This page shows what was measured, who it was measured in, and what that does not settle.
What Clonazepam does in the body
Panic disorder, with or without agoraphobia, as defined in DSM-V
From the FDA-approved label: Pharmacodynamics: The precise mechanism by which clonazepam exerts its antiseizure and antipanic effects is unknown, although it is believed to be related to its ability to enhance the activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Pharmacokinetics: Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%. Maximum plasma concentrations of clonazepam are reached within 1 to 4 hours after oral administration. Clonazepam is approximately 85% bound to plasma proteins.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · 5PE9FDE8GB · read 2026-08-29
Where each sentence above came from
The recorded explanation is written in label language rather than for a beginner. The page opens with what it is taken for instead, and the recorded explanation follows below.
Shown as the opening line on this page.
No statement of the main limit is recorded.
The four opening statements run to 111 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 25 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer1 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Cholesterol
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
pain intensity
Cholesterol
changes in total lipid quantities
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
1 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Percentage of patient with a cessation of seizures and absence of recurrence
✗ The study did not show it
Who was studied
NCT01870024
How many people
434
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Assessment of frequency and severity of adverse events
✗ The study did not show it
Who was studied
NCT02374567
How many people
407
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Rates of Remission (LSAS≤30) After 12 Weeks of Randomized Treatment During Phase II, Among Phase I Non-responders
✗ The study did not show it
Who was studied
NCT00282828
How many people
397
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Core Phase: European Medicine Agency (EMA): Seizure Frequency Response Rate
✗ The study did not show it
Who was studied
NCT01713946
How many people
366
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Change from baseline in affective social support at 1 month, 6 months, and 18 months
✗ The study did not show it
Who was studied
NCT06258512
How many people
264
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Number of Biochemically-confirmed Opioid Abstinent 2-week Time Periods
✗ The study did not show it
Who was studied
NCT04278586
How many people
260
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.1 registered measure of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.1 registered measure of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.3 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.2 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Mouse. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
clinical global impression improvement scale
pain intensity
clinical global impression severity scores at 8 weeks
Measured
Things only a test, a scale or a device shows.
changes in hemoglobin distribution
changes in mean corpuscular hemoglobin
Meaningful
Things that change how a life goes, not only a number.
mobility
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (19)
panic disorder symptoms phase 1
panic disorder symptoms phase 2
panic disorder symptoms phase 3
rate and extend of absorption
rate and extent of absorption
seizures
assessment of frequency and severity of adverse events
automated rem without atonia index
satisfaction
changes in leukocyte and components quantities
changes in leukocyte components ratios
quantity changes in megakaryocyte erythroid progenitor
changes in hematocrit
changes in plateletcrit
red cell distribution width coefficient of variation
changes in particulate matter sizes
changes in total lipid quantities
pharmacokinetic outcome measures
visual analog scale
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What it would be like to take◇Read from sources, not yet reviewed
How long anything takes
Nine different lengths of time that get confused with each other. None of them is worked out from another.
Before anything is noticed.RNAWiki does not store this separately, and never works it out from another figure on this page.
Before a test result moves.RNAWiki does not store this separately, and never works it out from another figure on this page.
Before performance moves.RNAWiki does not store this separately, and never works it out from another figure on this page.
How long the result was watched.No finished study window is recorded for a study that tested this substance.
How long people took it.How long people actually took it is not stored. The study window is not the same thing.
How long people were followed.Follow-up length is not stored separately. It is never read off the study window, which would be a different thing.
How fast the body clears it. 30 to 40 hours hours
Read from the label, which states: “The elimination half-life of clonazepam is typically 30 to 40 hours.”
How long effects linger.RNAWiki does not store this separately, and never works it out from another figure on this page.
Beyond the studies. Nothing is recorded about the long term.
The longest finished study sets the edge of what anyone measured.
A study window is not how long people took it, and neither is how long they were followed. Where RNAWiki holds only one of the three, it shows one.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Seizure Disorders: Clonazepam tablets are useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic, and myoclonic seizures. In patients with absence seizures (petit mal) who have failed to respond to succinimides, clonazepam tablets may be useful. Some loss of effect may occur during the course of clonazepam treatment (see PRECAUTIONS: Loss of Effect ).
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Safety and effectiveness in pediatric patients with panic disorder below the age of 18 have not been established.”
US prescribing information · 939dee35-3987-4ce2-9985-3751ceffa20e · read 2026-08-30
On older people, the label states: “Clinical studies of clonazepam did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.”
