This page shows what was measured, who it was measured in, and what that does not settle.
What Heparin (PORCINE; 7000 MW) does in the body
Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
From the FDA-approved label: Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo . Heparin acts at multiple sites in the normal coagulation system. Small amounts of heparin in combination with antithrombin III (heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin.
Why people take it. Heparin Sodium Injection is indicated for: Prophylaxis and treatment of venous thrombosis and pulmonary embolism;
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
What the registries record it as
24 registered substances share the start of this name, which is why a search for it can return more than one thing.
FDA substance registry · T2410KM04A · read 2026-08-29
Where each sentence above came from
A person wrote this explanation into the record, with the studies named in the path below.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 132 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Appropriate VTE prophylaxis
✗ The study did not show it
Who was studied
NCT03243708
How many people
90537
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
30-day all-cause mortality and bleeding requiring blood transfusion
✗ The study did not show it
Who was studied
NCT06020560
How many people
65000
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Incidence rate of Thromboembolic events
✗ The study did not show it
Who was studied
NCT03367325
How many people
63001
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
RBC Transfusions
✗ The study did not show it
Who was studied
NCT03578419
How many people
27411
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Composite of all-cause mortality and non-fatal myocardial re-infarction
✗ The study did not show it
Who was studied
NCT00077792
How many people
20506
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.7 registered measures of this kind. No reviewed result.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
□Symptoms and quality of lifeNo evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.No registered study measures this.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.1 registered measure of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Mouse, Rat, Dog. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
No registered study measured anything of this kind.
Measured
Things only a test, a scale or a device shows.
renal plasma flow
Meaningful
Things that change how a life goes, not only a number.
death
stroke
survival
stent arm death reinfarction stroke or stent thrombosis
minor ischemia during the index hospitalization
major ischemia during the index hospitalization
major bleeding during the index hospitalization
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (32)
q wave mi
repeat coronary revascularization
neonates requiring mechanical ventilation
thrombotic events compatible hit
clinically relevant bleeding events
occurrence of thromboembolic events during treatment
disease free interval
glomerular filtration rate
stent arm ischemic target lesion revascularization
primary outcome measure will be in hospital major bleeding
neurologic sequelae
thrombosis
who experience a response
lower incidence of infection
catheter infection
composite incidence of major and minor bleeding
incidences of postoperative mi and major morbidity
major bleeding and mace
favorable clinical outcome
chemical pregnancy rate
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What it would be like to take◇Read from sources, not yet reviewed
How long anything takes
Nine different lengths of time that get confused with each other. None of them is worked out from another.
Before anything is noticed.RNAWiki does not store this separately, and never works it out from another figure on this page.
Before a test result moves.RNAWiki does not store this separately, and never works it out from another figure on this page.
Before performance moves.RNAWiki does not store this separately, and never works it out from another figure on this page.
How long the result was watched.No finished study window is recorded for a study that tested this substance.
How long people took it.How long people actually took it is not stored. The study window is not the same thing.
How long people were followed.Follow-up length is not stored separately. It is never read off the study window, which would be a different thing.
How fast the body clears it. 0.5 to 2 h hours
Read from the label, which states: “The plasma half-life is dose-dependent and it ranges from 0.5 to 2 h.”
How long effects linger.RNAWiki does not store this separately, and never works it out from another figure on this page.
Beyond the studies. Nothing is recorded about the long term.
The longest finished study sets the edge of what anyone measured.
A study window is not how long people took it, and neither is how long they were followed. Where RNAWiki holds only one of the three, it shows one.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
& USAGE Heparin sodium injection is indicated for: • Prophylaxis and treatment of venous thrombosis and pulmonary embolism; • Prevention of postoperative deep venous thrombosis and pulmonary embolism in patients undergoing major abdominothoracic surgery or who, for other reasons, are at risk of developing thromboembolic disease; • Atrial fibrillation with embolization; • Treatment of acute and chronic consumptive…
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “There are no adequate and well controlled studies on heparin use in pediatric patients.”
