This page shows what was measured, who it was measured in, and what that does not settle.
What Haloperidol Decanoate does in the body
Haloperidol also binds to alpha-1 adrenergic receptors, but with lower affinity, and displays minimal binding to muscarinic cholinergic and histaminergic (H 1 ) receptors.
From the FDA-approved label: The mechanism of action of haloperidol decanoate injection for the treatment of schizophrenia in adults is unclear. However, its effect in schizophrenia could be mediated through its activity as an antagonist at central dopamine type 2 receptors.
Why people take it. Schizophrenia
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · AC20PJ4101 · read 2026-08-29
Its recorded molecular formula is C31H41ClFNO3, weighing 530.12.
US prescribing information · 1a0e38cb-fd9f-4962-9f81-5c0023ca6b4c · read 2026-08-30
Where each sentence above came from
A person wrote this explanation into the record, with the studies named in the path below.
The recorded use, written for a reader without medical training. Not signed off.
No statement of the main limit is recorded.
The four opening statements run to 76 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Formulation
A formulation is the exact made-up form a substance comes in.
A picture of it, and where the picture fails
It is like the difference between a whole bean and instant coffee.
Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.
What people get wrong. Two products with the same name are assumed to behave the same. They often do not.
The specific composition and physical form of a product, including salt, excipients and release profile.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Adherence to PONV Guidelines
✗ The study did not show it
Who was studied
NCT02625181
How many people
27034
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
One of the INCEPT core outcomes (varying between domains)
✗ The study did not show it
Who was studied
NCT06667999
How many people
10000
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Reconciliation of outpatient medications
✗ The study did not show it
Who was studied
NCT01195051
How many people
4818
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Study of metabolic profile
✗ The study did not show it
Who was studied
NCT00534183
How many people
2006
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
All cause mortality
✗ The study did not show it
Who was studied
NCT01785290
How many people
1800
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Percent of patients showing clinical improvement, defined as a >=20% reduction in the total PANSS score from baseline to end of double-blind treatment, and the mean change from baseline to end of double-blind treatment in total PANSS score.
✗ The study did not show it
Who was studied
NCT00249119
How many people
1579
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Injection
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Haloperidol Decanoate Injection is indicated for the treatment of schizophrenia in adults who were previously taking a stable dosage of an immediate-release oral haloperidol product. Haloperidol Decanoate Injection is a typical antipsychotic indicated for the treatment of schizophrenia in adults who were previously taking a stable dosage of an immediate-release oral haloperidol product ( 1 ).
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Safety and effectiveness of haloperidol decanoate have not been established in pediatric patients.”
US prescribing information · 1a0e38cb-fd9f-4962-9f81-5c0023ca6b4c · read 2026-08-30
On older people, the label states: “Clinical studies of haloperidol decanoate did not include sufficient numbers of patients 65 years of age and older to determine whether they respond differently from younger adult patients.”
US prescribing information · 1a0e38cb-fd9f-4962-9f81-5c0023ca6b4c · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary Available data from published epidemiologic studies of pregnant patients exposed to haloperidol have not established a drug-associated risk of major birth defects or miscarriage.”
US prescribing information · 1a0e38cb-fd9f-4962-9f81-5c0023ca6b4c · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary Literature reports suggest that haloperidol is detected in human milk of haloperidol-treated mothers with a relative infant dose ranging from 2% to 12%.”
US prescribing information · 1a0e38cb-fd9f-4962-9f81-5c0023ca6b4c · read 2026-08-30
On people with reduced liver function, the label states: “Haloperidol is extensively metabolized in the liver, therefore, haloperidol concentrations may be higher in patients with hepatic impairment compared to patients with normal hepatic function.”
US prescribing information · 1a0e38cb-fd9f-4962-9f81-5c0023ca6b4c · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
A different form was studied
The studied form is not the form on the shelf.
On this record: This record is linked to 1 related forms. Evidence does not carry across all of them.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
It was studied for a different goal
The studies measured something else entirely. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Given by a clinician
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Injection
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Suppression classes recorded: S6, S9.
No source is stored against this line.
What is in the pack
Sold as injectable, injection, solution, injection, given by the injection, intramuscular route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Injection
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
63 products list this as an active ingredient in the United States drug directory. 63 of them contain it and nothing else.
FDA National Drug Code directory · 72485-520 · read 2026-08-29
They are sold as injection, injection, solution and powder, taken intramuscular.
FDA National Drug Code directory · 72485-520 · read 2026-08-29
The regulator's established pharmacologic class for it is typical antipsychotic [epc].
FDA National Drug Code directory · 72485-520 · read 2026-08-29
25 published labels name it as an active ingredient. 25 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 15b82169-882b-40ef-bbda-5adc3e7eb930 · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · 15b82169-882b-40ef-bbda-5adc3e7eb930 · read 2026-08-29
6 marketed supplement labels list this ingredient, classed as amino acid/protein, non-nutrient/non-botanical and other combinations.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
Haloperidol Decanoate is intramuscular at 3 DOSAGE FORMS AND STRENGTHS • Haloperidol decanoate injection, 50 mg/mL is a clear colorless/pink to yellow amber oily liquid, free from visible foreign material, in a single-dose vial. • Haloperidol decanoate injectio…, recorded as fda label in effect 2026-07-14 in the United States.
US prescribing information · 1a0e38cb-fd9f-4962-9f81-5c0023ca6b4c · read 2026-08-30
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
This order is fixed in code and does not count clicks or time on the page.
What is not here
9 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
What was measured, goal by goal — found nothing in the sources checked.
How close this is to real life — found nothing in the sources checked.
The path through the body — found nothing in the sources checked.
Felt, measured, or meaningful — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (10)
Q2
On the Haloperidol Decanoate label: indicated for what?