US prescribing information · 939dee35-3987-4ce2-9985-3751ceffa20e · read 2026-08-30
On people who are pregnant, the label states: “Advise pregnant females that use of clonazepam late in pregnancy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in newborns (see WARNINGS: Neonatal Sedation and Withdrawal Syndrome and PRECAUTIONS: Pregnancy ).”
US prescribing information · 939dee35-3987-4ce2-9985-3751ceffa20e · read 2026-08-30
On people who are breastfeeding, the label states: “Nursing: Instruct patients to inform their healthcare provider if they are breastfeeding or intend to breastfeed.”
US prescribing information · 939dee35-3987-4ce2-9985-3751ceffa20e · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Suppression classes recorded: S6.
No source is stored against this line.
What is in the pack
Sold as tablet, orally disintegrating, tablet, given by the oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Clonazepam appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 7331 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
drug abuse — 1258 reaction mentions
somnolence — 1019 reaction mentions
suicide attempt — 868 reaction mentions
sopor — 679 reaction mentions
toxicity to various agents — 649 reaction mentions
drug interaction — 589 reaction mentions
anxiety — 586 reaction mentions
hypotension — 574 reaction mentions
depression — 559 reaction mentions
coma — 550 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
152 products list this as an active ingredient in the United States drug directory. 152 of them contain it and nothing else.
FDA National Drug Code directory · 72888-134 · read 2026-08-29
They are sold as powder, tablet and tablet, orally disintegrating, taken oral.
FDA National Drug Code directory · 72888-134 · read 2026-08-29
The regulator's established pharmacologic class for it is benzodiazepine [epc] and benzodiazepines [cs].
FDA National Drug Code directory · 72888-134 · read 2026-08-29
95 published labels name it as an active ingredient. 95 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 44f39aa8-a7bc-4e42-977c-31583e6388ae · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · 44f39aa8-a7bc-4e42-977c-31583e6388ae · read 2026-08-29
Clonazepam is oral at HOW SUPPLIED Clonazepam Tablets, USP are available as: 0.5 mg: light yellow, round with flat-faced beveled edge tablets, scored, debossed "2530" on one side and debossed "V" on the reverse side, available as follows: Bo…, recorded as fda label in effect 2026-03-30 in the United States.
US prescribing information · 939dee35-3987-4ce2-9985-3751ceffa20e · read 2026-08-30
Recorded price in US: 0.01973–0.86807 USD per one unit as the pricing file counts it — a tablet, capsule, patch or single item, across 82 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
Self-experiment planning is not offered for a prescription or clinician-supervised medicine. The questions below are for a clinician or pharmacist.
Questions worth asking
Which of the trials of Clonazepam studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Clonazepam are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
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No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
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Check any of this yourself
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How many documents were read
95 documents were read for this substance.
RNAWiki source record
94 of them state the same halfLife, and they agree.
RNAWiki source record
94 of them state the same bioavailability, and they agree.
RNAWiki source record
Where else this substance is registered
FDA substance identifier (UNII)
5PE9FDE8GB
RxNorm concept
197528
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How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
19 approved applications cover products containing this substance. The earliest was NDA017533, approved 19750604 to CHEPLAPHARM.
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5 questions this page could not answer
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Recorded evidence blocks (14)
Q2
What did Clonazepam's largest trial (434 people) and its longest (13 years) measure?
434 people in Clonazepam's largest registered study, 13 years in its longest registered window, measuring AUC last: Area under the curve of plasma concentration from administration up to time t (last sampling timepoint) calculated by trapezoid method. ClinicalTrials.gov · 2026-09-01
10 phase4, 7 na, 7 phase2, 5 phase1, 5 phase3, 1 early phase1; NCT02852577; 2012-08; no ageing endpoint recorded. Last human test completed 2024, NCT06357104.
Interpretation These counts include studies where Clonazepam was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase4
10
na
7
phase2
7
phase1
5
phase3
5
early phase1
1
1 more recorded row
Last recorded human testNCT06357104
2024-03-20
recorded 2026-09-01 · last checked 2026-09-04
Q3
From mouse to human: where has Clonazepam shown lifespan?
Interpretation AUC last: Area under the curve of plasma concentration from administration up to time t (last sampling timepoint) calculated by trapezoid method. — the recorded outcome words.
Show the evidence
mouse
lifespan
humanNCT00810316
biomarker; AUC last: Area under the curve of plasma concentration from administration up to time t (last sampling timepoint) calculated by trapezoid method.; 33
recorded 2026-09-01 · last checked 2026-09-04
Q4
3 of Clonazepam's trials stopped: accrual/recruitment, other?
