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Lenalidomide

  • Prescription medicine
  • Prescription only
  • Identity checked
  • Sources last checked 2026-09-04

This page shows what was measured, who it was measured in, and what that does not settle.

What Lenalidomide does in the body

The treatment of adult patients

From the FDA-approved label: Lenalidomide is an analogue of thalidomide with immunomodulatory, antiangiogenic, and antineoplastic properties. Cellular activities of lenalidomide are mediated through its target cereblon, a component of a cullin ring E3 ubiquitin ligase enzyme complex. In vitro , in the presence of drug, substrate proteins (including Aiolos, Ikaros, and CK1α) are targeted for ubiquitination and subsequent degradation leading to direct cytotoxic and immunomodulatory effects. Lenalidomide inhibits proliferation and induces apoptosis of certain hematopoietic tumor cells including MM, mantle cell lymphoma, and del (5q) myelodysplastic syndromes, follicular lymphoma and marginal zone lymphoma in vitro .

What happened in people

RNAWiki has not yet published a reviewed conclusion for this use.

A fixed RNAWiki sentence

Where this came from

Wording RNAWiki always uses, not a finding about this substance.

No reviewed claim names a result for any goal on this record.

No source is stored against this line.

The limit that matters most

Not recorded.

Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.

What the registries record it as

  • The substance registry classes this as chemical.

    FDA substance registry · F0P408N6V4 · read 2026-08-29

Where each sentence above came from

The recorded explanation is written in label language rather than for a beginner. The page opens with what it is taken for instead, and the recorded explanation follows below.

Shown as the opening line on this page.

No statement of the main limit is recorded.

The four opening statements run to 112 words.

Words this page uses

Four words worth knowing first

Chosen from what this page shows, with each one explained before the word it depends on.

Biomarker

A biomarker is a number from a test that stands in for something about health.

A picture of it, and where the picture fails

A biomarker is like a fuel gauge.

Where that stops being true. A gauge is wired to the tank. Many biomarkers are only loosely tied to health.

What people get wrong. A better number is read as a better life. Several medicines improved a number and helped nobody.

A measurable indicator used as a substitute for a clinical outcome of interest.

Placebo

A placebo is a dummy treatment given so the real one can be compared with it.

A picture of it, and where the picture fails

A placebo is like a blank control in an experiment.

Where that stops being true. A blank does nothing. People given a placebo often do get better.

What people get wrong. A placebo effect is read as imaginary. The improvement is measured and real.

An inactive intervention matched in appearance to the test intervention, used to control for non-specific effects.

Comparator

A comparator is whatever the treatment was measured against.

A picture of it, and where the picture fails

It is like the other runner in a race.

Where that stops being true. A race has one winner. A study can show both arms improved.

What people get wrong. Results are read without asking what the other group got. Beating nothing is not beating a treatment.

The control condition against which the experimental intervention is assessed.

What happened in peopleRead from sources, not yet reviewed

What happened in people

Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.

Overall survival

The study did not show it

Who was studied
NCT01554852
How many people
4420
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route. Oral

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA SPL label · a recorded source, not a stored snapshot
  • PubChem PUG-REST · a recorded source, not a stored snapshot

Incidence of Adverse Events Summarized by System Organ Class, Preferred Term, Severity, Seriousness, and Relationship to Treatment.

The study did not show it

Who was studied
NCT00179647
How many people
1913
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route. Oral

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA SPL label · a recorded source, not a stored snapshot
  • PubChem PUG-REST · a recorded source, not a stored snapshot

Kaplan-Meier Estimates of Progression-free Survival (PFS) Based on the Response Assessment by the Independent Review Adjudication Committee (IRAC)

The study did not show it

Who was studied
NCT00689936
How many people
1623
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route. Oral

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA SPL label · a recorded source, not a stored snapshot
  • PubChem PUG-REST · a recorded source, not a stored snapshot

Progression Free Survival (PFS)

The study did not show it

Who was studied
NCT05243797
How many people
1594
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route. Oral

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA SPL label · a recorded source, not a stored snapshot
  • PubChem PUG-REST · a recorded source, not a stored snapshot

Progression Free Survival (PFS)

The study did not show it

Who was studied
NCT05552222
How many people
1590
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route. Oral

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA SPL label · a recorded source, not a stored snapshot
  • PubChem PUG-REST · a recorded source, not a stored snapshot

For all registered patients: progression free survival (PFS) as defined by time from registration to progression or death from any cause (whichever occurs first).