"Haloperidol decanoate injection is indicated for the treatment of schizophrenia in adults who were previously taking a stable dosage of an immediate-release oral haloperidol product. Haloperidol decanoate injection is a typical antipsychotic indicated for the treatment of schizophrenia in adults who were previously…": indications and usage on Haloperidol Decanoate's label. DailyMed label · 1a0e38cb-fd9f-4962-9f81-5c0023ca6b4c · 2026-07-14
Q3
50 registered trials of Haloperidol Decanoate — at which phases?
Registered studies posting no result
31 of 50
50 registered studies of Haloperidol Decanoate: 20 phase4, 14 phase3, 9 na, 6 phase2, 3 na or unstated, 2 phase1. CLINICALTRIALS_SNAPSHOT · 2026-09-01
43 with a PubMed record
Show the evidence
phase4
20
phase3
14
na
9
phase2
6
na or unstated
3
phase1
2
6 more recorded rows
completed
29
terminated
12
active not recruiting
3
unknown
3
withdrawn
2
recruiting
1
recorded 2026-09-01 · last checked 2026-09-04
Q4
11 of Haloperidol Decanoate's trials stopped: accrual/recruitment, other?
"Study suspended due to low enrollment"; 11 of 50 registered studies
Show the evidence
Trial
NCT00124930
terminated; "Study suspended due to low enrollment"
NCT00300391
terminated; "Insufficient recruitment to meet aims."
NCT00599287
terminated; "Inclusion rate too low due to a lack of eligible patients and difficulties obtaining informed consent."
NCT00947375
terminated; "All of the mentioned aim and objectives were achieved before the February 2007"
NCT00954603
terminated; "few delirious patients were enrolled."
NCT01140529
terminated; "Slow recruitment"
5 further recorded trials
NCT02057549
terminated; "PI left institution"
NCT02098499
withdrawn; "No recruitment occurred and PI retired"
NCT02343575
terminated; "We did not recruit the research assistant and terminated the study"
NCT02893371
terminated; "Per PI, this study is not a clinical trial and was inadvertently entered in the system"
NCT02972502
terminated; "PI lapsed institutional training"
recorded 2026-09-01 · last checked 2026-09-04
Q5
Human studies of Haloperidol Decanoate used Haldol 10 mg Tablets (McNeil Pharmaceuticals) — over how long?
studies of Haloperidol Decanoate used the recorded amount. ClinicalTrials.gov · 2026-09-01
1 recorded entry; human; also "Haldol 10 mg Tablets (McNeil Pharmaceuticals)"
Show the evidence
humanNCT00946491
Haldol 10 mg Tablets (McNeil Pharmaceuticals)
recorded 2026-09-01 · last checked 2026-09-04
Q6
Haloperidol Decanoate's half-life is 6 days — which schedules were studied?
6 days, the half-life Haloperidol Decanoate's label states: "Absorption The plasma concentrations of haloperidol gradually rise, reaching a peak at about 6 days after the haloperidol decanoate injection, and fall thereafter, with an apparent half-life of about 3 weeks." DailyMed label · 1a0e38cb-fd9f-4962-9f81-5c0023ca6b4c · 2026-07-14
Show the evidence
half lifepharmacokinetics
6 days; Absorption The plasma concentrations of haloperidol gradually rise, reaching a peak at about 6 days after the haloperidol decanoate injection, and fall thereafter, with an apparent half-life of about 3 weeks.
metabolismpharmacokinetics
Elimination Metabolism : Haloperidol is metabolized by several routes.
recorded 2026-07-14 · last checked 2026-09-04
Q7
Which 16 trials of Haloperidol Decanoate posted no result?
Posted no result
16 of 16 completed trials
Registrations
NCT00946491, NCT00018642, NCT01123408, NCT00009217, NCT01139463 and NCT01161277, and 10 more
Completion dates
oldest 1987-05; newest 2023-05-22
Show the evidence
Trial
NCT00946491
1987-05
NCT00018642
2002-03
NCT01123408
2004-07
NCT00009217
2004-12
NCT01139463
2009-10
NCT01161277
2011-06
10 further recorded trials
NCT01750541
2013-01
NCT01174290
2014-03
NCT02043912
2014-04
NCT01530308
2015-10
NCT01862302
2016-07
NCT01785290
2017-03
NCT01539733
2017-04
NCT02909465
2017-07
NCT03056482
2019-07-07
NCT04764344
2023-05-22
Q8
At the median, Haloperidol Decanoate's trials enrolled 60 people — anything larger?
Median enrolment
60
Largest enrolment
1037352
Registered trials counted
49
Q9
What do 6388 spontaneous reports say about Haloperidol Decanoate — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Haloperidol Decanoate appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 6388 reaction mentions were counted: extrapyramidal disorder 1124; weight increased 977; neuroleptic malignant syndrome 970; somnolence 577. FAERS via Open Targets · CHEMBL1200986 · 2026-06-24
Show the evidence
extrapyramidal disorder
1124
weight increased
977
neuroleptic malignant syndrome
970
somnolence
577
drug interaction
505
agitation
469
4 more recorded rows
suicide attempt
464
dystonia
464
toxicity to various agents
419
tremor
419
recorded 2026-06-24 · last checked 2026-09-04
Q10
Which 10 reactions does Haloperidol Decanoate's label not list?
ChEMBL 37 — CC BY-SA 3.0 Unported · ClinicalTrials.gov — US Government work · Open Targets 26.06 — CC0 · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
✗ required summary fields resolved: 4 required field(s) not terminal: Why people use it, Best-supported result, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 6 source rows
✓ no critical contamination: no quarantine open
✓ canonical metadata passed: slug and display name present
✓ no raw internal fields: enforced by the copy-contract test over the rendered page
This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.