US prescribing information · feec2820-502f-4a97-84c9-f173729c51d3 · read 2026-08-30
On older people, the label states: “There are limited adequate and well-controlled studies in patients 65 years and older, however, a higher incidence of bleeding has been reported in patients, particularly women, over 60 years of age [see Warnings and Precautions ( 5.2 )] .”
US prescribing information · feec2820-502f-4a97-84c9-f173729c51d3 · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary There are no available data on heparin sodium use in pregnant women to inform a drug-associated risk of major birth defects and miscarriage.”
US prescribing information · feec2820-502f-4a97-84c9-f173729c51d3 · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary If available, preservative-free heparin sodium is recommended when heparin therapy is needed during lactation.”
US prescribing information · feec2820-502f-4a97-84c9-f173729c51d3 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Injection
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Suppression classes recorded: S1.
No source is stored against this line.
What is in the pack
Sold as injectable, solution, injection, solution, injection, given by the injection, n/a, intravenous route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Heparin (PORCINE; 7000 MW) appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 6278 reaction mentions were counted. One report can name several reactions.
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Injection
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
173 products list this as an active ingredient in the United States drug directory. 167 of them contain it and nothing else.
FDA National Drug Code directory · 72603-267 · read 2026-08-29
They are sold as bead, injection, injection, solution, liquid, powder and solution, taken intraluminal, intravenous and subcutaneous.
FDA National Drug Code directory · 72603-267 · read 2026-08-29
The regulator's established pharmacologic class for it is anti-coagulant [epc], heparin [cs] and unfractionated heparin [epc].
FDA National Drug Code directory · 72603-267 · read 2026-08-29
63 published labels name it as an active ingredient. 61 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · feec2820-502f-4a97-84c9-f173729c51d3 · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · feec2820-502f-4a97-84c9-f173729c51d3 · read 2026-08-29
163 marketed supplement labels list this ingredient, classed as multi-vitamin and mineral (mvm) and vitamin.
Those labels carry all other, approved health and nutrient claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
Heparin Sodium is intravenous at 3 DOSAGE FORMS AND STRENGTHS Heparin Sodium Injection, USP is available as: Heparin Sodium Injection, USP, preservative-free , is available as follows: 2,000 USP units per 2 mL, single-dose vial Heparin Sodium Injection…, recorded as fda label in effect 2025-11-18 in the United States.
US prescribing information · feec2820-502f-4a97-84c9-f173729c51d3 · read 2026-08-30
Recorded price in US: 1.17186–5.8995 USD per one millilitre, across 26 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
Self-experiment planning is not offered for a prescription or clinician-supervised medicine. The questions below are for a clinician or pharmacist.
Questions worth asking
Which of the trials of Heparin (PORCINE; 7000 MW) studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Heparin (PORCINE; 7000 MW) are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
◇Read from sources, not yet reviewed
No traced study record is stored for this substance.
Built from stored sources by fixed rules. No reviewer has signed it off.
How many documents were read
58 documents were read for this substance.
RNAWiki source record
53 of them state the same halfLife, and they agree.
RNAWiki source record
53 of them state the same volumeOfDistribution, and they agree.
RNAWiki source record
Checks this page had to pass
✓ Passed
Identity resolved
no open identity hold
✓ Passed
No unresolved merge across substance families
no quarantine open
✓ Passed
Every public sentence names a source
The opening statement carries the origin: Written into the record, not signed off.
✗ Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
✓ Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
✓ Passed
Safety mode resolved
Suppression classes recorded: S1.
✓ Passed
Canonical metadata present
slug and display name present
What is missing or unclear◇Read from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
89 approved applications cover products containing this substance. The earliest was NDA000552, approved 19390209 to ASPEN GLOBAL INC.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
What was measured, goal by goal — found nothing in the sources checked.
