This page shows what was measured, who it was measured in, and what that does not settle.
What Icosapent does in the body
The nutritional status of women throughout pregnancy and in the postnatal period for both lactating and nonlactating mothers
Studies suggest that EPA reduces hepatic very low-density lipoprotein triglycerides (VLDL-TG) synthesis and/or secretion and enhances TG clearance from circulating VLDL particles. Potential mechanisms of action include increased β-oxidation; inhibition of acyl-CoA:1,2-diacylglycerol acyltransferase (DGAT); decreased lipogenesis in the liver; and increased plasma lipoprotein lipase activity.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · AAN7QOV9EA · read 2026-08-29
The supplement label database classes it as fatty acid, under the name EPA (Eicosapentaenoic Acid).
No plain explanation of what this changes is stored. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 79 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Mood
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer4 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Cholesterol
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved6 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Focus
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Body weight
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved2 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Muscle
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Mood
on a depression severity rating scale over eight weeks; hamilton rating scale for depression; montgomery asberg depression scale; edinburgh postnatal depression scale; beck depression scale; depression severity; depressive symptoms
Cholesterol
triglycerides; total cholesterol; high density cholesterol; low density cholesterol; very low density cholesterol; low density lipoprotein cholesterol
Focus
attention; working memory; sustained attention; divided attention
Blood sugar
incident type 2 diabetes; hba1c
Body weight
body weight; body mass index
Muscle
skeletal muscle mass
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
4 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
△ Only a number moved
6 registered test measure.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Rate of confirmed viral URIs
✗ The study did not show it
Who was studied
NCT04505098
How many people
39600
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Change in blood pressure
✗ The study did not show it
Who was studied
NCT01653678
How many people
25875
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Dry Eye Disease
✗ The study did not show it
Who was studied
NCT01880463
How many people
25875
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
upper respiratory infection
✗ The study did not show it
Who was studied
NCT01758081
How many people
25874
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Incident total, non-vertebral, and hip fractures
✗ The study did not show it
Who was studied
NCT01704859
How many people
25871
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
COPD Exacerbations Expressed as Cumulative Rate/Year Over 5 Years
✗ The study did not show it
Who was studied
NCT01728571
How many people
25871
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.4 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.11 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
hamilton rating scale for depression
montgomery asberg depression scale
edinburgh postnatal depression scale
beck depression scale
Measured
Things only a test, a scale or a device shows.
serum albumin
triglycerides
total cholesterol
high density cholesterol
low density cholesterol
very low density cholesterol
body weight
body mass index
low density lipoprotein cholesterol
skeletal muscle mass
and 1 more.
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (25)
on a depression severity rating scale over eight weeks
hscrp levels after 8 weeks of treatment pufa
n 6 hufa in total hufa
incident autoimmune diseases
omega 3 index
incident type 2 diabetes
dropout rate
tg 4
tc 4
hd c 4
interleukin 6
tumor necrosis factor alpha
attention
working memory
sustained attention
stimulus reaction incompatibility
go/ no go
divided attention
alertness
phase i recommended phase ii dose of epa
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What it would be like to take◇Read from sources, not yet reviewed
How long anything takes
Nine different lengths of time that get confused with each other. None of them is worked out from another.
Before anything is noticed.RNAWiki does not store this separately, and never works it out from another figure on this page.
Before a test result moves.RNAWiki does not store this separately, and never works it out from another figure on this page.
Before performance moves.RNAWiki does not store this separately, and never works it out from another figure on this page.
How long the result was watched.No finished study window is recorded for a study that tested this substance.
How long people took it.How long people actually took it is not stored. The study window is not the same thing.
How long people were followed.Follow-up length is not stored separately. It is never read off the study window, which would be a different thing.
How fast the body clears it. 89 hours hours
Read from the label, which states: “The plasma elimination half-life (t1/2) of EPA is approximately 89 hours.”
How long effects linger.RNAWiki does not store this separately, and never works it out from another figure on this page.
Beyond the studies. Nothing is recorded about the long term.
The longest finished study sets the edge of what anyone measured.
A study window is not how long people took it, and neither is how long they were followed. Where RNAWiki holds only one of the three, it shows one.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
TriStart DHA™ is an orally administered multivitamin/multimineral fatty acid dietary supplement indicated to improve the nutritional status of women throughout pregnancy and in the postnatal period for both lactating and nonlactating mothers. TriStart DHA™ can also be beneficial in improving the nutritional status of women prior to conception.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Safety and effectiveness in pediatric patients have not been established.”
US prescribing information · 1aca884c-c464-900d-ac06-33aee7118df8 · read 2026-08-30
On older people, the label states: “Of the total number of patients in well-controlled clinical studies of icosapent ethyl, 45% were 65 years of age and over.”