The study did not show it

Who was studied
NCT01208766
How many people
1503
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route. Oral

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA Drugs@FDA · a recorded source, not a stored snapshot
  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA SPL label · a recorded source, not a stored snapshot
  • PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.

What is missing or unclearRead from sources, not yet reviewed

Were people like you studied?

RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.

Who was studied

People similar to this profile were included.

  • Lenalidomide capsules are a thalidomide analogue indicated for the treatment of adult patients with: • Multiple myeloma (MM), in combination with dexamethasone ( 1.1 ). • MM, as maintenance following autologous hematopoietic stem cell transplantation (auto-HSCT) ( 1.1 ).

Who is missing from the studies

  • Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

What the label states about particular groups

  • On pediatric, the label states: “Safety and effectiveness have not been established in pediatric patients.”

    US prescribing information · dffe719b-4f61-47e2-b71c-673322d487f5 · read 2026-08-30

  • On older people, the label states: “MM In Combination: Overall, of the 1613 patients in the NDMM study who received study treatment, 94% (1521 /1613) were 65 years of age or older, while 35% (561/1613) were over 75 years of age.”

    US prescribing information · dffe719b-4f61-47e2-b71c-673322d487f5 · read 2026-08-30

  • On people who are pregnant, the label states: “Exposure Registry There is a pregnancy exposure registry that monitors pregnancy outcomes in females exposed to lenalidomide during pregnancy as well as female partners of male patients who are exposed to lenalidomide.”

    US prescribing information · dffe719b-4f61-47e2-b71c-673322d487f5 · read 2026-08-30

  • On people who are breastfeeding, the label states: “Risk Summary There is no information regarding the presence of lenalidomide in human milk, the effects of lenalidomide on the breastfed child, or the effects of lenalidomide on milk production.”

    US prescribing information · dffe719b-4f61-47e2-b71c-673322d487f5 · read 2026-08-30

  • On people with reduced kidney function, the label states: “Adjust the starting dose of lenalidomide capsules based on the creatinine clearance value and for patients on dialysis [see Dosage and Administration (2.6)].”

    US prescribing information · dffe719b-4f61-47e2-b71c-673322d487f5 · read 2026-08-30

Where the result stopped carrying

  • This is a scope explorer, not a diagnosis engine.
  • It shows who was studied so you can see whether people similar to you were included.

RNAWiki cannot tell whether a study fits you. It can show who was in it.

What it would be like to takeRead from sources, not yet reviewed

Why it might seem to do nothing

A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.

It was studied in different people

The people in the studies were not much like the reader.

On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

The evidence may simply be wrong

Small early studies often do not hold up.

On this record: RNAWiki has not yet published a reviewed conclusion for this use.

Other reasons RNAWiki checked and found nothing for (11)
It was studied for a different goal
The studies measured something else entirely. Nothing in this record points to this reason.
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.

None of these is a reason to take more. Taking more is not a step this page ever suggests.

What it would be like to takeRead from sources, not yet reviewed

What taking it involves

The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.

How it is supplied

Prescription only

Quoted from a source

Where this came from

Copied from a source RNAWiki stored, with the source named.

Read from the recorded approval status.

No source is stored against this line.

Form and route

Oral

Source-linked record

Where this came from

A person wrote this into the record with the study named beside it. No reviewer has signed it off.

The form and route recorded on this substance.

No source is stored against this line.

Who oversees it

Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.

Quoted from a source

Where this came from

Copied from a source RNAWiki stored, with the source named.

Suppression classes recorded: S1, S3, S5, S6.

