This page shows what was measured, who it was measured in, and what that does not settle.
What Medroxyprogesterone Acetate does in the body
From the FDA-approved label: Depo-subQ provera 104 inhibits the secretion of gonadotropins, which primarily prevents follicular maturation and ovulation and causes thickening of cervical mucus.
These actions contribute to its contraceptive effect. Suppression of serum estradiol concentrations is likely to be responsible for the therapeutic effect on endometriosis-associated pain.
Why people take it. Medroxyprogesterone acetate injectable suspension is indicated for use by females of reproductive potential to prevent pregnancy.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · C2QI4IOI2G · read 2026-08-29
Where each sentence above came from
A person wrote this explanation into the record, with the studies named in the path below.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 76 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Focus
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved2 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Cholesterol
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Fertility and sexual health
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Sleep
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Focus
memory for emotionally valent words and neutral words; verbal memory immediate recall; verbal memory delayed recall
Blood sugar
serum hba1c at 3 months; auc insulin during 2 hour gtt at completion at 3 months
Cholesterol
hdl subpopulation distribution and composition
Fertility and sexual health
testosterone concentration
Sleep
polysomnography measures of sleep apnea and sleep
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
— Not recorded
Harms were not a registered measure for this goal.
… Waiting for a reviewer
Who was studied is listed further down the page.
△ Only a number moved
2 registered test measure.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Numbers of clinic directors engaged
✗ The study did not show it
Who was studied
NCT05056545
How many people
42377
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Compare risks of HIV acquisition between women randomized to DMPA, LNG and copper IUD
✗ The study did not show it
Who was studied
NCT02550067
How many people
7830
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Hormonal Birth Control and the Risk of Acquiring HIV
✗ The study did not show it
Who was studied
NCT00006324
How many people
6360
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Myocardial Infarction
✗ The study did not show it
Who was studied
NCT00319566
How many people
2430
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Relationship Satisfaction
✗ The study did not show it
Who was studied
NCT04950686
How many people
2184
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Change in student knowledge of full range of contraceptive methods (questionnaire)
✗ The study did not show it
Who was studied
NCT03519685
How many people
2086
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.1 registered measure of this kind. No reviewed result.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
□Symptoms and quality of lifeNo evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.No registered study measures this.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.10 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.1 registered measure inside human tissue.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
No registered study measured anything of this kind.
Measured
Things only a test, a scale or a device shows.
hdl subpopulation distribution and composition
bone mineral density of the spine at week 24
bone mineral density of the femur at week 24
testosterone concentration
dihydrotestosterone concentration
serum hba1c at 3 months
auc insulin during 2 hour gtt at completion at 3 months
endometrial biopsy and histological examination
mpa concentration at day 91
mpa concentration at day 104
and 1 more.
Meaningful
Things that change how a life goes, not only a number.
overall survival
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (28)
endometrial pathologic diagnosis
potential sebs relevant to endometrial carcinogenesis
intratesticular hormone levels
successful treatment
prostate specific antigen
bleeding or spotting days
clinical benefit rate
auc during oral gtt at completion at 3 months
t cell activation
bioequivalence based on cmax and auc
stai 6
memory for emotionally valent words and neutral words
verbal memory immediate recall
verbal memory delayed recall
randomization in hot flushes at week 4 of treatment
satisfaction the treatment
cmax
tmax
auc 0 91
cessation of bleeding within 5 days
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Depo-subQ provera 104 is indicated in females of reproductive age for: • Prevention of pregnancy and • Management of endometriosis-associated pain. Depo-subQ provera 104 is a progestin that is indicated in females of reproductive age for: • Prevention of pregnancy. ( 1 ) • Management of endometriosis-associated pain.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Medroxyprogesterone acetate injectable suspension is not indicated before menarche.”
US prescribing information · d1ea4098-6196-421f-b8e1-bcb31a061e04 · read 2026-08-30
On older people, the label states: “This product has not been studied in post-menopausal women and is not indicated in this population.”
US prescribing information · d1ea4098-6196-421f-b8e1-bcb31a061e04 · read 2026-08-30
On people who are pregnant, the label states: “Medroxyprogesterone acetate injectable suspension should not be administered during pregnancy. [ See Contraindications and Warnings and Precautions (5.17) .]”
US prescribing information · d1ea4098-6196-421f-b8e1-bcb31a061e04 · read 2026-08-30
On people who are breastfeeding, the label states: “Detectable amounts of drug have been identified in the milk of mothers receiving medroxyprogesterone acetate injectable suspension. [ See Warnings and Precautions (5.13) .]”
US prescribing information · d1ea4098-6196-421f-b8e1-bcb31a061e04 · read 2026-08-30
On people with reduced liver function, the label states: “The effect of hepatic impairment on medroxyprogesterone acetate injectable suspension pharmacokinetics has not been studied.”
