Its recorded molecular formula is C22H18O11, weighing 458.4.
PubChem record · 65064 · read 2026-08-29
Where each sentence above came from
No plain explanation of what this changes is stored.
No recorded use is stored in reader language.
No statement of the main limit is recorded.
The four opening statements run to 26 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 26 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Cholesterol
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer1 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Cholesterol
reduction of ldl c
Pain
postoperative pain
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
△ Only a number moved
1 registered test measure.
— Not recorded
Harms were not a registered measure for this goal.
… Waiting for a reviewer
Who was studied is listed further down the page.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
The rate of fatal cardiovascular events
✗ The study did not show it
Who was studied
NCT06590012
How many people
1228
Study design
Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Mammographic Density
✗ The study did not show it
Who was studied
NCT00917735
How many people
1075
Study design
Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Incidence of metachronous colorectal adenomas (tubulovillous, tubular, villous and serrated lesions) at the 3 year follow-up colonoscopy
✗ The study did not show it
Who was studied
NCT01360320
How many people
1001
Study design
Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Event of clinical acute respiratory disease with a diagnosis of COVID-19 confirmed with rtPCR
✗ The study did not show it
Who was studied
NCT04446065
How many people
524
Study design
Phase 2/Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Change in the highest percent Ki-67 expression
✗ The study did not show it
Who was studied
NCT04597359
How many people
360
Study design
Phase 2
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
EBV reactivation rates between EGCG and placebo group
✗ The study did not show it
Who was studied
NCT01744587
How many people
353
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.1 registered measure of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.2 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Drosophila (fruit fly), Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
postoperative pain
Measured
Things only a test, a scale or a device shows.
reduction of ldl c
changes in serum brain derived neurotrophic factor
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (23)
fat oxidation
experiencing serious adverse events
adas cog
safety and tolerability
adverse events
changes in executive function
changes in in executive function
glasgow coma scale
duration of mechanical ventilation
icu stay
salivary proteins
flavor intensity ratings
flavor rankings
changes in epigallocatechin
changes in epicatechin gallate
recruitment rates
retention rates
dose limiting toxicity
maximum tolerated dose
recommended phase 2 dose
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Suitable for:◆Healthy adults who are concerned aboutrespiratory health;◆Long-term smokers, those exposed tosecond-hand smoke, and people who arelong exposed to dust, harmful gases, andcooking fumes;People with lung problems such as coughsthose with sensitive respiratory systemsthose susceptible to viral infections, andthose with poor immunity
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Varies by country
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Sold as gel, capsule, given by the topical, oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
2 products list this as an active ingredient in the United States drug directory. None of them contains it on its own, so nothing on this page can separate it from what it is combined with.
FDA National Drug Code directory · 85631-011 · read 2026-08-29
They are sold as capsule and gel, taken oral and topical.
FDA National Drug Code directory · 85631-011 · read 2026-08-29
2 published labels name it as an active ingredient. None of them describes this substance alone, so no label text on this page can be attributed to it rather than to a combination.
US prescribing information · 57346a86-ab51-021a-e063-6394a90a1dc2 · read 2026-08-29
Those labels are classed as human otc drug.
US prescribing information · 57346a86-ab51-021a-e063-6394a90a1dc2 · read 2026-08-29
1410 marketed supplement labels list this ingredient, classed as botanical, botanical with nutrients, non-nutrient/non-botanical and other combinations.
Those labels carry all other, nutrient and qualified health claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (12)
Q1
What did Egcg's largest trial (353 people) and its longest (11 years) measure?
353 people in Egcg's largest registered study, 11 years in its longest registered window, measuring Change of physical frailty measured using the Short Physical Performance Battery (SPPB) in patients in the EGCG arm compared to placebo; change in SPPB scores from baseline to 12 weeks. ClinicalTrials.gov · 2026-09-01
19 phase2, 11 phase1, 8 phase3, 7 na, 2 early phase1, 2 na or unstated, 2 phase4; NCT01481818; 2022-08. Last human test completed 2026, NCT05811403.