No source is stored against this line.

What is in the pack

Sold as capsule, given by the oral route.

Source-linked record

Where this came from

A person wrote this into the record with the study named beside it. No reviewer has signed it off.

Recorded notes on how this is sold and what that means for what is in the pack.

No source is stored against this line.

Where it is registered

Regulatory records are listed in the technical disclosure at the foot of this page.

Counted from records

Where this came from

A count of rows RNAWiki holds. It describes our records, not your body.

Register entries are stored per jurisdiction and shown with their dates.

No source is stored against this line.

Why people stop

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

No record of why people stopped taking it is stored for this substance.

No source is stored against this line.

What it would be like to takeNothing found in the sources checked

What can go wrong

Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.

Nothing found in the sources checked

No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.

The sources listed were searched and held nothing. That is not the same as nothing existing.

Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.

Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

What is missing or unclearRead from sources, not yet reviewed

Does the exact form matter?

Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.

The form that was studied

Oral

Source-linked record

Where this came from

A person wrote this into the record with the study named beside it. No reviewer has signed it off.

The form used in the studies cited on this page.

No source is stored against this line.

What is sold

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

Nothing further is recorded about which forms are sold.

No source is stored against this line.

What is recorded as being sold

  • 135 products list this as an active ingredient in the United States drug directory. 135 of them contain it and nothing else.

    FDA National Drug Code directory · 73043-041 · read 2026-08-29

  • They are sold as capsule and powder, taken oral.

    FDA National Drug Code directory · 73043-041 · read 2026-08-29

  • The regulator's established pharmacologic class for it is thalidomide analog [epc].

    FDA National Drug Code directory · 73043-041 · read 2026-08-29

  • 21 published labels name it as an active ingredient. 21 of them describe this substance alone, which is where its own label text on this page comes from.

    US prescribing information · dffe719b-4f61-47e2-b71c-673322d487f5 · read 2026-08-29

  • Those labels are classed as human prescription drug.

    US prescribing information · dffe719b-4f61-47e2-b71c-673322d487f5 · read 2026-08-29

  • LENALIDOMIDE is oral at 3 DOSAGE FORMS AND STRENGTHS Capsules: ▪ 2.5 mg, Opaque white body, opaque light green cap, printed with “65 2.5mg” on the body in black ink ▪ 5 mg, Opaque white capsules, printed with “67 5mg” on the body in black ink…, recorded as fda label in effect 2025-08-25 in the United States.

    US prescribing information · dffe719b-4f61-47e2-b71c-673322d487f5 · read 2026-08-30

Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.

What it would be like to takeRead from sources, not yet reviewed

What you could measure

This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.

Self-experiment planning is not offered for a prescription or clinician-supervised medicine. The questions below are for a clinician or pharmacist.

Questions worth asking

  • Which of the trials of Lenalidomide studied people like me?
  • What was measured, and for how long?
  • Was the result a laboratory value or a health outcome?
  • What would we watch for, and when would we stop?

Tracking can show whether something changed for you. It cannot show what caused it.

RNAWiki records evidence. It does not say whether this substance is right for you.

What is missing or unclearRead from sources, not yet reviewed

What nobody knows yet

Open questions, each with why it is open and what would close it.

Missing populations

Which groups were under-represented in the studies has not been recorded.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Missing long-term data

No completed tested study window is recorded.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

No reviewed conclusion

RNAWiki has not yet published a reviewed conclusion for this use.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Missing interaction studies

No interaction was found in the registers checked. Not finding one is not the same as showing there is none.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Formulation uncertainty

Several salts, forms or products of Lenalidomide are recorded. Results from one form may not transfer to another.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Mechanism not reviewed

No reviewed mechanism story exists for this substance.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

What happened in peopleRead from sources, not yet reviewed

Check any of this yourself

Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.

How many documents were read

  • 20 documents were read for this substance.

    RNAWiki source record

  • 20 of them state the same halfLife, and they agree.

