This page shows what was measured, who it was measured in, and what that does not settle.
What Calcium Chloride does in the body
Potassium chloride extended-release tablets are indicated for the treatment and prophylaxis of hypokalemia with or without metabolic alkalosis, in patients for whom dietary management with potassium-rich foods or diuretic dose reduction is insufficient.
The potassium ion is the principal intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes including the maintenance of intracellular tonicity, the transmission of nerve impulses, the contraction of cardiac, skeletal and smooth muscle and the maintenance of normal renal function. The intracellular concentration of potassium is approximately 150 to 160 mEq per liter. The normal adult plasma concentration is 3.5 to 5 mEq per liter.
Why people take it. Potassium chloride extended-release tablets are indicated for the treatment and prophylaxis of hypokalemia with or without metabolic alkalosis, in patients for whom dietary management with potassium-rich foods or diuretic dose reduction is insufficient.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · M4I0D6VV5M · read 2026-08-29
The supplement label database classes it as mineral, under the name Calcium.
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 151 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer5 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Sleep
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
analgesic consumption of level 3 in the two treated groups; pain 6 hours postoperatively; pain 3 hours postoperatively; pain 24 hours postoperatively; pain; pain from baseline to average post op pain in pacu
Sleep
sleep apnea per hour
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
5 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Cumulative proportion of hyperkalemia treatment
✗ The study did not show it
Who was studied
NCT05118022
How many people
14989
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot
Disease Free Survival (DFS) in Average Risk (AR) Patients Based on the Methotrexate Dose Randomization
✗ The study did not show it
Who was studied
NCT01190930
How many people
9350
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot
Proportion of participants with Major Adverse Kidney Events within 30 days (MAKE30)
✗ The study did not show it
Who was studied
NCT04102371
How many people
9041
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot
Incidence of Composite of Adjudicated Total Venous Thromboembolism (VTE) and VTE-related Death During the Intended Treatment Period - Primary Efficacy Population
✗ The study did not show it
Who was studied
NCT00457002
How many people
6758
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot
Disease free survival (DFS) in randomization eligible patients with higher risk features (SR-High) or standard risk average (SR-Avg) B-ALL patients based on randomization with addition of blinatumomab
✗ The study did not show it
Who was studied
NCT03914625
How many people
6720
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot
Event Rate of Stroke/Systemic Embolism During the Intended-treatment Period
✗ The study did not show it
Who was studied
NCT00496769
How many people
6421
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
Europe PMC · a recorded source, not a stored snapshot
CMS National Average Drug Acquisition Cost · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.1 registered measure of this kind. 3 written-up studies measured this and did not show a benefit.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.8 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.5 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Drosophila (fruit fly), Mouse, Rat, Dog, Non-human primate. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
alcohol craving rating in response to saline infusion
alcohol craving rating in response to yohimbine infusion
cts symptom severity after treatment
pain 6 hours postoperatively
pain 3 hours postoperatively
pain 24 hours postoperatively
pain
pain from baseline to average post op pain in pacu
Measured
Things only a test, a scale or a device shows.
creatinine clearance
diastolic blood pressure by cuff 8 10 weeks minus baseline
plasma glucagon area under curve at 0 90 min and 90 180 min
postoperative hemoglobin
blood pressure
Meaningful
Things that change how a life goes, not only a number.
progression free survival
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (26)
prevention of pulmonary mucus obstruction
biochemical markers of bone turnover
polymyalgia rheumatica activity
lesion size
analgesic consumption of level 3 in the two treated groups
rate of non response to empiric antimicrobial treatment
correction of metabolic acidosis
improvement on mrs relative to placebo treated
length of hospital stay after surgery
diastolic dysfunction
visual acuity
gastric emptying
graft failure at week 39 and 52
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
No description of who was studied is recorded.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Safety and effectiveness in the pediatric population have not been established.”
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
On older people, the label states: “Clinical studies of potassium chloride extended-release tablets did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.”
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary There are no human data related to use of potassium chloride extended-release tablets during pregnancy, and animal reproduction studies have not been conducted.”