US prescribing information · d1ea4098-6196-421f-b8e1-bcb31a061e04 · read 2026-08-30
On people with reduced kidney function, the label states: “The effect of renal impairment on medroxyprogesterone acetate injectable suspension pharmacokinetics has not been studied.”
US prescribing information · d1ea4098-6196-421f-b8e1-bcb31a061e04 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Injection
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Suppression classes recorded: S3, S6.
No source is stored against this line.
What is in the pack
Sold as injectable, tablet, injection, suspension, tablet, sugar coated, given by the injection, oral-28, oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Medroxyprogesterone Acetate appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 2141 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
unintended pregnancy — 484 reaction mentions
drug hypersensitivity — 288 reaction mentions
hypersensitivity — 257 reaction mentions
breast cancer — 179 reaction mentions
back pain — 175 reaction mentions
metrorrhagia — 168 reaction mentions
erythema — 164 reaction mentions
hyperhidrosis — 158 reaction mentions
injection site reaction — 138 reaction mentions
vaginal haemorrhage — 130 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Injection
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
71 products list this as an active ingredient in the United States drug directory. 63 of them contain it and nothing else.
FDA National Drug Code directory · 0009-5097 · read 2026-08-29
They are sold as injection, suspension, injection, suspension, extended release, powder, tablet and tablet, sugar coated, taken intramuscular, oral and subcutaneous.
FDA National Drug Code directory · 0009-5097 · read 2026-08-29
The regulator's established pharmacologic class for it is progesterone congeners [cs] and progestin [epc].
FDA National Drug Code directory · 0009-5097 · read 2026-08-29
37 published labels name it as an active ingredient. 36 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 437edd12-2c08-4df4-8cf7-64c47e4779ac · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · 437edd12-2c08-4df4-8cf7-64c47e4779ac · read 2026-08-29
MEDROXYPROGESTERONE ACETATE is intramuscular at 3 DOSAGE FORMS AND STRENGTHS Sterile Aqueous suspension: 150 mg/mL Vials containing sterile aqueous suspension: 150 mg per mL ( 3 ), recorded as fda label in effect 2021-06-29 in the United States.
US prescribing information · d1ea4098-6196-421f-b8e1-bcb31a061e04 · read 2026-08-30
Recorded price in US: 0.11639–0.14817 USD per one unit as the pricing file counts it — a tablet, capsule, patch or single item, across 14 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Recorded price in US: 18.31336–28.49134 USD per one millilitre, across 17 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
Self-experiment planning is not offered for a prescription or clinician-supervised medicine. The questions below are for a clinician or pharmacist.
Questions worth asking
Which of the trials of Medroxyprogesterone Acetate studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Medroxyprogesterone Acetate are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
How many documents were read
37 documents were read for this substance.
RNAWiki source record
15 of them state the same proteinBinding, and they agree.
RNAWiki source record
Where else this substance is registered
FDA substance identifier (UNII)
C2QI4IOI2G
RxNorm concept
1000114
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How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
28 approved applications cover products containing this substance. The earliest was NDA011839, approved 19590618 to PFIZER.
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6 questions this page could not answer
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Recorded evidence blocks (11)
Q2
What did Medroxyprogesterone Acetate's largest trial (7830 people) and its longest (19 years) measure?
7830 people in Medroxyprogesterone Acetate's largest registered study, 19 years in its longest registered window, measuring Testosterone Concentration. ClinicalTrials.gov · 2026-09-01
35 phase3, 28 phase2, 20 phase4, 18 na, 13 phase1, 9 na or unstated, 3 early phase1; NCT00191113; 2007-12; no ageing endpoint recorded. Last human test completed 2025, NCT05651282.
Interpretation These counts include studies where Medroxyprogesterone Acetate was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase3
35
phase2
28
phase4
20
na
18
phase1
13
na or unstated
9
2 more recorded rows
early phase1
3
Last recorded human testNCT05651282
2025-11-30
recorded 2026-09-01 · last checked 2026-09-04
Q3
From rat to human: where has Medroxyprogesterone Acetate shown biomarker?
Interpretation Testosterone Concentration — the recorded outcome words.
Show the evidence
rat
mechanism-only
humanNCT00490555
biomarker; Testosterone Concentration; 114
recorded 2026-09-01 · last checked 2026-09-04
Q4
7 of Medroxyprogesterone Acetate's trials stopped: safety, accrual/recruitment, other?
safety (1), accrual/recruitment (2) and other (4): Medroxyprogesterone Acetate's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"Due to ethical concerns regard to the results from the WHI study"; 7 of 114 registered studies
Show the evidence
Trial
NCT01087593
terminated; "Due to ethical concerns regard to the results from the WHI study"
NCT01607320
terminated; "Over budget, slow recruitment, and personnel change"
NCT01718444
terminated; "The primary investigator moved from academic practice to join a private group, and could not get any one to take over as PI for the study."