    RNAWiki source record

Where else this substance is registered

FDA substance identifier (UNII)
F0P408N6V4
RxNorm concept
602910

Checks this page had to pass

  • Passed

    Identity resolved

    no open identity hold

  • Passed

    No unresolved merge across substance families

    no quarantine open

  • Passed

    Every public sentence names a source

    The opening statement carries the origin: Written into the record, not signed off.

  • Not passed

    Trial roles classified for highlighted evidence

    No registered study is classified as testing this substance.

  • Passed

    No internal keys in reader text

    enforced by the copy-contract test over the rendered page

  • Passed

    Safety mode resolved

    Suppression classes recorded: S1, S3, S5, S6.

  • Passed

    Canonical metadata present

    slug and display name present

What is missing or unclearRead from sources, not yet reviewed

How this medicine reached us

Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.

What the approval register records

  • 21 approved applications cover products containing this substance. The earliest was NDA021880, approved 20051227 to BRISTOL MYERS SQUIBB.

    Drugs@FDA application register · NDA021880 · read 2026-08-29

  • Marketing status on the register: discontinued and prescription.

    Drugs@FDA application register · NDA021880 · read 2026-08-29

  • The earliest marketing start date recorded for a listed product is 20051227.

    FDA National Drug Code directory · 73043-041 · read 2026-08-29

What is missing or unclearRead from sources, not yet reviewed

What to learn next

Ordered by what would most change how you read this page, starting with what is easiest to misunderstand.

This order is fixed in code and does not count clicks or time on the page.

What is not here

9 questions this page could not answer

These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.

  • What was measured, goal by goal — found nothing in the sources checked.
  • How close this is to real life — found nothing in the sources checked.
  • The path through the body — found nothing in the sources checked.
  • Felt, measured, or meaningful — found nothing in the sources checked.
  • How long anything takes — found nothing in the sources checked.
  • What it may clash with — found nothing in the sources checked.
  • Other ways to the same goal — found nothing in the sources checked.
  • Claims that go past the evidence — found nothing in the sources checked.
  • What changed on this page — found nothing in the sources checked.

The record as stored

The full record, for auditing

Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.

Recorded evidence blocks (8)

On the Lenalidomide label: indicated for what?


"Lenalidomide is a thalidomide analogue indicated for the treatment of adult patients with: Multiple myeloma (MM), in combination with dexamethasone ( 1.1 ). MM, as maintenance following autologous hematopoietic stem cell transplantation (auto-HSCT) ( 1.1 ).": indications and usage on Lenalidomide's label. DailyMed label · 1b2716cf-24b4-4157-a218-58ede63917bd · 2026-05-27

981 registered trials of Lenalidomide — at which phases?


Registered studies posting no result
626 of 981

981 registered studies of Lenalidomide: 596 phase2, 338 phase1, 159 phase3, 23 na or unstated, 14 phase4, 11 na, 8 early phase1. CLINICALTRIALS_SNAPSHOT · 2026-09-01

1035 with a PubMed record

Show the evidence
  • phase2
    596
  • phase1
    338
  • phase3
    159
  • na or unstated
    23
  • phase4
    14
  • na
    11
11 more recorded rows
  • early phase1
    8
  • completed
    462
  • terminated
    137
  • active not recruiting
    134
  • recruiting
    103
  • unknown
    79
  • withdrawn
    37
  • not yet recruiting
    23
  • enrolling by invitation
    2
  • no longer available
    2
  • suspended
    2

recorded 2026-09-01 · last checked 2026-09-04

160 of Lenalidomide's trials stopped: safety, futility/efficacy, accrual/recruitment, funding/business, sponsor decision unspecified, other?


safety (19), futility/efficacy (10), accrual/recruitment (59), funding/business (19), sponsor decision unspecified (6) and other (47): Lenalidomide's stop wording, clustered. CLINICALTRIALS_SNAPSHOT · 2026-09-01

"Interim analysis showed the primary outcome was not reached"; 160 of 981 registered studies