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary The normal potassium ion content of human milk is about 13 mEq per liter.”
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
On people with reduced kidney function, the label states: “Patients with renal impairment have reduced urinary excretion of potassium and are at substantially increased risk of hyperkalemia.”
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No form or route is recorded.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing is recorded about product quality.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
The exact form studied is not recorded.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
1600 products list this as an active ingredient in the United States drug directory. 713 of them contain it and nothing else.
FDA National Drug Code directory · 71742-0004 · read 2026-08-29
They are sold as aerosol, foam, aerosol, spray, capsule, capsule, coated, extended release, capsule, extended release and cream, taken auricular (otic), buccal, cutaneous and extracorporeal.
FDA National Drug Code directory · 71742-0004 · read 2026-08-29
The regulator's established pharmacologic class for it is blood coagulation factor [epc], calcium [cs] and cations.
FDA National Drug Code directory · 71742-0004 · read 2026-08-29
1270 published labels name it as an active ingredient. 506 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 37c111ec-5b62-42b9-bbb2-3b0c530e34c9 · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · 37c111ec-5b62-42b9-bbb2-3b0c530e34c9 · read 2026-08-29
12997 marketed supplement labels list this ingredient, classed as mineral.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
Potassium Chloride is oral at 3 DOSAGE FORMS AND STRENGTHS Potassium chloride extended-release tablets USP are supplied as: 600 mg (8 mEq) are pink, circular, film-coated biconvex tablet debossed with “N 31” on one side and plain on other side. 750…, recorded as fda label in effect 2026-03-30 in the United States.
US prescribing information · 9088ca44-5585-4551-8e2c-168f306520d4 · read 2026-08-30
Recorded price in US: 0.00206–0.32018 USD per one millilitre, across 23 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Recorded price in US: 0.06907 USD per one unit as the pricing file counts it — a tablet, capsule, patch or single item, across 3 priced products whose strengths and pack forms differ, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Recorded price in US: 3.06206 USD per one gram, for the one priced product, as of 2026-08-26, paid by retail pharmacies buying the product, as surveyed by the Centers for Medicare & Medicaid Services. It is not a list price, an insurance price, or what anyone pays at a counter..
Recorded source · 2026-08-26 · read 2026-08-28
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
RNAWiki could not confidently classify this substance, so no self-experiment plan is offered.
Questions worth asking
Which of the trials of Calcium Chloride studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
How fast does the body clear it?
The sources RNAWiki checked hold nothing for this field.
Why it matters. Without this, nothing on this page can say how long anything lasts.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Calcium Chloride are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
Where else this substance is registered
FDA substance identifier (UNII)
M4I0D6VV5M
RxNorm concept
828525
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How this medicine reached us
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408 approved applications cover products containing this substance. The earliest was NDA013025, approved 19651216 to HOSPIRA.
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6 questions this page could not answer
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Recorded evidence blocks (12)
Q1
What did Calcium Chloride's largest trial (3000 people) and its longest (13 years) measure?
3000 people in Calcium Chloride's largest registered study, 13 years in its longest registered window, measuring All cause mortality. ClinicalTrials.gov · 2026-09-01
96 phase4, 83 na, 76 phase2, 60 phase3, 45 phase1, 7 early phase1, 5 na or unstated; NCT07423910; 2038-01. Last human test completed 2026, NCT04069897.
Interpretation These counts include studies where Calcium Chloride was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase4
96
na
83
phase2
76
phase3
60
phase1
45
early phase1
7
2 more recorded rows
na or unstated
5
Last recorded human testNCT04069897
2026-06-13
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has Calcium Chloride shown lifespan?
treatment success event rates in each group; 2026-09-01
biomarkers
rate of non response to empiric antimicrobial treatment; 2026-09-01
biomarkers
correction of metabolic acidosis; 2026-09-01
human trials at or under30
97
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT01074918; PHASE1/PHASE2; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q7
Which of afib or afl in who underwent cabg or valvular surgery, alcohol craving rating in response to saline infusion and alcohol craving rating in response to yohimbine infusion did Calcium Chloride's trials measure?
