This page shows what was measured, who it was measured in, and what that does not settle.
What Chlortalidone does in the body
THALITONE is a thiazide-like diuretic indicated: • For the treatment of hypertension, to lower blood pressure.
From the FDA-approved label: Chlorthalidone is a long-acting oral diuretic with antihypertensive activity. Chlorthalidone produces diuresis with increased excretion of sodium and chloride. The site of action appears to be the cortical diluting segment of the ascending limb of Henle’s loop of the nephron. The diuretic effects of chlorthalidone lead to decreased extracellular fluid volume, plasma volume, cardiac output, total exchangeable sodium, glomerular filtration rate, and renal plasma flow. Although the mechanism of action of chlorthalidone and related drugs is not wholly clear, sodium and water depletion appear to provide a basis for its antihypertensive effect.
Why people take it. THALITONE is a thiazide-like diuretic indicated: • For the treatment of hypertension, to lower blood pressure.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · Q0MQD1073Q · read 2026-08-29
Where each sentence above came from
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 137 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Biomarker
A biomarker is a number from a test that stands in for something about health.
A picture of it, and where the picture fails
A biomarker is like a fuel gauge.
Where that stops being true. A gauge is wired to the tank. Many biomarkers are only loosely tied to health.
What people get wrong. A better number is read as a better life. Several medicines improved a number and helped nobody.
A measurable indicator used as a substitute for a clinical outcome of interest.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 37 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Healthy ageing
…Waiting for a reviewer3 registered study measure of this kind. No reviewed result yet.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Fertility and sexual health
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Healthy ageing
all cause hospitalization or all cause mortality; all cause mortality; mortality days in hospital decongestion
Blood sugar
fasting plasma glucose from week 4 to week 16
Fertility and sexual health
urine concentration of testosterone metabolites
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
… Waiting for a reviewer
3 registered study measure of this kind. No reviewed result yet.
∅ Nothing in the sources checked
No registered study lists a performance measure for this goal.
— Not recorded
Harms were not a registered measure for this goal.
△ Only a number moved
1 registered test measure.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Time From Randomization to Composite Primary Outcome
✗ The study did not show it
Who was studied
NCT02185417
How many people
20723
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
First Occurrence of a Major Cardiovascular Event (MCE); Specifically Nonfatal Heart Attack, Nonfatal Stroke, or Cardiovascular Death (Measured Throughout the Study) in the Glycemia Trial.
✗ The study did not show it
Who was studied
NCT00000620
How many people
10251
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Persistance and adherence to treatment
✗ The study did not show it
Who was studied
NCT00408512
How many people
2500
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Number of Covid-19 positive participants who die, require intubation in ICU, or require hospitalization for non-invasive ventilation (NIV)
✗ The study did not show it
Who was studied
NCT04330300
How many people
2414
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Conversion to chlorthalidone, number of patients with primary fills
✗ The study did not show it
Who was studied
NCT02591628
How many people
2027
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Blood pressure (mmHg)
✗ The study did not show it
Who was studied
NCT01643434
How many people
2000
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.3 registered measures of this kind. 1 written-up study measured this and did not show a benefit.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
□Symptoms and quality of lifeNo evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.No registered study measures this.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.18 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
□AnimalsNo evidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.No animal record is stored.
□Cells in a dishNo evidence recorded. Cells or chemistry on a bench, far from a whole body.No cell or bench record is stored.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
No registered study measured anything of this kind.
Measured
Things only a test, a scale or a device shows.
blood pressure
diastolic blood pressure by cuff 8 10 weeks minus baseline
blood pressure from baseline to treatment
systolic 24 hour ambulatory blood pressure
fasting plasma glucose from week 4 to week 16
seated automated office systolic blood pressure
urinary calcium excretion
24 h systolic blood pressure measured by abpm
24 h diastolic blood pressure measured by abpm
urine concentration of bupropion metabolites
and 8 more.
