This page shows what was measured, who it was measured in, and what that does not settle.
What Ivermectin does in the body
SOOLANTRA cream is indicated for the treatment of inflammatory lesions of rosacea.
From the FDA-approved label: The mechanism of action of ivermectin cream in treating rosacea lesions is unknown.
Why people take it. SOOLANTRA cream is indicated for the treatment of inflammatory lesions of rosacea.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The substance registry classes this as mixture.
FDA substance registry · 8883YP2R6D · read 2026-08-29
Where each sentence above came from
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 52 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Biomarker
A biomarker is a number from a test that stands in for something about health.
A picture of it, and where the picture fails
A biomarker is like a fuel gauge.
Where that stops being true. A gauge is wired to the tank. Many biomarkers are only loosely tied to health.
What people get wrong. A better number is read as a better life. Several medicines improved a number and helped nobody.
A measurable indicator used as a substitute for a clinical outcome of interest.
Placebo
A placebo is a dummy treatment given so the real one can be compared with it.
A picture of it, and where the picture fails
A placebo is like a blank control in an experiment.
Where that stops being true. A blank does nothing. People given a placebo often do get better.
What people get wrong. A placebo effect is read as imaginary. The improvement is measured and real.
An inactive intervention matched in appearance to the test intervention, used to control for non-specific effects.
Comparator
A comparator is whatever the treatment was measured against.
A picture of it, and where the picture fails
It is like the other runner in a race.
Where that stops being true. A race has one winner. A study can show both arms improved.
What people get wrong. Results are read without asking what the other group got. Beating nothing is not beating a treatment.
The control condition against which the experimental intervention is assessed.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Comparison of Arms - Benin
✗ The study did not show it
Who was studied
NCT03014167
How many people
357716
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Prevalence of Onchocerca volvulus microfilariae
✗ The study did not show it
Who was studied
NCT07145736
How many people
52000
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
To determine the safety (in humans) and efficacy of ivermectin MDA, administered to humans, or humans and livestock simultaneously (only in Mozambique) for the prevention of malaria.
✗ The study did not show it
Who was studied
NCT04966702
How many people
48145
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Prevalence of infection with Plasmodium falciparum
✗ The study did not show it
Who was studied
NCT04844905
How many people
24000
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Number of participants with treatment-related adverse events as assessed by modified CTCAE v4.0 scale
✗ The study did not show it
Who was studied
NCT02899936
How many people
23789
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Self Reported Adverse Event
✗ The study did not show it
Who was studied
NCT03676140
How many people
20000
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Directions Important: Read warnings before use.Children 6 months of age to under 12 years of age: an adult should supervise use Adults and children 6 months of age and over: Inspect All houschold members should be checked by anothe!person for lice and/or nits (eggs) Use a magnifying glassin bright light to help you see thelice and/or nits(eggs) Use a tool, such as a comb or two unsharpened pencilsto lift and part…
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Safety and effectiveness of SOOLANTRA cream in pediatric patients have not been established.”
US prescribing information · b1d5b166-ab06-4ab5-b0c6-31126238118a · read 2026-08-30
On older people, the label states: “Of the 1371 subjects in the two pivotal clinical studies of SOOLANTRA cream, 170 (12.4%) were 65 and over, while 37 (2.7%) were 75 and over.”
US prescribing information · b1d5b166-ab06-4ab5-b0c6-31126238118a · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary The available data on the use of ivermectin, including SOOLANTRA cream, in pregnant women are insufficient to establish a drug- associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.”
US prescribing information · b1d5b166-ab06-4ab5-b0c6-31126238118a · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary The presence of ivermectin in human milk following topical administration of ivermectin has not been evaluated.”
US prescribing information · b1d5b166-ab06-4ab5-b0c6-31126238118a · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (11)
It was studied for a different goal
The studies measured something else entirely. Nothing in this record points to this reason.
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as lotion, tablet, cream, emulsion, given by the topical, oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
70 products list this as an active ingredient in the United States drug directory. 70 of them contain it and nothing else.
FDA National Drug Code directory · 72162-2294 · read 2026-08-29
They are sold as cream, emulsion, lotion, lotion/shampoo, paste and powder, taken oral and topical.
FDA National Drug Code directory · 72162-2294 · read 2026-08-29
The regulator's established pharmacologic class for it is antiparasitic [epc] and pediculicide [epc].
FDA National Drug Code directory · 72162-2294 · read 2026-08-29
38 published labels name it as an active ingredient. 38 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 014e33e7-c07d-4feb-a2cf-7cd160b1facd · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · 014e33e7-c07d-4feb-a2cf-7cd160b1facd · read 2026-08-29
SOOLANTRA is topical at 3 DOSAGE FORMS AND STRENGTHS Cream, 1%., recorded as fda label in effect 2024-10-24 in the United States.