afib or afl in who underwent cabg or valvular surgery, alcohol craving rating in response to saline infusion and alcohol craving rating in response to yohimbine infusion lead 40 outcome terms across Calcium Chloride's trials. ClinicalTrials.gov · 2026-09-01
biochemical markers of bone turnover, polymyalgia rheumatica activity, lesion size, alcohol craving rating in response to saline infusion, alcohol craving rating in response to yohimbine infusion and analgesic consumption of level 3 in the two treated groups follow.
Show the evidence
prevention of pulmonary mucus obstruction
1
creatinine clearance
1
diastolic blood pressure by cuff 8 10 weeks minus baseline
1
biochemical markers of bone turnover
1
polymyalgia rheumatica activity
1
lesion size
1
14 more recorded rows
alcohol craving rating in response to saline infusion
1
alcohol craving rating in response to yohimbine infusion
1
analgesic consumption of level 3 in the two treated groups
1
contrast induced nephropathy incidence
1
dosage and time on norepinephrine treatment
1
occurrence of contrast induced nephropathy
1
plasma glucagon area under curve at 0 90 min and 90 180 min
Difference in estimated glomerular filtration rate (eGFR); Clinically important VTE; latest 2038-07-01
Show the evidence
Trial
NCT03253172
"Potassium Supplementation in CKD"; n 532; "Difference in estimated glomerular filtration rate (eGFR)"; 2026-10-01
NCT03559114
"PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST)"; n 1100; "Clinically important VTE"; 2027-12
NCT03944876
"Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache"; n 112; "Difference in change from baseline week 5-8 in mean number of cluster headache attacks per week at weeks 5-8 post-intervention in the treatment group versus the placebo group"; 2025-09
NCT04048278
"Lidocaine Infusion in Pancreatic Cancer"; n 46; "Specimen outcome measure."; 2028-01-01
NCT04216329
"Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma"; n 11; "Maximum Tolerated Dose (MTD) of Selinexor"; 2028-07-30
NCT04334668
"Oral Sodium to Preserve Renal EfficiencY in Acute Heart Failure"; n 67; "Change in Weight"; 2026-12-31
14 further recorded trials
NCT04445285
"Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure"; n 44; "Mortality at 28 days"; 2022-02-28
NCT04913649
"Intravenous Iron to Treat Postoperative Anemia in Older Cardiac Surgery Patients"; n 310; "Disability"; 2026-12
NCT04913805
"Matching Perfusion and Metabolic Activity in HFpEF"; n 53; "Submaximal Exercise Endurance"; 2027-05-01
NCT05056220
"Personalized Long-term Human Albumin Treatment in Patients With Decompensated Cirrhosis and Ascites"; n 240; "Cumulative number of liver-related clinical outcomes"; 2026-09
NCT05091242
"The PREVENT AGITATION Trial II - Children ≤1 Year"; n 336; "Incidence of emergence agitation during stay in postanaesthetic care unit (PACU)"; 2028-01-31
NCT05136976
"Rituximab Therapy in Anti-Myelin Associated Glycoprotein Patients With Characteristics of Good Responders"; n 90; "I-RODS score"; 2028-12
NCT05139849
"VAsopressin and STeroids in Addition to Adrenaline in Cardiac Arrest - a Randomized Clinical Trial"; n 1276; "Survival at 30 days"; 2027-04-30
NCT05147909
"Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity"; n 124; "oxygen uptake (VO2) during peak exercise"; 2028-03-30
NCT05212337
"FITMI - First In Treating Male Infertility"; n 180; "The difference in sperm concentration (million pr. mL) on day 80"; 2025-09-30
NCT05242419
"A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery"; n 40; "Incidence of delirium within 7 days after operation"; 2025-12-30
NCT05468073
"Therapeutic Evaluation of Low-dose IL-2-based Immunomodulatory Approach in Patients With Early AD"; n 40; "Change from baseline CDR score at 18 months"; 2028-06-08
NCT05564130
"Bicarbonate for In-Hospital Cardiac Arrest"; n 778; "Number of Participants With Return of Spontaneous Circulation"; 2027-02-11
NCT05649605
"Early Mental Response - The EMRE Study"; n 70; "Changes in baseline gender incongruence at 2 and 6 weeks respectively"; 2026-12-30
NCT05654649
"Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section"; n 90; "the time to first passage of flatus and or stool"; 2024-12
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which running trial of Calcium Chloride could settle lifespan?