Meaningful
Things that change how a life goes, not only a number.
all cause hospitalization or all cause mortality
all cause mortality
mortality days in hospital decongestion
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (16)
part a auc cmax of telmisartan
flow mediated vasodilatation
fluorescence intensity of pac 1
time from randomization to composite primary outcome
had a composite primary outcome
auclast
cmax
bioequivalence study is based on cmax and auc parameters
average daytime sbp
hypercalcemia
hyperglycemia
pulse wave velocity
stress myocardial perfusion reserve on cardiac mri
area under the curve from time zero to infinity calculated
elimination rate
myocardial flow reserve
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What it would be like to take◇Read from sources, not yet reviewed
How long anything takes
Nine different lengths of time that get confused with each other. None of them is worked out from another.
Before anything is noticed.RNAWiki does not store this separately, and never works it out from another figure on this page.
Before a test result moves.RNAWiki does not store this separately, and never works it out from another figure on this page.
Before performance moves.RNAWiki does not store this separately, and never works it out from another figure on this page.
How long the result was watched.No finished study window is recorded for a study that tested this substance.
How long people took it.How long people actually took it is not stored. The study window is not the same thing.
How long people were followed.Follow-up length is not stored separately. It is never read off the study window, which would be a different thing.
How fast the body clears it. 40 to 60 hours hours
Read from the label, which states: “Elimination The mean plasma half-life of chlorthalidone is about 40 to 60 hours.”
How long effects linger.RNAWiki does not store this separately, and never works it out from another figure on this page.
Beyond the studies. Nothing is recorded about the long term.
The longest finished study sets the edge of what anyone measured.
A study window is not how long people took it, and neither is how long they were followed. Where RNAWiki holds only one of the three, it shows one.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Diuretics such as chlorthalidone are indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Safety and effectiveness in children have not been established.”
US prescribing information · bc5a0299-115b-4e60-bb3f-c75a95c51c15 · read 2026-08-30
On older people, the label states: “Clinical studies of THALITONE did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.”
US prescribing information · bc5a0299-115b-4e60-bb3f-c75a95c51c15 · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary Available data over decades from observational studies and reports with chlorthalidone use in pregnant women have not identified a drug-associated risk of major birth defects or miscarriage.”
US prescribing information · bc5a0299-115b-4e60-bb3f-c75a95c51c15 · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary Chlorthalidone is present in human milk.”
US prescribing information · bc5a0299-115b-4e60-bb3f-c75a95c51c15 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as tablet, capsule, given by the oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Chlortalidone appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 648 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
hyponatraemia — 121 reaction mentions
hypokalaemia — 109 reaction mentions
nausea — 91 reaction mentions
hypotension — 65 reaction mentions
dizziness — 55 reaction mentions
acute kidney injury — 50 reaction mentions
hypertension — 41 reaction mentions
oedema peripheral — 41 reaction mentions
syncope — 39 reaction mentions
renal failure — 36 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
143 products list this as an active ingredient in the United States drug directory. 114 of them contain it and nothing else.
FDA National Drug Code directory · 71335-3074 · read 2026-08-29
They are sold as powder and tablet, taken oral.
FDA National Drug Code directory · 71335-3074 · read 2026-08-29
The regulator's established pharmacologic class for it is increased diuresis [pe] and thiazide-like diuretic [epc].
FDA National Drug Code directory · 71335-3074 · read 2026-08-29
91 published labels name it as an active ingredient. 79 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · a6794dfa-adbb-491b-9d48-f89a44e866c5 · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · a6794dfa-adbb-491b-9d48-f89a44e866c5 · read 2026-08-29
Thalitone is oral at 3 DOSAGE FORMS AND STRENGTHS THALITONE 15 mg tablets are white biconvex, kidney shaped tablets with “L” on lower punch and “96” on the upper punch., recorded as fda label in effect 2026-06-25 in the United States.
US prescribing information · bc5a0299-115b-4e60-bb3f-c75a95c51c15 · read 2026-08-30
Recorded price in US: 0.08397–0.12095 USD per one unit as the pricing file counts it — a tablet, capsule, patch or single item, across 59 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
RNAWiki could not confidently classify this substance, so no self-experiment plan is offered.
Questions worth asking
Which of the trials of Chlortalidone studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Chlortalidone are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
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FDA substance identifier (UNII)
Q0MQD1073Q
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197499
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84 approved applications cover products containing this substance. The earliest was NDA012283, approved 19600407 to SANOFI AVENTIS US.
