This page shows what was measured, who it was measured in, and what that does not settle.
What Hydrogen Peroxide does in the body
first aid to help prevent the rise of infection in minor cuts, scrapes and burns aids in the removal of phlegm, mucus, or other secretions associated with occasional sore mouth
Why people take it. first aid to help prevent the rise of infection in minor cuts, scrapes and burns aids in the removal of phlegm, mucus, or other secretions associated with occasional sore mouth
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · BBX060AN9V · read 2026-08-29
The supplement label database classes it as non-nutrient/non-botanical, under the name Hydrogen peroxide.
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 73 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Protein
A protein is a folded chain your body builds to do a specific job.
A picture of it, and where the picture fails
A protein is like a tool bent into one shape for one task.
Where that stops being true. A tool keeps its shape. A protein can change shape and stop working.
What people get wrong. Protein in food and a protein in the body are related but not the same thing.
A polymer of amino acids folded into a defined structure that determines its function.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 9 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer1 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
post operative pain
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
1 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Examination of the change in biochemical parameters from the beginning, TAS sample
✗ The study did not show it
Who was studied
NCT05438901
How many people
12317546
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Antimicrobial utilization at the ICU level
✗ The study did not show it
Who was studied
NCT07233837
How many people
5000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
recurrence rate
✗ The study did not show it
Who was studied
NCT04683575
How many people
5000
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Change in Length for Age Z score
✗ The study did not show it
Who was studied
NCT02812615
How many people
1575
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
recurrence-free survival (RFS)
✗ The study did not show it
Who was studied
NCT06722300
How many people
856
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Efficacy as measured by lesion counts
✗ The study did not show it
Who was studied
NCT06090721
How many people
520
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.0 registered measures of this kind. 1 written-up study measured this and did not show a benefit.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.1 registered measure of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.1 registered measure of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.1 registered measure of this kind.
□A number that stands in for healthNo evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.No registered study measures this.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.1 registered measure inside human tissue.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Drosophila (fruit fly), Mouse. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
post operative pain
Measured
Things only a test, a scale or a device shows.
relative gene expression by real time pcr
exercise capacity
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (6)
rate of postoperative complications
biofilm analyses cell viability
biofilm analysis extracellular polysaccharides
sars cov 2 viral load
bacterial colony forming
lesion size
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
• Aids in the removal of phlegm, mucus, or other secretions associated with occasional sore mouth. • For temporary use in cleansing minor wounds or minor gum inflammation resulting from minor dental procedures, dentures, orthodontic appliances, accidental injury, or other irritations of the mouth and gums. • For temporary use to cleanse canker sores.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as solution, liquid, paste, dentifrice, cloth, given by the topical, dental, oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Hydrogen Peroxide appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 74 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
application site discolouration — 17 reaction mentions
application site erythema — 10 reaction mentions
application site pain — 7 reaction mentions
chemical injury — 7 reaction mentions
product complaint — 7 reaction mentions
suicide attempt — 7 reaction mentions
hypertrophic scar — 6 reaction mentions
swelling of eyelid — 5 reaction mentions
gastritis erosive — 4 reaction mentions
shock haemorrhagic — 4 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
162 products list this as an active ingredient in the United States drug directory. 150 of them contain it and nothing else.
FDA National Drug Code directory · 76162-327 · read 2026-08-29
They are sold as cloth, gel, liquid, mouthwash, paste, dentifrice and rinse, taken buccal, dental, oral and periodontal.
FDA National Drug Code directory · 76162-327 · read 2026-08-29
155 published labels name it as an active ingredient. 143 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 4989f1cd-4555-405a-a5f8-8714d472983c · read 2026-08-29
Those labels are classed as human otc drug.
US prescribing information · 4989f1cd-4555-405a-a5f8-8714d472983c · read 2026-08-29
83 marketed supplement labels list this ingredient, classed as mineral, non-nutrient/non-botanical and other combinations.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
Recorded price in US: 0.00154–0.01814 USD per one millilitre, across 6 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
RNAWiki could not confidently classify this substance, so no self-experiment plan is offered.
Questions worth asking
Which of the trials of Hydrogen Peroxide studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
How fast does the body clear it?
The sources RNAWiki checked hold nothing for this field.
Why it matters. Without this, nothing on this page can say how long anything lasts.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Hydrogen Peroxide are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
Where else this substance is registered
FDA substance identifier (UNII)
BBX060AN9V
RxNorm concept
91349
Checks this page had to pass
✓ Passed
Identity resolved
no open identity hold
✓ Passed
No unresolved merge across substance families
no quarantine open
✓ Passed
Every public sentence names a source
The opening statement carries the origin: Quoted from a stored source.
✗ Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
✓ Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
✗ Not passed
Safety mode resolved
No register row and no identity class settled the question.
✓ Passed
Canonical metadata present
slug and display name present
What is missing or unclear◇Read from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
1 approved application covers products containing this substance. The earliest was NDA209305, approved 20171214 to ACLARIS.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (12)
Q1
What did Hydrogen Peroxide's largest trial (5000 people) and its longest (8.1 years) measure?