NCT04445285 measures Mortality at 28 days, reading out 2022-02-28.
5 open trials; n 44; "Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure"
Show the evidence
Trial
NCT04445285
"Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure"; n 44; "Mortality at 28 days"; 2022-02-28
NCT07449442
"SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty"; n 60; "Systemic Inflammation Response Index (SIRI)"; 2026-06-30
NCT07449403
"SII Levels Following PENG Block in Hip Arthroplasty"; n 60; "Systemic Inflammation Response Index (SIRI)"; 2026-09-30
NCT05139849
"VAsopressin and STeroids in Addition to Adrenaline in Cardiac Arrest - a Randomized Clinical Trial"; n 1276; "Survival at 30 days"; 2027-04-30
NCT06701760
"Sodium Lactate in Severe TBI"; n 264; "mortality"; 2038-07-01
Q10
Which 142 trials of Calcium Chloride posted no result?
Posted no result
142 of 142 completed trials
Registrations
NCT00999284, NCT06745856, NCT00069082, NCT00408785, NCT00406679 and NCT00131521, and 136 more
Completion dates
oldest 1998-04; newest 2024-09-02
Show the evidence
Trial
NCT00999284
1998-04
NCT06745856
2003-06
NCT00069082
2004-01
NCT00408785
2007-05-09
NCT00406679
2007-10
NCT00131521
2007-12
14 further recorded trials
NCT00531024
2008-03
NCT00111605
2008-05
NCT00921102
2008-05
NCT00353340
2009-05
NCT00621907
2009-05
NCT00524381
2009-09
NCT01012063
2009-10
NCT01565681
2009-12
NCT00796354
2010-02
NCT00913796
2010-03
NCT00448903
2010-04
NCT00639912
2010-10
NCT01191645
2010-11
NCT00820989
2011-02
Q11
At the median, Calcium Chloride's trials enrolled 60 people — anything larger?
Median enrolment
60
Largest enrolment
3000
Registered trials counted
349
Q12
Was Calcium Chloride studied with fasting and exercise?
fasting and exercise are named in Calcium Chloride's label sentences: "This was a single-institution, prospective, randomized controlled pilot study examining magnesium supplementation taken with meals versus while fasting in patients with a history of calcium oxalate stones and isolated hyperoxaluria." openfda-label+europepmc · 2026-08-06
2 recorded statements; fasting, exercise
Show the evidence
fasting
This was a single-institution, prospective, randomized controlled pilot study examining magnesium supplementation taken with meals versus while fasting in patients with a history of calcium oxalate stones and isolated hyperoxaluria.
exercise
Using a randomized crossover design, 20 participants (age: 36±5years; BMI: 38.7±7.6kg/m2) completed high-intensity interval exercise (HIIE; 10x1-min cycling intervals at ≥90%HRmax) followed by consumption of GY (247kcal, 14g carbohydrate, 32g protein, 350mg calcium) or isoenergetic CP (247kcal, 62g carbohydrate, 0g protein, 0mg calcium).
recorded 2026-08-06 · last checked 2026-09-04
Q13
What is recorded about Calcium Chloride and mTOR?
"In this study, we demonstrate for the first time that <i>miR-17-5p</i> inhibits CSFV replication through an autophagy-dependent mechanism by targeting polycystin-2 (<i>PKD2</i>), a key calcium channel protein that regulates the AMPK/mTOR signaling pathway." — where Calcium Chloride and mTOR appear together. Europe PMC · pathway abstract search · 2026-06-11
"In this study, we demonstrate for the first time that <i>miR-17-5p</i> inhibits CSFV replication through an autophagy-dependent mechanism by targeting polycystin-2 (<i>PKD2</i>), a key calcium channel protein that regulates the AMPK/mTOR signaling pathway."
