This page shows what was measured, who it was measured in, and what that does not settle.
What Magnesium Sulfate Anhydrous does in the body
relieves occasional constipation (irregularity) generally produces bowel movement in 1/2 to 6 hours
Why people take it. relieves occasional constipation (irregularity) generally produces bowel movement in 1/2 to 6 hours
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
What the registries record it as
The substance registry classes this as mixture.
FDA substance registry · DE08037SAB · read 2026-08-29
Where each sentence above came from
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 41 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Biomarker
A biomarker is a number from a test that stands in for something about health.
A picture of it, and where the picture fails
A biomarker is like a fuel gauge.
Where that stops being true. A gauge is wired to the tank. Many biomarkers are only loosely tied to health.
What people get wrong. A better number is read as a better life. Several medicines improved a number and helped nobody.
A measurable indicator used as a substitute for a clinical outcome of interest.
Placebo
A placebo is a dummy treatment given so the real one can be compared with it.
A picture of it, and where the picture fails
A placebo is like a blank control in an experiment.
Where that stops being true. A blank does nothing. People given a placebo often do get better.
What people get wrong. A placebo effect is read as imaginary. The improvement is measured and real.
An inactive intervention matched in appearance to the test intervention, used to control for non-specific effects.
Comparator
A comparator is whatever the treatment was measured against.
A picture of it, and where the picture fails
It is like the other runner in a race.
Where that stops being true. A race has one winner. A study can show both arms improved.
What people get wrong. Results are read without asking what the other group got. Beating nothing is not beating a treatment.
The control condition against which the experimental intervention is assessed.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Maternal or Perinatal death or morbidity
✗ The study did not show it
Who was studied
NCT01911494
How many people
87500
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
30-day ordinal composite of hospital mortality and days free of atrial fibrillation in ICU
✗ The study did not show it
Who was studied
NCT07173855
How many people
3253
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Composite outcome of death or moderate to severe cerebral palsy
✗ The study did not show it
Who was studied
NCT00014989
How many people
2136
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Randomized Study of Nimodipine Versus Magnesium Sulfate in the Prevention of Eclamptic Seizures in Patients With Severe Preeclampsia
✗ The study did not show it
Who was studied
NCT00004399
How many people
2000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Mortality
✗ The study did not show it
Who was studied
NCT03925025
How many people
1728
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
Modified Rankin Scale
✗ The study did not show it
Who was studied
NCT00059332
How many people
1700
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
openFDA Drugs@FDA · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
No description of who was studied is recorded.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (11)
It was studied for a different goal
The studies measured something else entirely. Nothing in this record points to this reason.
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No form or route is recorded.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing is recorded about product quality.
No source is stored against this line.
Where it is registered
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No register entry is recorded.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
The exact form studied is not recorded.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
24 products list this as an active ingredient in the United States drug directory. 20 of them contain it and nothing else.
FDA National Drug Code directory · 35484-924 · read 2026-08-29
They are sold as crystal, granule, liquid, lotion, powder and spray, taken oral and topical.
FDA National Drug Code directory · 35484-924 · read 2026-08-29
The regulator's established pharmacologic class for it is calculi dissolution agent [epc], increased large intestinal motility [pe] and inhibition large intestine fluid/electrolyte absorption [pe].
FDA National Drug Code directory · 35484-924 · read 2026-08-29
22 published labels name it as an active ingredient. 18 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · cde87f95-73c0-46f5-9349-37e04096048c · read 2026-08-29
Those labels are classed as human otc drug.
US prescribing information · cde87f95-73c0-46f5-9349-37e04096048c · read 2026-08-29
10931 marketed supplement labels list this ingredient, classed as mineral, non-nutrient/non-botanical and other combinations.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
9 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
What was measured, goal by goal — found nothing in the sources checked.
How close this is to real life — found nothing in the sources checked.
The path through the body — found nothing in the sources checked.
Felt, measured, or meaningful — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (8)
Q1
On the Magnesium Sulfate Anhydrous label: indicated for what?
safety (2), futility/efficacy (1), accrual/recruitment (9), funding/business (2) and other (12): Magnesium Sulfate Anhydrous's stop wording, clustered. CLINICALTRIALS_SNAPSHOT · 2026-09-01
"Funding completed"; 26 of 378 registered studies
Show the evidence
Trial
NCT00116623
terminated; "Funding completed"
NCT00306462
terminated; "No enrollment in past year, lack of interest"
NCT00463736
terminated; "enrollment proceeding too slowly"
NCT00998738
terminated; "lack of accrual"
NCT01074918
withdrawn; "none enrolled per PI"
NCT01261702
terminated; "not include patient anymore"
14 further recorded trials
NCT01333488
terminated; "Low accrual"
NCT01426165
terminated; "Issues with recruitment. PI decided to terminate study"
NCT01502761
terminated; "No safety issues. Low enrollment secondary to negative stroke studies 2013"
NCT01627353
terminated; "Funding withdrawn"
NCT01794247
terminated; "low recruitment rate"
NCT02453373
terminated; "The study has achieved its objectives of showing feasibility, safety, and trend for improved mRS. FDA and LRS agreed that this study should be terminated, and that a new, PIVOTAL trial should be started."
