This page shows what was measured, who it was measured in, and what that does not settle.
What Cordycepic Acid does in the body
The following therapeutic uses
From the FDA-approved label: Mannitol, when administered intravenously, exerts its osmotic diuretic effect as a solute of relatively small molecular size being largely confined to the extracellular space. Mannitol hinders tubular reabsorption of water and enhances excretion of sodium and chloride by elevating the osmolarity of the glomerular filtrate. This increase in extracellular osmolarity affected by the intravenous administration of mannitol will induce the movement of intracellular water to the extracellular and vascular spaces. This action underlies the role of mannitol in reducing intracranial pressure, intracranial edema, and intraocular pressure.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · 3OWL53L36A · read 2026-08-29
The supplement label database classes it as non-nutrient/non-botanical, under the name Mannitol.
Its recorded molecular formula is C6H14O6, weighing 182.2.
US prescribing information · 5387a4fb-b894-4cba-88a3-a947217d34da · read 2026-08-30
Where each sentence above came from
No recorded sentence describes the change this makes in a way that stands on its own. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 107 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer4 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Sleep
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Recovery
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Cholesterol
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Healthy ageing
…Waiting for a reviewer1 registered study measure of this kind. No reviewed result yet.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
worst nrs pain; average nrs pain; bpi pain interference improvement 3 months; visual analogue scale pain at injection site at time zero
Sleep
sleep apnea per hour; sleep polysomnography in normal baseline sleep
Recovery
coma recovery time
Cholesterol
changes in cholesterol metabolism
Healthy ageing
incidence of mortality
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
4 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
△ Only a number moved
1 registered test measure.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Length-for-Age Z-scores
✗ The study did not show it
Who was studied
NCT01704105
How many people
8246
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Pneumonia free survival; acute respiratory distress syndrome (ARDS) free survival; or death
✗ The study did not show it
Who was studied
NCT04386070
How many people
6400
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Length-for-Age Z-scores
✗ The study did not show it
Who was studied
NCT01590095
How many people
5040
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
HAPE：Recovery
✗ The study did not show it
Who was studied
NCT07639931
How many people
3035
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Seroconversion rate of HI antibody
✗ The study did not show it
Who was studied
NCT05158777
How many people
2480
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Overall Survival (OS)
✗ The study did not show it
Who was studied
NCT03970447
How many people
2250
Study design
Phase 2/Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.5 registered measures of this kind. 2 written-up studies measured this and did not show a benefit.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.6 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.4 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Yeast, Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
heroin craving
worst nrs pain
average nrs pain
symptom
bpi pain interference improvement 3 months
visual analogue scale pain at injection site at time zero
Measured
Things only a test, a scale or a device shows.
changes in cholesterol metabolism
serum creatinine
creatinine clearance according to cockroft gault equation
arterial blood pressure
Meaningful
Things that change how a life goes, not only a number.
overall survival
progression free survival
national institutes of health stroke severity scale
transplant free survival
incidence of mortality
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (25)
coma recovery time
free radical production and markers of neuronal damage
fev1
cr rate
response rate
time to best response
incidence of adverse events
maximum tolerated dose
sleep apnea per hour
time
modified rankin
neurological status of the
nrs heat once per minute
intraoperative blood loss
visual analog scale
brain relaxation
acute kidney injury
blood urea nitrogen
relevant parenchymatous brain injury on postoperative mri
poor outcomes
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
For Intravenous Injection Mannitol Injection, USP is indicated for the following therapeutic uses: • The promotion of diuresis, in the prevention and/or treatment of the oliguric phase of acute renal failure before irreversible renal failure becomes established. • The reduction of intracranial pressure and treatment of cerebral edema by reducing brain mass.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “The use of ARIDOL for this indication is supported by evidence from two clinical studies that included 246 pediatric patients 6 to 17 years of age [ see Clinical Studies ( 14 )].”
US prescribing information · 5387a4fb-b894-4cba-88a3-a947217d34da · read 2026-08-30
On older people, the label states: “Clinical studies of ARIDOL did not include sufficient numbers of patients 50 years of age and older to determine whether they respond differently from younger adult patients.”
US prescribing information · 5387a4fb-b894-4cba-88a3-a947217d34da · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary There are no available human data regarding inhaled mannitol to evaluate a drug-associated risk for major birth defects, miscarriage, or other adverse maternal or fetal outcomes.”
US prescribing information · 5387a4fb-b894-4cba-88a3-a947217d34da · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary There are no data on the presence of mannitol in human or animal milk, the effects on the breastfed infant, or the effects on milk production.”