5 recorded entries; human; also "ClonazePAM 0.5 MG", "Clonazepam 1.5mg", "Clonazepam 0.5 MG"
Show the evidence
human
NCT03255642
ClonazePAM 0.5 MG
NCT03375034
Clonazepam 1.5mg
NCT04364321
Clonazepam 0.5 MG
NCT06834503
Clonazepam TQ 2 mg
NCT07313371
clonazepam 0,25 mg
recorded 2026-09-01 · last checked 2026-09-04
Q6
More Clonazepam was worse in human: at what point?
U-shaped in human: "Clonazepam was more sedative than CBD 300 and 900 mg and induced a smaller increase in systolic and diastolic blood pressure than CBD 300 mg. The results confirmed that the acute administration of CBD induced anxiolytic effects with a dose-dependent inverted U-shaped curve in healthy subjects, since the subjective…" Europe PMC · dose-response search · 2017-05-11
5 recorded sentences naming Clonazepam; U-shaped, hormetic, Dose-response, biphasic
Show the evidence
U-shapedPMID 28553229
"Clonazepam was more sedative than CBD 300 and 900 mg and induced a smaller increase in systolic and diastolic blood pressure than CBD 300 mg. The results confirmed that the acute administration of CBD induced anxiolytic effects with a dose-dependent inverted U-shaped curve in healthy subjects, since the subjective anxiety measures were reduced with CBD 300 mg, but not with CBD 100 and 900 mg, in…"
hormeticPMID 21237231
"The benzodiazepines produced a hormetic (inverted U-shaped) dose-response profile, with intermediate doses producing anxiolysis and no effect at higher doses; clonazepam, a high-potency benzodiazepine agonist, produced a locomotor impairment at the highest dose."
Dose-responsePMID 26255153
"Dose-response functions for combinations of triazolam/pregnanolone, clonazepam/ganaxolone, triazolam/ganaxolone, and clonazepam/pregnanolone were then determined."
biphasic
PMID 15319339
"The metabolism of triazolam, clonazepam, and diazepam was monoexponential at all cell densities using hepatocytes; however, with microsomes, biphasic depletion was apparent, particularly at higher microsomal protein concentrations (2-5 mg/ml)."
PMID 15319339
"For clonazepam (a low clearance substrate), these biphasic profiles could be explained by loss of enzyme activity."
recorded 2017-05-11 · last checked 2026-09-04
Q7
Clonazepam's half-life is 30 to 40 hours — which schedules were studied?
30 to 40 hours, the half-life Clonazepam's label states. openfda-label · 9c3b1b37-8bc0-427a-8c7a-14da7bd49a7f · 2026-08-30
bioavailability 90% %.
Show the evidence
half life
30 to 40 hours hours; The elimination half-life of clonazepam is typically 30 to 40 hours.
bioavailability
90% %; The absolute bioavailability of clonazepam is about 90%.
metabolism
Clonazepam is highly metabolized, with less than 2% unchanged clonazepam being excreted in the urine.
recorded 2026-08-30 · last checked 2026-09-04
Q8
Which of assessment of frequency and severity of adverse events, automated rem without atonia index and changes in hematocrit did Clonazepam's trials measure?
assessment of frequency and severity of adverse events, automated rem without atonia index and changes in hematocrit lead 25 outcome terms across Clonazepam's trials. ClinicalTrials.gov · 2026-09-01
Interpretation rate and extend of absorption, rate and extent of absorption, seizures, clinical global impression improvement scale, assessment of frequency and severity of adverse events and pain intensity follow.
Show the evidence
panic disorder symptoms phase 1
1
panic disorder symptoms phase 2
1
panic disorder symptoms phase 3
1
rate and extend of absorption
1
rate and extent of absorption
1
seizures
1
14 more recorded rows
clinical global impression improvement scale
1
assessment of frequency and severity of adverse events
1
pain intensity
1
clinical global impression severity scores at 8 weeks
1
automated rem without atonia index
1
satisfaction
1
changes in leukocyte and components quantities
1
changes in leukocyte components ratios
1
quantity changes in megakaryocyte erythroid progenitor
1
changes in hemoglobin distribution
1
changes in mean corpuscular hemoglobin
1
changes in hematocrit
1
changes in plateletcrit
1
red cell distribution width coefficient of variation
1
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which of Clonazepam's 4 ongoing trials reports first?