The path through the body — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
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Recorded evidence blocks (14)
Q2
What did Heparin (PORCINE; 7000 MW)'s largest trial (6012 people) and its longest (17 years) measure?
6012 people in Heparin (PORCINE; 7000 MW)'s largest registered study, 17 years in its longest registered window, measuring CRRT-filter life span in hours. ClinicalTrials.gov · 2026-09-01
49 phase3, 46 phase4, 39 na, 37 phase2, 22 phase1, 11 na or unstated, 2 early phase1; NCT00427310; 2001-02. Last human test completed 2026, NCT05204550.
These counts include studies where Heparin (PORCINE; 7000 MW) was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
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phase3
49
phase4
46
na
39
phase2
37
phase1
22
na or unstated
11
2 more recorded rows
early phase1
2
Last recorded human testNCT05204550
2026-04-01
recorded 2026-09-01 · last checked 2026-09-04
Q3
From mouse to human: where has Heparin (PORCINE; 7000 MW) shown lifespan?
More Heparin (PORCINE; 7000 MW) was worse in human: at what point?
U-shaped in human: "DNA origami and heparin molecules were incorporated into various nanocomplexes, consisting of a U-shaped DNA origami cage, heparins of different lengths (tetrasaccharide, hexasaccharide, decasaccharide), and a spermidine-functionalized linker positioned near the viral RBD." Europe PMC · dose-response search · 2026-07-10
"DNA origami and heparin molecules were incorporated into various nanocomplexes, consisting of a U-shaped DNA origami cage, heparins of different lengths (tetrasaccharide, hexasaccharide, decasaccharide), and a spermidine-functionalized linker positioned near the viral RBD."
dose-response
"However, the biological origin of heparin inherently results in batch-to-batch variability, large dispersity indexes, and potential contamination, leading to inconsistent activity and patient-dependent dose-response."
PMID 42469074
"To determine whether individualized heparin dosing guided by a heparin dose-response (HDR) curve is noninferior to conventional weight-based dosing in achieving target activated clotting time (ACT) of ≥480 seconds before cardiopulmonary bypass (CPB) and to compare total heparin and protamine requirements, postoperative blood loss, and transfusion needs in children younger than 14 years undergoing…"
PMID 42469074
"The HDR group received an initial test dose of 100 IU/kg of heparin, and an individualized ACT dose-response curve was constructed to determine the dose required to target an ACT of 480 seconds."
biphasicPMID 41996853
"As a potential heparin sulfate analog, which also demonstrates a similar biphasic effect on cell proliferation, it was hypothesized that AOS may act on fibroblast growth factors (FGFs) and their receptors (FGFR) like heparin."
recorded 2026-07-10 · last checked 2026-09-04
Q7
Heparin (PORCINE; 7000 MW)'s half-life is 0.5 to 2 h hours — which schedules were studied?
0.5 to 2 h hours, the half-life Heparin (PORCINE; 7000 MW)'s label states. openfda-label · c8c4edd2-ee9e-4558-6b8c-b83adc242a0a · 2026-08-30
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half life
0.5 to 2 h hours; The plasma half-life is dose-dependent and it ranges from 0.5 to 2 h.
metabolism
The volume of distribution is 0.07 L/kg. Elimination Metabolism Heparin does not undergo enzymatic degradation.
recorded 2026-08-30 · last checked 2026-09-04
Q8
Which of bleeding events, catheter infection and chemical pregnancy rate did Heparin (PORCINE; 7000 MW)'s trials measure?
bleeding events, catheter infection and chemical pregnancy rate lead 40 outcome terms across Heparin (PORCINE; 7000 MW)'s trials. ClinicalTrials.gov · 2026-09-01
Interpretation stroke, neonates requiring mechanical ventilation, thrombotic events compatible hit, clinically relevant bleeding events, occurrence of thromboembolic events during treatment and disease free interval follow.