US prescribing information · 5387a4fb-b894-4cba-88a3-a947217d34da · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Injection
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as injectable, solution, powder, cream, given by the injection, irrigation, inhalation route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Cordycepic Acid appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 193 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
renal failure acute — 35 reaction mentions
maculopathy — 26 reaction mentions
condition aggravated — 25 reaction mentions
acute kidney injury — 24 reaction mentions
hyperkalaemia — 22 reaction mentions
chills — 14 reaction mentions
hyponatraemia — 14 reaction mentions
nephropathy toxic — 12 reaction mentions
paralysis — 11 reaction mentions
anaphylactic reaction — 10 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Injection
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
15 products list this as an active ingredient in the United States drug directory. 12 of them contain it and nothing else.
FDA National Drug Code directory · 0404-9905 · read 2026-08-29
They are sold as cream, injection, solution, irrigant and powder, taken intravenous, topical and urethral.
FDA National Drug Code directory · 0404-9905 · read 2026-08-29
The regulator's established pharmacologic class for it is increased diuresis [pe], osmotic activity [moa] and osmotic diuretic [epc].
FDA National Drug Code directory · 0404-9905 · read 2026-08-29
12 published labels name it as an active ingredient. 9 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 0d914965-7001-45cb-ba51-d7c5964b05bc · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · 0d914965-7001-45cb-ba51-d7c5964b05bc · read 2026-08-29
1242 marketed supplement labels list this ingredient, classed as non-nutrient/non-botanical.
Those labels carry all other and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (12)
Q1
What did Cordycepic Acid's largest trial (1358 people) and its longest (17 years) measure?
1358 people in Cordycepic Acid's largest registered study, 17 years in its longest registered window, measuring Incidence of mortality. ClinicalTrials.gov · 2026-09-01
35 phase2, 33 na, 25 phase3, 20 phase1, 11 phase4, 5 na or unstated, 3 early phase1; NCT00293475; 2023-01-31. Last human test completed 2026, NCT07605260.
Interpretation These counts include studies where Cordycepic Acid was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase2
35
na
33
phase3
25
phase1
20
phase4
11
na or unstated
5
2 more recorded rows
early phase1
3
Last recorded human testNCT07605260
2026-06-30
recorded 2026-09-01 · last checked 2026-09-04
Q2
From yeast to human: where has Cordycepic Acid shown lifespan?
2 recorded entries; human; also "30% Mannitol in vehicle cream"
Show the evidence
human
NCT01520207
Mannitol (20%)
NCT01963910
30% Mannitol in vehicle cream
recorded 2026-09-01 · last checked 2026-09-04
Q5
More Cordycepic Acid was worse in human: at what point?
Hormetic in human: "Both the toxicity and the chemical-hormetic effect provoked by chromate were substantially decreased when it was used in combination with d-mannitol, and the possible causes for this double inhibition are briefly discussed." Europe PMC · dose-response search · 2024-10-20
5 recorded sentences naming Cordycepic Acid; hormetic, biphasic, dose-response
Show the evidence
hormeticPMID 16959593
"Both the toxicity and the chemical-hormetic effect provoked by chromate were substantially decreased when it was used in combination with d-mannitol, and the possible causes for this double inhibition are briefly discussed."
biphasicPMID 39603744
"Although more cost-effective and accessible, biphasic agents like PEG and mannitol are relatively discomforting for patients."
dose-response
PMID 31785175
"Deep inhalations did not significantly influence the provocative dose of mannitol causing a 15% fall in forced expiratory volume in 1 second ((P = .73; n = 7) or the mannitol dose-response slope (P = .26; n = 20)."
PMID 31785175
"FeNO levels were significantly correlated to sputum eosinophilia (P = .02; n = 15), responsiveness to deep inhalation methacholine (P = .005; n = 20), the dose-response slopes from deep inhalation mannitol (P = .01; n = 20), and the dose-response slope from non-deep inhalation mannitol (P = .005; n = 20)."
biphasicPMID 28736667
"The biphasic behavior of cellular parameters was explained by water and mannitol dynamics through the electropermeabilized cell membrane."
recorded 2024-10-20 · last checked 2026-09-04
Q6
Could one person measure Cordycepic Acid's effect on coma recovery time?
Coma recovery time: measured in Cordycepic Acid's trials.
Interpretation coma recovery time is the recorded endpoint.