US prescribing information · b1d5b166-ab06-4ab5-b0c6-31126238118a · read 2026-08-30
Recorded price in US: 1.23244–2.96753 USD per one gram, across 5 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Recorded price in US: 2.06325–9.75916 USD per one unit as the pricing file counts it — a tablet, capsule, patch or single item, across 6 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
RNAWiki could not confidently classify this substance, so no self-experiment plan is offered.
Questions worth asking
Which of the trials of Ivermectin studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Ivermectin are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
How many documents were read
34 documents were read for this substance.
RNAWiki source record
Where else this substance is registered
FDA substance identifier (UNII)
8883YP2R6D
RxNorm concept
311207
Checks this page had to pass
✓ Passed
Identity resolved
no open identity hold
✓ Passed
No unresolved merge across substance families
no quarantine open
✓ Passed
Every public sentence names a source
The opening statement carries the origin: Quoted from a stored source.
✗ Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
✓ Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
✗ Not passed
Safety mode resolved
No register row and no identity class settled the question.
✓ Passed
Canonical metadata present
slug and display name present
What is missing or unclear◇Read from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
15 approved applications cover products containing this substance. The earliest was NDA050742, approved 19961122 to MERCK SHARP DOHME.
This order is fixed in code and does not count clicks or time on the page.
What is not here
9 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
What was measured, goal by goal — found nothing in the sources checked.
How close this is to real life — found nothing in the sources checked.
The path through the body — found nothing in the sources checked.
Felt, measured, or meaningful — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (11)
Q1
On the Ivermectin label: indicated for what?
"Ivermectin is indicated for the treatment of the following infections: Strongyloidiasis of the intestinal tract Ivermectin is indicated for the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis . This indication is based on clinical studies of both…": indications and usage on Ivermectin's label. DailyMed label · 104a5045-94b1-4022-bc49-719521f30f0d · 2026-03-03
Q2
139 registered trials of Ivermectin — at which phases?
Registered studies posting no result
101 of 139
139 registered studies of Ivermectin: 51 phase3, 46 phase2, 20 phase1, 18 phase4, 11 na, 6 na or unstated, 4 early phase1. CLINICALTRIALS_SNAPSHOT · 2026-09-01
706 with a PubMed record
Show the evidence
phase3
51
phase2
46
phase1
20
phase4
18
na
11
na or unstated
6
8 more recorded rows
early phase1
4
completed
87
unknown
29
terminated
8
recruiting
6
active not recruiting
4
withdrawn
3
not yet recruiting
2
recorded 2026-09-01 · last checked 2026-09-04
Q3
11 of Ivermectin's trials stopped: futility/efficacy, accrual/recruitment, funding/business, other?
futility/efficacy (2), accrual/recruitment (1), funding/business (1) and other (7): Ivermectin's stop wording, clustered. CLINICALTRIALS_SNAPSHOT · 2026-09-01
"As of November 2013, the security situation in rural Northern Mozambique is no longer suitable for this clinical trial."; 11 of 139 registered studies
Show the evidence
Trial
NCT01903057
withdrawn; "As of November 2013, the security situation in rural Northern Mozambique is no longer suitable for this clinical trial."
NCT03553615
withdrawn; "Limited clinical capacity"
NCT03605758
terminated; "The original study PI passed away. Primary and Study Completion dates revised to reflect last participant examination date."
NCT04374019
terminated; "slow accrual,"
NCT04431466
terminated; "Preliminary data from a pilot study suggest that the administration of ivermectin in patients with SARS-CoV-2 is safe, reducing symptoms and viral load. The antiviral effects of ivermectin appear to depend on the dose administered."
NCT04438850
terminated; "Incidence has dramatically dropped and there is lack of eligible patients"
5 further recorded trials
NCT04447235
terminated; "futility analysis has demonstrated no difference between arms"
NCT04602507
terminated; "Lack of severe COVID-19 cases in the place of study"
NCT04891250
withdrawn; "Insufficient funding"
NCT05231603
terminated; "Poor response"
NCT05993143
terminated; "Study was stopped because no statistically significant difference was observed in the interim analysis. With high vaccine rates in those over 50 and an expected low incidence, it would not be feasible to complete recruitment within a short…"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Ivermectin used Ivermectin 1% cream — over how long?
