From the FDA-approved label: Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action of SERNIVO Spray in psoriasis is unknown. 1 How Supplied/Storage SERNIVO Spray is a slightly thickened, white to off-white, non-sterile emulsion supplied in high density polyethylene bottles with a heat induction seal lined polypropylene cap.
Why people take it. Dermatologic Diseases Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome).
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
Where each sentence above came from
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 100 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Formulation
A formulation is the exact made-up form a substance comes in.
A picture of it, and where the picture fails
It is like the difference between a whole bean and instant coffee.
Where that stops being true. Coffee tastes different. A formulation can change how much reaches the blood.
What people get wrong. Two products with the same name are assumed to behave the same. They often do not.
The specific composition and physical form of a product, including salt, excipients and release profile.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer1 registered performance measure of this kind.
…Waiting for a reviewer11 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Healthy ageing
…Waiting for a reviewer1 registered study measure of this kind. No reviewed result yet.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Strength
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer1 registered performance measure of this kind.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
visual analogue pain; pain improvement; injection pain as measured by vas for both treatment groups; visual analog scale of pain finklestein test; pain; pain scores; pain vas; pain severity
Healthy ageing
all cause mortality
Strength
strength
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
1 registered performance measure of this kind.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Perinatal Mortality or Substantial Neonatal Morbidity
✗ The study did not show it
Who was studied
NCT05114096
How many people
3254
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
severe RDS defined as need for exogenous intra-tracheal surfactant in the first 48 hours of life
✗ The study did not show it
Who was studied
NCT02897076
How many people
3250
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Neonatal Composite Outcome
✗ The study did not show it
Who was studied
NCT01222247
How many people
2831
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Respiratory morbidity
✗ The study did not show it
Who was studied
NCT05698966
How many people
1510
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Overall disease severity according to investigator's assessment at week 8
✗ The study did not show it
Who was studied
NCT00216827
How many people
1485
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
- Patients with "Controlled disease" ("Absence of disease" or "Very mild disease") according to investigator's global assessment of disease severity at week 8.
✗ The study did not show it
Who was studied
NCT00216840
How many people
1350
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Topical
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.1 registered measure of this kind. No reviewed result.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.2 registered measures of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.2 registered measures of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.12 registered measures of this kind.
□A number that stands in for healthNo evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.No registered study measures this.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Rat. A result in animals says what to test next. It does not say what happens in people.
□Cells in a dishNo evidence recorded. Cells or chemistry on a bench, far from a whole body.No cell or bench record is stored.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
visual analogue pain
global impression of change
pain improvement
injection pain as measured by vas for both treatment groups
visual analog scale of pain finklestein test
pain
pain scores
pain vas
pain severity
incidence of pain
and 2 more.
Measured
Things only a test, a scale or a device shows.
strength
Meaningful
Things that change how a life goes, not only a number.
all cause mortality
shoulder pain and disability index
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (25)
neonatal respiratory distress
constant
neonatal composite outcome
sore throat
cough
intraocular pressure
total sign change
postoperative nausea and vomiting
caloric function
based on visual analog scale and size of the lesion
opiate consumption
resolution of symptoms
treatment emergent adverse events
laboratory test abnormalities
clinical response rate
range of motion
acute radiation dermatitis grading
time to first new flare
numeric rating scale
treatment related adverse events assessed by nci ctcae
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
When oral therapy is not feasible, the intramuscular use of Betamethasone Sodium Phosphate and Betamethasone Acetate Injectable Suspension is indicated as follows: Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis,…
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “The efficacy and safety of corticosteroids in the pediatric population are based on the well-established course of effect of corticosteroids, which is similar in pediatric and adult populations.”
US prescribing information · a363b861-4873-465e-8009-0e9690666224 · read 2026-08-30
On older people, the label states: “No overall differences in safety or effectiveness were observed between elderly subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and young patients, but greater sensitivity of some older individuals cannot be ruled out.”
US prescribing information · a363b861-4873-465e-8009-0e9690666224 · read 2026-08-30
On people who are pregnant, the label states: “Teratogenic Effects Corticosteroids have been shown to be teratogenic in many species when given in doses equivalent to the human dose.”
US prescribing information · a363b861-4873-465e-8009-0e9690666224 · read 2026-08-30
On people who are breastfeeding, the label states: “Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects.”
US prescribing information · a363b861-4873-465e-8009-0e9690666224 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
A different form was studied
The studied form is not the form on the shelf.