NCT01750476
terminated; "PI and lab have re-located study to The Ohio State University"
NCT01776203
terminated; "Inadequate enrollment"
NCT02449161
terminated; "Missing fund to continue"
1 further recorded trialNCT06904274
withdrawn; "Bayer cancelled study 22923 due to enrollment challenges, including difficulties identifying eligible patients, participation requirements, and site burden. The decision was unrelated to safety and does not change Mirena's benefit-risk…"
recorded 2026-09-01 · last checked 2026-09-04
Q5
Human studies of Medroxyprogesterone Acetate used Provera 10 mg — over how long?
9 recorded entries; human; intramuscular; also "Provera 10 mg", "Depo-Provera® CI (150mg/mL, intramuscular)", "Depo-Provera® CI (300mg/2mL, intramuscular)"
Show the evidence
human
NCT00543634
Provera 10 mg
NCT02456584
intramuscular; Depo-Provera® CI (150mg/mL, intramuscular)
NCT02456584
intramuscular; Depo-Provera® CI (300mg/2mL, intramuscular)
Which of adherence, auc 0 91 and auc during oral gtt at completion at 3 months did Medroxyprogesterone Acetate's trials measure?
adherence, auc 0 91 and auc during oral gtt at completion at 3 months lead 40 outcome terms across Medroxyprogesterone Acetate's trials. ClinicalTrials.gov · 2026-09-01
intratesticular hormone levels, overall survival, successful treatment, bone mineral density of the spine at week 24, bone mineral density of the femur at week 24 and prostate specific antigen follow.
Show the evidence
endometrial pathologic diagnosis
1
potential sebs relevant to endometrial carcinogenesis
1
hdl subpopulation distribution and composition
1
intratesticular hormone levels
1
overall survival
1
successful treatment
1
14 more recorded rows
bone mineral density of the spine at week 24
1
bone mineral density of the femur at week 24
1
prostate specific antigen
1
testosterone concentration
1
dihydrotestosterone concentration
1
bleeding or spotting days
1
clinical benefit rate
1
serum hba1c at 3 months
1
auc insulin during 2 hour gtt at completion at 3 months
1
auc during oral gtt at completion at 3 months
1
endometrial biopsy and histological examination
1
t cell activation
1
bioequivalence based on cmax and auc
1
stai 6
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of Medroxyprogesterone Acetate's 10 ongoing trials reports first?
10 registered trials of Medroxyprogesterone Acetate are open; earliest completion 2025-12-31. ClinicalTrials.gov · 2026-09-01
Pathologic Response; Complete response rates within 16 weeks of treatment; latest 2035-01
Show the evidence
Trial
NCT03463252
"Value of LNG-IUS as Fertility-preserving Treatment of EAH and EC"; n 224; "Pathologic Response"; 2030-12-30
NCT05247268
"Gonadotropin-releasing Hormone Agonist (GnRHa) Plus Letrozole In Young Women With Early Endometrial Cancer"; n 104; "Complete response rates within 16 weeks of treatment"; 2027-09-10
NCT05255653
"Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features"; n 1615; "p53abn-RED trial"; 2031-01-01
NCT05760144
"Endometrial Biopsy in Progestin Contraceptive Users"; n 52; "The proportion of participants who experienced endometrial changes"; 2026-11
NCT06637189
"Protocol with Progestin-primed Ovarian Stimulation (PPOS) from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A."; n 144; "Number of Euploid Embryos"; 2025-12-31
NCT06665997
"Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease"; n 65; "Frequency of acute vaso-occlusive episodes"; 2028-07-31
4 further recorded trials
NCT06671548
"Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids"; n 120; "Percentage Of Participants Who Achieved A Menstrual Blood Loss (MBL) Volume Of < 80 mL And ≥ 50% Reduction From Baseline MBL Volume"; 2027-01-07
NCT07124195
"Nanocrystalline Megestrol for Managing Chemotherapy-Induced Nausea and Vomiting"; n 126; "the efficacy of medroxyprogesterone acetate oral suspension (Meishiya®) in the whole-process management of preventing nausea and vomiting induced by single-day moderate to high emetogenic chemotherapy (MEC/HEC) drugs."; 2026-12-31
NCT07319429
"Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification"; n 260; "The complete response rate (CRR) at 32 weeks after initiating treatment."; 2029-12-31
NCT07462663
"SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer"; n 80; "Recruitment Rate"; 2035-01
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which 48 trials of Medroxyprogesterone Acetate posted no result?
