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Creatine Gluconate

  • Hormone
  • Varies by country
  • Identity checked
  • Sources last checked 2026-09-04

This page shows what was measured, who it was measured in, and what that does not settle.

What Creatine Gluconate does in the body

RNAWiki has not recorded what this substance changes in the body.

What happened in people

RNAWiki has not yet published a reviewed conclusion for this use.

A fixed RNAWiki sentence

Where this came from

Wording RNAWiki always uses, not a finding about this substance.

No reviewed claim names a result for any goal on this record.

No source is stored against this line.

The limit that matters most

Not recorded.

Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.

What the registries record it as

  • The supplement label database classes it as non-nutrient/non-botanical, under the name Creatine gluconate.

    NIH Dietary Supplement Label Database · 7147 · read 2026-08-29

Where each sentence above came from

No plain explanation of what this changes is stored.

No recorded use is stored in reader language.

No statement of the main limit is recorded.

The four opening statements run to 26 words.

Words this page uses

Four words worth knowing first

Chosen from what this page shows, with each one explained before the word it depends on.

Stand-in result

A stand-in result is a number measured because the real result takes too long.

A picture of it, and where the picture fails

It is like judging a journey by the speedometer rather than by arriving.

Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.

What people get wrong. A stand-in result is often reported as the result itself.

A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.

Enzyme

An enzyme is a protein that speeds up one chemical change.

A picture of it, and where the picture fails

An enzyme is like a machine on a production line doing one cut.

Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.

What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.

A catalytic protein that lowers the activation energy of a specific reaction.

Receptor

A receptor is a part of a cell that a signal fits into.

A picture of it, and where the picture fails

A receptor is like a lock waiting for one key.

Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.

What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.

A protein that binds a specific ligand and converts that binding into a cellular response.

Pathway

A pathway is a chain of steps inside a cell, each one setting off the next.

A picture of it, and where the picture fails

A pathway is like a row of dominoes.

Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.

What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.

An ordered series of molecular interactions producing a defined cellular change.

What happened in peopleRead from sources, not yet reviewed

What was measured, goal by goal

One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.

Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.

There is no single score. A strong test result and a weak life result are different facts.

Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
GoalLife outcomeWhat a body can doHow a person feelsA test resultA step in the bodyHarmsHow longWho was studied
MoodNothing in the sources checkedNo registered study lists a life outcome for this goal.Nothing in the sources checkedNo registered study lists a performance measure for this goal.Waiting for a reviewer5 registered symptom measure.Nothing in the sources checkedNo registered study lists a test result for this goal.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
StrengthNothing in the sources checkedNo registered study lists a life outcome for this goal.Waiting for a reviewer3 registered performance measure of this kind.Nothing in the sources checkedNo registered study lists a symptom measure for this goal.Nothing in the sources checkedNo registered study lists a test result for this goal.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
MuscleNothing in the sources checkedNo registered study lists a life outcome for this goal.Nothing in the sources checkedNo registered study lists a performance measure for this goal.Nothing in the sources checkedNo registered study lists a symptom measure for this goal.Only a number moved2 registered test measure.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
Blood sugarNothing in the sources checkedNo registered study lists a life outcome for this goal.Nothing in the sources checkedNo registered study lists a performance measure for this goal.Nothing in the sources checkedNo registered study lists a symptom measure for this goal.Only a number moved1 registered test measure.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
Healthy ageingNothing in the sources checkedNo registered study lists a life outcome for this goal.Nothing in the sources checkedNo registered study lists a performance measure for this goal.Nothing in the sources checkedNo registered study lists a symptom measure for this goal.Only a number moved1 registered test measure.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
EnergyNothing in the sources checkedNo registered study lists a life outcome for this goal.Nothing in the sources checkedNo registered study lists a performance measure for this goal.Waiting for a reviewer1 registered symptom measure.Nothing in the sources checkedNo registered study lists a test result for this goal.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
Body weightNothing in the sources checkedNo registered study lists a life outcome for this goal.Nothing in the sources checkedNo registered study lists a performance measure for this goal.Nothing in the sources checkedNo registered study lists a symptom measure for this goal.Only a number moved1 registered test measure.Nothing in the sources checkedNo registered study lists a body-step measure for this goal.Not recordedHarms were not a registered measure for this goal.Not recordedNo finished study window is recorded.Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Mood
hamilton depression rating scale cgi; hamilton depression rating scale; children s depression rating scale; montgomery asberg depression rating scale; madrs
Strength
strength; muscle strength; handgrip strength hand dynamometer
Muscle
lean mass; corrected arm muscle area
Blood sugar
glycated hemoglobin
Healthy ageing
global dna methylation in serum
Energy
fatigue severity scale
Body weight
body mass index

Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.

What each mark on this table means
Nothing in the sources checked
No registered study lists a life outcome for this goal.
Waiting for a reviewer
5 registered symptom measure.
Not recorded
Harms were not a registered measure for this goal.
Only a number moved
2 registered test measure.

What happened in peopleRead from sources, not yet reviewed

What happened in people

Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.

Working Memory Performance

The study did not show it

Who was studied
NCT07319117
How many people
40
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route.

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA SPL label · a recorded source, not a stored snapshot
  • NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
  • PubChem PUG-REST · a recorded source, not a stored snapshot

Loughborough Soccer Passing Test (LSPT) Performance

The study did not show it

Who was studied
NCT07496944
How many people
40
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated

What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.

The limits of this study, and where it came from

Main limit. No limitation is recorded for this study.

How far it carries. This study is recorded from the curated record, not from the registry match.

Form and route.

Interval reported. Not recorded in this summary

Written into the record, not signed off as a reviewed claim.

  • openFDA NDC Directory · a recorded source, not a stored snapshot
  • openFDA SPL label · a recorded source, not a stored snapshot
  • NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
  • PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 2 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.

What happened in peopleRead from sources, not yet reviewed

How close this is to real life

The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.

  1. Living longer, or avoiding a major event No evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
  2. What a body can do day to day Evidence recorded. Walking, dressing, breathing, recovering.8 registered measures of this kind.
  3. Measured performance Evidence recorded. How much was lifted, how far was run, how fast.8 registered measures of this kind.
  4. Symptoms and quality of life Evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.8 registered measures of this kind.
  5. A number that stands in for health Evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.15 registered measures of this kind.
  6. A step measured inside a person Evidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
  7. Animals Evidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Mouse, Rat, Dog. A result in animals says what to test next. It does not say what happens in people.
  8. Cells in a dish Evidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
  9. A guess from software No evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.

Higher on these steps means closer to something a person would feel. It does not mean better done.

What it would be like to takeRead from sources, not yet reviewed

Felt, measured, or meaningful

Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.

Felt

Things a person could notice without a test.

  • positive and negative syndrome scale
  • clincal global impression
  • hamilton depression rating scale cgi
  • hamilton depression rating scale
  • children s depression rating scale
  • montgomery asberg depression rating scale
  • fatigue severity scale
  • madrs

Measured

Things only a test, a scale or a device shows.

  • brachial artery flow mediated dilation
  • glycated hemoglobin
  • blood arsenic concentrations
  • lumbar spine bone mineral density
  • global dna methylation in serum
  • strength
  • muscle strength
  • serum creatinine
  • urine creatinine
  • kidney function

and 9 more.

Meaningful

Things that change how a life goes, not only a number.

  • upper extremity motor function after 3 weeks
  • upper extremity motor function after 9 months
  • total functional capacity
  • als functional rating scale revised

A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.

Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.

Measured, but not felt. A number moves. The person notices nothing. Both can be true.

Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.

Matters, but takes years. The result that counts may take longer than anyone would keep watching.

Names that fit none of the three (9)
  • who gain weight over 1 month
  • completion of study
  • safety
  • rett syndrome motor and behavioral assessment
  • tolerability
  • hamd rating scores
  • objectively assessed whole body function
  • muscle function
  • manual wheelchair slalom test

These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.