Interpretation These counts include studies where Egcg was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase2
19
phase1
11
phase3
8
na
7
early phase1
2
na or unstated
2
2 more recorded rows
phase4
2
Last recorded human testNCT05811403
2026-06-01
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has Egcg shown lifespan?
Interpretation Change of physical frailty measured using the Short Physical Performance Battery (SPPB) in patients in the EGCG arm compared to placebo; change in SPPB scores… — the recorded outcome words.
Show the evidence
C. elegans
lifespan
Drosophila
lifespan
mouse
lifespan
rat
lifespan
humanNCT06068543
healthspan; Change of physical frailty measured using the Short Physical Performance Battery (SPPB) in patients in the EGCG arm compared to placebo; change in SPPB scores from baseline to 12 weeks.; 43
7 recorded entries; human; orally; also "EGCG 300 mg", "Dietary Supplement: EGCG Capsules with EGCG (at least 94% purity). 300 mg EGCG (2 capsules) taken orally daily for 12…", "Placebo for EGCG 300 mg"
Show the evidence
human
NCT01744587
EGCHAC-purified EGCG 90% capsules
NCT06265532
EGCG 300 mg
NCT06265532
orally; Dietary Supplement: EGCG Capsules with EGCG (at least 94% purity). 300 mg EGCG (2 capsules) taken orally daily for 12 weeks.
NCT06265532
Placebo for EGCG 300 mg
NCT06265532
EGCG 600 mg
NCT06265532
orally; Dietary Supplement: EGCG Capsules with EGCG (at least 94% purity). 600 mg EGCG (4 capsules) taken orally daily for 12 weeks.
1 more recorded row
humanNCT06265532
Placebo for EGCG 600 mg
recorded 2026-09-01 · last checked 2026-09-04
Q5
More Egcg was worse in human: at what point?
U-shaped in human: "In response to this challenge, this study introduces a novel U-shaped model specifically designed for pulmonary nodule segmentation." Europe PMC · dose-response search · 2026-03-18
5 recorded sentences naming Egcg; U-shaped, biphasic, dose-response
Show the evidence
U-shapedPMID 38815486
"In response to this challenge, this study introduces a novel U-shaped model specifically designed for pulmonary nodule segmentation."
biphasic
PMID 41897783
"Pairwise Combination Index analysis further demonstrated concentration-dependent biphasic interactions, exemplified by the epigallocatechin-3-gallate (EGCG)-TFDG pair, while molecular docking suggested overlapping binding sites as a potential structural basis for competitive inhibition."
PMID 41313379
"The EGCG-loaded Col-HA scaffold exhibited a porous microstructure (~ 120 µm pore size) and a biphasic release profile, with sustained EGCG release up to 14 days."
dose-responsePMID 40832777
"We aimed to uncover the protective effects of green tea or EGCG against cancer, and to assess the dose-response relationship between cancer risk and green tea consumption by performing a comprehensive meta-analysis of cohort studies."
biphasicPMID 41200099
"Binding kinetics and thermodynamics studies further reveal that allosteric modulator epigallocatechin-3-gallate (EGCG) binds to the enzyme in a biphasic manner and disrupts the active/inactive conformational dynamics and locks the enzyme in an inactive conformation."
recorded 2026-03-18 · last checked 2026-09-04
Q6
Could one person measure Egcg's effect on fat oxidation?
Fat oxidation: measured in Egcg's trials.
Interpretation fat oxidation is the recorded endpoint.
Show the evidence
biomarkers
fat oxidation; 2026-09-01
experiencing serious adverse events; 2026-09-01
adas cog; 2026-09-01
safety and tolerability; 2026-09-01
adverse events; 2026-09-01
changes in executive function; 2026-09-01
14 more recorded rows
biomarkers
changes in in executive function; 2026-09-01
biomarkers
reduction of ldl c; 2026-09-01
biomarkers
glasgow coma scale; 2026-09-01
biomarkers
duration of mechanical ventilation; 2026-09-01
biomarkers
icu stay; 2026-09-01
biomarkers
salivary proteins; 2026-09-01
biomarkers
flavor intensity ratings; 2026-09-01
biomarkers
flavor rankings; 2026-09-01
biomarkers
changes in epigallocatechin; 2026-09-01
biomarkers
changes in epicatechin gallate; 2026-09-01
biomarkers
recruitment rates; 2026-09-01
biomarkers
retention rates; 2026-09-01
biomarkers
dose limiting toxicity; 2026-09-01
biomarkers
maximum tolerated dose; 2026-09-01
human trials at or under30
14
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT00434499; PHASE2; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q7
Which of adas cog, adverse events and changes in epicatechin gallate did Egcg's trials measure?