On this record: This record is linked to 1 related forms. Evidence does not carry across all of them.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (9)
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as gel, augmented, lotion, augmented, cream, ointment, given by the topical, oral, injection route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Betamethasone appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 1262 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
premature baby — 161 reaction mentions
pain in extremity — 149 reaction mentions
hypersensitivity — 139 reaction mentions
urticaria — 138 reaction mentions
pneumonia — 134 reaction mentions
hepatic function abnormal — 120 reaction mentions
muscle spasms — 120 reaction mentions
stomatitis — 113 reaction mentions
epistaxis — 110 reaction mentions
erythema — 78 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Topical
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
31 products list this as an active ingredient in the United States drug directory. 31 of them contain it and nothing else.
FDA National Drug Code directory · 0517-0720 · read 2026-08-29
They are sold as injection, suspension and powder, taken intra-articular, intralesional, intramuscular and soft tissue.
FDA National Drug Code directory · 0517-0720 · read 2026-08-29
The regulator's established pharmacologic class for it is corticosteroid hormone receptor agonists [moa] and corticosteroid [epc].
FDA National Drug Code directory · 0517-0720 · read 2026-08-29
8 published labels name it as an active ingredient. 8 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · a363b861-4873-465e-8009-0e9690666224 · read 2026-08-29
Those labels are classed as human prescription drug.
US prescribing information · a363b861-4873-465e-8009-0e9690666224 · read 2026-08-29
Betamethasone Sodium Phosphate and Betamethasone Acetate is intra-articular at HOW SUPPLIED NDC 0517-0720-01: Betamethasone Sodium Phosphate and Betamethasone Acetate Injectable Suspension, 5 mL multiple-dose vial; box of one., recorded as fda label in effect 2024-09-05 in the United States.
US prescribing information · a363b861-4873-465e-8009-0e9690666224 · read 2026-08-30
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (12)
Q1
What did Betamethasone's largest trial (3250 people) and its longest (12 years) measure?
3250 people in Betamethasone's largest registered study, 12 years in its longest registered window, measuring Composite outcome: including neonatal mortality/stillbirth, severe RDS, chronic lung disease, grade III/IV IVH, PVL. ClinicalTrials.gov · 2026-09-01
28 phase4, 27 phase2, 23 phase3, 20 na, 15 phase1, 7 na or unstated, 1 early phase1; NCT01222247; 2022-08-31; no ageing endpoint recorded. Last human test completed 2025, NCT06626568.
Interpretation These counts include studies where Betamethasone was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
phase4
28
phase2
27
phase3
23
na
20
phase1
15
na or unstated
7
2 more recorded rows
early phase1
1
Last recorded human testNCT06626568
2025-09-02
recorded 2026-09-01 · last checked 2026-09-04
Q2
From rat to human: where has Betamethasone shown lifespan?
Interpretation Composite outcome: including neonatal mortality/stillbirth, severe RDS, chronic lung disease, grade III/IV IVH, PVL — the recorded outcome words.
Show the evidence
rat
lifespan
humanNCT00015002
lifespan; Composite outcome: including neonatal mortality/stillbirth, severe RDS, chronic lung disease, grade III/IV IVH, PVL; 111
recorded 2026-09-01 · last checked 2026-09-04
Q3
16 of Betamethasone's trials stopped: safety, accrual/recruitment, funding/business, other?
safety (1), accrual/recruitment (5), funding/business (2) and other (8): Betamethasone's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"Concerns regarding neonatal data"; 16 of 111 registered studies
Show the evidence
Trial
NCT00015002
terminated; "Concerns regarding neonatal data"
NCT00139256
terminated; "Slow enrollment and lack of funds."
NCT00670956
terminated; "Recruitment has been poor. Study drug is being offered as part of standard care of women carrying a pregnancy diagnosed with CCAM"
NCT00685880
terminated; "Unable to recruit adequate numbers of patients"
NCT00914836
withdrawn; "difficulties in the department"
NCT00933023
withdrawn; "Patient numbers estimated to be too low to complete the trial in less than 10 years"
10 further recorded trials
NCT02038634
terminated; "not enough patient data"
NCT02351310
withdrawn; "Company decided not to pursue this study."
NCT02527421
terminated; "Not able to recruit patients with the current enrollment criteria."
NCT02586961
terminated; "Removal of Adrénaline lots for safety reasons."
NCT02912182
terminated; "Placebo medication expired"
NCT02939742
terminated; "Low study recruitment"
NCT03395132
terminated; "Due to business strategic reasons, LEO Pharma has decided to close down the FCF-38 trial."
NCT03770546
withdrawn; "Failure of institution to reach agreement with company supplying injections"
NCT04931511
terminated; "Since the COVID-19 pendemic, the regular follow-up of participant became very hard. The participant were not willing to go back to the hospital for repeat measurement. So we stop the study and plan to redesign the protocol."