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5 questions this page could not answer
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Recorded evidence blocks (12)
Q1
What did Chlortalidone's largest trial (37939 people) and its longest (13 years) measure?
37939 people in Chlortalidone's largest registered study, 13 years in its longest registered window, measuring All-Cause-Hospitalization or All-Cause Mortality. ClinicalTrials.gov · 2026-09-01
15 phase4, 12 phase3, 9 phase2, 6 na, 6 phase1, 4 na or unstated, 1 early phase1; NCT00000620; 2012-12; no ageing endpoint recorded. Last human test completed 2026, NCT06287580.
Interpretation These counts include studies where Chlortalidone was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase4
15
phase3
12
phase2
9
na
6
phase1
6
na or unstated
4
2 more recorded rows
early phase1
1
Last recorded human testNCT06287580
2026-02-20
recorded 2026-09-01 · last checked 2026-09-04
Q2
Chlortalidone was tested only in human — what did it show?
Interpretation All-Cause-Hospitalization or All-Cause Mortality — the recorded outcome words.
Show the evidence
humanNCT04467931
lifespan; All-Cause-Hospitalization or All-Cause Mortality; 53
recorded 2026-09-01 · last checked 2026-09-04
Q3
8 of Chlortalidone's trials stopped: futility/efficacy, accrual/recruitment, other?
futility/efficacy (2), accrual/recruitment (1) and other (5): Chlortalidone's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"Based on results from an ALTITUDE study interim analysis, testing aliskiren concomitantly with an ACE inhibitor or ARB, in diabetics with renal impairment"; 8 of 53 registered studies
Show the evidence
Trial
NCT01368536
terminated; "Based on results from an ALTITUDE study interim analysis, testing aliskiren concomitantly with an ACE inhibitor or ARB, in diabetics with renal impairment"
NCT01748123
withdrawn; "Slow enrollment"
NCT01822860
withdrawn; "Study subjects were not able to be recruited"
NCT02030314
withdrawn; "The patient population changed. Unable to find patients that meet study criteria"
NCT02357004
withdrawn; "Change in priority of interventional protocols"
NCT03325114
terminated; "COVID restrictions prohibit further study activies"
2 further recorded trials
NCT05275907
withdrawn; "Screened participants did not meet inclusion criteria prior to study completion date"
NCT05915286
terminated; "Personnel/staffing issues."
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Chlortalidone used Chlorthalidone 25mg — over how long?
24 h systolic blood pressure measured by abpm; 2026-09-01
half life
2026-09-04; halfLife; hours; 40 to 60 hours; 2026-08-30
human trials at or under30
14
smallest human trial
0; NCT01748123; PHASE4; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q7
Which of 24 h diastolic blood pressure measured by abpm, 24 h systolic blood pressure measured by abpm and all cause hospitalization or all cause mortality did Chlortalidone's trials measure?
24 h diastolic blood pressure measured by abpm, 24 h systolic blood pressure measured by abpm and all cause hospitalization or all cause mortality lead 37 outcome terms across Chlortalidone's trials. ClinicalTrials.gov · 2026-09-01
systolic 24 hour ambulatory blood pressure, part a auc cmax of telmisartan, flow mediated vasodilatation, fluorescence intensity of pac 1, time from randomization to composite primary outcome and had a composite primary outcome follow.
Show the evidence
blood pressure
1
diastolic blood pressure by cuff 8 10 weeks minus baseline
1
blood pressure from baseline to treatment
1
systolic 24 hour ambulatory blood pressure
1
part a auc cmax of telmisartan
1
flow mediated vasodilatation
1
14 more recorded rows
fluorescence intensity of pac 1
1
time from randomization to composite primary outcome
1
had a composite primary outcome
1
auclast
1
cmax
1
bioequivalence study is based on cmax and auc parameters
1
average daytime sbp
1
fasting plasma glucose from week 4 to week 16
1
seated automated office systolic blood pressure
1
urinary calcium excretion
1
hypercalcemia
1
hyperglycemia
1
pulse wave velocity
1
24 h systolic blood pressure measured by abpm
1
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which of Chlortalidone's 3 ongoing trials reports first?