AMPKPMID 41656913
"In this study, we demonstrate for the first time that <i>miR-17-5p</i> inhibits CSFV replication through an autophagy-dependent mechanism by targeting polycystin-2 (<i>PKD2</i>), a key calcium channel protein that regulates the AMPK/mTOR signaling pathway."
autophagyPMID 41656913
"In this study, we demonstrate for the first time that <i>miR-17-5p</i> inhibits CSFV replication through an autophagy-dependent mechanism by targeting polycystin-2 (<i>PKD2</i>), a key calcium channel protein that regulates the AMPK/mTOR signaling pathway."
mTORPMID 41656913
"Mechanistically, <i>PKD2</i> regulates intracellular calcium dynamics, modulating the AMPK/mTOR-autophagy axis to promote CSFV proliferation."
AMPKPMID 41656913
"Mechanistically, <i>PKD2</i> regulates intracellular calcium dynamics, modulating the AMPK/mTOR-autophagy axis to promote CSFV proliferation."
autophagy
PMID 41656913
"Mechanistically, <i>PKD2</i> regulates intracellular calcium dynamics, modulating the AMPK/mTOR-autophagy axis to promote CSFV proliferation."
PMID 41656913
"This work uncovers a novel host antiviral mechanism in which a miRNA controls virus-induced autophagy via calcium signaling."
NAD+PMID 40905115
"Alizarin red staining and calcium content assay revealed that pharmacological inhibition or knockdown of NAMPT exacerbated vascular smooth muscle cell calcification, whereas overexpression of NAMPT reduced mineral deposition under osteogenic conditions."
mTOR
"Fluctuating energetic states reconfigure AMP‑activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), calcium/calmodulin‑dependent protein kinase II (CaMKII) and sirtuin‑1 (SIRT1) signaling, influencing DNA methylation, histone acetylation, and microRNA programs governed by peroxisome proliferator‑activated receptor‑γ coactivator‑1α (PGC‑1α) and brain‑derived neurotrophic factor…"
AMPK
"Fluctuating energetic states reconfigure AMP‑activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), calcium/calmodulin‑dependent protein kinase II (CaMKII) and sirtuin‑1 (SIRT1) signaling, influencing DNA methylation, histone acetylation, and microRNA programs governed by peroxisome proliferator‑activated receptor‑γ coactivator‑1α (PGC‑1α) and brain‑derived neurotrophic factor…"
sirtuin
"Fluctuating energetic states reconfigure AMP‑activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), calcium/calmodulin‑dependent protein kinase II (CaMKII) and sirtuin‑1 (SIRT1) signaling, influencing DNA methylation, histone acetylation, and microRNA programs governed by peroxisome proliferator‑activated receptor‑γ coactivator‑1α (PGC‑1α) and brain‑derived neurotrophic factor…"
PMID 42353025
"Mechanistically, SC regulated multiple signaling pathways, including mitogen-activated protein kinase (MAPK), toll-like receptor 4/nuclear factor kappa B (TLR4/ NF-κB), PI3K/AKT, nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1), and the calcium/calmodulin-dependent protein kinase kinase-AMP-activated protein kinase-sirtuin 1 (CaMKK-AMPK-Sirt1) axis."
PMID 39636756
"Overall, SIRT1 plays a protective role in diabetic cardiomyopathy by reducing apoptosis, regulating autophagy and mitophagy, and modulating calcium channel activity."
IGF-1
"In neocortical neurons, by contrast, IGF-1 consistently reduced glutamate- and AMPA-evoked calcium peaks, suggesting an inhibitory effect on AMPA receptors."
recorded 2026-06-11 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
✗ required summary fields resolved: 3 required field(s) not terminal: Best-supported result, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 9 source rows
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