adas cog, adverse events and changes in epicatechin gallate lead 26 outcome terms across Egcg's trials. ClinicalTrials.gov · 2026-09-01
Interpretation safety and tolerability, adverse events, changes in executive function, changes in in executive function, reduction of ldl c and glasgow coma scale follow.
Participant Recruitment Rates; Cumulative live birth rate.; latest 2029-12-01
Show the evidence
Trial
NCT01317953
"Oral Green Tea Extract for Small Cell Lung Cancer"
NCT04871412
"The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III"; n 20; "Participant Recruitment Rates"; 2029-12-01
NCT05364008
"FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea"; n 33; "Cumulative live birth rate."; 2026-09-30
NCT06015022
"EGCG for Hepatocellular Carcinoma Chemoprevention"; n 60; "Change in Prognostic Liver Secretome signature (PLSec) score"; 2028-08-31
NCT06531863
"Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance"; n 64; "Changes in total distress as measured via DASS-21 total score."; 2025-08-01
NCT07149506
"Oral or Topical Catechins for Radiation Dermatitis"; n 162; "Change in the incidence of chronic radiation fibrosis"; 2027-03-01
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which 18 trials of Egcg posted no result?
Posted no result
18 of 18 completed trials
Registrations
NCT00611416, NCT00525668, NCT01018615, NCT01662232, NCT02116517 and NCT00951834, and 12 more
Completion dates
oldest 2006-02; newest 2024-07-02
Show the evidence
Trial
NCT00611416
2006-02
NCT00525668
2012-11
NCT01018615
2013-07
NCT01662232
2013-09
NCT02116517
2013-12
NCT00951834
2015-02
12 further recorded trials
NCT01923597
2015-03
NCT01855971
2015-10-31
NCT02731495
2016-01
NCT03199430
2016-02
NCT02558933
2017-09
NCT02015312
2017-10-11
NCT01116336
2018-05
NCT01183767
2018-09-06
NCT01744587
2023-05-16
NCT03978052
2023-06-28
NCT05039983
2024-01-02
NCT06924749
2024-07-02
Q10
At the median, Egcg's trials enrolled 39.5 people — anything larger?
Median enrolment
39.5
Largest enrolment
353
Registered trials counted
42
Q11
Was Egcg studied with fasting and exercise?
fasting and exercise are named in Egcg's label sentences: "Moreover, EGCG+RES reduced fasting (P-time × treatment = 0.03) and postprandial respiratory quotient (P-time × treatment = 0.01) compared with placebo." openfda-label+europepmc · 2025-04-14
Clinical trial data showed improved blood lactate clearance and higher post-exercise blood glucose levels in the AA-EGCG group compared to the placebo group.
recorded 2025-04-14 · last checked 2026-09-04
Q12
What is recorded about Egcg and mTOR?
"Mechanistically, EGCG rescued synaptic structural integrity by suppressing the pro-inflammatory JNK pathway, restoring hippocampal insulin signaling (IRS1/Akt), and stimulating neuronal autophagy through the AMPK/mTOR/ULK1 axis." — where Egcg and mTOR appear together. Europe PMC · pathway abstract search · 2026-08-21
"Mechanistically, EGCG rescued synaptic structural integrity by suppressing the pro-inflammatory JNK pathway, restoring hippocampal insulin signaling (IRS1/Akt), and stimulating neuronal autophagy through the AMPK/mTOR/ULK1 axis."
AMPKPMID 42243131
"Mechanistically, EGCG rescued synaptic structural integrity by suppressing the pro-inflammatory JNK pathway, restoring hippocampal insulin signaling (IRS1/Akt), and stimulating neuronal autophagy through the AMPK/mTOR/ULK1 axis."
autophagy
PMID 42243131
"Mechanistically, EGCG rescued synaptic structural integrity by suppressing the pro-inflammatory JNK pathway, restoring hippocampal insulin signaling (IRS1/Akt), and stimulating neuronal autophagy through the AMPK/mTOR/ULK1 axis."