NCT07297264
terminated; "There was a change in the protocol of the study"
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Betamethasone used Betamethasone 4 mg — over how long?
11 recorded entries; human; also "calcipotriol 50 mcg/g and betamethasone 0.5 mg/g (as dipropionate)", "betamethasone 24 mg", "12mg betamethasone +placebo"
Show the evidence
human
NCT01033097
Betamethasone 4 mg
NCT01536938
calcipotriol 50 mcg/g and betamethasone 0.5 mg/g (as dipropionate)
NCT02897076
betamethasone 24 mg
NCT02897076
12mg betamethasone +placebo
NCT03026478
Betamethasone Dipropionate 0.05% gel
NCT03117894
Betamethason 4 mg
5 more recorded rows
humanNCT03668860
Betamethasone 4 mg/ml
humanNCT03668860
Celestone Soluspan 6Mg/Ml Suspension for Injection
humanNCT03758365
Betamethasone Dipropionate 0.05% Cream
humanNCT04494529
12 mg betamethasone + placebo
humanNCT04494529
24 mg betamethasone
recorded 2026-09-01 · last checked 2026-09-04
Q5
Could one person measure Betamethasone's effect on neonatal respiratory distress?
Neonatal respiratory distress: measured in Betamethasone's trials.
Interpretation neonatal respiratory distress is the recorded endpoint.
Show the evidence
biomarkers
neonatal respiratory distress; 2026-09-01
visual analogue pain; 2026-09-01
constant; 2026-09-01
neonatal composite outcome; 2026-09-01
global impression of change; 2026-09-01
pain improvement; 2026-09-01
14 more recorded rows
biomarkers
injection pain as measured by vas for both treatment groups; 2026-09-01
biomarkers
sore throat; 2026-09-01
biomarkers
cough; 2026-09-01
biomarkers
intraocular pressure; 2026-09-01
biomarkers
total sign change; 2026-09-01
biomarkers
visual analog scale of pain finklestein test; 2026-09-01
biomarkers
postoperative nausea and vomiting; 2026-09-01
biomarkers
pain; 2026-09-01
biomarkers
caloric function; 2026-09-01
biomarkers
pain scores; 2026-09-01
biomarkers
based on visual analog scale and size of the lesion; 2026-09-01
biomarkers
opiate consumption; 2026-09-01
biomarkers
all cause mortality; 2026-09-01
biomarkers
resolution of symptoms; 2026-09-01
human trials at or under30
31
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT00914836; NA; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q6
Which of acute and chronic postoperative pain, acute radiation dermatitis grading and all cause mortality did Betamethasone's trials measure?
acute and chronic postoperative pain, acute radiation dermatitis grading and all cause mortality lead 40 outcome terms across Betamethasone's trials. ClinicalTrials.gov · 2026-09-01
Interpretation neonatal composite outcome, global impression of change, pain improvement, injection pain as measured by vas for both treatment groups, sore throat and cough follow.
Show the evidence
neonatal respiratory distress
1
visual analogue pain
1
constant
1
neonatal composite outcome
1
global impression of change
1
pain improvement
1
14 more recorded rows
injection pain as measured by vas for both treatment groups
1
sore throat
1
cough
1
intraocular pressure
1
total sign change
1
visual analog scale of pain finklestein test
1
postoperative nausea and vomiting
1
pain
1
caloric function
1
pain scores
1
based on visual analog scale and size of the lesion
1
opiate consumption
1
all cause mortality
1
resolution of symptoms
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of Betamethasone's 11 ongoing trials reports first?