Posted no result
48 of 48 completed trials
Registrations
NCT00000466, NCT01472315, NCT00000559, NCT00000605, NCT00830414 and NCT00006324, and 42 more
Completion dates
oldest 2000-10; newest 2023-09-07
Show the evidence
Trial
NCT00000466
2000-10
NCT01472315
2000-11
NCT00000559
2001-08
NCT00000605
2002-07
NCT00830414
2002-09
NCT00006324
2002-12
14 further recorded trials
NCT00016601
2004-05
NCT00332553
2004-05
NCT00291369
2005-02
NCT00416429
2005-02
NCT00350480
2005-06
NCT00156650
2005-07
NCT00745108
2005-07-21
NCT00161447
2006-04
NCT00030914
2006-09
NCT00083824
2007-02
NCT00026286
2007-06-15
NCT00066157
2007-12
NCT00543634
2007-12
NCT01011751
2007-12
Q9
At the median, Medroxyprogesterone Acetate's trials enrolled 80 people — anything larger?
Median enrolment
80
Largest enrolment
7830
Registered trials counted
110
Q10
What do 2141 spontaneous reports say about Medroxyprogesterone Acetate — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Medroxyprogesterone Acetate appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 2141 reaction mentions were counted: unintended pregnancy 484; drug hypersensitivity 288; hypersensitivity 257; breast cancer 179. open-targets-adr · CHEMBL717 · 2026-06-24
Show the evidence
unintended pregnancy
484
drug hypersensitivity
288
hypersensitivity
257
breast cancer
179
back pain
175
metrorrhagia
168
4 more recorded rows
erythema
164
hyperhidrosis
158
injection site reaction
138
vaginal haemorrhage
130
recorded 2026-06-24 · last checked 2026-09-04
Q11
Medroxyprogesterone Acetate and CYP3A4: shared by which compounds?
CYP3A4 appear in Medroxyprogesterone Acetate's recorded interaction sentences, 2 in all. openfda-label+europepmc · 2026-08-25
Interpretation drug_interactions
Show the evidence
CYP3A4
drug_interactions
7 DRUG INTERACTIONS Drugs or herbal products that induce certain enzymes, including CYP3A4, may decrease the effectiveness of contraceptive drug products.
drug_interactions
( 7.1 ) 7.1 Changes in Contraceptive Effectiveness Associated with Co-Administration of Other Products If a woman on hormonal contraceptives takes a drug or herbal product that induces enzymes, including CYP3A4, that metabolize contraceptive hormones, counsel her to use additional contraception or a different method of contraception.
recorded 2026-08-25 · last checked 2026-09-04
Q12
What is recorded about Medroxyprogesterone Acetate and mTOR?
"Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACACA (acetyl-CoA carboxylase alpha); AICAR: 5-aminoimidazole-4-carboximide riboside; AKT: AKT serine/threonine kinase; AMPK: AMP-activated protein kinase; ATG: autophagy…" — where Medroxyprogesterone Acetate and mTOR appear together. Europe PMC · pathway abstract search · 2020-05-13
"Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACACA (acetyl-CoA carboxylase alpha); AICAR: 5-aminoimidazole-4-carboximide riboside; AKT: AKT serine/threonine kinase; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG12: autophagy related 12; ATG16L1: autophagy…"
AMPKPMID 32401642
"Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACACA (acetyl-CoA carboxylase alpha); AICAR: 5-aminoimidazole-4-carboximide riboside; AKT: AKT serine/threonine kinase; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG12: autophagy related 12; ATG16L1: autophagy…"
sirtuinPMID 32401642
"Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACACA (acetyl-CoA carboxylase alpha); AICAR: 5-aminoimidazole-4-carboximide riboside; AKT: AKT serine/threonine kinase; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG12: autophagy related 12; ATG16L1: autophagy…"
autophagyPMID 32401642
"Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACACA (acetyl-CoA carboxylase alpha); AICAR: 5-aminoimidazole-4-carboximide riboside; AKT: AKT serine/threonine kinase; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG12: autophagy related 12; ATG16L1: autophagy…"
IGF-1PMID 32401642
"Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discussed.<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACACA (acetyl-CoA carboxylase alpha); AICAR: 5-aminoimidazole-4-carboximide riboside; AKT: AKT serine/threonine kinase; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG12: autophagy related 12; ATG16L1: autophagy…"
mTORPMID 25104960
"We report the outcome of one patient with pretreated, progressing low grade metastatic ESS treated with medroxyprogesterone acetate in combination with the mTOR inhibitor sirolimus."
1 more recorded row
autophagyPMID 11872957
"In this study, the FM3A murine breast tumor cell line was treated with epirubicin alone and with medroxyprogesterone acetate (MPA) or tamoxifen, to determine if structural and kinetic signs of autophagy may also occur in an enhanced manner during epirubicin sensitization via hormonal agents."
recorded 2020-05-13 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · openFDA / DailyMed — US Government work
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✓ source coverage passed: 10 source rows
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