No plain explanation of what this changes is stored. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 34 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Formulation
A formulation is the exact made-up form a substance comes in.
A picture of it, and where the picture fails
It is like the difference between a whole bean and instant coffee.
Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.
What people get wrong. Two products with the same name are assumed to behave the same. They often do not.
The specific composition and physical form of a product, including salt, excipients and release profile.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Mood
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer4 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Cholesterol
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved5 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Focus
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Body weight
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved2 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Mood
on a depression severity rating scale over eight weeks; hamilton rating scale for depression; montgomery asberg depression scale; edinburgh postnatal depression scale; beck depression scale
Cholesterol
triglycerides; total cholesterol; high density cholesterol; low density cholesterol; very low density cholesterol
Focus
attention; working memory; sustained attention
Body weight
body weight; body mass index
Blood sugar
incident type 2 diabetes
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
4 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
△ Only a number moved
5 registered test measure.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Rate of confirmed viral URIs
✗ The study did not show it
Who was studied
NCT04505098
How many people
39600
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Change in blood pressure
✗ The study did not show it
Who was studied
NCT01653678
How many people
25875
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Dry Eye Disease
✗ The study did not show it
Who was studied
NCT01880463
How many people
25875
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
upper respiratory infection
✗ The study did not show it
Who was studied
NCT01758081
How many people
25874
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Incident total, non-vertebral, and hip fractures
✗ The study did not show it
Who was studied
NCT01704859
How many people
25871
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
COPD Exacerbations Expressed as Cumulative Rate/Year Over 5 Years
✗ The study did not show it
Who was studied
NCT01728571
How many people
25871
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.4 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.11 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Drosophila (fruit fly), Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
hamilton rating scale for depression
montgomery asberg depression scale
edinburgh postnatal depression scale
beck depression scale
Measured
Things only a test, a scale or a device shows.
heart rate variability
serum albumin
heart rate
triglycerides
total cholesterol
high density cholesterol
low density cholesterol
very low density cholesterol
body weight
body mass index
and 1 more.
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (25)
humphrey field analyzer total 30 2 program
gestational age
birth weight
on a depression severity rating scale over eight weeks
clinical global impressions improvement scale
executive function
pulmonary function
n 6 hufa in total hufa
incident autoimmune diseases
incident type 2 diabetes
necrotizing enterocolitis
days to return to full unrestricted athletic participation
pocket depth
dropout rate
liver volume
reporting serious adverse events
tg 4
tc 4
hd c 4
presence of retinopathy of prematurity
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
PRENATE PIXIE ® is a multivitamin/multimineral fatty acid dietary supplement indicated for use in improving the nutritional status of women throughout pregnancy and in the postnatal period for both lactating and nonlactating mothers.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
A different form was studied
The studied form is not the form on the shelf.
On this record: This record is linked to 1 related forms. Evidence does not carry across all of them.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (9)
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Varies by country
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Sold as tablet, film coated, given by the oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Doconexent appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 309 reaction mentions were counted. One report can name several reactions.
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
1 product lists this as an active ingredient in the United States drug directory. None of them contains it on its own, so nothing on this page can separate it from what it is combined with.
FDA National Drug Code directory · 75854-316 · read 2026-08-29
They are sold as tablet, film coated, taken oral.
FDA National Drug Code directory · 75854-316 · read 2026-08-29
1 published label names it as an active ingredient. None of them describes this substance alone, so no label text on this page can be attributed to it rather than to a combination.
US prescribing information · fe0a737e-4f28-40d8-b4a7-090edf86a823 · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · fe0a737e-4f28-40d8-b4a7-090edf86a823 · read 2026-08-29
25085 marketed supplement labels list this ingredient, classed as fat/fatty acid and other combinations.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (14)
Q1
What did Doconexent's largest trial (25871 people) and its longest (15 years) measure?
25871 people in Doconexent's largest registered study, 15 years in its longest registered window, measuring To determine whether supplementation with LOVAZA will exert an anti-inflammatory effect by decreasing levels of the inflammatory biomarker high sensitivity C Reactive Protein (hsCRP) in children and… ClinicalTrials.gov · 2026-09-01
28 na, 19 phase2, 19 phase3, 9 phase1, 4 early phase1, 3 phase4; NCT01351805; 2025-02; no ageing endpoint recorded. Last human test completed 2025, NCT06294067.
Interpretation These counts include studies where Doconexent was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
28
phase2
19
phase3
19
phase1
9
early phase1
4
phase4
3
1 more recorded row
Last recorded human testNCT06294067
2025-03-26
recorded 2026-09-01 · last checked 2026-09-04
Q2
From Drosophila to human: where has Doconexent shown lifespan?