Show the evidence
death
1
q wave mi
1
repeat coronary revascularization
1
stroke
1
neonates requiring mechanical ventilation
1
thrombotic events compatible hit
1
14 more recorded rows
clinically relevant bleeding events
1
occurrence of thromboembolic events during treatment
1
disease free interval
1
survival
1
renal plasma flow
1
glomerular filtration rate
1
stent arm ischemic target lesion revascularization
1
stent arm death reinfarction stroke or stent thrombosis
1
minor ischemia during the index hospitalization
1
major ischemia during the index hospitalization
1
major bleeding during the index hospitalization
1
primary outcome measure will be in hospital major bleeding
1
neurologic sequelae
1
thrombosis
1
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which of Heparin (PORCINE; 7000 MW)'s 19 ongoing trials reports first?
19 registered trials of Heparin (PORCINE; 7000 MW) are open; earliest completion 2026-02-28. ClinicalTrials.gov · 2026-09-01
Change in LH Pulse Amplitude Before and After Acute or Chronic FFA Administration; Allogeneic transfusions of red blood cells; latest 2031-07-09
Show the evidence
Trial
NCT02653092
"Reprometabolic Syndrome Mediates Subfertility in Obesity"; n 84; "Change in LH Pulse Amplitude Before and After Acute or Chronic FFA Administration"; 2026-12-11
NCT03302195
"Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery"; n 410; "Allogeneic transfusions of red blood cells"; 2027-12-31
NCT03537586
"A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction"; n 206; "Platelet Activity measured by the Index of Microcirculatory Resistance (IMR)"; 2026-06-30
NCT04227678
"Postprandial Fatty Acid Metabolism in Subjects With Lipoprotein Lipase Deficiency"; n 16; "Organ-specific Dietary Fatty Acid (DFA) partitioning"; 2027-03-30
NCT04374799
"Heparin vs Placebo for Cardiac Catheterization"; n 1623; "radial artery occlusion"; 2026-12
NCT05257213
"Heparin Solution Versus Anti-adhesion Barrier Gel for Intrauterine Adhesions Prevention After Operative Hysteroscopy"; n 100; "Number of patients with post-operative intrauterine adhesion formation"; 2026-02-28
13 further recorded trials
NCT05737121
"Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPS"; n 120; "Sum of bladder pain intensity differences from baseline to 12 hours post-dose (SPID-12)"; 2026-06
NCT05848713
"AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia"; n 4000; "Ordinal endpoint reflecting survival"; 2029-03-31
NCT05959252
"BivaLirudin versUS Heparin in Extracorporeal Membrane Oxygenation"; n 80; "Time in therapeutic range"; 2026-09-01
NCT06080074
"Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System"; n 50; "Survival to 30 days, recovery, ventricular assist device implant or transplant in the absence of severe symptomatic stroke (primary device effectiveness)"; 2029-09
NCT06112262
"Comparison Between Haparin and Herodin in HD"; n 98; "Number of bleeding events and efficacy of dialysis during dialysis"; 2026-09
NCT06375616
"Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI"; n 156; "Platelet decline rate"; 2027-04
NCT06381661
"Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial"; n 2000; "All-cause mortality"; 2031-07-09
NCT06453876
"Percutaneous Embolectomy, Low Dose Thrombolysis or Heparin for Intermediate High Risk Pulmonary Embolism (STRATIFY II)"; n 210; "Thrombus burdon reduction (intervention vs. heparin)"; 2029-10-31
NCT06583889
"Endovascular Treatment or Standard Medical Care for Cerebral Venous Sinus Thrombosis(ESCORT)"; n 224; "Efficacy endpoint"; 2029-08
NCT06676085
"A Novel Strategy of ECMO Management Using Nafamostat for Regional Combined With Low Intensity Systematic Anticoagulation"; n 140; "incidence of ECMO related bleeding or thrombotic events"; 2027-12-31
NCT06822426
"Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)"; n 200; "Comparison between treatment groups of proportion of participants who experience a Central Line-Associated Bloodstream Infections (CLABSI) within 12 months of the start of the study"; 2028-01
NCT06869291
"Observation of the Effect and Mechanism of Multi Tunnel Minimally Invasive Treatment for Xanthelasma Palpebrarum"; n 270; "Proportion of regression area of xanthelasma palpebrarum"; 2029-02-01
NCT07759167
"Study of 3 Monoclonal Antibodies (REGN9933, REGN7508, and REGN9533) in Adult Participants With End-Stage Kidney Disease on Hemodialysis"; n 36; "Occurrence of Treatment-Emergent Adverse Events (TEAEs)"; 2027-03-25
recorded 2026-09-01 · last checked 2026-09-04
Q10
Which running trial of Heparin (PORCINE; 7000 MW) could settle lifespan?
