This page shows what was measured, who it was measured in, and what that does not settle.
What Choriogonadotropin beta does in the body
HCG HAS NOT BEEN DEMONSTRATED TO BE EFFECTIVE ADJUNCTIVE THERAPY IN THE TREATMENT OF OBESITY.
From the FDA-approved label: The action of HCG is virtually identical to that of pituitary LH, although HCG appears to have a small degree of FSH activity as well. It stimulates production of gonadal steroid hormones by stimulating the interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone. Androgen stimulation in the male leads to the development of secondary sex characteristics and may stimulate testicular descent when no anatomical impediment to descent is present. This descent is usually reversible when HCG is discontinued.
Why people take it. HCG HAS NOT BEEN DEMONSTRATED TO BE EFFECTIVE ADJUNCTIVE THERAPY IN THE TREATMENT OF OBESITY.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
What the registries record it as
2 registered substances share the start of this name, which is why a search for it can return more than one thing.
FDA substance registry · 20ED16GHEB · read 2026-08-29
Where each sentence above came from
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 135 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Fertility and sexual health
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved2 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
△ Only a number moved
2 registered test measure.
— Not recorded
Harms were not a registered measure for this goal.
… Waiting for a reviewer
Who was studied is listed further down the page.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters
✗ The study did not show it
Who was studied
NCT00006445
How many people
38000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Adverse pregnancy outcome
✗ The study did not show it
Who was studied
NCT05934318
How many people
2960
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Live birth
✗ The study did not show it
Who was studied
NCT04407871
How many people
2728
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Live Birth
✗ The study did not show it
Who was studied
NCT01857310
How many people
2370
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
live birth rate per transferred cycle
✗ The study did not show it
Who was studied
NCT03809221
How many people
1892
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Percentage of Participants With an Ongoing Pregnancy (Ongoing Pregnancy Rate)
✗ The study did not show it
Who was studied
NCT00696800
How many people
1509
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
□Symptoms and quality of lifeNo evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.No registered study measures this.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.5 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.2 registered measures inside human tissue.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Mouse, Rat, Non-human primate. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
No registered study measured anything of this kind.
Measured
Things only a test, a scale or a device shows.
serum testosterone
serum luteinizing hormone
serum follicle stimulating hormone
endometrial gene expression profile
day 3 embryos for biopsy available
sperm concentration
serum calcium
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (33)
mature oocytes
implantation rate
intratesticular testosterone
pregnancy rate
oocyte retrieved
who met both index 1 and index 2
who had at least one follicle greater than 17mm in diameter
who refused to take hcg injection
cumulus oocyte complexes retrieved during oocyte pick up
mii oocytes
clinical pregnancy rate per embryo transfer
clinical pregnancy rates
live birth
clinical pregnancy rate
phase i mtd
complete response
partial response
ovulation rate
clinical pregnancy rate per cycle and per woman
testosterone
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
HCG HAS NOT BEEN DEMONSTRATED TO BE EFFECTIVE ADJUNCTIVE THERAPY IN THE TREATMENT OF OBESITY. THERE IS NO SUBSTANTIAL EVIDENCE THAT IT INCREASES WEIGHT LOSS BEYOND THAT RESULTING FROM CALORIC RESTRICTION, THAT IT CAUSES A MORE ATTRACTIVE OR ‘‘NORMAL’’ DISTRIBUTION OF FAT, OR THAT IT DECREASES THE HUNGER AND DISCOMFORT ASSOCIATED WITH CALORIE-RESTRICTED DIETS. 1.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Safety and effectiveness of chorionic gonadotropin in children below the age of four have not been established.”
US prescribing information · f93b2baa-03ac-4650-b35a-20b818d712d6 · read 2026-08-30
On people who are pregnant, the label states: “Teratogenic Effects: Chorionic gonadotropin may cause fetal harm when administered to a pregnant woman.”
US prescribing information · f93b2baa-03ac-4650-b35a-20b818d712d6 · read 2026-08-30
On people who are breastfeeding, the label states: “It is not known whether chorionic gonadotropin is excreted in human milk.”
US prescribing information · f93b2baa-03ac-4650-b35a-20b818d712d6 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Varies by country
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Sold as liquid, given by the oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Choriogonadotropin beta appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 1659 reaction mentions were counted. One report can name several reactions.
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
2 products list this as an active ingredient in the United States drug directory. 2 of them contain it and nothing else.
FDA National Drug Code directory · 67657-0005 · read 2026-08-29
They are sold as liquid and powder, taken oral.
FDA National Drug Code directory · 67657-0005 · read 2026-08-29
3 published labels name it as an active ingredient. 3 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · c52c048d-bd76-42ab-b328-b82cc3849fb0 · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · c52c048d-bd76-42ab-b328-b82cc3849fb0 · read 2026-08-29
2 marketed supplement labels list this ingredient, classed as other combinations.
Those labels carry all other and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (11)
Q1
What did Choriogonadotropin beta's largest trial (750 people) and its longest (7.5 years) measure?