Change in myocardial flow reserve; Primary outcome component 1 - calcium oxalate supersaturation in urine; latest 2027-12-31
Show the evidence
Trial
NCT05593055
"Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension"; n 75; "Change in myocardial flow reserve"; 2027-12-31
NCT06111885
"Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention"; n 99; "Primary outcome component 1 - calcium oxalate supersaturation in urine"; 2027-06-30
NCT07225764
"CaOx Stone Prevention"; n 80; "Changes in super saturation of calcium oxalate"; 2027-12-31
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which 17 trials of Chlortalidone posted no result?
Posted no result
17 of 17 completed trials
Registrations
NCT00000499, NCT00000522, NCT00000513, NCT00000514, NCT00000542 and NCT00006294, and 11 more
Completion dates
oldest 1983-05; newest 2023-10
Show the evidence
Trial
NCT00000499
1983-05
NCT00000522
1994-05
NCT00000513
1994-11
NCT00000514
1996-10
NCT00000542
2002-03
NCT00006294
2005-08
11 further recorded trials
NCT01806363
2013-06
NCT02152969
2014-11
NCT02496910
2015-09
NCT02644395
2016-12-19
NCT01083017
2017-05
NCT02711670
2017-06
NCT03560804
2017-09-15
NCT05090449
2020-05-25
NCT04467931
2020-12-31
NCT04757532
2021-03-10
NCT02847338
2023-10
Q10
At the median, Chlortalidone's trials enrolled 71 people — anything larger?
Median enrolment
71
Largest enrolment
37939
Registered trials counted
47
Q11
What do 648 spontaneous reports say about Chlortalidone — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Chlortalidone appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 648 reaction mentions were counted: hyponatraemia 121; hypokalaemia 109; nausea 91; hypotension 65. open-targets-adr · CHEMBL1055 · 2026-06-24
Show the evidence
hyponatraemia
121
hypokalaemia
109
nausea
91
hypotension
65
dizziness
55
acute kidney injury
50
4 more recorded rows
hypertension
41
oedema peripheral
41
syncope
39
renal failure
36
recorded 2026-06-24 · last checked 2026-09-04
Q12
Was Chlortalidone studied with fasting and exercise?
fasting and exercise are named in Chlortalidone's label sentences: "In participants with metabolic syndrome, at 4 years of follow-up, the incidence of newly diagnosed diabetes (fasting glucose >or=126 mg/dl) was 17.1% for chlorthalidone, 16.0% for amlodipine (P = 0.49, chlorthalidone vs. amlodipine) and 12.6% for lisinopril (P < 0.05, lisinopril vs. chlorthalidone)." openfda-label+europepmc · 2020-11-01
2 recorded statements; fasting, exercise
Show the evidence
fasting
In participants with metabolic syndrome, at 4 years of follow-up, the incidence of newly diagnosed diabetes (fasting glucose >or=126 mg/dl) was 17.1% for chlorthalidone, 16.0% for amlodipine (P = 0.49, chlorthalidone vs. amlodipine) and 12.6% for lisinopril (P < 0.05, lisinopril vs. chlorthalidone).
exercise
One fair-quality trial, conducted from 1979 to 1981 in the United States and using a combination of a pharmacological treatment (low-dose propranolol/chlorthalidone) and lifestyle interventions (dietary and exercise modifications for children and parents), reported a statistically significant reduction of SBP (−7.6 mmHg) and DBP (−6.9 mmHg) after 6 months.
recorded 2020-11-01 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
Chlorthalidone component of clorpres, Chlorthalidone component of combipres, Chlorthalidone component of demi-regroton, Chlorthalidone component of edarbyclor, Chlorthalidone component of kerledex, Chlorthalidone component of lopressidone, Chlorthalidone component of regroton, Chlorthalidone component of tenoretic, Hygroton, Thalitone, Chlorthalidone Chlorthalidone, Hemiclor
Development code
G-33182, NSC-69200
Sources (9)
Sources
ClinicalTrials.govclinicaltrials.gov ·
ClinicalTrials.govClinicalTrials.gov API v2 snapshot 2026-09-01T09:00:05 ·
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 9 source rows
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