NCT05848713 measures Ordinal endpoint reflecting survival, reading out 2029-03-31.
3 open trials; n 4000; "AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia"
Show the evidence
Trial
NCT05848713
"AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia"; n 4000; "Ordinal endpoint reflecting survival"; 2029-03-31
NCT06080074
"Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System"; n 50; "Survival to 30 days, recovery, ventricular assist device implant or transplant in the absence of severe symptomatic stroke (primary device effectiveness)"; 2029-09
NCT06381661
"Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial"; n 2000; "All-cause mortality"; 2031-07-09
Q11
Which 59 trials of Heparin (PORCINE; 7000 MW) posted no result?
Posted no result
59 of 59 completed trials
Registrations
NCT00000472, NCT00269880, NCT00271401, NCT00004694, NCT00004875 and NCT00431665, and 53 more
Completion dates
oldest 1995-06; newest 2024-08-20
Show the evidence
Trial
NCT00000472
1995-06
NCT00269880
1995-12
NCT00271401
1997-09
NCT00004694
1998-09
NCT00004875
1999-03
NCT00431665
2000-06
14 further recorded trials
NCT00005684
2001-01
NCT00427310
2001-02
NCT00079586
2004-11
NCT00062803
2005-10
NCT00001713
2006-01
NCT00361348
2006-07
NCT00587444
2007-10
NCT00890214
2008-05
NCT00448461
2008-06
NCT00885300
2008-09
NCT01044888
2008-09
NCT05148377
2008-12-01
NCT00182143
2010-06
NCT01214772
2010-06
Q12
At the median, Heparin (PORCINE; 7000 MW)'s trials enrolled 100 people — anything larger?
Median enrolment
100
Largest enrolment
6012
Registered trials counted
188
Q13
What do 6278 spontaneous reports say about Heparin (PORCINE; 7000 MW) — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Heparin (PORCINE; 7000 MW) appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 6278 reaction mentions were counted: heparin-induced thrombocytopenia 1840; thrombocytopenia 852; haemorrhage 635; hypotension 564. open-targets-adr · CHEMBL4650299 · 2026-06-24
Show the evidence
heparin-induced thrombocytopenia
1840
thrombocytopenia
852
haemorrhage
635
hypotension
564
haemoglobin decreased
464
premature baby
454
4 more recorded rows
deep vein thrombosis
397
haematoma
397
pulmonary embolism
349
thrombosis
326
recorded 2026-06-24 · last checked 2026-09-04
Q14
Was Heparin (PORCINE; 7000 MW) studied with fasting and exercise?
fasting and exercise are named in Heparin (PORCINE; 7000 MW)'s label sentences: "Before each imaging, patients were randomized to one of three preparations: (1) hyperlipidic-hypoglycemic diet; (2) fasting longer than 12 hours; and (3) fasting associated with intravenous heparin." openfda-label+europepmc · 2025-01-01
2 recorded statements; fasting, exercise
Show the evidence
fasting
Before each imaging, patients were randomized to one of three preparations: (1) hyperlipidic-hypoglycemic diet; (2) fasting longer than 12 hours; and (3) fasting associated with intravenous heparin.
exercise
Following the injection, one of four interventions was performed in randomized order on four separate occasions, each lasting 1 h: (1) no exercise, (2) double-legged exercise, (3) single-legged exercise with the non-dominant leg (where heparin was injected), and (4) single-legged exercise with the dominant leg.
recorded 2025-01-01 · last checked 2026-09-04
Q15
What is recorded about Heparin (PORCINE; 7000 MW) and IGF-1?