Show the evidence
biomarkers
coma recovery time; 2026-09-01
free radical production and markers of neuronal damage; 2026-09-01
fev1; 2026-09-01
cr rate; 2026-09-01
overall survival; 2026-09-01
progression free survival; 2026-09-01
14 more recorded rows
biomarkers
response rate; 2026-09-01
biomarkers
time to best response; 2026-09-01
biomarkers
incidence of adverse events; 2026-09-01
biomarkers
maximum tolerated dose; 2026-09-01
biomarkers
sleep apnea per hour; 2026-09-01
biomarkers
time; 2026-09-01
biomarkers
changes in cholesterol metabolism; 2026-09-01
biomarkers
heroin craving; 2026-09-01
biomarkers
modified rankin; 2026-09-01
biomarkers
national institutes of health stroke severity scale; 2026-09-01
biomarkers
neurological status of the; 2026-09-01
biomarkers
nrs heat once per minute; 2026-09-01
biomarkers
intraoperative blood loss; 2026-09-01
biomarkers
worst nrs pain; 2026-09-01
half life
2026-09-04; halfLife; 2026-04-23
human trials at or under30
37
smallest human trial
0; NCT00446667; PHASE1/PHASE2; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q7
Which of acute kidney injury, apnea hypopnea index and arterial blood pressure did Cordycepic Acid's trials measure?
acute kidney injury, apnea hypopnea index and arterial blood pressure lead 40 outcome terms across Cordycepic Acid's trials. ClinicalTrials.gov · 2026-09-01
Interpretation cr rate, overall survival, progression free survival, response rate, time to best response and incidence of adverse events follow.
Show the evidence
coma recovery time
1
free radical production and markers of neuronal damage
1
fev1
1
cr rate
1
overall survival
1
progression free survival
1
14 more recorded rows
response rate
1
time to best response
1
incidence of adverse events
1
maximum tolerated dose
1
sleep apnea per hour
1
time
1
changes in cholesterol metabolism
1
heroin craving
1
modified rankin
1
national institutes of health stroke severity scale
1
neurological status of the
1
nrs heat once per minute
1
intraoperative blood loss
1
worst nrs pain
1
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which of Cordycepic Acid's 15 ongoing trials reports first?
Gut microbiome composition in placebo versus experimental arm; Relevant parenchymatous brain injury on postoperative MRI; latest 2030-08-31
Show the evidence
Trial
NCT03851159
"Nyaditum Resae® as a Co-adjuvant During Treatment for Active Pulmonary Tuberculosis and Its Impact on the Gut Microbiota"; n 48; "Gut microbiome composition in placebo versus experimental arm"; 2026-12-31
NCT04217421
"Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass"; n 236; "Relevant parenchymatous brain injury on postoperative MRI"; 2028-12-31
NCT05325502
"Does Caffeine Facilitate Human Reward Learning Behaviors?"; n 36; "The accuracy (% of correct answers) in implicit learning through different probabilities of monetary reward feedback"; 2026-12-31
NCT06473779
"Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma."; n 326; "Proportion of patients who reduced their SYMBICORT® daily maintenance dose without the loss of asthma control at the end of the step-down phase."; 2027-06-25
NCT06540352
"A Study to Select the Dose and Evaluate the Effectiveness and Safety of the Drug Refralon®, Tablets, 1 mg for Long-term Use to Prevent Recurrence of Atrial Fibrillation/Flutter After Terminating Its Persistent Form"; n 175; "Proportion of subjects in the group who were shown to maintain sinus rhythm at the end of 6 months of follow-up;"; 2026-12-31
NCT06768268
"A Dose-Image Optimization Trial Evaluating Mannitol and Voluven as Adjuncts for Indocyanine Green"; n 30; "Number of sentinel lymph nodes"; 2025-12-31
9 further recorded trials
NCT06841406
"Budesonide as a Treatment for Functional Dyspepsia"; n 56; "Effect of Budesonide on the reduction of the number of eosinophils on duodenal biopsies in patients with functional dyspepsia"; 2026-12-31
NCT06884657
"Effect of Mannitol on Propofol Level"; n 40; "Serum propofol levels"; 2025-10-30
NCT06914310
"Memantine as an Additive Therapy in Patients With Traumatic Brain Injury"; n 80; "The difference between the 2 groups regarding mean Montreal Cognitive Assessment (MOCA) scores at the end of treatment"; 2025-11-30
NCT07080567
"Manipulating the Peri-Infarct Area Using Maraviroc to Enhance Motor Skills After Stroke"; n 80; "Upper Extremity Fugl-Meyer Assessment (FMA-UE) Score"; 2027-12
NCT07433023
"tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy"; n 80; "Spatiotemporal Gait Symmetry via Instrumented Gait-Mat"; 2029-01-01
NCT07434492
"Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy"; n 60; "6 Minute Walking Test"; 2030-08-31
NCT07569861
"Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome"; n 144; "Overall Diagnostic Accuracy"; 2030-06
NCT07726134
"The Impact of Intraoperative Diuretic Use on Delayed Graft Function Following Deceased Donor Renal Transplantation"; n 160; "Recruitment rate"; 2028-12
NCT07786324
"Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography"; n 100; "Change in ONSD (mm) from baseline, after treatment (e.g., at 2 hour, 6 hours, and 24 hours)."; 2029-09-30
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which 62 trials of Cordycepic Acid posted no result?