5000 people in Hydrogen Peroxide's largest registered study, 8.1 years in its longest registered window, measuring Percentage of Participants With Rosenberg Score at Indicated Time Points. ClinicalTrials.gov · 2026-09-01
20 na, 9 phase2, 7 phase3, 4 phase4, 2 early phase1, 1 na or unstated, 1 phase1; NCT03886389; 2017-07-07; no ageing endpoint recorded. Last human test completed 2026, NCT05024760.
Interpretation These counts include studies where Hydrogen Peroxide was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
20
phase2
9
phase3
7
phase4
4
early phase1
2
na or unstated
1
2 more recorded rows
phase1
1
Last recorded human testNCT05024760
2026-05-01
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has Hydrogen Peroxide shown lifespan?
"The funder decided not to continue funding, causing enrollment to cease prematurely and curtailing originally planned analyses. Participants with any samples collected after the baseline pre-rinse samples were included in the analysis."; 3 of 43 registered studies
Show the evidence
Trial
NCT04409873
terminated; "The funder decided not to continue funding, causing enrollment to cease prematurely and curtailing originally planned analyses. Participants with any samples collected after the baseline pre-rinse samples were included in the analysis."
NCT04748783
terminated; "Funding withdrawn"
NCT04878042
withdrawn; "No participants"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Hydrogen Peroxide used 3% hydrogen peroxide — over how long?
5 recorded entries; human; also "hydrogen peroxide 45%", "1% Hydrogen Peroxide", "Hydrogen Peroxide 30 % Topical Solution"
Show the evidence
human
NCT03057821
3% hydrogen peroxide
NCT03687372
hydrogen peroxide 45%
NCT04603794
1% Hydrogen Peroxide
NCT04929535
Hydrogen Peroxide 30 % Topical Solution
NCT07534865
3% hydrogen peroxide solution
recorded 2026-09-01 · last checked 2026-09-04
Q5
More Hydrogen Peroxide was worse in human: at what point?
Hormetic in human: "Behavioral assessments conducted at the end of the treatment period showed that chronic O₃ exposure did not alter appetitive or consummatory sexual behaviors; however, it significantly reduced serum testosterone levels, increased serum total oxidant status (TOS), and decreased testicular hydrogen peroxide…" Europe PMC · dose-response search · 2026-08-19
5 recorded sentences naming Hydrogen Peroxide; hormetic, hormesis, biphasic
Show the evidence
hormeticPMID 41655483
"Behavioral assessments conducted at the end of the treatment period showed that chronic O₃ exposure did not alter appetitive or consummatory sexual behaviors; however, it significantly reduced serum testosterone levels, increased serum total oxidant status (TOS), and decreased testicular hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) levels, suggesting a hormetic response."
hormesisPMID 37741385
"In this paper, the luminescence inhibition toxicities of chlorinated sodium phosphate (CSP), dodecyl dimethyl benzyl ammonium bromide (DOB), dodecyl dimethyl benzyl ammonium chloride (DOC), ethanol (EtOH), glutaraldehyde (GLA), hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), isopropyl alcohol (IPA), n-propanol (NPA), and 20 mixture rays in four mixture systems (EtOH-H<sub>2</sub>O<sub>2</sub>,…"
biphasic
PMID 42676963
"The self-contained sensing platform is demonstrated for biphasic detection of potassium ions, albumin, and hydrogen peroxide based on mechanisms including analyte-induced deprotonation of a hydrophobic pH indicator, analyte-induced back extraction of a fluorescent dye, and reaction of the analyte with a fluorescent probe."
PMID 42122852
"Malondialdehyde (MDA) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) contents showed a delayed response, increasing significantly only at 48 hpi, whereas SOD activity exhibited a biphasic pattern."
PMID 40168424
"In biphasic epoxidations, this approach allows the use of environmentally benign hydrogen peroxide as oxidant."
recorded 2026-08-19 · last checked 2026-09-04
Q6
Could one person measure Hydrogen Peroxide's effect on rate of postoperative complications?
Rate of postoperative complications: measured in Hydrogen Peroxide's trials.
Interpretation rate of postoperative complications is the recorded endpoint.
Show the evidence
biomarkers
rate of postoperative complications; 2026-09-01
relative gene expression by real time pcr; 2026-09-01
0; NCT04878042; NA; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q7
Which of bacterial colony forming, biofilm analyses cell viability and biofilm analysis extracellular polysaccharides did Hydrogen Peroxide's trials measure?