Human studies of Ivermectin used "Ivermectin 1% cream". ClinicalTrials.gov · 2026-09-01
17 recorded entries; human; also "ivermectin cream 0.5%", "CD5024 0.3% cream", "Ivermectin Lotion, 0.5%"
Show the evidence
human
NCT01493947
Ivermectin 1% cream
NCT02036229
ivermectin cream 0.5%
NCT03250624
CD5024 0.3% cream
NCT03257943
Ivermectin Lotion, 0.5%
NCT03257943
SKLICE (ivermectin) Lotion, 0.5%
NCT04392713
Ivermectin 6 MG Oral Tablet (2 tablets)
11 more recorded rows
humanNCT04438850
Ivermectin 9 mg cp by Chemo group
humanNCT04700423
ivermectin (200 µg/kg) / albendazole (400 mg)
humanNCT04700423
ivermectin (200 µg/kg)
humanNCT04703205
Ivermectin 3 MG
humanNCT04726969
Ivermectin 3 mg Oral Tablet
humanNCT04832945
Ivermectin 6 Mg Oral Tablet
humanNCT04848688
Ivermectin 3 mg
humanNCT04966702
Veterinary Ivermectin 1%
humanNCT05082753
Ivermectin tablets (3 mg Ivermectin)
humanNCT05993143
Ivermectin 9 mg and 18 mg
humanNCT06184399
Ivermectin 1.5 mg ODT
recorded 2026-09-01 · last checked 2026-09-04
Q5
Ivermectin's half-life is 18 hours — which schedules were studied?
18 hours; The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
tmaxpharmacokinetics
4 hours; In two studies, after single 12-mg doses of ivermectin tablets in fasting healthy volunteers (representing a mean dose of 165 mcg/kg), the mean peak plasma concentrations of the major component (H 2 B 1a ) were 46.6 (±21.9) (range: 16.4 - 101.1) and 30.6 (±15.6) (range: 13.9 - 68.4) ng/mL, respectively, at approximately 4 hours after dosing.
metabolismpharmacokinetics
Ivermectin is metabolized in the liver, and ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine.
recorded 2026-03-03 · last checked 2026-09-04
Q6
Which running trial of Ivermectin could settle lifespan?
NCT02735707 measures All-cause mortality, reading out 2028-02.
1 open trial; n 20000; "Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia"
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TrialNCT02735707
"Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia"; n 20000; "All-cause mortality"; 2028-02
Q7
Which 47 trials of Ivermectin posted no result?
Posted no result
47 of 47 completed trials
Registrations
NCT00819520, NCT00921674, NCT00921154, NCT00921219, NCT00604084 and NCT01050452, and 41 more
Completion dates
oldest 2004-10; newest 2024-07-22
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Trial
NCT00819520
2004-10
NCT00921674
2005-04
NCT00921154
2005-09
NCT00921219
2005-11
NCT00604084
2008-05
NCT01050452
2009-08
14 further recorded trials
NCT00765024
2010-04
NCT00339417
2011-08-17
NCT00790998
2012-05
NCT02511353
2016-07
NCT03238131
2016-10
NCT02963324
2017-01
NCT03257943
2017-08-18
NCT01975441
2018-06
NCT01570504
2018-06-08
NCT03074435
2018-08
NCT03052998
2018-08-01
NCT02974049
2018-09-25
NCT03664063
2019-01-01
NCT03852303
2019-07-01
Q8
At the median, Ivermectin's trials enrolled 172 people — anything larger?
Median enrolment
172
Largest enrolment
52000
Registered trials counted
139
Q9
What do 2728 spontaneous reports say about Ivermectin — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Ivermectin appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 2728 reaction mentions were counted: asthenia 510; headache 508; pyrexia 357; ocular hyperaemia 252. FAERS via Open Targets · CHEMBL6067487 · 2026-06-24
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asthenia
510
headache
508
pyrexia
357
ocular hyperaemia
252
conjunctival haemorrhage
233
vertigo
199
4 more recorded rows
coma
192
back pain
178
diarrhoea
158
pruritus
141
recorded 2026-06-24 · last checked 2026-09-04
Q10
Which 10 reactions does Ivermectin's label not list?
In vitro studies using human liver microsomes and recombinant CYP450 enzymes have shown that ivermectin is primarily metabolized by CYP3A4.
pharmacokinetics
Depending on the in vitro method used, CYP2D6 and CYP2E1 were also shown to be involved in the metabolism of ivermectin but to a significantly lower extent compared to CYP3A4.
pharmacokinetics
The findings of in vitro studies using human liver microsomes suggest that clinically relevant concentrations of ivermectin do not significantly inhibit the metabolizing activities of CYP3A4, CYP2D6, CYP2C9, CYP1A2, and CYP2E1.
clinical_pharmacology
In vitro studies using human liver microsomes and recombinant CYP450 enzymes have shown that ivermectin is primarily metabolized by CYP3A4.
clinical_pharmacology
Depending on the in vitro method used, CYP2D6 and CYP2E1 were also shown to be involved in the metabolism of ivermectin but to a significantly lower extent compared to CYP3A4.
clinical_pharmacology
The findings of in vitro studies using human liver microsomes suggest that clinically relevant concentrations of ivermectin do not significantly inhibit the metabolizing activities of CYP3A4, CYP2D6, CYP2C9, CYP1A2, and CYP2E1.
ChEMBL 37 — CC BY-SA 3.0 Unported · ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Open Targets 26.06 — CC0 · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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