"In this study, to facilitate a more controlled release of IGF-1, we added IGF-binding protein 5 (IGFBP-5) to anisotropic collagen sponges with finely tuned pore sizes via heparin conjugation to stabilize the IGFBP-5/IGF-1 complex." — where Heparin (PORCINE; 7000 MW) and IGF-1 appear together. Europe PMC · pathway abstract search · 2026-08-04
"In this study, to facilitate a more controlled release of IGF-1, we added IGF-binding protein 5 (IGFBP-5) to anisotropic collagen sponges with finely tuned pore sizes via heparin conjugation to stabilize the IGFBP-5/IGF-1 complex."
autophagy
PMID 42550314
"This study investigates the mechanism by which heparin-binding epidermal growth factor (HB-EGF) maintains cartilage homeostasis in osteoarthritis (OA) through the epidermal growth factor receptor (EGFR)-mitochondrial autophagy axis."
PMID 38266152
"We previously found that heparin-binding hemagglutinin (HBHA) inhibits autophagy in A549 cells; however, its role in macrophage autophagy and polarization remains unclear."
PMID 41209015
"Heparin-binding hemagglutinin (HBHA), a virulence factor of Mtb, plays a critical role in LTBI by inhibiting autophagy in macrophages, though the underlying molecular mechanism has remained unclear."
mTOR
PMID 38429120
"Specifically, photosensitizer zinc phthalocyanine (ZnPc) and PI3K/mTOR inhibitor BEZ235 (BEZ) were co-loaded into PLS which was constructed by click chemistry conjugating MEK inhibitor selumetinib (SEL) to low molecular weight heparin with ROS-responsive oxalate bond."
PMID 37688744
"The mRNA and protein expression levels of heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF), EGF receptor (EGFR), phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), mammalian target of rapamycin (mTOR), and hypoxia-inducible factor-1α (HIF-1α) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot, respectively."
PMID 33920748
"Among them, we mention (1) lysosomotropic agents, which can prevent CoVs infection by alkalinizing the acid pH in the endolysosomal system, such as chloroquine and hydroxychloroquine, azithromycin, artemisinins, two-pore channel modulators and imatinib; (2) protease inhibitors that can inhibit the proteolytic cleavage of the spike CoVs protein, which is necessary for viral entry into host cells,…"
AMPKPMID 32866426
"Our findings demonstrate a critical role of epidermal autophagy in wound healing <i>in vivo</i> and elucidate a critical molecular machinery coordinating keratinocyte-fibroblast interaction in skin repair.<b>Abbreviations</b>: ACTA2/α-SMA: actin alpha 2, smooth muscle; ACTB: β-actin; ADGRE1: adhesion G protein-coupled receptor E1; AMPK: AMP-activated protein kinase; AP1: activator protein 1;…"
sirtuinPMID 30622668
"Kallistatin via its heparin-binding site antagonizes TNF-<i>α</i>-induced senescence and superoxide formation, while kallistatin's active site is essential for inhibiting miR-34a synthesis, thus elevating sirtuin 1 (SIRT1)/eNOS synthesis in EPCs."
IGF-1PMID 35656112
"We also found that SKF38393 and NaHS inhibited insulin-like growth factor-1 (IGF-1)/IGF-1R and heparin-binding EGF-like growth factor (HB-EGF)/EGFR, as well as their downstream PI3K/Akt, JAK2/STAT3 and ERK1/2 pathways."
recorded 2026-08-04 · last checked 2026-09-04
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