This page shows what was measured, who it was measured in, and what that does not settle.
What Benzocaine does in the body
Reduce pain or discomfort caused by minor dental procedures • minor gum injury • canker sores • sore throat • minor mouth or gum irritations caused by dentures or orthodontic appliances.
From the FDA-approved label: Action The onset of Cetacaine Topical Anesthetic Gel produced anesthesia is rapid (approximately 30 seconds) and the duration of anesthesia is typically 30-60 minutes, when used as directed. This effect is due to the rapid onset, but short duration of action of Benzocaine coupled with the slow onset, but extended duration of Tetracaine HCl and bridged by the intermediate action of Butamben. It is believed that all of these agents act by reversibly blocking nerve conduction.
Why people take it. Reduce pain or discomfort caused by minor dental procedures • minor gum injury • canker sores • sore throat • minor mouth or gum irritations caused by dentures or orthodontic appliances.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · U3RSY48JW5 · read 2026-08-29
Where each sentence above came from
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 145 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Biomarker
A biomarker is a number from a test that stands in for something about health.
A picture of it, and where the picture fails
A biomarker is like a fuel gauge.
Where that stops being true. A gauge is wired to the tank. Many biomarkers are only loosely tied to health.
What people get wrong. A better number is read as a better life. Several medicines improved a number and helped nobody.
A measurable indicator used as a substitute for a clinical outcome of interest.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 13 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer7 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Pain
assessment of immediate post injection pain severity by; pain; summed pain intensity difference; time to meaningful pain relief; pain behavoir; self perception of pain; pain level
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
7 registered symptom measure.
— Not recorded
Harms were not a registered measure for this goal.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Arriving hospital within 4.5 hours after symptom onset among incident acute ischemic stroke cases within participating community units
✗ The study did not show it
Who was studied
NCT07135310
How many people
1696000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Dental
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Change in Average Daily Active Minutes
✗ The study did not show it
Who was studied
NCT07382804
How many people
227000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Dental
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Number of participants who receive cervical cancer screening
✗ The study did not show it
Who was studied
NCT07226037
How many people
80000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Dental
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Year 1 RCCT: Change From Baseline in the Percentage of Participants Who Were Vaccinated at the End of Year 1
✗ The study did not show it
Who was studied
NCT01868334
How many people
70549
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Dental
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Composite of organ injury or in-hospital death within 30 days of surgery
✗ The study did not show it
Who was studied
NCT07224243
How many people
54000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Dental
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Incidence of PPH
✗ The study did not show it
Who was studied
NCT06684080
How many people
52000
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Dental
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.0 registered measures of this kind. 1 written-up study measured this and did not show a benefit.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.7 registered measures of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.1 registered measure of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
□AnimalsNo evidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.No animal record is stored.
□Cells in a dishNo evidence recorded. Cells or chemistry on a bench, far from a whole body.No cell or bench record is stored.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
assessment of immediate post injection pain severity by
pain
summed pain intensity difference
time to meaningful pain relief
pain behavoir
self perception of pain
pain level
Measured
Things only a test, a scale or a device shows.
heart rate
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (5)
a response
visual analogue scale
visual analogue scale 5 likert scale
postoperative acute kidney injury
radial artery spasm
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
Discontinue use and consult a doctor if This product, used as directed does not provide relief You or your partner develops a rash or irritation, such as burning or itching Condition worsens or if symptoms persist for more than 7 days or clear up and occur again within a few days The following symptoms appear: weakness, confusion, headache, difficulty breathing and/or pale, gray or blue colored skin as these may be…
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Dental
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Sold as gel, solution, lozenge, cream, given by the dental, topical, oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Benzocaine appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 651 reaction mentions were counted. One report can name several reactions.
The recorded terms (10)
methaemoglobinaemia — 103 reaction mentions
drug hypersensitivity — 97 reaction mentions
arthropathy — 67 reaction mentions
arthralgia — 60 reaction mentions
infection — 59 reaction mentions
hypersensitivity — 56 reaction mentions
dyspnoea — 54 reaction mentions
confusional state — 53 reaction mentions
pruritus — 52 reaction mentions
joint swelling — 50 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Dental
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
623 products list this as an active ingredient in the United States drug directory. 434 of them contain it and nothing else.
