The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 35 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer1 registered performance measure of this kind.
…Waiting for a reviewer7 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
visual analog scale pain; visual analogue scale for pain; visual analogue pain of the 50 foot walk test at week 26; pain between baseline and month 1 scores; assessment of womac a1 pain when walking; pain severity after 3 weeks; knee pain during a single leg squat; vas for pain
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
1 registered performance measure of this kind.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Change From Baseline in Lissamine Green Staining (LGS) Total Score at Day 7
✗ The study did not show it
Who was studied
NCT01382225
How many people
1936
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Live birth rate
✗ The study did not show it
Who was studied
NCT06492785
How many people
858
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Pain sub-score
✗ The study did not show it
Who was studied
NCT01372475
How many people
800
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Improvement in shoulder pain on movement in previous 24 hours, based upon 100 mm VAS score up to 3 months after baseline for the 3 i.a. and 5 i.a. sodium hyaluronate injections compared to PB-Saline control
✗ The study did not show it
Who was studied
NCT00377624
How many people
602
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Change From Baseline in the WOMAC Pain Score in the Target Knee at Week 26 [Western Ontario and McMaster Universities Arthritis Index (WOMAC®)]
✗ The study did not show it
Who was studied
NCT02495857
How many people
599
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Change From Baseline in the Visual Analogue Score (VAS) Pain Score of the 50-foot Walk Test at Week 26
✗ The study did not show it
Who was studied
NCT00988091
How many people
596
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.2 registered measures of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.2 registered measures of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.8 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.2 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Mouse. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
visual analog scale pain
symptom frequency
visual analogue scale for pain
pain between baseline and month 1 scores
assessment of womac a1 pain when walking
pain severity after 3 weeks
knee pain during a single leg squat
vas for pain
Measured
Things only a test, a scale or a device shows.
an acute inflammatory reaction in the injected knee
positive urinary culture
Meaningful
Things that change how a life goes, not only a number.
gait analysis gaitrite software
visual analogue pain of the 50 foot walk test at week 26
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (28)
time to graft reepithelialization
staining of the cornea and conjunctiva
responders oarsi 2004 at the end of follow up
improvment of symptomes
conjunctival staining by lissamine green
cornea staining
ankle osteoarthritis scale at 6 months
rasch analysis modified objective scar assessment value
harris hip
womac
joint space width
global assessment
womac section a b c
rescue medicine consumption
ocular surface index
blood count
adverse events
ikdc
cartilage thickness at 12 months by mri
adverse events as a measure of safety and tolerability
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
"Guard" Wash:.cleanses the anal area. refreshes the skin for a cleanfeeling.maintains natural pH balance of the skin. prepares skin for further careand treatment.suitable for daily use, promoting regular care "Lubricate" Pre-care:.cleanses and prepares the anorectal area beforeactivities.reduces friction,moisturizes.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as concentrate, liquid, cream, given by the topical, rectal route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
24 products list this as an active ingredient in the United States drug directory. 17 of them contain it and nothing else.
FDA National Drug Code directory · 71052-038 · read 2026-08-29
They are sold as concentrate, cream, gel, liquid, powder and solution, taken cutaneous, ophthalmic, rectal and topical.
FDA National Drug Code directory · 71052-038 · read 2026-08-29
11 published labels name it as an active ingredient. 4 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 4c592b9b-53ad-4fe6-e063-6294a90ae979 · read 2026-08-29
Those labels are classed as human otc drug.
US prescribing information · 4c592b9b-53ad-4fe6-e063-6294a90ae979 · read 2026-08-29
1144 marketed supplement labels list this ingredient, classed as non-nutrient/non-botanical and other combinations.
Those labels carry all other and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (11)
Q1
What did Hyaluronate's largest trial (800 people) and its longest (11 years) measure?
800 people in Hyaluronate's largest registered study, 11 years in its longest registered window, measuring concentration of Interleukin-1α. ClinicalTrials.gov · 2026-09-01
130 na, 57 phase2, 53 phase4, 47 phase3, 29 phase1, 11 early phase1, 7 na or unstated; NCT01787630; 2021-03. Last human test completed 2026, NCT07745660.
Interpretation These counts include studies where Hyaluronate was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
130
phase2
57
phase4
53
phase3
47
phase1
29
early phase1
11
2 more recorded rows
na or unstated
7
Last recorded human testNCT07745660
2026-07-29
recorded 2026-09-01 · last checked 2026-09-04
Q2
From mouse to human: where has Hyaluronate shown biomarker?
concentration of Interleukin-1α — the recorded outcome words.