Interpretation To determine whether supplementation with LOVAZA will exert an anti-inflammatory effect by decreasing levels of the inflammatory biomarker high sensitivity C… — the recorded outcome words.
Show the evidence
Drosophila
lifespan
mouse
mechanism-only
rat
mechanism-only
humanNCT01202812
biomarker; To determine whether supplementation with LOVAZA will exert an anti-inflammatory effect by decreasing levels of the inflammatory biomarker high sensitivity C Reactive Protein (hsCRP) in children and adolescents with Sickle Cell Disease…; 72
recorded 2026-09-01 · last checked 2026-09-04
Q3
6 of Doconexent's trials stopped: accrual/recruitment, other?
"decision made not to proceed -- no subjects were ever enrolled"; 6 of 72 registered studies
Show the evidence
Trial
NCT00691418
withdrawn; "decision made not to proceed -- no subjects were ever enrolled"
NCT01965054
withdrawn; "Logistics unresolved at the IRB at Elmhurst Hospital"
NCT02137408
withdrawn; "PI no longer at Institution"
NCT03101527
terminated; "Insufficient recruitment"
NCT03101540
terminated; "Insufficient recruitment"
NCT03402789
withdrawn; "Hopkins failed to review contract with company providing complimentary dha, support was withdrawn necessitating me to get more grant money to fund study which was unsucccessful."
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Doconexent used Docosahexaenoic acid 1000 mg — over how long?
2 recorded entries; human; also "Docosahexaenoic acid (DHA) 1000 mg"
Show the evidence
human
NCT02137408
Docosahexaenoic acid 1000 mg
NCT06302023
Docosahexaenoic acid (DHA) 1000 mg
recorded 2026-09-01 · last checked 2026-09-04
Q5
Did Doconexent move PhenoAge, and by how much?
PhenoAge: "In multivariate linear regression models, eight of the twelve individual serum PUFAs showed a significantly negative association with PhenoAge acceleration, Specifically, per-unit increases in linoleic acid (LA), gamma-linolenic acid (GLA), arachidonic acid (AA), alpha-linolenic acid (ALA), stearidonic acid (SDA),…" Europe PMC · epigenetic clock search · 2025-03-08
1 recorded sentence; 2025; biomarker
Show the evidence
PhenoAgePMID 40057623
2025; "In multivariate linear regression models, eight of the twelve individual serum PUFAs showed a significantly negative association with PhenoAge acceleration, Specifically, per-unit increases in linoleic acid (LA), gamma-linolenic acid (GLA), arachidonic acid (AA), alpha-linolenic acid (ALA), stearidonic acid (SDA), eicosapentaenoic acid (EPA), docosapentaenoic acid (n-3 DPA), and docosahexaenoic…"
recorded 2025-03-08 · last checked 2026-09-04
Q6
More Doconexent was worse in human: at what point?
Hormetic in human: "For egg quality, HT reduced yolk TBARS linearly after 30 days at 22 ± 4°C (P < 0.001), while Haugh units showed a quadratic, hormetic response with best preservation at 10-20 mg/kg (P < 0.001) and lower efficacy at 50 mg/kg. Docosahexaenoic acid (DHA) content in yolk was highest at 20 mg/kg (P = 0.032), with a…" Europe PMC · dose-response search · 2026-04-20
2 recorded sentences naming Doconexent; hormetic, dose-response
Show the evidence
hormeticPMID 42102754
"For egg quality, HT reduced yolk TBARS linearly after 30 days at 22 ± 4°C (P < 0.001), while Haugh units showed a quadratic, hormetic response with best preservation at 10-20 mg/kg (P < 0.001) and lower efficacy at 50 mg/kg. Docosahexaenoic acid (DHA) content in yolk was highest at 20 mg/kg (P = 0.032), with a quadratic response for eicosapentaenoic acid (EPA) concentration (Quadratic effect: P =…"
dose-responsePMID 35647665
"Background Current evidence might support the use of omega-3 fatty acids (preferably docosahexaenoic acid and eicosapentaenoic acid) for lowering blood pressure (BP), but the strength and shape of the dose-response relationship remains unclear."
recorded 2026-04-20 · last checked 2026-09-04
Q7
Could one person measure Doconexent's effect on humphrey field analyzer total 30 2 program?
Humphrey field analyzer total 30 2 program: measured in Doconexent's trials.
humphrey field analyzer total 30 2 program is the recorded endpoint.