What is missing or unclearRead from sources, not yet reviewed

Were people like you studied?

RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.

Who was studied

People similar to this profile were included.

  • May temporarily relieve symptoms associated with exertions, such as muscle pain, muscle weakness, trembling of limbs, and cramps. Label footnote: Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated.

Who is missing from the studies

  • Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

Where the result stopped carrying

  • This is a scope explorer, not a diagnosis engine.
  • It shows who was studied so you can see whether people similar to you were included.

RNAWiki cannot tell whether a study fits you. It can show who was in it.

What it would be like to takeRead from sources, not yet reviewed

Why it might seem to do nothing

A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.

It was studied for a different goal

The studies measured something else entirely.

On this record: Some registered studies measured things that match no goal on this page.

It was studied in different people

The people in the studies were not much like the reader.

On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

The evidence may simply be wrong

Small early studies often do not hold up.

On this record: RNAWiki has not yet published a reviewed conclusion for this use.

Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.

None of these is a reason to take more. Taking more is not a step this page ever suggests.

What it would be like to takeRead from sources, not yet reviewed

What taking it involves

The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.

How it is supplied

Varies by country

Quoted from a source

Where this came from

Copied from a source RNAWiki stored, with the source named.

Read from the recorded approval status.

No source is stored against this line.

Form and route

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

No form or route is recorded.

No source is stored against this line.

Who oversees it

Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.

Quoted from a source

Where this came from

Copied from a source RNAWiki stored, with the source named.

The identity record classes it as a supplement ingredient; no medicines register records an approval.

No source is stored against this line.

What is in the pack

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

Nothing is recorded about product quality.

No source is stored against this line.

Where it is registered

Regulatory records are listed in the technical disclosure at the foot of this page.

Counted from records

Where this came from

A count of rows RNAWiki holds. It describes our records, not your body.

Register entries are stored per jurisdiction and shown with their dates.

No source is stored against this line.

Why people stop

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

No record of why people stopped taking it is stored for this substance.

No source is stored against this line.

What it would be like to takeNothing found in the sources checked

What can go wrong

Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.

Nothing found in the sources checked

No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.

The sources listed were searched and held nothing. That is not the same as nothing existing.

Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.

Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.

What is missing or unclearRead from sources, not yet reviewed

Does the exact form matter?

Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.

The form that was studied

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

The exact form studied is not recorded.

No source is stored against this line.

What is sold

Not recorded.

Nothing recorded

Where this came from

RNAWiki holds nothing here and says so rather than guessing.

Nothing further is recorded about which forms are sold.

No source is stored against this line.

What is recorded as being sold

  • 4314 marketed supplement labels list this ingredient, classed as mineral and non-nutrient/non-botanical.

    NIH Dietary Supplement Label Database · 244633 · read 2026-08-29

  • Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.

    NIH Dietary Supplement Label Database · 244633 · read 2026-08-29

Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.

What it would be like to takeRead from sources, not yet reviewed

What you could measure

This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.

A single-person plan is offered only as a structure for observing yourself. It never calculates an amount to take, and it cannot prove cause.

Questions worth asking

  • Which of the trials of Creatine Gluconate studied people like me?
  • What was measured, and for how long?
  • Was the result a laboratory value or a health outcome?
  • What would we watch for, and when would we stop?

Tracking can show whether something changed for you. It cannot show what caused it.

RNAWiki records evidence. It does not say whether this substance is right for you.

What is missing or unclearRead from sources, not yet reviewed

What nobody knows yet

Open questions, each with why it is open and what would close it.

How much did people take in the studies?

The sources RNAWiki checked hold nothing for this field.

Why it matters. A result belongs to an amount. Without the amount the result floats free.

What would answer it

A stored source that records it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

How fast does the body clear it?

The sources RNAWiki checked hold nothing for this field.

Why it matters. Without this, nothing on this page can say how long anything lasts.