Show the evidence
mouse
mechanism-only
humanNCT02540785
biomarker; concentration of Interleukin-1α; 303
recorded 2026-09-01 · last checked 2026-09-04
Q3
11 of Hyaluronate's trials stopped: safety, accrual/recruitment, funding/business, other?
safety (1), accrual/recruitment (7), funding/business (1) and other (2): Hyaluronate's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"For safety concerns"; 11 of 303 registered studies
Show the evidence
Trial
NCT00642382
terminated; "For safety concerns"
NCT00958425
withdrawn; "Failure of funding"
NCT01543737
terminated; "post transfer of company ownership from Smith \& Nephew to Bioventus LLC"
NCT01738243
terminated; "recruitment challenges"
NCT01810848
terminated; "Enrollment too low."
NCT02034890
withdrawn; "Difficulty in recruiting patients"
5 further recorded trials
NCT03384095
withdrawn; "study abandoned prior to opening to accrual or study start"
NCT04373603
withdrawn; "Study closed prior to opening to enrollment, due to funding availability for study"
NCT05082480
terminated; "poor enrollment"
NCT06437054
withdrawn; "This study was withdrawn before enrollment due to challenges in participant recruitment. A revised study protocol will be initiated under a new research project."
NCT06839222
withdrawn; "Change in scope"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Hyaluronate used 20 mg/ml non-animal stabilized hyaluronic acid (NASHA) — over how long?
visual analogue pain of the 50 foot walk test at week 26; 2026-09-01
biomarkers
harris hip; 2026-09-01
biomarkers
womac; 2026-09-01
biomarkers
joint space width; 2026-09-01
biomarkers
global assessment; 2026-09-01
biomarkers
womac section a b c; 2026-09-01
biomarkers
rescue medicine consumption; 2026-09-01
biomarkers
ocular surface index; 2026-09-01
human trials at or under30
89
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT00958425; PHASE3; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q6
Which of adverse events, adverse events as a measure of safety and tolerability and an acute inflammatory reaction in the injected knee did Hyaluronate's trials measure?
adverse events, adverse events as a measure of safety and tolerability and an acute inflammatory reaction in the injected knee lead 40 outcome terms across Hyaluronate's trials. ClinicalTrials.gov · 2026-09-01
symptom frequency, responders oarsi 2004 at the end of follow up, improvment of symptomes, visual analogue scale for pain, conjunctival staining by lissamine green and gait analysis gaitrite software follow.
Show the evidence
visual analog scale pain
1
time to graft reepithelialization
1
staining of the cornea and conjunctiva
1
symptom frequency
1
responders oarsi 2004 at the end of follow up
1
improvment of symptomes
1
14 more recorded rows
visual analogue scale for pain
1
conjunctival staining by lissamine green
1
gait analysis gaitrite software
1
cornea staining
1
ankle osteoarthritis scale at 6 months
1
rasch analysis modified objective scar assessment value
1
visual analogue pain of the 50 foot walk test at week 26
1
harris hip
1
womac
1
joint space width
1
global assessment
1
womac section a b c
1
rescue medicine consumption
1
ocular surface index
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of Hyaluronate's 53 ongoing trials reports first?
Cartilage Thickness on MRI; Compare percent change of skeletal muscle mass; latest 2030-03-19
Show the evidence
Trial
NCT03491761
"Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis"; n 100; "Cartilage Thickness on MRI"; 2027-12
NCT05018481
"HA35 Moderate Alcoholic Hepatitis (AH) Study"; n 54; "Compare percent change of skeletal muscle mass"; 2027-10-01
NCT05025865
"HA35 Acute Alcohol Study"; n 24; "Change in Aspartate Aminotransferase (AST)"; 2027-10-01
NCT05086939
"Multicenter Clinical Trial Comparing Treatment with Allogeneic Mesenchymal Cells Versus Autologous Mesenchymal Cells and Versus Active Control with Hyaluronic Acid in Patients with Knee Osteoarthritis."; n 124; "Range of motion."; 2026-05
NCT05937100
"New Vital Pulpotomy Medications in Primary Molars"; n 48; "clinically successful pulpotomy"; 2025-08-01
NCT06082531
"Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis"; n 300; "X-ray"; 2026-12-31