Show the evidence

Trial

  • NCT00109772
    terminated; "Interim analysis showed the primary outcome was not reached"
  • NCT00142168
    terminated; "Toxicity"
  • NCT00474188
    terminated; "Business decision"
  • NCT00482911
    terminated; "Investigator left the institute."
  • NCT00522392
    terminated; "Slow accrual"
  • NCT00538824
    terminated; "low enrollment"
14 further recorded trials
  • NCT00543114
    terminated; "lack of efficacy and tolerability"
  • NCT00567229
    terminated; "Lack of Accrual"
  • NCT00655668
    terminated; "Decision not to pursue as single agent in the study population."
  • NCT00665652
    terminated; "The study has been suspended for slower than anticipated enrollment to date."
  • NCT00671801
    terminated; "Toxicity"
  • NCT00675441
    terminated; "Terminated due to slow accrual."
  • NCT00684242
    terminated; "Low accrual."
  • NCT00687674
    terminated; "Due to study design (and toxicity), this trial closed to accrual prior to opening the phase II portion."
  • NCT00699842
    terminated; "Administratively terminated per FDA recommendation"
  • NCT00704691
    terminated; "Closed due to futility with only 1 patient accrued"
  • NCT00720850
    terminated; "Low recruitment, scientific rationale not applicable anymore to all patients and possible induction of GvHD by the study drug"
  • NCT00751296
    terminated; "Seven years of follow-up \& final analysis done in Dec 2012."
  • NCT00790842
    terminated; "Slow enrollment"
  • NCT00833534
    withdrawn; "No patient enrolled on study. Did not get patients in timely fashion. All referrals for study when assessed were not eligible."

recorded 2026-09-01 · last checked 2026-09-04

Human studies of Lenalidomide used Lenalidomide 5 mg — over how long?


studies of Lenalidomide used the recorded amount. ClinicalTrials.gov · 2026-09-01

20 recorded entries; human; also "Lenalidomide 5 mg", "Lenalidomide 10 mg", "Dasatinib, 70 mg + Lenalidomide, 15 mg + Dexamethasone, 40 mg"

Show the evidence

human

  • NCT00179621
    Lenalidomide 5 mg
  • NCT00179621
    Lenalidomide 10 mg
  • NCT00560391
    Dasatinib, 70 mg + Lenalidomide, 15 mg + Dexamethasone, 40 mg
  • NCT00560391
    Dasatinib, 70 mg + Lenalidomide, 20 mg + Dexamethasone, 40 mg
  • NCT00560391
    Dasatinib, 100 mg + Lenalidomide, 20 mg + Dexamethasone, 40 mg
  • NCT00560391
    Dasatinib, 100 mg + Lenalidomide, 25 mg + Dexamethasone, 40 mg
14 more recorded rows
  • human NCT00560391
    Dasatinib, 140 mg + Lenalidomide, 25 mg + Dexamethasone, 40 mg
  • human NCT00867308
    Lenalidomide 50 mg
  • human NCT00867308
    Lenalidomide 15 mg
  • human NCT01116193
    Revlimid ®, 25mg
  • human NCT01243476
    Revlimid 5 mg
  • human NCT01380106
    Lenalidomide 15mg
  • human NCT01380106
    Lenalidomide 25mg
  • human NCT01953692
    Lenalidomide 20 mg
  • human NCT01953692
    Lenalidomide 25 mg
  • human NCT03050450
    25 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®)
  • human NCT03050450
    50 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®)
  • human NCT03050450
    100 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®)
  • human NCT03050450
    150 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®)
  • human NCT03050450
    150 mg/m2 Lenalidomide (Revlimid®) and 230 mg/m2 Vorinostat (Zolinza®)

recorded 2026-09-01 · last checked 2026-09-04

Lenalidomide's half-life is 3 hours — which schedules were studied?


