This page shows what was measured, who it was measured in, and what that does not settle.
What Ginger does in the body
SEFUDUN 7-Day Nail Fungus Treatment is designed to repair and strengthen nails and cuticles, promoting healthier and stronger nails for both handsand feet.
Why people take it. SEFUDUN 7-Day Nail Fungus Treatment is designed to repair and strengthen nails and cuticles, promoting healthier and stronger nails for both handsand feet.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
What the registries record it as
The substance registry classes this as structurallydiverse.
FDA substance registry · C5529G5JPQ · read 2026-08-29
It is recorded as coming from ZINGIBER OFFICINALE WHOLE. The part recorded is rhizome.
FDA substance registry · C5529G5JPQ · read 2026-08-29
The organism is Zingiber officinale, a species. It is also called ginger.
NCBI Taxonomy · 94328 · read 2026-08-29
The supplement label database classes it as botanical, under the name Ginger.
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 59 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 14 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved3 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer2 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Energy
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Endurance
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer1 registered performance measure of this kind.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Blood sugar
fasting blood glucose at 12 weeks; hba1c at 12 weeks; insulin resistance at 3 months
Pain
postoperative pain severity; brief pain inventory
Energy
energy expenditure
Endurance
time to exhaustion
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
△ Only a number moved
3 registered test measure.
— Not recorded
Harms were not a registered measure for this goal.
… Waiting for a reviewer
Who was studied is listed further down the page.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Number of participants with Adverse events
✗ The study did not show it
Who was studied
NCT07517263
How many people
5700
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
The difference in the change in the average amount of red meat served in treatment vs. control dining halls from the pre-intervention to intervention period based on service data from dining hall operations staff
✗ The study did not show it
Who was studied
NCT05131529
How many people
3003
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Number of participants with treatment-TOMEKA® usage
✗ The study did not show it
Who was studied
NCT04537585
How many people
2000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Quality of Bowel Preparation
✗ The study did not show it
Who was studied
NCT02621658
How many people
1000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Change from baseline in the last 6-hr mean DBP & SBP as measured by ABPM at the end of and 8-wk treatment period (T80 vs R5 mg) and 14-wk treatment period (T80 vs R10 mg)
✗ The study did not show it
Who was studied
NCT00274599
How many people
812
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Change from baseline in the last 6-hour mean (relative to dose time) diastolic blood pressure (DBP) as measured by ABPM (Ambulatory Blood Pressure Monitoring)
✗ The study did not show it
Who was studied
NCT00274638
How many people
805
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.1 registered measure of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.1 registered measure of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.3 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.3 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Drosophila (fruit fly), Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
sf 36 questionnaire
postoperative pain severity
brief pain inventory
Measured
Things only a test, a scale or a device shows.
fasting blood glucose at 12 weeks
hba1c at 12 weeks
insulin resistance at 3 months
time to exhaustion
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (7)
energy expenditure
oxygenation
endothelial function measured by endopat system
alt level
nausea
viability count measurement
fractional exhaled nitric oxide
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
SEFUDUN 7-Day Nail Fungus Treatment is designed to repair and strengthen nails and cuticles, promoting healthier and stronger nails for both handsand feet.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Sold as spray, patch, liquid, pellet, given by the oral, topical, sublingual route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Ginger appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 184 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
macular degeneration — 45 reaction mentions
pain — 22 reaction mentions
constipation — 17 reaction mentions
malaise — 15 reaction mentions
pyrexia — 15 reaction mentions
chronic sinusitis — 14 reaction mentions
dyspepsia — 14 reaction mentions
infusion related reaction — 14 reaction mentions
nausea — 14 reaction mentions
procedural pain — 14 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
110 products list this as an active ingredient in the United States drug directory. 10 of them contain it and nothing else.
FDA National Drug Code directory · 83027-0052 · read 2026-08-29
They are sold as capsule, granule, liquid, patch, pellet and pill, taken intradermal, nasal, oral and percutaneous.
FDA National Drug Code directory · 83027-0052 · read 2026-08-29
The regulator's established pharmacologic class for it is allergens [cs], cell-mediated immunity [pe] and dietary proteins [cs].
FDA National Drug Code directory · 83027-0052 · read 2026-08-29
101 published labels name it as an active ingredient. 2 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 377f4a5b-bcbb-47b7-b4f4-d198b98c8427 · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · 377f4a5b-bcbb-47b7-b4f4-d198b98c8427 · read 2026-08-29
3655 marketed supplement labels list this ingredient, classed as botanical, botanical with nutrients and other combinations.
Those labels carry all other and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (12)
Q1
What did Ginger's largest trial (745 people) and its longest (8.8 years) measure?