Posted no result
62 of 62 completed trials
Registrations
NCT00252291, NCT00446771, NCT00390624, NCT00117208, NCT00277537 and NCT00251056, and 56 more
Completion dates
oldest 2006-09; newest 2024-07-04
Show the evidence
Trial
NCT00252291
2006-09
NCT00446771
2006-11
NCT00390624
2006-12
NCT00117208
2008-02
NCT00277537
2008-07
NCT00251056
2008-08
14 further recorded trials
NCT01076491
2009-04
NCT00792714
2009-09
NCT00585260
2010-02-16
NCT00446680
2010-05
NCT00916526
2010-09
NCT01048684
2011-05
NCT01181570
2011-09
NCT01591226
2012-09
NCT01865201
2012-09
NCT01642745
2013-02
NCT01718964
2013-07
NCT01843088
2013-07
NCT01748838
2013-09
NCT01598649
2013-10
Q10
At the median, Cordycepic Acid's trials enrolled 48.5 people — anything larger?
Median enrolment
48.5
Largest enrolment
1358
Registered trials counted
116
Q11
What do 193 spontaneous reports say about Cordycepic Acid — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Cordycepic Acid appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 193 reaction mentions were counted: renal failure acute 35; maculopathy 26; condition aggravated 25; acute kidney injury 24. open-targets-adr · CHEMBL689 · 2026-06-24
Show the evidence
renal failure acute
35
maculopathy
26
condition aggravated
25
acute kidney injury
24
hyperkalaemia
22
chills
14
4 more recorded rows
hyponatraemia
14
nephropathy toxic
12
paralysis
11
anaphylactic reaction
10
recorded 2026-06-24 · last checked 2026-09-04
Q12
What is recorded about Cordycepic Acid and mTOR?
"Furthermore, we observed through Western blot and immunofluorescence analyses that combination of BMSCs and mannitol enhanced the activation of PI3K, AKT, and mTOR through phosphorylation, while it reduced the expression levels of LC3B and beclin-1." — where Cordycepic Acid and mTOR appear together. Europe PMC · pathway abstract search · 2025-03-31
"Furthermore, we observed through Western blot and immunofluorescence analyses that combination of BMSCs and mannitol enhanced the activation of PI3K, AKT, and mTOR through phosphorylation, while it reduced the expression levels of LC3B and beclin-1."
AMPK
PMID 33807329
"D-mannitol also increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase 1 (ACC), suggesting a possible role in lipolysis and fat oxidation."
PMID 33807329
"Moreover, an increase in the expression of genes associated with D-mannitol-induced browning was strongly correlated with the activation of the β3-adrenergic receptor as well as AMPK, protein kinase A (PKA), and PPARγ coactivator 1α (PGC1α)."
sirtuinPMID 36881408
"HG stress induced a decline in SIRT1 expression and caused TXNIP/NLRP3 inflammasome activation in a concentration-dependent manner in HLECs, which was not observed in the high mannitol-treated groups."
autophagyPMID 35283832
"In time-dependent analysis of the metabolome, metabolites associated with oxidative stress and autophagy changed significantly, including mannitol, trehalose, myo-inositol, glucose, leucine, valine, glutamine, and 4-aminobutyric acid."
NAD+PMID 34116746
"Despite a regio- and stereo-selective enzymatic synthesis of l-gulose from d-sorbitol using a variant of NAD<sup>+</sup>-dependent mannitol-1-dehydrogenase from Apium graveolens (mMDH) was explored, low efficiency and productivity caused by NADH accumulation or insufficient amount of NAD<sup>+</sup> limited the practical utility of this process."
mTORPMID 34657574
"Collectively, this study uncovered a previously unrecognized function for YTHDC1 in modulating autophagy via regulating the stability of <i>SQSTM1</i> nuclear mRNA in diabetic keratinocytes.<b>Abbreviations:</b> ACTB: actin beta; AGEs: glycation end products; AL: autolysosome; AP: autophagosome; ATG: autophagy related; AKT: AKT serine/threonine kinase; ANOVA: analysis of variance; BECN1: beclin…"
autophagyPMID 34657574
"Collectively, this study uncovered a previously unrecognized function for YTHDC1 in modulating autophagy via regulating the stability of <i>SQSTM1</i> nuclear mRNA in diabetic keratinocytes.<b>Abbreviations:</b> ACTB: actin beta; AGEs: glycation end products; AL: autolysosome; AP: autophagosome; ATG: autophagy related; AKT: AKT serine/threonine kinase; ANOVA: analysis of variance; BECN1: beclin…"
recorded 2025-03-31 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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