US prescribing information · 1aca884c-c464-900d-ac06-33aee7118df8 · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary The available data from published case reports and the pharmacovigilance database on the use of icosapent ethyl in pregnant women are insufficient to identify a drug-associated risk for major birth defects, miscarriage or adverse maternal or fetal outcomes.”
US prescribing information · 1aca884c-c464-900d-ac06-33aee7118df8 · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary Published studies have detected omega-3 fatty acids, including EPA, in human milk.”
US prescribing information · 1aca884c-c464-900d-ac06-33aee7118df8 · read 2026-08-30
On people with reduced liver function, the label states: “In patients with hepatic impairment, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels should be monitored periodically during therapy with icosapent ethyl.”
US prescribing information · 1aca884c-c464-900d-ac06-33aee7118df8 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as capsule, gelatin coated, capsule, coated, capsule, liquid filled, given by the oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Icosapent appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 607 reaction mentions were counted. One report can name several reactions.
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
8 products list this as an active ingredient in the United States drug directory. 3 of them contain it and nothing else.
FDA National Drug Code directory · 15370-250 · read 2026-08-29
They are sold as capsule, capsule, coated, capsule, gelatin coated and capsule, liquid filled, taken oral.
FDA National Drug Code directory · 15370-250 · read 2026-08-29
4 published labels name it as an active ingredient. None of them describes this substance alone, so no label text on this page can be attributed to it rather than to a combination.
US prescribing information · e5acfb2a-0959-4542-9b4c-790be194d581 · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · e5acfb2a-0959-4542-9b4c-790be194d581 · read 2026-08-29
4222 marketed supplement labels list this ingredient, classed as fat/fatty acid and other combinations.
Those labels carry all other, nutrient and qualified health claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
Icosapent is oral at 3 DOSAGE FORMS AND STRENGTHS Icosapent ethyl capsules are supplied as: 1 gram transparent natural colored oblong shaped soft gelatin capsules imprinted with “RDY 267” in white ink on one side., recorded as fda label in effect 2026-07-22 in the United States.
US prescribing information · 1aca884c-c464-900d-ac06-33aee7118df8 · read 2026-08-30
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
RNAWiki could not confidently classify this substance, so no self-experiment plan is offered.
Questions worth asking
Which of the trials of Icosapent studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
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Open questions, each with why it is open and what would close it.
How much did people take in the studies?
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Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
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A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
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Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
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Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Icosapent are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
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A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
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No reviewed mechanism story exists for this substance.
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Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
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Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
Where else this substance is registered
FDA substance identifier (UNII)
AAN7QOV9EA
CAS registry number
10417-94-4
PubChem compound
446284
ChEMBL
CHEMBL460026
ChEBI
28364
WHO international nonproprietary name list entry
6328
RxNorm concept
90
EMA substance identifier
100000079270
DrugBank
DB00159
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How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
The earliest marketing start date recorded for a listed product is 20090417.
FDA National Drug Code directory · 15370-250 · read 2026-08-29
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Recorded evidence blocks (14)
Q1
What did Icosapent's largest trial (25871 people) and its longest (15 years) measure?
25871 people in Icosapent's largest registered study, 15 years in its longest registered window, measuring Plasma Levels of Triglycerides and Lipoprotein Cholesterol. ClinicalTrials.gov · 2026-09-01
14 na, 10 phase3, 5 phase2, 5 phase4, 3 early phase1, 2 phase1, 1 na or unstated; NCT01351805; 2025-02; no ageing endpoint recorded. Last human test completed 2026, NCT07711444.
Interpretation These counts include studies where Icosapent was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
14
phase3
10
phase2
5
phase4
5
early phase1
3
phase1
2
2 more recorded rows
na or unstated
1
Last recorded human testNCT07711444
2026-06-01
recorded 2026-09-01 · last checked 2026-09-04
Q2
From mouse to human: where has Icosapent shown lifespan?
"CRP is no longer SOC - enrollment halted and will analyze available data."; 6 of 37 registered studies
Show the evidence
Trial
NCT00578578
terminated; "CRP is no longer SOC - enrollment halted and will analyze available data."
NCT02422446
terminated; "Difficulty enrolling patients with elevated triglycerides under statin treatment"
NCT03101527
terminated; "Insufficient recruitment"
NCT03101540
terminated; "Insufficient recruitment"
NCT03915535
terminated; "Several impacts of COVID-19 on recruitment and organization"
NCT04006847
terminated; "Product complaint"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Did Icosapent move PhenoAge, and by how much?