745 people in Ginger's largest registered study, 8.8 years in its longest registered window, measuring Change From Baseline of Peak Acute Nausea. ClinicalTrials.gov · 2026-09-01
14 na, 11 phase2, 5 early phase1, 4 phase4, 3 phase3, 1 phase1; NCT00040742; 2011-12; no ageing endpoint recorded. Last human test completed 2025, NCT07150533.
Interpretation These counts include studies where Ginger was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
14
phase2
11
early phase1
5
phase4
4
phase3
3
phase1
1
1 more recorded row
Last recorded human testNCT07150533
2025-07-30
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has Ginger shown lifespan?
"Slow accrual; Received grant funding for a similar but different study."; 2 of 35 registered studies
Show the evidence
Trial
NCT02670941
terminated; "Slow accrual; Received grant funding for a similar but different study."
NCT03125551
withdrawn; "Study requires Medicines Control council approval"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Could one person measure Ginger's effect on energy expenditure?
Energy expenditure: measured in Ginger's trials.
Interpretation energy expenditure is the recorded endpoint.
Show the evidence
biomarkers
energy expenditure; 2026-09-01
oxygenation; 2026-09-01
endothelial function measured by endopat system; 2026-09-01
alt level; 2026-09-01
nausea; 2026-09-01
viability count measurement; 2026-09-01
8 more recorded rows
biomarkers
sf 36 questionnaire; 2026-09-01
biomarkers
fractional exhaled nitric oxide; 2026-09-01
biomarkers
postoperative pain severity; 2026-09-01
biomarkers
fasting blood glucose at 12 weeks; 2026-09-01
biomarkers
hba1c at 12 weeks; 2026-09-01
biomarkers
insulin resistance at 3 months; 2026-09-01
biomarkers
brief pain inventory; 2026-09-01
biomarkers
time to exhaustion; 2026-09-01
human trials at or under30
6
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT03125551; NA; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q5
Which of alt level, brief pain inventory and endothelial function measured by endopat system did Ginger's trials measure?
alt level, brief pain inventory and endothelial function measured by endopat system lead 14 outcome terms across Ginger's trials. ClinicalTrials.gov · 2026-09-01
alt level, nausea, viability count measurement, sf 36 questionnaire, fractional exhaled nitric oxide and postoperative pain severity follow.
Change from baseline in Insulin Resistance (IR) at 3 months; Reduction in Nausea and Vomiting based on Pregnancy-Unique Quantification of Emesis Score; latest 2029-07-31
Show the evidence
Trial
NCT06769035
"Effect of a Food Supplement with Natural Extracts of Cocoa, Amaranth Seed and Ginger in Overweight or Obese Patients"; n 40; "Change from baseline in Insulin Resistance (IR) at 3 months"; 2025-06
NCT06772974
"Tablet Ginger Versus Tablet Doxylamine Succinate in Control of Nausea and Vomiting in Pregnancy"; n 66; "Reduction in Nausea and Vomiting based on Pregnancy-Unique Quantification of Emesis Score"; 2025-07-15
NCT06817018
"Ginger Root Extract for Sciatic Pain Individuals"; n 80; "plasma lipopolysaccharide binding protein (LBP)"; 2028-02-28
NCT07190495
"Ginger to Prevent Nausea and Vomiting After Laparoscopic Cholecystectomy"; n 102; "Incidence of postoperative nausea and vomiting (PONV) within 2 hours post-surgery"; 2026-12
NCT07595640
"Effect of Ginger on Heavy Menstrual Bleeding in Women With Coagulation Disorders"; n 74; "Parametric or non-parametric tests"; 2029-07-31
NCT07596979
"Ginger in the Modulation of Inflammatory Cytokines and Oxidative Stress in Patients With Coronary Artery Disease"; n 50; "Change of inflammatory status in the participants"; 2028-12
1 further recorded trialNCT07792395
"Ginger's Therapeutic Potential in Asthma"; n 32; "PD20 dose of methacholine"; 2029-03
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which running trial of Ginger could settle insulin sensitivity?
NCT06769035 measures Change from baseline in Insulin Resistance (IR) at 3 months, reading out 2025-06.
1 open trial; n 40; "Effect of a Food Supplement with Natural Extracts of Cocoa, Amaranth Seed and Ginger in Overweight or Obese Patients"
Show the evidence
TrialNCT06769035
"Effect of a Food Supplement with Natural Extracts of Cocoa, Amaranth Seed and Ginger in Overweight or Obese Patients"; n 40; "Change from baseline in Insulin Resistance (IR) at 3 months"; 2025-06
Q8
Which 20 trials of Ginger posted no result?