"Enhancing Mobility and Mental Health in Dementia Patients"; n 6; "Mobility"; 2025-12-20
NCT06834503
"Bioequivalence Study of Clonazepam 2 Mg Tablets"; n 24; "Pharmacokinetic Outcome Measures"; 2025-11-01
NCT07313371
"Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine and Crack Use Disorder"; n 36; "Visual Analog Scale (VAS)"; 2027-07
NCT07498387
"Management of Catatonic Features in Adolescents With Profound Autism"; n 30; "Change in Pediatric Catatonia Rating Scale (PCRS) score from baseline to week 12"; 2026-10
recorded 2026-09-01 · last checked 2026-09-04
Q10
Which 14 trials of Clonazepam posted no result?
Posted no result
14 of 14 completed trials
Registrations
NCT00652639, NCT00652912, NCT00810316, NCT01011036, NCT01291316 and NCT02852577, and 8 more
Completion dates
oldest 2004-04; newest 2024-03-20
Show the evidence
Trial
NCT00652639
2004-04
NCT00652912
2004-05
NCT00810316
2008-11
NCT01011036
2010-06
NCT01291316
2011-11
NCT02852577
2012-08
8 further recorded trials
NCT02382029
2014-11
NCT02312908
2016-03
NCT03375034
2018-01-31
NCT01870024
2018-02-23
NCT04884503
2020-09-06
NCT03255642
2020-12-01
NCT06217731
2023-12-10
NCT06357104
2024-03-20
Q11
At the median, Clonazepam's trials enrolled 34 people — anything larger?
Median enrolment
34
Largest enrolment
434
Registered trials counted
33
Q12
What do 7331 spontaneous reports say about Clonazepam — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Clonazepam appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 7331 reaction mentions were counted: drug abuse 1258; somnolence 1019; suicide attempt 868; sopor 679. open-targets-adr · CHEMBL452 · 2026-06-24
Show the evidence
drug abuse
1258
somnolence
1019
suicide attempt
868
sopor
679
toxicity to various agents
649
drug interaction
589
4 more recorded rows
anxiety
586
hypotension
574
depression
559
coma
550
recorded 2026-06-24 · last checked 2026-09-04
Q13
Clonazepam and CYP3A4 and Cytochrome P450: shared by which compounds?
CYP3A4 and Cytochrome P450 appear in Clonazepam's recorded interaction sentences, 2 in all. openfda-label+europepmc · 2026-08-18
Interpretation drug_interactions
Show the evidence
CYP3A4drug_interactions
The selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate (CYP2C19 inhibitor and CYP3A4 inducer) do not affect the pharmacokinetics of clonazepam.
Cytochrome P450drug_interactions
Cytochrome P450 inducers, such as phenytoin, carbamazepine, lamotrigine, and phenobarbital induce clonazepam metabolism, causing an approximately 38% decrease in plasma clonazepam levels.
recorded 2026-08-18 · last checked 2026-09-04
Q14
Was Clonazepam studied with fasting?
fasting is named in Clonazepam's label sentences: "A randomized, two-way crossover study was conducted in 24 fasting healthy male volunteers of Indian origin to compare the bioavailability of two brands of a fixed dose combination of escitalopram oxalate (CAS 219861-08-2) 10 mg and clonazepam (CAS 1622-61-3) 0.5 mg tablets, using Estomine-zee as…" openfda-label+europepmc · 2026-08-18
1 recorded statement; fasting
Show the evidence
fasting
A randomized, two-way crossover study was conducted in 24 fasting healthy male volunteers of Indian origin to compare the bioavailability of two brands of a fixed dose combination of escitalopram oxalate (CAS 219861-08-2) 10 mg and clonazepam (CAS 1622-61-3) 0.5 mg tablets, using Estomine-zee as test and a commercially available formulation as the reference product.
recorded 2026-08-18 · last checked 2026-09-04
Q15
What is recorded about Clonazepam and NAD+?
"All the studied benzodiazepines (phenazepam, nitrazepam, clonazepam, flunitrazepam) are able to displace [14C] NAD from its receptor sites, the mixed type of inhibition being manifested." — where Clonazepam and NAD+ appear together. Europe PMC · pathway abstract search · 1991-05-01
NAD+; PMID 1926588
Show the evidence
NAD+PMID 1926588
"All the studied benzodiazepines (phenazepam, nitrazepam, clonazepam, flunitrazepam) are able to displace [14C] NAD from its receptor sites, the mixed type of inhibition being manifested."
recorded 1991-05-01 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
✗ required summary fields resolved: 5 required field(s) not terminal: Why people use it, Best-supported result, Most important common problem, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 11 source rows
✓ no critical contamination: no quarantine open
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This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.