What would answer it

A stored source that records it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Missing populations

Which groups were under-represented in the studies has not been recorded.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Missing long-term data

No completed tested study window is recorded.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

No reviewed conclusion

RNAWiki has not yet published a reviewed conclusion for this use.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Missing interaction studies

No interaction was found in the registers checked. Not finding one is not the same as showing there is none.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Formulation uncertainty

Several salts, forms or products of Creatine Gluconate are recorded. Results from one form may not transfer to another.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

Mechanism not reviewed

No reviewed mechanism story exists for this substance.

Why it matters. Recorded by the evidence model as a gap on this record.

What would answer it

A study that measures it, and a reviewer to sign it off.

Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.

What happened in peopleNothing found in the sources checked

Check any of this yourself

Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.

Nothing found in the sources checked

No traced study record is stored for this substance.

The sources listed were searched and held nothing. That is not the same as nothing existing.

Checks this page had to pass

  • Passed

    Identity resolved

    no open identity hold

  • Passed

    No unresolved merge across substance families

    no quarantine open

  • Not passed

    Every public sentence names a source

    The opening statement carries no source: the record holds neither an explanation nor a recorded use.

  • Not passed

    Trial roles classified for highlighted evidence

    No registered study is classified as testing this substance.

  • Passed

    No internal keys in reader text

    enforced by the copy-contract test over the rendered page

  • Passed

    Safety mode resolved

    The identity record classes it as a supplement ingredient; no medicines register records an approval.

  • Passed

    Canonical metadata present

    slug and display name present

What is missing or unclearRead from sources, not yet reviewed

What to learn next

Ordered by what would most change how you read this page, starting with what is easiest to misunderstand.

This order is fixed in code and does not count clicks or time on the page.

What is not here

7 questions this page could not answer

These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.

  • The path through the body — found nothing in the sources checked.
  • How long anything takes — found nothing in the sources checked.
  • What it may clash with — found nothing in the sources checked.
  • Other ways to the same goal — found nothing in the sources checked.
  • Claims that go past the evidence — found nothing in the sources checked.
  • How this medicine reached us — found nothing in the sources checked.
  • What changed on this page — found nothing in the sources checked.

The record as stored

The full record, for auditing

Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.

Recorded evidence blocks (12)

What did Creatine Gluconate's largest trial (1741 people) and its longest (13 years) measure?

1741 people in Creatine Gluconate's largest registered study, 13 years in its longest registered window, measuring Change in the prevalence of Sarcopenia. ClinicalTrials.gov · 2026-09-01

87 na, 16 phase2, 13 phase3, 8 phase4, 3 early phase1, 3 phase1, 1 na or unstated; NCT00081250; 2017-07. Last human test completed 2026, NCT06675708.

Interpretation These counts include studies where Creatine Gluconate was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.

Show the evidence
  • na
    87
  • phase2
    16
  • phase3
    13
  • phase4
    8
  • early phase1
    3
  • phase1
    3
2 more recorded rows
  • na or unstated
    1
  • Last recorded human test NCT06675708
    2026-06-30

recorded 2026-09-01 · last checked 2026-09-04

From mouse to human: where has Creatine Gluconate shown lifespan?

mouse: lifespan, rat: lifespan, dog: lifespan and human: healthspan (129): the rungs where Creatine Gluconate has a recorded finding. Europe PMC and ClinicalTrials.gov · organism ladder · 2026-09-01

Interpretation Change in the prevalence of Sarcopenia — the recorded outcome words.