PMID 42243131
"Together, these data provide translational evidence that EGCG counteracts obesity-linked neurodegeneration by linking metabolic health to hippocampal integrity through the inflammation-insulin-autophagy axis, motivating dietary trials to mitigate cognitive impairment."
PMID 42627559
"Notably, EGCG exerts a context‑dependent bidirectional modulation of autophagy in CVDs, restoring protective autophagy when it is deficient in conditions such as diabetic cardiomyopathy, and suppressing excessive autophagic flux when it is overactivated in conditions such as myocardial ischemia/reperfusion injury."
mTORPMID 42627559
"Emerging studies suggest that EGCG regulates autophagic activity in CVDs through multiple signaling pathways, such as mTOR, SIRT, FoxO, miRNA, and ERK."
AMPK
PMID 41781118
"Mechanistically, EGCG activates the adenosine 5'-monophosphate-activated protein kinase (AMPK)/transcription factor EB (TFEB) signaling axis, leading to enhanced lysosomal biogenesis and ATP production, thereby promoting autophagic clearance."
PMID 41781118
"These findings reveal a novel mechanism by which EGCG inhibits HBV: EGCG promotes autophagic degradation of the viral core protein via activation of the AMPK/TFEB signaling pathway."
sirtuinPMID 42001834
"Mechanistically, EGCG suppressed the NMU-NMUR1-ILC2 axis to reduce the secretion of inflammatory cytokines (TNF-α, IL-6, and IL-8), while concurrently increasing the abundance of beneficial gut microbes and altering signature microbial community functions (energy metabolism pathways); accordingly, EGCG maintained the energy supply balance in gut epithelial cells and promoted the activity of…"
mTORPMID 40706940
"Furthermore, EGCG effectively inhibited the BPA-induced upregulation of the expression level of AMPK (p-AMPKα/AMPKα), significantly restored the BPA-mediated downregulation of the expression levels of p-mTOR/mTOR, p-AKT/AKT and Raptor."
sirtuin
PMID 40918353
"Multiple lines of evidence suggest that EGCG alleviates vascular aging by activating sirtuin 1 (SIRT1), which promotes autophagy and inhibits ferroptosis."
PMID 42392245
"However, EGCG, l-theanine and theophylline effectively abolished all these high-glucose-induced effects on senescence and SIRT1/PGC-1α axis in PTECs, EMT in DTECs, and renal fibroblast activation."
IGF-1
PMID 40552775
"This study reveals how Firmicutes-dominant microbial imbalance drives BPH progression via IGF-1 signaling and identifies the green tea polyphenol epigallocatechin-3-gallate (EGCG) as a dual-action therapeutic."
PMID 40552775
"EGCG emerged as a potent modulator of this gut-prostate axis: it selectively reduced Firmicutes overgrowth in BPH mice, normalized IGF-1 levels, and inhibited downstream PI3K/AKT/mTOR signaling."
PMID 40552775
"Our findings position EGCG as a promising intervention for MetS-associated BPH, simultaneously targeting microbial dysbiosis and IGF-1 signaling."
NAD+
PMID 40774472
"Ten-1 increased the acetylation level of CLDN4, which was inhibited by EGCG without affecting NAD<sup>+</sup> content, a substrate for SIRT2."
PMID 41900981
"Special focus is given to natural compounds, including curcumin, thymoquinone, resveratrol, carnosine, and EGCG, that prevent glycation or restore ALDH function via carbonyl scavenging, antioxidant activation, and NAD<sup>+</sup>/SIRT1 pathway modulation."
PMID 40751793
"Twenty-four-hour supplementation of aged neurons with the NAD precursor nicotinamide and the Nrf2 redox modulator EGCG restored GTP levels to youthful levels and mobilized endocytosis and lysosomal consumption for autophagy via the respective GTPases Rab7 and Arl8b."
recorded 2026-08-21 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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