bacterial colony forming, biofilm analyses cell viability and biofilm analysis extracellular polysaccharides lead 9 outcome terms across Hydrogen Peroxide's trials. ClinicalTrials.gov · 2026-09-01
Complete tumour response based on best response assessed by contrast enhanced MRI according to criteria outlined in Section 3.2.1 of the trial protocol, performed up to and…; Resolution of the disease; latest 2028-12-01
Show the evidence
Trial
NCT03946202
"KORTUC Phase II - Intra-tumoural Radiation Sensitizer in Patients With Locally Advanced/Recurrent Breast Cancer"; n 184; "Complete tumour response based on best response assessed by contrast enhanced MRI according to criteria outlined in Section 3.2.1 of the trial protocol, performed up to and including 12 months post radiotherapy"; 2028-06-30
NCT05615051
"Influence of Implant Surface Decontamination on the Reconstructive Outcomes of Peri-implantitis"; n 60; "Resolution of the disease"; 2026-07-10
NCT06831422
"Post-incision Antimicrobial Wash vs C. Acnes in Shoulder Arthroplasty"; n 150; "Incidence of C. Acnes"; 2027-09
NCT06949176
"Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal"; n 44; "Reduction of total bacterial load after chemomechanical preparation using 2.5% and 5% NaOCl."; 2025-06-23
NCT07233837
"Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care Units"; n 5000; "Antimicrobial utilization at the ICU level"; 2027-03-01
NCT07534865
"Hyperthermia Combined With Hydrogen Peroxide Microneedle Patch for Viral Warts"; n 210; "Complete clearance rate of warts"; 2028-12-01
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which 16 trials of Hydrogen Peroxide posted no result?
Posted no result
16 of 16 completed trials
Registrations
NCT00909701, NCT00978861, NCT01048307, NCT01533675, NCT01231243 and NCT02463318, and 10 more
Completion dates
oldest 2009-05; newest 2022-09-01
Show the evidence
Trial
NCT00909701
2009-05
NCT00978861
2009-08
NCT01048307
2010-07
NCT01533675
2011-08
NCT01231243
2011-09
NCT02463318
2015-09
10 further recorded trials
NCT01167387
2016-03
NCT03019224
2016-08
NCT03886389
2017-07-07
NCT03678012
2018-08-16
NCT03536637
2019-01-28
NCT03057821
2019-03
NCT04027413
2020-10-02
NCT02757651
2020-11-12
NCT04707742
2021-09-30
NCT05576194
2022-09-01
Q10
At the median, Hydrogen Peroxide's trials enrolled 70 people — anything larger?
Median enrolment
70
Largest enrolment
5000
Registered trials counted
43
Q11
What do 74 spontaneous reports say about Hydrogen Peroxide — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Hydrogen Peroxide appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 74 reaction mentions were counted: application site discolouration 17; application site erythema 10; application site pain 7; chemical injury 7. open-targets-adr · CHEMBL71595 · 2026-06-24
Show the evidence
application site discolouration
17
application site erythema
10
application site pain
7
chemical injury
7
product complaint
7
suicide attempt
7
4 more recorded rows
hypertrophic scar
6
swelling of eyelid
5
gastritis erosive
4
shock haemorrhagic
4
recorded 2026-06-24 · last checked 2026-09-04
Q12
What is recorded about Hydrogen Peroxide and NAD+?
"Furthermore, Mel significantly reduced intracellular and mitochondrial reactive oxygen species, and alleviated cell senescence and apoptosis of hDPSCs exposed to hydrogen peroxide through ameliorating NAD<sup>+</sup> depletion and mitochondrial dysfunction." — where Hydrogen Peroxide and NAD+ appear together. Europe PMC · pathway abstract search · 2026-07-13
"Furthermore, Mel significantly reduced intracellular and mitochondrial reactive oxygen species, and alleviated cell senescence and apoptosis of hDPSCs exposed to hydrogen peroxide through ameliorating NAD<sup>+</sup> depletion and mitochondrial dysfunction."
autophagy
PMID 42181893
"The association between PIP5K and the ROS-autophagy-Nrf2 pathway was examined in hepatocellular carcinoma (HCC) tissue samples (n = 36) and hepatic cancer cell lines. <i>In vitro</i>, HepG2 cells (expressing high PIP5K levels) were treated with PIP5K isoform-specific inhibitors, autophagy inhibitors, and Nrf2 inhibitors in the presence of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)."
PMID 42251963
"The GTP-bound form of MoGtr1 activates TOR signaling, maintains basal autophagy, and confers tolerance to hydrogen peroxide, whereas its GDP-bound form inhibits TOR, promotes autophagy, and increases sensitivity to hydrogen peroxide."
sirtuinPMID 41242268
"In vitro, hydrogen peroxide (H₂O₂)-induced MC3T3-E1 cell models were employed to evaluate osteoblast differentiation and apoptosis via alkaline phosphatase (ALP) staining, flow cytometry, and Western blot analysis focusing on the SIRT1-P53-CASPASE-3 axis."
autophagyPMID 41433247
"Increasing evidence indicates that autophagy is activated in response to oxidative stress, as autophagy-deficient mutants tend to accumulate hydrogen peroxide (H2O2), lipid peroxides, and oxidized proteins."
sirtuin
"Conclusion The findings of the study suggest that magnolol may protect mitochondrial integrity and diminish cellular senescence in rat nucleus pulposus (NPCs) subjected to hydrogen peroxide, through the SIRT1/PGC-1α signalling cascade."
recorded 2026-07-13 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md
✗ required summary fields resolved: 5 required field(s) not terminal: Why people use it, Best-supported result, Most important common problem, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 9 source rows
✓ no critical contamination: no quarantine open
✓ canonical metadata passed: slug and display name present
✓ no raw internal fields: enforced by the copy-contract test over the rendered page
This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.