750 people in Choriogonadotropin beta's largest registered study, 7.5 years in its longest registered window, measuring Sperm concentration. ClinicalTrials.gov · 2026-09-01
30 phase4, 17 na, 14 phase2, 10 phase3, 9 phase1, 5 na or unstated; NCT02147964; 2026-12; no ageing endpoint recorded. Last human test completed 2024, NCT06725004.
Interpretation These counts include studies where Choriogonadotropin beta was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase4
30
na
17
phase2
14
phase3
10
phase1
9
na or unstated
5
1 more recorded row
Last recorded human testNCT06725004
2024-06-30
recorded 2026-09-01 · last checked 2026-09-04
Q2
From mouse to human: where has Choriogonadotropin beta shown lifespan?
3 recorded entries; human; also "Pregnyl 7500 IU", "Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU)"
Show the evidence
human
NCT00415766
Pregnyl 5000 IU
NCT00415766
Pregnyl 7500 IU
NCT01601327
Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU)
recorded 2026-09-01 · last checked 2026-09-04
Q5
Could one person measure Choriogonadotropin beta's effect on mature oocytes?
Mature oocytes: measured in Choriogonadotropin beta's trials.
Interpretation mature oocytes is the recorded endpoint.
Show the evidence
biomarkers
mature oocytes; 2026-09-01
implantation rate; 2026-09-01
serum testosterone; 2026-09-01
serum luteinizing hormone; 2026-09-01
serum follicle stimulating hormone; 2026-09-01
intratesticular testosterone; 2026-09-01
14 more recorded rows
biomarkers
pregnancy rate; 2026-09-01
biomarkers
oocyte retrieved; 2026-09-01
biomarkers
who met both index 1 and index 2; 2026-09-01
biomarkers
who had at least one follicle greater than 17mm in diameter; 2026-09-01
biomarkers
who refused to take hcg injection; 2026-09-01
biomarkers
cumulus oocyte complexes retrieved during oocyte pick up; 2026-09-01
biomarkers
endometrial gene expression profile; 2026-09-01
biomarkers
mii oocytes; 2026-09-01
biomarkers
clinical pregnancy rate per embryo transfer; 2026-09-01
biomarkers
day 3 embryos for biopsy available; 2026-09-01
biomarkers
sperm concentration; 2026-09-01
biomarkers
clinical pregnancy rates; 2026-09-01
biomarkers
live birth; 2026-09-01
biomarkers
clinical pregnancy rate; 2026-09-01
human trials at or under30
12
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT01599494; PHASE3; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q6
Which of clinical pregnancy rate, clinical pregnancy rate per cycle and per woman and clinical pregnancy rate per embryo transfer did Choriogonadotropin beta's trials measure?
clinical pregnancy rate, clinical pregnancy rate per cycle and per woman and clinical pregnancy rate per embryo transfer lead 40 outcome terms across Choriogonadotropin beta's trials. ClinicalTrials.gov · 2026-09-01
serum luteinizing hormone, serum follicle stimulating hormone, intratesticular testosterone, pregnancy rate, oocyte retrieved and who met both index 1 and index 2 follow.
Show the evidence
mature oocytes
1
implantation rate
1
serum testosterone
1
serum luteinizing hormone
1
serum follicle stimulating hormone
1
intratesticular testosterone
1
14 more recorded rows
pregnancy rate
1
oocyte retrieved
1
who met both index 1 and index 2
1
who had at least one follicle greater than 17mm in diameter
1
who refused to take hcg injection
1
cumulus oocyte complexes retrieved during oocyte pick up
1
endometrial gene expression profile
1
mii oocytes
1
clinical pregnancy rate per embryo transfer
1
day 3 embryos for biopsy available
1
sperm concentration
1
clinical pregnancy rates
1
live birth
1
clinical pregnancy rate
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of Choriogonadotropin beta's 6 ongoing trials reports first?
"Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome"; n 150; "Design 1 : sperm retrieval rate at mTESE biopsy"; 2027-04-30
NCT06754332
"The Study of Human Chorionic Gonadotropin (HCG) Activating the Dormant Follicles ."; n 60; "focilles"; 2029-08-31
NCT06904599
"Efficacy of Human Chorionic Gonadotropin in Acute GVHD Treatment"; n 20; "Measurement of GVHD response"; 2026-01-31
NCT07523022
"Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups"; n 500; "sperm DNA fragmentation"; 2026-12-01
NCT07633002
"The Application of HCG in Luteal Support for Frozen Embryo Transfer in Ovulation Cycle of Obese Women"; n 750; "Live birth"; 2027-12-31
NCT07771283
"Purpose to Evaluate the Effectiveness of the Superovulation Stimulation Protocol Using Human Chorionic Gonadotropin (hCG) by Demonstrating Its Equivalence to Standard Controlled Ovarian Stimulation Protocols in Terms of Oocytes Retrieved, Blastulation While Maintaining an Economic Advantage"; n 360; "Number of oocytes retrieved (oocyte yield)"; 2028-05-01
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which 38 trials of Choriogonadotropin beta posted no result?