3 hours, the half-life Lenalidomide's label states: "Elimination The mean half-life of lenalidomide is 3 hours in healthy subjects and 3 to 5 hours in patients with MM, MDS or MCL." DailyMed label · 1b2716cf-24b4-4157-a218-58ede63917bd · 2026-05-27

Show the evidence
  • half life pharmacokinetics
    3 hours; Elimination The mean half-life of lenalidomide is 3 hours in healthy subjects and 3 to 5 hours in patients with MM, MDS or MCL.
  • metabolism pharmacokinetics
    Metabolism Lenalidomide undergoes limited metabolism.

recorded 2026-05-27 · last checked 2026-09-04

Which running trial of Lenalidomide could settle lifespan?


NCT04737889 measures 2-year progression-free survival, reading out 2026-01-13.

59 open trials; n 30; "Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System Lymphoma"

Show the evidence

Trial

  • NCT04737889
    "Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System Lymphoma"; n 30; "2-year progression-free survival"; 2026-01-13
  • NCT02538198
    "Lenalidomide Maintenance in Plasma Cell Myeloma"; n 108; "progression-free survival"; 2026-08
  • NCT05248633
    "Chemotherapy Combined With Radiotherapy Versus Radiotherapy Alone for Solitary Plasmacytoma"; n 220; "event-free survival"; 2026-10
  • NCT01208662
    "Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65"; n 729; "Median Progression-Free Survival (PFS)"; 2026-12
  • NCT02544308
    "Trial of Immunomodulatory Therapy in High Risk Solitary Bone Plasmacytoma"; n 36; "Progression-free survival (progression defined as development of myeloma or a new plasmacytoma outside the radiotherapy field)"; 2026-12
  • NCT03729804
    "Carfilzomib, Lenalidomide, and Dexamethasone Versus Bortezomib, Lenalidomide and Dexamethasone (KRd vs. VRd) in Patients With Newly Diagnosed Multiple Myeloma (COBRA)"; n 250; "Number of Participants with progression free survival with the group taking KRd versus VRd after randomization"; 2026-12-28
14 further recorded trials
  • NCT01856192
    "Rituximab and Combination Chemotherapy With or Without Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Diffuse Large B Cell Lymphoma"; n 349; "3-year Progression-free Survival Rate"; 2026-12-31
  • NCT04404283
    "Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL"; n 239; "Overall survival (OS)"; 2026-12-31
  • NCT05861050
    "Glofitamab With Obinutuzumab, Venetoclax, and Lenalidomide for the Treatment of Patients With Newly Diagnosed High Risk Mantle Cell Lymphoma"; n 50; "Progression free survival (PFS)"; 2027-02-01
  • NCT00602641
    "Melphalan, Prednisone, and Thalidomide or Lenalidomide in Treating Patients With Newly Diagnosed Multiple Myeloma"; n 306; "Progression-Free Survival (PFS)"; 2027-02-20
  • NCT07187167
    "Efficacy and Safety of the RD Regimen(Lenalidomide, Dexamethasone) for Rosai-Dorfman Disease"; n 40; "Progression-free survival time (PFS)"; 2027-04-12
  • NCT02420860
    "Elotuzumab and Lenalidomide After Stem Cell Transplant in Treating Patients With Newly Diagnosed Multiple Myeloma"; n 113; "Progression free survival"; 2027-04-30
  • NCT04009109
    "Study of Lenalidomide/Ixazomib/Dexamethasone/Daratumumab in Transplant-Ineligible Patients With Newly Diagnosed MM"; n 79; "Impact of Study Treatment on Progression Free Survival (PFS)"; 2027-06
  • NCT00644228
    "Lenalidomide and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Multiple Myeloma"; n 525; "Progression-free Survival"; 2027-06-10
  • NCT03319667
    "A Study to Investigate the Clinical Benefit of Isatuximab in Combination With Bortezomib, Lenalidomide and Dexamethasone in Adults With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant"; n 475; "Progression free survival (PFS)"; 2027-06-30
  • NCT03004287
    "2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy"; n 50; "Measure the progression-free survival in patients with high risk multiple myeloma"; 2027-10
  • NCT06140966
    "Study to Evaluate the Safety and Efficacy of Daratumumab and Carfilzomib-based Induction/Consolidation/Maintenance Therapy in Transplant-eligible, Ultra High-risk, Newly Diagnosed Multiple Myeloma"; n 54; "2-year progression-free survival"; 2027-10-20
  • NCT02659293
    "Trial of Carfilzomib, Lenalidomide, Dexamethasone Versus Lenalidomide Alone After Stem-cell Transplant for Multiple Myeloma"; n 180; "Progression free survival rates in participants receiving drug combination"; 2027-11
  • NCT06669143
    "Zanubrutinib-based Maintenance Therapy of Newly Diagnosed DLBCL With Initial Remission"; n 19; "2-year recurrence-free survival"; 2027-12
  • NCT04566328
    "Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial"; n 1450; "Consolidation overall survival"; 2027-12-31