FDA National Drug Code directory · 71363-101 · read 2026-08-29
They are sold as aerosol, spray, cloth, cream, dressing, gel and gel, dentifrice, taken buccal, dental, oral and periodontal.
FDA National Drug Code directory · 71363-101 · read 2026-08-29
The regulator's established pharmacologic class for it is allergens [cs], cell-mediated immunity [pe] and increased histamine release [pe].
FDA National Drug Code directory · 71363-101 · read 2026-08-29
583 published labels name it as an active ingredient. 397 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · 03a4a7ce-4cff-a608-e063-6294a90ad65d · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · 03a4a7ce-4cff-a608-e063-6294a90ad65d · read 2026-08-29
3 marketed supplement labels list this ingredient, classed as non-nutrient/non-botanical, other combinations and vitamin.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (10)
Q1
What did Benzocaine's largest trial (22435 people) and its longest (7.3 years) measure?
22435 people in Benzocaine's largest registered study, 7.3 years in its longest registered window, measuring Primary Endpoint: Time-weighted average of the pain intensity difference from pre-dose baseline over the first 3 hours after the first lozenge expressed as a ratio of the pre-dose baseline (SPIDnorm). ClinicalTrials.gov · 2026-09-01
16 na, 9 phase4, 6 phase2, 6 phase3, 4 phase1, 1 early phase1; NCT02537314; 2022-12-08. Last human test completed 2026, NCT07198022.
Interpretation These counts include studies where Benzocaine was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
16
phase4
9
phase2
6
phase3
6
phase1
4
early phase1
1
1 more recorded row
Last recorded human testNCT07198022
2026-01-15
recorded 2026-09-01 · last checked 2026-09-04
Q2
Benzocaine was tested only in human — what did it show?
Primary Endpoint: Time-weighted average of the pain intensity difference from pre-dose baseline over the first 3 hours after the first lozenge expressed as a… — the recorded outcome words.
Show the evidence
humanNCT00148499
mechanism-only; Primary Endpoint: Time-weighted average of the pain intensity difference from pre-dose baseline over the first 3 hours after the first lozenge expressed as a ratio of the pre-dose baseline (SPIDnorm); 41
recorded 2026-09-01 · last checked 2026-09-04
Q3
3 of Benzocaine's trials stopped: accrual/recruitment, other?
13 recorded entries; human; oral; also "14.0% benzocaine and 2.0% tetracaine HCl", "14.0% benzocaine and 2.0% tetracaine", "14.0% benzocaine and Placebo"
Show the evidence
human
NCT02908620
14.0% benzocaine
NCT02908620
14.0% benzocaine and 2.0% tetracaine HCl
NCT02908620
14.0% benzocaine and 2.0% tetracaine
NCT02908620
14.0% benzocaine and Placebo
NCT02908620
14.0% benzocaine and Vehicle Control
NCT02908620
14.0% benzocaine and Control
7 more recorded rows
humanNCT03432923
Benzocaine 8 mg
humanNCT03779659
Centrix LolliCaine 2% xylocaine with 20% benzocaine
humanNCT04317508
Topicale GelPatch (Benzocaine 18%)
humanNCT04317508
oral; Benzocaine oral gel 20%
humanNCT05060913
20% Benzocaine
humanNCT06011005
Benzocaine gel 20% (group B)
humanNCT06951191
Benzocaine 20%
recorded 2026-09-01 · last checked 2026-09-04
Q5
Could one person measure Benzocaine's effect on a response?
A response: measured in Benzocaine's trials.
Interpretation a response is the recorded endpoint.