Posted no result
20 of 20 completed trials
Registrations
NCT00065221, NCT00317655, NCT00611156, NCT00958685, NCT00537875 and NCT01085019, and 14 more
Completion dates
oldest 2007-01; newest 2023-08-08
Show the evidence
Trial
NCT00065221
2007-01
NCT00317655
2007-04
NCT00611156
2007-06
NCT00958685
2009-01
NCT00537875
2009-09
NCT01085019
2011-12
14 further recorded trials
NCT02666807
2015-11
NCT02390648
2016-02
NCT02701491
2016-09
NCT06423248
2016-11-13
NCT03519698
2017-06-22
NCT02809027
2017-06-30
NCT03219463
2018-06-01
NCT03626441
2018-06-14
NCT05682911
2018-06-30
NCT03617900
2019-05-25
NCT02289235
2020-02-01
NCT05499793
2022-06-01
NCT05221892
2023-03-31
NCT06200415
2023-08-08
Q9
At the median, Ginger's trials enrolled 54 people — anything larger?
Median enrolment
54
Largest enrolment
745
Registered trials counted
35
Q10
What do 184 spontaneous reports say about Ginger — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Ginger appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 184 reaction mentions were counted: macular degeneration 45; pain 22; constipation 17; malaise 15. open-targets-adr · CHEMBL2108465 · 2026-06-24
Show the evidence
macular degeneration
45
pain
22
constipation
17
malaise
15
pyrexia
15
chronic sinusitis
14
4 more recorded rows
dyspepsia
14
infusion related reaction
14
nausea
14
procedural pain
14
recorded 2026-06-24 · last checked 2026-09-04
Q11
Was Ginger studied with fasting and exercise?
fasting and exercise are named in Ginger's label sentences: "The mean of FBS (P = 0.04), fasting insulin (P = 0.01), and HOMA index (P = 0.05) was reduced significantly in the ginger group six weeks after intervention in comparison to the placebo group." openfda-label+europepmc · 2026-07-29
2 recorded statements; fasting, exercise
Show the evidence
fasting
The mean of FBS (P = 0.04), fasting insulin (P = 0.01), and HOMA index (P = 0.05) was reduced significantly in the ginger group six weeks after intervention in comparison to the placebo group.
exercise
Ratings of perceived exertion (RPE) and countermovement jump (CMJ) variables were evaluated before and after exercise. <b>Results:</b> Ginger supplementation significantly improved AMRAP performance compared with placebo (241.6 ± 18.2 vs. 225.9 ± 17.5 repetitions; F<sub>1,29</sub> = 5.95, <i>p</i> = 0.021, ηp<sup>2</sup> = 0.17).
recorded 2026-07-29 · last checked 2026-09-04
Q12
What is recorded about Ginger and AMPK?
"In terms of cellular hallmarks of aging, rosemary plus ginger feeding leads to AMPK activation and improved markers of autophagy and proteostasis in aged flies." — where Ginger and AMPK appear together. Europe PMC · pathway abstract search · 2025-11-19
"In terms of cellular hallmarks of aging, rosemary plus ginger feeding leads to AMPK activation and improved markers of autophagy and proteostasis in aged flies."
autophagyPMID 40072366
"In terms of cellular hallmarks of aging, rosemary plus ginger feeding leads to AMPK activation and improved markers of autophagy and proteostasis in aged flies."
AMPKPMID 41296467
"Zingerone, a primary bioactive compound in ginger, demonstrates protective effects in vascular calcification, non-alcoholic fatty liver disease, and asthma via AMPK activation."
mTORPMID 38331338
"We also provide evidence that the ginger-derived compounds attenuate DC functionality via inhibiting the nuclear factor-κB (NF-kB), mitogen activated protein kinase (MAPK), and mammalian target of rapamycin (mTOR) signaling cascades."
AMPKPMID 40577283
"This study evaluates the effects of a ginger phenol mixture on mitochondrial density and function, AMPK activation, lipid droplet content, and lipolysis markers in adipocytes differentiated in vitro."
mTORPMID 40397499
"6-Shogaol (6-S), a pungent constituent of ginger, has been demonstrated to inhibit metastasis in renal cancer cells, human endometrial carcinoma, and lung and breast cancers by downregulating the PI3K/Akt/mTOR and Ras/Raf/MAPK pathways."
2 more recorded rows
sirtuinPMID 31200315
"Additionally, stimulation of the browning program by ginger may be partly regulated by the sirtuin-1 (SIRT1)/AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) pathway."
mTORPMID 34882874
"It was shown that ginger is a potent inhibitor of the nuclear factor kappa B (NF-κB), signal transducer of activators of transcription (STATs), Nod-like receptor family proteins (NLRPs), toll-like receptors (TLRs), mitogen-activated protein kinase (MAPKs), and mTOR (mTOR) pathways, as well as inhibiting various pro-inflammatory cytokines."
recorded 2025-11-19 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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