEN-AKT-mTOR signalling."
AMPKPMID 42677956
"Sotagliflozin reduced cell viability, clonogenic survival, migration, and invasion, and these effects were accompanied by G2/M cell-cycle arrest, increased AMPK activation, and changes in PTEN-AKT-mTOR signalling."
recorded 2026-09-01 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
✗ required summary fields resolved: 4 required field(s) not terminal: Why people use it, Best-supported result, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 10 source rows
✓ no critical contamination: no quarantine open
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This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.