NCT02498496
withdrawn; "financing delays"
NCT02521753
terminated; "It was not possible to continue recruiting due to SARSCov2 pandemia. Results obtained at that time were already published"
NCT02523911
withdrawn; "investigator graduated and is not longer at this institution"
NCT02680626
terminated; "Pfannenstiel hysterectomies are now rarely performed so cannot recruit eligible patients"
NCT03206008
terminated; "hard to get an informed concent because of small number of indiaiton of surgery"
NCT03253224
terminated; "Because the principle investigator will participate a visiting scholar program for one year in other country, this study has been terminated."
NCT03439358
suspended; "Could not recruit patients"
NCT03749590
terminated; "The design of the MagPEP trial is no longer in compliance with the current state of science."
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Magnesium Sulfate Anhydrous used Magnesium 400Mg — over how long?
Human studies of Magnesium Sulfate Anhydrous used "Magnesium 400Mg". ClinicalTrials.gov · 2026-09-01
20 recorded entries; human; also "Magnesium sulfate 50%", "Composition - Magnesium Lactate 470mg, Pyridoxine HCl 5mg", "Magnesium Sulfate Injection 50% Baxter. Number 5430"
Magnesium Sulfate Injection 50% Baxter. Number 5430
NCT03088852
Magnesium Citrate 100 MG
NCT03208452
10% magnesium sulfate
14 more recorded rows
humanNCT03344679
Magnesium Sulphate 500 mg
humanNCT03846284
Magnesium sulfate 50mg
humanNCT03846284
Magnesium sulfate 30 mg
humanNCT03879707
Magnesium 500Mg Oral Tablet
humanNCT04249804
Magnesium Sulfate 1000 MG
humanNCT05904808
Oral Magnesium citrate 600mg
humanNCT06376916
Magnesium Sulfate 2 G
humanNCT06376916
Magnesium Sulfate 2 gram/50ml 0.9% NaCl
humanNCT06376916
Magnesium Sulfate 4 G
humanNCT06376916
Magnesium Sulfate 4g/50ml 0.9% NaCl
humanNCT06516861
Magnesium Sulfate 20 MG/ML
humanNCT07298564
Magnesium 500 mg
humanNCT07359612
Magnesium 250 mg
humanNCT07632157
Magnesium Sulfate 2g
recorded 2026-09-01 · last checked 2026-09-04
Q5
Which running trial of Magnesium Sulfate Anhydrous could settle lifespan?
NCT03088852 measures compare mortality, reading out 2026-12.
1 open trial; n 330; "Magnesium Deficiency In Patients Hospitalized in Internal Medicine Wards"
Show the evidence
TrialNCT03088852
"Magnesium Deficiency In Patients Hospitalized in Internal Medicine Wards"; n 330; "compare mortality"; 2026-12
Q6
Which 160 trials of Magnesium Sulfate Anhydrous posted no result?
Posted no result
160 of 160 completed trials
Registrations
NCT00004399, NCT00000610, NCT00040235, NCT00004730, NCT00120588 and NCT00325299, and 154 more
Completion dates
oldest 2000-08; newest 2024-06-15
Show the evidence
Trial
NCT00004399
2000-08
NCT00000610
2003-11
NCT00040235
2004-02
NCT00004730
2005-05
NCT00120588
2005-07
NCT00325299
2005-09
14 further recorded trials
NCT00029510
2006-06
NCT00553072
2006-08
NCT00346658
2006-09
NCT00014989
2007-06
NCT01136421
2007-06
NCT00405977
2008-08
NCT00994981
2008-10
NCT00704990
2009-12
NCT01032213
2010-10
NCT01205997
2011-01
NCT01332734
2011-01
NCT00994006
2011-03
NCT01153256
2011-03
NCT01360060
2011-03
Q7
At the median, Magnesium Sulfate Anhydrous's trials enrolled 75 people — anything larger?
Median enrolment
75
Largest enrolment
87500
Registered trials counted
373
Q8
What do 296 spontaneous reports say about Magnesium Sulfate Anhydrous — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Magnesium Sulfate Anhydrous appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 296 reaction mentions were counted: premature baby 85; premature delivery 54; hypotension 39; low birth weight baby 28. FAERS via Open Targets · CHEMBL2021423 · 2026-06-24
Show the evidence
premature baby
85
premature delivery
54
hypotension
39
low birth weight baby
28
migraine
17
treatment failure
17
4 more recorded rows
hypomagnesaemia
15
ventricular tachycardia
15
blood pressure decreased
14
normal newborn
12
recorded 2026-06-24 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
✗ required summary fields resolved: 3 required field(s) not terminal: Best-supported result, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 5 source rows
✓ no critical contamination: no quarantine open
✓ canonical metadata passed: slug and display name present
✓ no raw internal fields: enforced by the copy-contract test over the rendered page
This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.