Yeast C. elegans Drosophila Mouse lifespanRat lifespanDog lifespanNon-human primate Human healthspan
Show the evidence
  • mouse
    lifespan
  • rat
    lifespan
  • dog
    lifespan
  • human NCT06925880
    healthspan; Change in the prevalence of Sarcopenia; 129

recorded 2026-09-01 · last checked 2026-09-04

10 of Creatine Gluconate's trials stopped: futility/efficacy, accrual/recruitment, funding/business, other?

futility/efficacy (2), accrual/recruitment (1), funding/business (3) and other (4): Creatine Gluconate's stop wording, clustered. ClinicalTrials.gov · 2026-09-01

"Futility"; 10 of 129 registered studies

Show the evidence

Trial

  • NCT00449865
    terminated; "Futility"
  • NCT00712426
    terminated; "Results of an interim analysis showed that it was unlikely that creatine was effective in slowing loss of function in early symptomatic Huntington's Disease."
  • NCT01175616
    withdrawn; "Study withdrawn from ClinicalTrials.gov."
  • NCT02189915
    terminated; "Received funding for the next phase of the study"
  • NCT02463305
    withdrawn; "inability to enroll"
  • NCT02661334
    terminated; "Failure to recruit"
4 further recorded trials
  • NCT03202095
    withdrawn; "No referral from diabetes clinic."
  • NCT03433651
    withdrawn; "Unable to locate grant funding."
  • NCT05856916
    suspended; "Project is on indefinite hold due to a lack of funding"
  • NCT06832423
    withdrawn; "Unable to obtain dietary intervention due to manufacturer withdrawing product from market."

recorded 2026-09-01 · last checked 2026-09-04

More Creatine Gluconate was worse in human: at what point?

Hormetic in human: "However, the degree to which creatine-dependent and -independent systems of phosphate shuttling progressively worsen or potentially adapt in a hormetic manner throughout disease progression remains unknown." Europe PMC · dose-response search · 2024-08-20

4 recorded sentences naming Creatine Gluconate; hormetic, hormesis, U-shaped

Show the evidence
  • hormetic PMID 39178732
    "However, the degree to which creatine-dependent and -independent systems of phosphate shuttling progressively worsen or potentially adapt in a hormetic manner throughout disease progression remains unknown."
  • hormesis PMID 39178732
    "In summary, creatine-dependent mitochondrial bioenergetics are attenuated in older D2.mdx mice in relation to mtCK thiol oxidation that seem to be countered by increased creatine-independent phosphate shuttling as a unique form of mitohormesis."
  • hormetic PMID 39178732
    "These results demonstrate a specific relationship between redox stress and mitochondrial hormetic reprogramming during dystrophin deficiency with proof-of-principle evidence that creatine-dependent bioenergetics could be modified with mitochondrial-targeting small peptide therapeutics."
  • U-shaped PMID 35620514
    "A creatine kinase before the start of PD between 111 and 179 IU/L was associated with a lower risk of death than a higher or lower creatine kinase, resulting in a U-shaped association curve."

recorded 2024-08-20 · last checked 2026-09-04

Could one person measure Creatine Gluconate's effect on upper extremity motor function after 3 weeks?

Upper extremity motor function after 3 weeks: measured in Creatine Gluconate's trials.

upper extremity motor function after 3 weeks is the recorded endpoint.

Show the evidence

biomarkers

  • upper extremity motor function after 3 weeks; 2026-09-01
  • upper extremity motor function after 9 months; 2026-09-01
  • who gain weight over 1 month; 2026-09-01
  • positive and negative syndrome scale; 2026-09-01
  • clincal global impression; 2026-09-01
  • hamilton depression rating scale cgi; 2026-09-01
14 more recorded rows
  • biomarkers
    brachial artery flow mediated dilation; 2026-09-01
  • biomarkers
    completion of study; 2026-09-01
  • biomarkers
    safety; 2026-09-01
  • biomarkers
    total functional capacity; 2026-09-01
  • biomarkers
    hamilton depression rating scale; 2026-09-01
  • biomarkers
    children s depression rating scale; 2026-09-01
  • biomarkers
    glycated hemoglobin; 2026-09-01
  • biomarkers
    blood arsenic concentrations; 2026-09-01
  • biomarkers
    lumbar spine bone mineral density; 2026-09-01
  • biomarkers
    global dna methylation in serum; 2026-09-01
  • biomarkers
    rett syndrome motor and behavioral assessment; 2026-09-01
  • biomarkers
    montgomery asberg depression rating scale; 2026-09-01
  • biomarkers
    strength; 2026-09-01
  • biomarkers
    muscle strength; 2026-09-01
  • human trials at or under30
    57
  • Not recorded for this substance
    a recorded half-life
  • smallest human trial
    0; NCT01175616; PHASE4; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN

Which of als functional rating scale revised, blood arsenic concentrations and body mass index did Creatine Gluconate's trials measure?

als functional rating scale revised, blood arsenic concentrations and body mass index lead 40 outcome terms across Creatine Gluconate's trials. ClinicalTrials.gov · 2026-09-01

Interpretation positive and negative syndrome scale, clincal global impression, hamilton depression rating scale cgi, brachial artery flow mediated dilation, completion of study and safety follow.

Show the evidence
  • upper extremity motor function after 3 weeks
    1
  • upper extremity motor function after 9 months
    1
  • who gain weight over 1 month
    1
  • positive and negative syndrome scale
    1
  • clincal global impression
    1
  • hamilton depression rating scale cgi
    1
14 more recorded rows
  • brachial artery flow mediated dilation
    1
  • completion of study
    1
  • safety
    1
  • total functional capacity
    1
  • hamilton depression rating scale
    1
  • children s depression rating scale
    1
  • glycated hemoglobin
    1
  • blood arsenic concentrations
    1
  • lumbar spine bone mineral density
    1
  • global dna methylation in serum
    1
  • rett syndrome motor and behavioral assessment
    1
  • montgomery asberg depression rating scale
    1
  • strength
    1
  • muscle strength
    1

recorded 2026-09-01 · last checked 2026-09-04

Which of Creatine Gluconate's 27 ongoing trials reports first?

27 registered trials of Creatine Gluconate are open; earliest completion 2017-05. ClinicalTrials.gov · 2026-09-01

Multidimensional Fatigue Inventory (MFI) score; Hamilton Depression Rating Scale (HAMD) Scores; latest 2030-09