Show the evidence
biomarkers
a response; 2026-09-01
visual analogue scale; 2026-09-01
assessment of immediate post injection pain severity by; 2026-09-01
visual analogue scale 5 likert scale; 2026-09-01
pain; 2026-09-01
summed pain intensity difference; 2026-09-01
7 more recorded rows
biomarkers
postoperative acute kidney injury; 2026-09-01
biomarkers
radial artery spasm; 2026-09-01
biomarkers
time to meaningful pain relief; 2026-09-01
biomarkers
pain behavoir; 2026-09-01
biomarkers
self perception of pain; 2026-09-01
biomarkers
heart rate; 2026-09-01
biomarkers
pain level; 2026-09-01
human trials at or under30
9
Not recorded for this substance
a recorded half-life
smallest human trial
0; NCT03779659; NA; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Q6
Which of a response, assessment of immediate post injection pain severity by and heart rate did Benzocaine's trials measure?
a response, assessment of immediate post injection pain severity by and heart rate lead 13 outcome terms across Benzocaine's trials. ClinicalTrials.gov · 2026-09-01
visual analogue scale 5 likert scale, pain, summed pain intensity difference, postoperative acute kidney injury, radial artery spasm and time to meaningful pain relief follow.
Show the evidence
a response
1
visual analogue scale
1
assessment of immediate post injection pain severity by
1
visual analogue scale 5 likert scale
1
pain
1
summed pain intensity difference
1
7 more recorded rows
postoperative acute kidney injury
1
radial artery spasm
1
time to meaningful pain relief
1
pain behavoir
1
self perception of pain
1
heart rate
1
pain level
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of Benzocaine's 3 ongoing trials reports first?
Pain perception during needle insertion in different anesthetic techniques Using SEM scale; Mechanical pain sensitivity (300g Von Frey monofilament); latest 2026-04
Show the evidence
Trial
NCT06841601
"Effectiveness of Vibratory Versus Cold Stimuli on Pain Perception in Children"; n 72; "Pain perception during needle insertion in different anesthetic techniques Using SEM scale"; 2025-03-25
NCT07034456
"Sensory and Vascular Effects of Kinesio and Magnetic Tape in Healthy Subjects"; n 30; "Mechanical pain sensitivity (300g Von Frey monofilament)"; 2026-01
NCT07558720
"Effect of Diode Laser and 20% Benzocaine Anesthetic Gel on Pain Reduction Following Tooth Separation With Elastomeric Separators in Fixed Orthodontic Patients: A Randomized Trial in Karachi-Pakistan"; n 72; "mean difference in pain scores"; 2026-04
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which 17 trials of Benzocaine posted no result?
Posted no result
17 of 17 completed trials
Registrations
NCT00148499, NCT01606046, NCT01588535, NCT02044341, NCT02092454 and NCT02667054, and 11 more
Completion dates
oldest 2006-06; newest 2024-06-01
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Trial
NCT00148499
2006-06
NCT01606046
2011-08
NCT01588535
2012-08
NCT02044341
2014-03
NCT02092454
2014-03
NCT02667054
2016-01
11 further recorded trials
NCT02601924
2018-04
NCT03432923
2018-04-21
NCT03953001
2018-06-01
NCT02326623
2018-07-30
NCT05267938
2020-01-30
NCT04317508
2020-02-19
NCT05060913
2022-03-04
NCT05912335
2022-05-03
NCT02537314
2022-12-08
NCT05083975
2023-05-06
NCT07242157
2024-06-01
Q9
At the median, Benzocaine's trials enrolled 65 people — anything larger?
Median enrolment
65
Largest enrolment
22435
Registered trials counted
41
Q10
What do 651 spontaneous reports say about Benzocaine — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Benzocaine appears in spontaneous reports to regulators. Across the 10 most-reported reaction terms, 651 reaction mentions were counted: methaemoglobinaemia 103; drug hypersensitivity 97; arthropathy 67; arthralgia 60. open-targets-adr · CHEMBL278172 · 2026-06-24
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methaemoglobinaemia
103
drug hypersensitivity
97
arthropathy
67
arthralgia
60
infection
59
hypersensitivity
56
4 more recorded rows
dyspnoea
54
confusional state
53
pruritus
52
joint swelling
50
recorded 2026-06-24 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ChEMBL ATC CC BY-SA · ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md
✗ required summary fields resolved: 5 required field(s) not terminal: Why people use it, Best-supported result, Most important common problem, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 8 source rows
✓ no critical contamination: no quarantine open
✓ canonical metadata passed: slug and display name present
✓ no raw internal fields: enforced by the copy-contract test over the rendered page
This is a record of evidence. It is not medical advice, and it does not say this substance suits you. Nothing here says any substance on RNAWiki is appropriate for a child.