Show the evidence
biomarkers
humphrey field analyzer total 30 2 program; 2026-09-01
gestational age; 2026-09-01
birth weight; 2026-09-01
on a depression severity rating scale over eight weeks; 2026-09-01
clinical global impressions improvement scale; 2026-09-01
heart rate variability; 2026-09-01
14 more recorded rows
biomarkers
serum albumin; 2026-09-01
biomarkers
executive function; 2026-09-01
biomarkers
heart rate; 2026-09-01
biomarkers
pulmonary function; 2026-09-01
biomarkers
n 6 hufa in total hufa; 2026-09-01
biomarkers
incident autoimmune diseases; 2026-09-01
biomarkers
incident type 2 diabetes; 2026-09-01
biomarkers
necrotizing enterocolitis; 2026-09-01
biomarkers
days to return to full unrestricted athletic participation; 2026-09-01
biomarkers
pocket depth; 2026-09-01
biomarkers
dropout rate; 2026-09-01
biomarkers
liver volume; 2026-09-01
biomarkers
reporting serious adverse events; 2026-09-01
biomarkers
triglycerides; 2026-09-01
human trials at or under30
13
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT00585390; PHASE2/PHASE3; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; COMPLETED
Q8
Which of 8 isoprostane level in urine, attention and beck depression scale did Doconexent's trials measure?
8 isoprostane level in urine, attention and beck depression scale lead 40 outcome terms across Doconexent's trials. ClinicalTrials.gov · 2026-09-01
Interpretation on a depression severity rating scale over eight weeks, clinical global impressions improvement scale, heart rate variability, serum albumin, executive function and heart rate follow.
Show the evidence
humphrey field analyzer total 30 2 program
1
gestational age
1
birth weight
1
on a depression severity rating scale over eight weeks
1
clinical global impressions improvement scale
1
heart rate variability
1
14 more recorded rows
serum albumin
1
executive function
1
heart rate
1
pulmonary function
1
n 6 hufa in total hufa
1
incident autoimmune diseases
1
incident type 2 diabetes
1
necrotizing enterocolitis
1
days to return to full unrestricted athletic participation
1
pocket depth
1
dropout rate
1
liver volume
1
reporting serious adverse events
1
triglycerides
1
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which of Doconexent's 6 ongoing trials reports first?
Changes in eicosanoids/metabolites including PGE2, PGE3 in breast adipose tissue; Average Change in Perceived Stress Scale (PSS) Score From Visit 1 to Visit 4; latest 2030-09
Show the evidence
Trial
NCT02295059
"Omega 3 Fatty Acids and ERPR(-)HER2(+/-) Breast Cancer Prevention"; n 80; "Changes in eicosanoids/metabolites including PGE2, PGE3 in breast adipose tissue"; 2027-02-05
NCT02647723
"Improving Maternal and Child Health Through Prenatal Fatty Acid Supplementation"; n 168; "Average Change in Perceived Stress Scale (PSS) Score From Visit 1 to Visit 4"; 2027-12-31
NCT03831178
"Docosahexaenoic Acid (DHA) for Women With Breast Cancer in the Neoadjuvant Setting"; n 76; "Percent change in Ki67 index from baseline to surgical excision."; 2030-09
NCT03965988
"Docosahexaenoic Acid on Breath Holding Spells in Children"; n 60; "Frequency of the spells"; 2028-12
NCT06074250
"Perinatal Depression & Anxiety (PDA) and Maternal Gut Microbiome"; n 100; "Feasibility of participant recruitment"; 2028-03
NCT06494488
"Differential Thrombogenesis by EPA and DHA Mediated by HDL"; n 80; "Percentage of Platelet Aggregation Area Under the Curve (AUC) Over Time"; 2028-03-31
recorded 2026-09-01 · last checked 2026-09-04
Q10
Which 33 trials of Doconexent posted no result?
Posted no result
33 of 33 completed trials
Registrations
NCT00004827, NCT00000116, NCT00678067, NCT00610922, NCT00577447 and NCT00662142, and 27 more
Completion dates
oldest 2002-06; newest 2022-05-25
Show the evidence
Trial
NCT00004827
2002-06
NCT00000116
2002-09
NCT00678067
2006-11
NCT00610922
2006-12
NCT00577447
2007-11
NCT00662142
2008-01
14 further recorded trials
NCT00014027
2008-04-11
NCT00585390
2009-11
NCT00749307
2009-11
NCT02537236
2009-12
NCT00892554
2010-01
NCT01200446
2011-01
NCT00885313
2011-03
NCT01947426
2011-04
NCT01558193
2011-07
NCT00530244
2011-10
NCT00325013
2012-05
NCT01049529
2012-09
NCT01796262
2015-06
NCT01940640
2015-11
Q11
At the median, Doconexent's trials enrolled 60 people — anything larger?