Which 188 trials of Lenalidomide posted no result?


Posted no result
188 of 188 completed trials
Registrations
NCT00446433, NCT00055562, NCT00057616, NCT00093028, NCT00179686 and NCT00046735, and 182 more
Completion dates
oldest 2003-12; newest 2024-07-02
Show the evidence

Trial

  • NCT00446433
    2003-12
  • NCT00055562
    2004-12
  • NCT00057616
    2005-07-15
  • NCT00093028
    2006-01
  • NCT00179686
    2006-07
  • NCT00046735
    2006-09-28
14 further recorded trials
  • NCT00051116
    2006-10
  • NCT00179712
    2006-11
  • NCT00044382
    2007-01-30
  • NCT00064974
    2007-02
  • NCT00044018
    2007-02-15
  • NCT00065351
    2007-03-01
  • NCT00179608
    2007-06-01
  • NCT00415116
    2007-07
  • NCT00067743
    2007-08
  • NCT00091624
    2007-09
  • NCT00120120
    2007-11
  • NCT00396045
    2008-01
  • NCT00412581
    2008-03
  • NCT00253344
    2008-06

At the median, Lenalidomide's trials enrolled 45 people — anything larger?


Median enrolment
45
Largest enrolment
4420
Registered trials counted
975
Where it is registered
Identifiers, relations and other names

The exact record

ChEMBL id
CHEMBL6068337
PubChem CID
40461270
CAS number
874946-00-6
RxCUI
602910
InChIKey
GOTYRUGSSMKFNF-UHFFFAOYSA-N
Also called
LENALIDOMIDE HYDROCHLORIDE MONOHYDRATE, Lenalidomida, imids, len, nsc-703813, rd, rev, vrd, LENALIDOMIDE [EMA EPAR], LENALIDOMIDE [JAN], LENALIDOMIDE [MART.], LENALIDOMIDE [MI]
Trade name
Lenalidomide krka d.d., Lenalidomide krka d.d. novo mesto (previously lenalidomide krka), Lenalidomide krka (previously lenalidomide krka d.d. novo mesto), Lenalidomide accord, Lenalidomide mylan, Revlimid
Development code
CC-5013, CDC-501, NSC-747972, SYP-1512
Sources (5)

Sources

  • chembl+drugsfda+ema chembl+drugsfda+ema ·
  • CLINICALTRIALS_SNAPSHOT K1:F0P408N6V4 ·
  • ClinicalTrials.gov clinicaltrials.gov ·
  • DailyMed label 1b2716cf-24b4-4157-a218-58ede63917bd ·
  • Drugs@FDA K1:F0P408N6V4 ·

ChEMBL 37 — CC BY-SA 3.0 Unported · ClinicalTrials.gov — US Government work · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work

How these records are assembled · Which registers were checked

Index-quality checks
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  • required summary fields resolved: 4 required field(s) not terminal: Why people use it, Best-supported result, Biggest unanswered question, Human evidence
  • public claims reviewed: 0 reviewed claim(s); drafts are never rendered
  • source coverage passed: 5 source rows
  • no critical contamination: no quarantine open
  • canonical metadata passed: slug and display name present
  • no raw internal fields: enforced by the copy-contract test over the rendered page

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