PhenoAge: "In multivariate linear regression models, eight of the twelve individual serum PUFAs showed a significantly negative association with PhenoAge acceleration, Specifically, per-unit increases in linoleic acid (LA), gamma-linolenic acid (GLA), arachidonic acid (AA), alpha-linolenic acid (ALA), stearidonic acid (SDA),…" Europe PMC · epigenetic clock search · 2025-03-08
1 recorded sentence; 2025; biomarker
Show the evidence
PhenoAgePMID 40057623
2025; "In multivariate linear regression models, eight of the twelve individual serum PUFAs showed a significantly negative association with PhenoAge acceleration, Specifically, per-unit increases in linoleic acid (LA), gamma-linolenic acid (GLA), arachidonic acid (AA), alpha-linolenic acid (ALA), stearidonic acid (SDA), eicosapentaenoic acid (EPA), docosapentaenoic acid (n-3 DPA), and docosahexaenoic…"
recorded 2025-03-08 · last checked 2026-09-04
Q5
More Icosapent was worse in human: at what point?
Hormetic in human: "For egg quality, HT reduced yolk TBARS linearly after 30 days at 22 ± 4°C (P < 0.001), while Haugh units showed a quadratic, hormetic response with best preservation at 10-20 mg/kg (P < 0.001) and lower efficacy at 50 mg/kg. Docosahexaenoic acid (DHA) content in yolk was highest at 20 mg/kg (P = 0.032), with a…" Europe PMC · dose-response search · 2026-04-20
2 recorded sentences naming Icosapent; hormetic, dose-response
Show the evidence
hormeticPMID 42102754
"For egg quality, HT reduced yolk TBARS linearly after 30 days at 22 ± 4°C (P < 0.001), while Haugh units showed a quadratic, hormetic response with best preservation at 10-20 mg/kg (P < 0.001) and lower efficacy at 50 mg/kg. Docosahexaenoic acid (DHA) content in yolk was highest at 20 mg/kg (P = 0.032), with a quadratic response for eicosapentaenoic acid (EPA) concentration (Quadratic effect: P =…"
dose-responsePMID 35647665
"Background Current evidence might support the use of omega-3 fatty acids (preferably docosahexaenoic acid and eicosapentaenoic acid) for lowering blood pressure (BP), but the strength and shape of the dose-response relationship remains unclear."
recorded 2026-04-20 · last checked 2026-09-04
Q6
Icosapent's half-life is 89 hours — which schedules were studied?
89 hours, the half-life Icosapent's label states. openfda-label · 2026-08-30
Show the evidence
half life
89 hours hours; The plasma elimination half-life (t1/2) of EPA is approximately 89 hours.
recorded 2026-08-30 · last checked 2026-09-04
Q7
Could one person measure Icosapent's effect on on a depression severity rating scale over eight weeks?
On a depression severity rating scale over eight weeks: measured in Icosapent's trials.
Interpretation on a depression severity rating scale over eight weeks is the recorded endpoint.
Show the evidence
biomarkers
on a depression severity rating scale over eight weeks; 2026-09-01
hscrp levels after 8 weeks of treatment pufa; 2026-09-01
serum albumin; 2026-09-01
n 6 hufa in total hufa; 2026-09-01
incident autoimmune diseases; 2026-09-01
omega 3 index; 2026-09-01
14 more recorded rows
biomarkers
incident type 2 diabetes; 2026-09-01
biomarkers
dropout rate; 2026-09-01
biomarkers
triglycerides; 2026-09-01
biomarkers
total cholesterol; 2026-09-01
biomarkers
high density cholesterol; 2026-09-01
biomarkers
low density cholesterol; 2026-09-01
biomarkers
very low density cholesterol; 2026-09-01
biomarkers
body weight; 2026-09-01
biomarkers
body mass index; 2026-09-01
biomarkers
tg 4; 2026-09-01
biomarkers
tc 4; 2026-09-01
biomarkers
hd c 4; 2026-09-01
biomarkers
interleukin 6; 2026-09-01
biomarkers
tumor necrosis factor alpha; 2026-09-01
half life
2026-09-04; halfLife; hours; 89 hours; 2026-08-30
human trials at or under30
8
smallest human trial
0; NCT00585390; PHASE2/PHASE3; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; COMPLETED
Q8
Which of adverse events, alertness and attention did Icosapent's trials measure?
Changes in eicosanoids/metabolites including PGE2, PGE3 in breast adipose tissue; Percentage of Platelet Aggregation Area Under the Curve (AUC) Over Time; latest 2028-09
Show the evidence
Trial
NCT02295059
"Omega 3 Fatty Acids and ERPR(-)HER2(+/-) Breast Cancer Prevention"; n 80; "Changes in eicosanoids/metabolites including PGE2, PGE3 in breast adipose tissue"; 2027-02-05
NCT06494488
"Differential Thrombogenesis by EPA and DHA Mediated by HDL"; n 80; "Percentage of Platelet Aggregation Area Under the Curve (AUC) Over Time"; 2028-03-31
NCT07439744
"NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acids Status"; n 50; "Depression Diagnosis"; 2027-12
NCT07462013
"Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice"; n 120; "Depressive Symptoms"; 2028-09
recorded 2026-09-01 · last checked 2026-09-04
Q10
Which 13 trials of Icosapent posted no result?