Posted no result
38 of 38 completed trials
Registrations
NCT00702806, NCT01081756, NCT00223860, NCT00750100, NCT00953628 and NCT00809107, and 32 more
Completion dates
oldest 2002-10-15; newest 2024-06-30
Show the evidence
Trial
NCT00702806
2002-10-15
NCT01081756
2004-09
NCT00223860
2007-12
NCT00750100
2008-11
NCT00953628
2008-12
NCT00809107
2009-01
14 further recorded trials
NCT00844311
2010-06
NCT00870025
2010-09
NCT00947713
2010-12
NCT01601327
2012-03
NCT02427529
2012-12
NCT01888744
2013-06
NCT02788136
2014-07
NCT04605107
2015-03-08
NCT02739516
2015-08
NCT03208972
2015-11
NCT02148393
2017-02-28
NCT03334877
2017-10-01
NCT02397551
2018-01
NCT02397642
2018-01
Q9
At the median, Choriogonadotropin beta's trials enrolled 100 people — anything larger?
Median enrolment
100
Largest enrolment
750
Registered trials counted
78
Q10
What do 1659 spontaneous reports say about Choriogonadotropin beta — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Choriogonadotropin beta appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 1659 reaction mentions were counted: ovarian hyperstimulation syndrome 879; ascites 262; dyspnoea 106; abdominal pain 98. open-targets-adr · CHEMBL1201509 · 2026-06-24
Show the evidence
ovarian hyperstimulation syndrome
879
ascites
262
dyspnoea
106
abdominal pain
98
abdominal distension
85
pleural effusion
72
4 more recorded rows
abortion spontaneous
63
abdominal pain lower
33
peritoneal haemorrhage
31
adnexal torsion
30
recorded 2026-06-24 · last checked 2026-09-04
Q11
What is recorded about Choriogonadotropin beta and mTOR?
"This review focuses on the biological mechanisms that may provide an avenue for improved clinical outcomes by enhancing oocyte quality through more targeted therapy: differing follicle-stimulating hormone isoforms; follicle-stimulating hormone dose effects; distinct signaling pathways of luteinizing hormone and human chorionic…" — where Choriogonadotropin beta and mTOR appear together. Europe PMC · pathway abstract search · 2026-05-18
"This review focuses on the biological mechanisms that may provide an avenue for improved clinical outcomes by enhancing oocyte quality through more targeted therapy: differing follicle-stimulating hormone isoforms; follicle-stimulating hormone dose effects; distinct signaling pathways of luteinizing hormone and human chorionic gonadotropin (hCG); androgen priming; growth hormone; letrozole…"
IGF-1PMID 34399087
"JEG-3 cells were treated with DEX, an expression plasmid encoding human glucocorticoid receptor α (GRα), pcDNA3.1-GRα, GRα short interference (si) RNA, LY294002, xanthine oxidase (XO)/hypoxanthine (HX), rapamycin, insulin-like growth factor (IGF) 1, N-acetylcysteine (NAC) or phosphatidic acid (PA), and cell proliferation, apoptosis, mitochondrial membrane potential (MMP), human chorionic…"
autophagyPMID 40395319
"Our findings might have important clinical implications by opening a new avenue for the understanding and treatment of a wide range of diseases varying from reproductive disorders to sex hormone-producing neoplasms and hormone dependent malignancies, such as carcinomas of breast, endometrium, and prostate. <b>Abbreviations:</b> ACAT, Acyl-coenzyme A-cholesterol-acyl-transferase; AMBRA1, autophagy…"
mTORPMID 31983283
"Collectively, this study highlights a vital role of m<sup>6</sup>A RNA methylation in the modulation of testosterone synthesis in LCs, providing insight into novel therapeutic strategies by exploiting m<sup>6</sup>A RNA methylation as targets for treating azoospermatism and oligospermatism patients with reduction in serum testosterone.<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACTB: Actin,…"
AMPKPMID 31983283
"Collectively, this study highlights a vital role of m<sup>6</sup>A RNA methylation in the modulation of testosterone synthesis in LCs, providing insight into novel therapeutic strategies by exploiting m<sup>6</sup>A RNA methylation as targets for treating azoospermatism and oligospermatism patients with reduction in serum testosterone.<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACTB: Actin,…"
autophagyPMID 38074457
"Human chorionic gonadotropin (hCG)-stimulated T production in Leydig cells was not remarkably altered in the presence of an autophagy inhibitor 3-methyladenine (3-MA)."
2 more recorded rows
mTORPMID 31329230
"Using cultured human or mouse granulosa cells, our study revealed the time-dependent activation of the mTOR signaling pathway after human chorionic gonadotropin (hCG) treatment."
sirtuinPMID 28108987
"We investigated the immune-suppressive mechanisms of the human pregnancy hormone, chorionic gonadotropin (hCG), in the liver. hCG signaling activates silent mating type information regulation 2 homolog 1 (SIRT1), which deacetylates forkhead box o3 (FOXO3a), leading to repression of proapoptotic gene expression, because the immunosuppressive consequence attributed to the absence of caspase-3…"
recorded 2026-05-18 · last checked 2026-09-04
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