Median enrolment
60
Largest enrolment
25871
Registered trials counted
72
Q12
What do 309 spontaneous reports say about Doconexent — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Doconexent appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 309 reaction mentions were counted: somnolence 67; coma 65; gastrooesophageal reflux disease 65; pneumonia aspiration 65. open-targets-adr · CHEMBL367149 · 2026-06-24
Show the evidence
somnolence
67
coma
65
gastrooesophageal reflux disease
65
pneumonia aspiration
65
hepatotoxicity
10
drug-induced liver injury
8
4 more recorded rows
myocardial infarction
8
drug dependence
7
hepatic cirrhosis
7
respiratory depression
7
recorded 2026-06-24 · last checked 2026-09-04
Q13
Was Doconexent studied with exercise?
exercise is named in Doconexent's label sentences: "In this work, a meta-analysis was conducted that adhered to the PRISMA 2020 criteria, incorporating evidence from 41 randomized controlled trials on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation, all of which had been conducted as evidence between 2011 and 2025 and…" openfda-label+europepmc · 2026-04-01
1 recorded statement; exercise
Show the evidence
exercise
In this work, a meta-analysis was conducted that adhered to the PRISMA 2020 criteria, incorporating evidence from 41 randomized controlled trials on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation, all of which had been conducted as evidence between 2011 and 2025 and evaluated the effects of EPA and DHA supplementation on the primary markers of the impact of exercise on…
recorded 2026-04-01 · last checked 2026-09-04
Q14
What is recorded about Doconexent and autophagy?
"Here, we develop a tumor-targeted nanoplatform (HSO-OMDs) loaded with autophagy-induced metformin, docosahexaenoic acid, and chemotherapeutic drug oxaliplatin conjugated to hyaluronic acid, which enhances tumor cell autophagy for the effective elimination of intracellular bacteria." — where Doconexent and autophagy appear together. Europe PMC · pathway abstract search · 2026-06-02
"Here, we develop a tumor-targeted nanoplatform (HSO-OMDs) loaded with autophagy-induced metformin, docosahexaenoic acid, and chemotherapeutic drug oxaliplatin conjugated to hyaluronic acid, which enhances tumor cell autophagy for the effective elimination of intracellular bacteria."
PMID 41910637
"These findings support our prior research, suggesting that DHA’s neuroprotective effects during hypoxia may involve the activation of autophagy pathways, highlighting its potential as a therapeutic strategy.Impact StatementThis study reveals that docosahexaenoic acid (DHA), an omega-3 fatty acid abundant in the brain, enhances neuronal resilience to hypoxia–reoxygenation injury by restoring…"
sirtuinPMID 42311412
"Previously our group demonstrated that the cardioprotective properties of both 19,20-epoxydocosapentaenoic acid (EDP), a CYP450-derived metabolite of docosahexaenoic acid (DHA), and a synthetic structural analog SA-22, were SIRT3-dependent."
AMPKPMID 41265329
"A previous study indicates that 25 μM docosahexaenoic acid (DHA) improves energy metabolism and developmental competence during porcine oocyte in vitro maturation (IVM), demonstrating that its effects could be mediated by AMPK activation since AMPK plays a pivotal role in energy metabolism and homeostasis maintenance."
mTORPMID 41753657
"Metabolomic analysis revealed that NCG modulated key pathways such as sphingolipid metabolism and mTOR signaling pathway, leading to significant changes in metabolites including L-arginine, ceramide, and docosahexaenoic acid (<i>p</i> < 0.05)."
autophagyPMID 41460033
"To investigate the neuroprotective mechanism by which docosahexaenoic acid (DHA) promotes microglial autophagy via the miR-589-5p/toll-like receptor 4 (TLR4) axis in Alzheimer's disease."
recorded 2026-06-02 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
Pnv-Dha, Prenate Enhance, Prenate Mini, Pnv-Omega, Bp Vit 3, Vitafol Ultra, Pnv-Dha / Prenate Enhance / Prenate Mini / Pnv-Omega / Bp Vit 3 / Vitafol Ultra, Prenate Pixie, Sold as fish oil, cod liver oil, krill oil and algal oil. The prescription esters are separate approved drugs: Vascepa (icosapent ethyl) and Lovaza (omega-3-acid ethyl esters).
Sources (11)
Sources
ClinicalTrials.govclinicaltrials.gov ·
ClinicalTrials.govClinicalTrials.gov API v2 snapshot 2026-09-01T09:00:05 ·
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
✗ required summary fields resolved: 5 required field(s) not terminal: Why people use it, Best-supported result, Most important common problem, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 11 source rows
✓ no critical contamination: no quarantine open
✓ canonical metadata passed: slug and display name present
✓ no raw internal fields: enforced by the copy-contract test over the rendered page
This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.