Posted no result
13 of 13 completed trials
Registrations
NCT00031707, NCT00114595, NCT00014027, NCT00432913, NCT00585390 and NCT02537236, and 7 more
Completion dates
oldest 2004-01; newest 2021-07-14
Show the evidence
Trial
NCT00031707
2004-01
NCT00114595
2005-03
NCT00014027
2008-04-11
NCT00432913
2008-06
NCT00585390
2009-11
NCT02537236
2009-12
7 further recorded trials
NCT01369550
2011-01
NCT03258840
2014-08
NCT02179372
2016-11
NCT03192579
2017-06-02
NCT02101970
2018-08-27
NCT03693131
2019-06-29
NCT04221217
2021-07-14
Q11
At the median, Icosapent's trials enrolled 60 people — anything larger?
Median enrolment
60
Largest enrolment
25871
Registered trials counted
37
Q12
What do 607 spontaneous reports say about Icosapent — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Icosapent appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 607 reaction mentions were counted: blood triglycerides increased 137; product odour abnormal 75; gastrooesophageal reflux disease 67; somnolence 64. open-targets-adr · CHEMBL460026 · 2026-06-24
Show the evidence
blood triglycerides increased
137
product odour abnormal
75
gastrooesophageal reflux disease
67
somnolence
64
coma
62
pneumonia aspiration
62
4 more recorded rows
myalgia
47
abdominal discomfort
34
eructation
33
atrial fibrillation
26
recorded 2026-06-24 · last checked 2026-09-04
Q13
Was Icosapent studied with fasting and exercise?
fasting and exercise are named in Icosapent's label sentences: "Randomization to treatment with 2 g twice daily of icosapent ethyl or matching placebo was performed among 8179 participants receiving statin therapy with established cardiovascular disease or age ≥50 years with diabetes and ≥1 additional risk factor, fasting triglyceride 1.69-5.63 mmol/L, and…" openfda-label+europepmc · 2026-04-01
2 recorded statements; fasting, exercise
Show the evidence
fasting
Randomization to treatment with 2 g twice daily of icosapent ethyl or matching placebo was performed among 8179 participants receiving statin therapy with established cardiovascular disease or age ≥50 years with diabetes and ≥1 additional risk factor, fasting triglyceride 1.69-5.63 mmol/L, and low-density lipoprotein cholesterol 1.06-2.59 mmol/L. Total hospitalizations were analyzed with a…
exercise
In this work, a meta-analysis was conducted that adhered to the PRISMA 2020 criteria, incorporating evidence from 41 randomized controlled trials on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation, all of which had been conducted as evidence between 2011 and 2025 and evaluated the effects of EPA and DHA supplementation on the primary markers of the impact of exercise on…
recorded 2026-04-01 · last checked 2026-09-04
Q14
What is recorded about Icosapent and autophagy?
"Therapeutically, interventions such as the SGLT2 inhibitor empagliflozin and eicosapentaenoic acid restore lysosomal function and autophagic activity." — where Icosapent and autophagy appear together. Europe PMC · pathway abstract search · 2025-07-21
"Therapeutically, interventions such as the SGLT2 inhibitor empagliflozin and eicosapentaenoic acid restore lysosomal function and autophagic activity."
sirtuinPMID 36574744
"Icosapent alleviated acetic acid-induced colitis via its anti-inflammatory, antioxidant, and anti-apoptotic effects mediated in part by SIRT1 pathway activation."
autophagyPMID 40761352
"Omega-3 PUFAs [including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA)] may mitigate prostate cancer risk through various molecular mechanisms, such as inhibiting pro-inflammatory eicosanoid production via COX-2 pathway, regulating apoptosis and autophagy, and potentially influencing other signaling pathways like NF-κB."
sirtuinPMID 31408587
"The present study aims to determine whether supplementation of the maternal diet with eicosapentaenoic acid (EPA) can decrease placental lipid deposition and improve antioxidant ability, in a SIRT1-dependent manner."
autophagyPMID 37450014
"Eicosapentaenoic acid ethyl ester (EPA-E) is an antihyperlipidemic derivative of omega-3 fatty acids that exhibited affinity to peroxisome proliferator-activated receptor-γ (PPAR-γ) that possesses both antioxidant and autophagy modulating properties."
recorded 2025-07-21 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
✗ required summary fields resolved: 5 required field(s) not terminal: Why people use it, Best-supported result, Most important common problem, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 11 source rows
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