Show the evidence

Trial

  • NCT02374112
    "Creatine Supplementation in Chronic Fatigue Syndrome"; n 60; "Multidimensional Fatigue Inventory (MFI) score"; 2025-12
  • NCT02568878
    "Creatine for Depressed Male and Female Methamphetamine Users"; n 29; "Hamilton Depression Rating Scale (HAMD) Scores"; 2017-05
  • NCT05895747
    "5-HTP and Creatine for Depression R33 Phase"; n 106; "17-Item Hamilton Depression Rating Scale"; 2027-09-30
  • NCT06112990
    "Creatine Supplementation and Resistance Training to Preserve Muscle Mass and Attenuate Cancer Progression"; n 200; "Change in total lean mass (kg) as measured by whole-body dual energy x-ray absorptiometry (DXA) scan from baseline to end-of-study (end of week 52) in the Cr+RT arm compared with the PLA+RT arm"; 2028-11-30
  • NCT06208813
    "Creatine Supplementation in Concussion Recovery"; n 20; "Days to asymptomatic"; 2027-05-31
  • NCT06395506
    "THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation"; n 60; "Change in strength in breast cancer survivors"; 2028-05-31
14 further recorded trials
  • NCT06495567
    "Proof of Concept Creatine Supplementation for Homocystinuria Study"; n 9; "Carbon 13 Oxidation"; 2026-12-01
  • NCT06576466
    "Effect of Supplementation With Creatine on the Recovery of Ischemic Stroke"; n 92; "Physical performance"; 2027-07-01
  • NCT06604793
    "Creatine Supplementation in Young Healthy Adults"; n 42; "Whole-body lean mass (kg)"; 2025-01-31
  • NCT06925880
    "Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty"; n 262; "Change in muscle mass"; 2027-10-31
  • NCT06937190
    "Pre-Sleep Creatine Enhances Anaerobic Power in Recreationally Active Females"; n 24; "Average Power Output (Watts) - 30-Second Wingate Test"; 2025-07-10
  • NCT06948149
    "Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment"; n 140; "Corsi Span - Corsi Block Tapping Task"; 2027-12
  • NCT06992414
    "Exploring the Therapeutic Effects of Creatine Supplementation for Long COVID-19"; n 24; "Oxygen consumption at ventilatory threshold"; 2026-10-31
  • NCT07029243
    "Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis"; n 100; "Frailty"; 2026-12
  • NCT07233707
    "Load and Hold: Impact of 7-Day Creatine Monohydrate Loading on Breath-Hold Cycling Performance"; n 26; "Total Work"; 2026-08-26
  • NCT07275996
    "Neuromuscular and Multi-Omics Synergy of Combined Creatine × HMB Supplementation Plus Exercise to Improve Muscle Function in Sarcopenic Frailty"; n 50; "Short Physical Performance Battery (SPPB)"; 2027-05-30
  • NCT07310043
    "Creatine and Perioperative Brain Health"; n 120; "Preoperative cognitive function assessed with the Montreal Cognitive Assessment (MoCA)"; 2028-08-30
  • NCT07372144
    "Creatine and Cognitive Health in Patients With Early-stage Breast Cancer During and After Chemotherapy Treatment"; n 227; "Change in patient-reported cognitive function"; 2028-06-01
  • NCT07451496
    "PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)"; n 20; "Change from baseline in cardiorespiratory fitness (VO₂peak)"; 2026-06-30
  • NCT07463092
    "Creatine Supplementation and Resistance Training to Improve Sarcopenia Parameters in Patients With Prostate Cancer After Androgen Deprivation Therapy"; n 34; "Muscle Density (Ultrasound-derived Echo Intensity and Thickness)"; 2029-01

recorded 2026-09-01 · last checked 2026-09-04

Which running trial of Creatine Gluconate could settle vo2max?

NCT07451496 measures Change from baseline in cardiorespiratory fitness (VO₂peak), reading out 2026-06-30.

4 open trials; n 20; "PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)"

Show the evidence

Trial

  • NCT07451496
    "PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)"; n 20; "Change from baseline in cardiorespiratory fitness (VO₂peak)"; 2026-06-30
  • NCT07029243
    "Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis"; n 100; "Frailty"; 2026-12
  • NCT07275996
    "Neuromuscular and Multi-Omics Synergy of Combined Creatine × HMB Supplementation Plus Exercise to Improve Muscle Function in Sarcopenic Frailty"; n 50; "Short Physical Performance Battery (SPPB)"; 2027-05-30
  • NCT06576466
    "Effect of Supplementation With Creatine on the Recovery of Ischemic Stroke"; n 92; "Physical performance"; 2027-07-01

Which 50 trials of Creatine Gluconate posted no result?

Posted no result
50 of 50 completed trials
Registrations
NCT00063193, NCT00551434, NCT00140192, NCT00070993, NCT00026988 and NCT00016653, and 44 more
Completion dates
oldest 2005-07; newest 2024-07-03
Show the evidence

Trial

  • NCT00063193
    2005-07
  • NCT00551434
    2005-12
  • NCT00140192
    2006-03
  • NCT00070993
    2006-05
  • NCT00026988
    2006-06
  • NCT00016653
    2006-12
14 further recorded trials
  • NCT00797407
    2006-12
  • NCT00355576
    2007-05
  • NCT01147575
    2009-01
  • NCT01367717
    2009-06
  • NCT00992043
    2010-01
  • NCT01050556
    2011-06
  • NCT01213719
    2011-07
  • NCT01057680
    2012-02
  • NCT00729755
    2012-05
  • NCT00592995
    2012-09
  • NCT01411150
    2012-09
  • NCT01817673
    2013-02
  • NCT01411163
    2013-05
  • NCT02058654
    2014-06-24

At the median, Creatine Gluconate's trials enrolled 38 people — anything larger?