14 further recorded trials
NCT06105112
"Periodontal Regeneration With Hyaluronic Acid or Enamel Matrix Derivatives"; n 60; "Clinical attachment level change"; 2026-10-01
NCT06238934
"Treatment of Knee Osteoarthritis With Bone Marrow Aspirate Matrix: Prospective, Randomized Trial"; n 90; "Knee Society Score"; 2027-03
NCT06324474
"Clinical and Immunological Evaluation of HA in Treatment of Periodontitis"; n 24; "Changes in Plaque Index"; 2025-12-12
NCT06376981
"Hyaluronic Acid in Shoulder Tendinopathy"; n 132; "Visual analog scale pain on activity ranging from 0 to 100 mm at month 3."; 2030-03-19
NCT06570291
"Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis"; n 520; "WOMAC score"; 2028-12
NCT06618560
"Effect of Enamel Matrix Derivative or Hyaluronic Acid on Non-Surgical Treatment of Peri-Implantitis"; n 60; "Change in peri-implant pocket depth"; 2026-01-30
NCT06665594
"Effect of TXA on Reducing Bruising After Filler Injection"; n 40; "Intensity of bruising on TXA + HA half of face"; 2026-11
NCT06693739
"Regenerative Ability of Immature Necrotic Permanent Teeth Using Different Scaffolds"; n 30; "Clinically by absence of pain and/or swelling"; 2024-12-20
NCT06694532
"EffIcacy Between Arthrocentesis With High Versus Low Molecular Weight Hyaluronic Acid in Treatment of TMJ Disorders"; n 30; "EFFICACY between injection of high versus low molecular weight hyaluronic acid in TMJ arthrocentesis"; 2026-02-28
NCT06818487
"Ganyan-1 in Dry Eye"; n 219; "OSDI"; 2027-02-01
NCT06842368
"Immediate Implant Placement Using Xenograft Mixed with Vitamin D Versus Hyaluronic Acid."; n 24; "Implant secondary stability"; 2025-10-30
NCT06878599
"Intratympanic Injection of Dexamethasone With Hyaluronic Acid in Treatment of Sudden Sensorineural Hearing Loss"; n 70; "Degree of hearing improvement"; 2028-10
NCT06914583
"Safety and Efficacy Evaluation of Sodium Hyaluronate 32mg/ml in Improving Facial Skin Dryness and Dullness"; n 500; "GAIS (Global Aesthetic Improvement Scale) - Blinded evaluator"; 2026-02
NCT06935877
"Additional Effect of Steroid on Hyaluronic Acid in Subdeltoid Bursitis"; n 60; "Shoulder Pain and Disability Index"; 2026-06-30
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which 111 trials of Hyaluronate posted no result?
Posted no result
111 of 111 completed trials
Registrations
NCT00377624, NCT00731289, NCT00423371, NCT00599716, NCT00570648 and NCT01239810, and 105 more
Completion dates
oldest 2004-09; newest 2024-09-01
Show the evidence
Trial
NCT00377624
2004-09
NCT00731289
2005-12
NCT00423371
2007-09
NCT00599716
2008-05
NCT00570648
2008-06
NCT01239810
2008-12
14 further recorded trials
NCT00728611
2009-03
NCT00809198
2009-05
NCT01267214
2011-07
NCT01076673
2012-05
NCT01829451
2012-08
NCT01365260
2012-11
NCT01372475
2013-02
NCT00993707
2013-03
NCT01948583
2013-07
NCT01588925
2014-01
NCT02091674
2014-03
NCT01670578
2014-05
NCT04833738
2014-05-28
NCT02958761
2014-07
Q9
At the median, Hyaluronate's trials enrolled 53.5 people — anything larger?
"<b><i>Purpose:</i></b> Evaluation of marketed eye drops with or without trehalose, a nonreducing natural osmoprotector disaccharide, in autophagy modulation and its role in cell survival during desiccation. <b><i>Methods:</i></b> Eye drops containing either sodium hyaluronate (SH) (Hyabak<sup>®</sup>, Thea, France) or a combination of SH…" — where Hyaluronate and autophagy appear together. Europe PMC · pathway abstract search · 2021-07-06
autophagy, IGF-1; PMID 34227851, 8514850
Show the evidence
autophagyPMID 34227851
"<b><i>Purpose:</i></b> Evaluation of marketed eye drops with or without trehalose, a nonreducing natural osmoprotector disaccharide, in autophagy modulation and its role in cell survival during desiccation. <b><i>Methods:</i></b> Eye drops containing either sodium hyaluronate (SH) (Hyabak<sup>®</sup>, Thea, France) or a combination of SH with trehalose (Thealose Duo<sup>®</sup>, Thea, France)…"
IGF-1PMID 8514850
"These results indicate that hyaluronate activation of CD44 induces cytokine expression and macrophage-derived IGF-1 production is dependent on TNF alpha expression."
recorded 2021-07-06 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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