To collect and evaluate single-cell multiomics data (RNAseq, CITEseq, TCRseq); Mean number of accelerations on fetal cardiotocography; latest 2031-01
Show the evidence
Trial
NCT05535738
"Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation"; n 45; "To collect and evaluate single-cell multiomics data (RNAseq, CITEseq, TCRseq)"; 2027-12-31
NCT07078786
"Effect of Pre-delivery Dexamethasone in Comparison With Betamethasone on Fetal Heart Trace"; n 110; "Mean number of accelerations on fetal cardiotocography"; 2025-10-15
NCT07341776
"Steroid Use in Treatment of Allergic Reactions to Food"; n 160; "Time to complete resolution of allergic symptoms"; 2026-12
NCT07348016
"Safety and Efficacy of Platelet-Rich Plasma Combined With Compound Betamethasone in Arthroscopic Surgery for Rotator Cuff Injury With Shoulder Adhesion: A Prospective, Multicenter, Randomized Controlled Trial"; n 70; "Change in Constant-Murley Shoulder Score"; 2028-12-01
NCT07409779
"Capsular Distension Versus Corticosteroid Injection in Adhesive Capsulitis"; n 50; "Shoulder Pain Intensity (Visual Analog Scale)"; 2026-12
NCT07416916
"Ultrasound-Guided Intra-Articular vs Gluteal Intramuscular Corticosteroid Injection for Frozen Shoulder"; n 528; "Change in Shoulder Pain and Disability Index (SPADI) Total Score from Baseline to Week 8"; 2031-01
5 further recorded trials
NCT07447739
"Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively?"; n 100; "The rate of successful respiratory weaning"; 2029-03
NCT07453004
"A Study to Evaluate the Efficacy,Safety,Tolerability,Pharmacokinetics,and Immunogenicty of Plonmarlimab in Subjects With Acute Gouty Arthritis"; n 170; "Visual Analogue Scale(VAS) score"; 2027-12-31
NCT07547605
"PRP vs PRP+Betamethasone vs Betamethasone Injection for Upper Trapezius Myofascial Pain"; n 150; "Change in Visual Analog Scale (VAS) Pain Score"; 2027-01
NCT07668895
"Evaluation of the Efficacy and Safety of Compound Betamethasone in Pulmonary Sarcoidosis"; n 126; "Change from baseline in percent predicted FVC after 24 weeks of treatment (%)"; 2028-07
NCT07681804
"Betamethasone vs Dextrose Injections in Trigger Finger"; n 42; "Change in pain intensity assessed by Numeric Rating Scale (NRS)"; 2027-05
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which 40 trials of Betamethasone posted no result?
Posted no result
40 of 40 completed trials
Registrations
NCT00358384, NCT00963573, NCT00576238, NCT00576550, NCT00542139 and NCT00910676, and 34 more
Completion dates
oldest 2006-02-24; newest 2024-07-26
Show the evidence
Trial
NCT00358384
2006-02-24
NCT00963573
2006-11
NCT00576238
2008-02
NCT00576550
2008-05
NCT00542139
2008-11
NCT00910676
2009-03
14 further recorded trials
NCT00675246
2010-05
NCT01033097
2011-07
NCT01466478
2011-12
NCT01071369
2012-06
NCT01646567
2012-11
NCT02114021
2013-03
NCT00446953
2013-11
NCT02575729
2014-07
NCT02066844
2014-08
NCT02114073
2015-02
NCT01885481
2015-04
NCT02376049
2015-07
NCT01808586
2016-12
NCT02744495
2016-12
Q9
At the median, Betamethasone's trials enrolled 60 people — anything larger?
Median enrolment
60
Largest enrolment
3250
Registered trials counted
111
Q10
What do 1262 spontaneous reports say about Betamethasone — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Betamethasone appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 1262 reaction mentions were counted: premature baby 161; pain in extremity 149; hypersensitivity 139; urticaria 138. open-targets-adr · CHEMBL632 · 2026-06-24
Show the evidence
premature baby
161
pain in extremity
149
hypersensitivity
139
urticaria
138
pneumonia
134
hepatic function abnormal
120
4 more recorded rows
muscle spasms
120
stomatitis
113
epistaxis
110
erythema
78
recorded 2026-06-24 · last checked 2026-09-04
Q11
Betamethasone and CYP3A4: shared by which compounds?
CYP3A4 appear in Betamethasone's recorded interaction sentences, 2 in all. openfda-label+europepmc · 2026-04-24
Interpretation drug_interactions
Show the evidence
CYP3A4
drug_interactions
Interactions with Strong CYP3A4 Inhibitors Corticosteroids (including betamethasone) are metabolized by CYP3A4.
drug_interactions
Coadministration with other strong CYP3A4 inhibitors (eg, itraconazole, clarithromycin, ritonavir, cobicistat-containing products) may lead to increased exposures of corticosteroids and therefore the potential for increased risk of systemic corticosteroid side effects.
recorded 2026-04-24 · last checked 2026-09-04
Q12
Was Betamethasone studied with exercise?
exercise is named in Betamethasone's label sentences: "Compared with 432 children from the term reference cohort, ALPS children had more wheezing with exercise in the past year (7.2% betamethasone vs 4.4% term control group, adjusted RR 1.77, 95% CI, 1.03-3.06; 8.8% placebo vs term control group, adjusted RR 2.09, 95% CI, 1.25-3.48)." openfda-label+europepmc · 2026-04-24
1 recorded statement; exercise
Show the evidence
exercise
Compared with 432 children from the term reference cohort, ALPS children had more wheezing with exercise in the past year (7.2% betamethasone vs 4.4% term control group, adjusted RR 1.77, 95% CI, 1.03-3.06; 8.8% placebo vs term control group, adjusted RR 2.09, 95% CI, 1.25-3.48).
recorded 2026-04-24 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
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This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.