Median enrolment
38
Largest enrolment
1741
Registered trials counted
127

Was Creatine Gluconate studied with exercise?

exercise is named in Creatine Gluconate's label sentences: "Eight weeks of this multi-ingredient MCT-leucine-creatine-based supplement induced a modest increase in muscle mass and attenuated the decline in handgrip strength observed in the placebo group among sarcopenic older adults without a structured exercise program, supporting further investigation as…" openfda-label+europepmc · 2026-08-14

1 recorded statement; exercise

Show the evidence
  • exercise
    Eight weeks of this multi-ingredient MCT-leucine-creatine-based supplement induced a modest increase in muscle mass and attenuated the decline in handgrip strength observed in the placebo group among sarcopenic older adults without a structured exercise program, supporting further investigation as a safe and practical nutritional adjunct in geriatric care.

recorded 2026-08-14 · last checked 2026-09-04

What is recorded about Creatine Gluconate and AMPK?

"Mechanistically, disruption of creatine metabolism leads to decreased ATP levels, which not only disturbs actin-related protein 2 (ARP2) distribution and inhibits ARP2-mediated assembly of F-actin but also activates AMPK." — where Creatine Gluconate and AMPK appear together. Europe PMC · pathway abstract search · 2026-07-06

AMPK, mTOR; PMID 42155769, 41077254, 42450333

Show the evidence

AMPK

  • PMID 42155769
    "Mechanistically, disruption of creatine metabolism leads to decreased ATP levels, which not only disturbs actin-related protein 2 (ARP2) distribution and inhibits ARP2-mediated assembly of F-actin but also activates AMPK."
  • PMID 42155769
    "Exogenous supplementation with creatine, YAP agonists, or AMPK inhibitors can partially reverse the aforementioned abnormalities."

mTOR

  • PMID 41077254
    "Additionally, creatine enhanced activation of the PI3K/AKT/mTOR/p70S6K pathway and prevented the ouabain-induced activation of GSK-3β, a kinase involved in mood regulation."
  • PMID 41077254
    "Notably, rapamycin, an mTOR inhibitor, reversed the behavioral effects of creatine, suggesting a mechanistic role for this pathway."
  • "Western blot for relative quantification of protein levels, it was found in this study that creatine could elevate the protein levels of BDNF (Brain Derived Neurotrophic Factor) as well as phosphorylated activation of the AKT (Protein Kinase B) /mTOR (Mechanistic Target of Rapamycin Kinase) and the ERK (Extracellular Signal-Regulated Kinase)/p90RSK (90 KDa Ribosomal Protein S6 Kinase) in the…"
  • AMPK PMID 42450333
    "It also involves failure of the creatine kinase/phosphocreatine (CK/PCr) and adenylate kinase/AMP-activated protein kinase (AK-AMPK) systems, which normally support local ATP buffering, high-energy phosphate transfer, and intracellular energy homeostasis."

recorded 2026-07-06 · last checked 2026-09-04

Where it is registered
Identifiers, relations and other names
Salt form
Creatine, Creatine Monohydrate
Trade name
Recovatone, Colotox, Energy Regulation Combination 9308, Growth Hormone Drops 2160, Recovatone / Colotox / Energy Regulation Combination 9308 / Growth Hormone Drops 2160
Sources (8)

Sources

2 more sources
  • openfda-label+europepmc K4:creatine gluconate ·
  • national registers US ·

ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work

How these records are assembled · Which registers were checked

Index-quality checks
  • identity passed: no open identity hold
  • required summary fields resolved: 4 required field(s) not terminal: Why people use it, Best-supported result, Biggest unanswered question, Human evidence
  • public claims reviewed: 0 reviewed claim(s); drafts are never rendered
  • source coverage passed: 8 source rows
  • no critical contamination: no quarantine open
  • canonical metadata passed: slug and display name present
  • no raw internal fields: enforced by the copy-contract test over the rendered page

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