No plain explanation of what this changes is stored.
No recorded use is stored in reader language.
No statement of the main limit is recorded.
The four opening statements run to 26 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 9 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved2 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Body weight
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
△ Only a number moved
2 registered test measure.
— Not recorded
Harms were not a registered measure for this goal.
… Waiting for a reviewer
Who was studied is listed further down the page.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Change from Baseline Added-Sugar Consumption at 6 Weeks
✗ The study did not show it
Who was studied
NCT05823597
How many people
702
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Aronchick scale
✗ The study did not show it
Who was studied
NCT03992365
How many people
472
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Weight Change at 6 months
✗ The study did not show it
Who was studied
NCT04567108
How many people
461
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Mortality
✗ The study did not show it
Who was studied
NCT04542473
How many people
400
Study design
Phase 2/Phase 3
Compared against
Not recorded for this study
Kind of result
Living longer, or avoiding a major event
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
24-hour triglyceride area under the curve
✗ The study did not show it
Who was studied
NCT01103921
How many people
214
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
Body Weight
✗ The study did not show it
Who was studied
NCT02928653
How many people
187
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Oral
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
□Living longer, or avoiding a major eventNo evidence recorded. Death, a heart attack, a stroke, a hospital stay.No registered study measures this.
□What a body can do day to dayNo evidence recorded. Walking, dressing, breathing, recovering.No registered study measures this.
□Measured performanceNo evidence recorded. How much was lifted, how far was run, how fast.No registered study measures this.
□Symptoms and quality of lifeNo evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.No registered study measures this.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.3 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in C. elegans (roundworm), Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
No registered study measured anything of this kind.
Measured
Things only a test, a scale or a device shows.
body weight from baseline
change oral glucose tolerance
blood glucose level
Meaningful
Things that change how a life goes, not only a number.
No registered study measured anything of this kind.
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (6)
performance
glp 1 secretion change sucralose
salivary flow from baseline
brain function
disinhibited eating behavior
body mass
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
HOMEOPATHIC INDICATIONS: For temporary relief of symptoms related to food additives, herbicides and insecticides including muscle weakness, skin irritation, poor muscle coordination, headache, cough, occasional diarrhea, dizziness, fatigue, fever, stomach pain and vomiting. **These statements are based upon homeopathic principles. They have not been reviewed by the Food and Drug Administration.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Varies by country
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a supplement ingredient; no medicines register records an approval.
No source is stored against this line.
What is in the pack
Sold as liquid, given by the oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Reports sent to a regulator
These are reports people sent to a regulator. They do not show the medicine caused the reaction.
Nobody counted how many people took the medicine and reported nothing.
The same event can be reported more than once, and many reports are incomplete.
News coverage, lawsuits and new warnings change how often people report.
A count is not a rate and not a risk.
Aspartame appears in spontaneous reports to regulators. Across the 1 most-reported reaction terms, 38 reaction mentions were counted. One report can name several reactions.
The recorded terms (1)
drug hypersensitivity — 38 reaction mentions
open-targets-adr · recorded 2026-06-24 · a recorded source, not a stored snapshot
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
12 products list this as an active ingredient in the United States drug directory. None of them contains it on its own, so nothing on this page can separate it from what it is combined with.
FDA National Drug Code directory · 43742-2066 · read 2026-08-29
They are sold as liquid, taken oral.
FDA National Drug Code directory · 43742-2066 · read 2026-08-29
12 published labels name it as an active ingredient. None of them describes this substance alone, so no label text on this page can be attributed to it rather than to a combination.
US prescribing information · 8a3b75ca-8fec-4318-8a55-8bde0b82637d · read 2026-08-29
Those labels are classed as human otc drug.
US prescribing information · 8a3b75ca-8fec-4318-8a55-8bde0b82637d · read 2026-08-29
951 marketed supplement labels list this ingredient, classed as botanical with nutrients, fiber and other nutrients, non-nutrient/non-botanical and other combinations.
Those labels carry all other, approved health and nutrient claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
6 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (11)
Q1
What did Aspartame's largest trial (120 people) and its longest (6.4 years) measure?
120 people in Aspartame's largest registered study, 6.4 years in its longest registered window, measuring Performance (time to complete a physical performance task). ClinicalTrials.gov · 2026-09-01
10 na, 2 phase1, 2 phase2, 1 na or unstated; NCT01200940; 2017-03-30; no ageing endpoint recorded. Last human test completed 2025, NCT06576674.
Interpretation These counts include studies where Aspartame was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
10
phase1
2
phase2
2
na or unstated
1
Last recorded human testNCT06576674
2025-04-09
recorded 2026-09-01 · last checked 2026-09-04
Q2
From C. elegans to human: where has Aspartame shown lifespan?
Interpretation Performance (time to complete a physical performance task) — the recorded outcome words.
Show the evidence
C. elegans
lifespan
rat
lifespan
humanNCT00731510
mechanism-only; Performance (time to complete a physical performance task); 13
recorded 2026-09-01 · last checked 2026-09-04
Q3
More Aspartame was worse in human: at what point?
Hormetic in human: "Notably, MBGS exhibited broad adaptive tolerance to varying aspartame concentrations, displaying a typical hormetic response: low-level aspartame exposure exerted a stimulatory effect on MBGS performance, whereas high-level exposure triggered evident inhibitory impacts." Europe PMC · dose-response search · 2026-08-26
5 recorded sentences naming Aspartame; hormetic, dose-response, dose response
Show the evidence
hormetic
PMID 42648381
"Notably, MBGS exhibited broad adaptive tolerance to varying aspartame concentrations, displaying a typical hormetic response: low-level aspartame exposure exerted a stimulatory effect on MBGS performance, whereas high-level exposure triggered evident inhibitory impacts."
PMID 42648381
"This study not only elucidates aspartame's environmental behavior and ecological risks but also provides a novel theoretical framework for leveraging the hormetic effect in MBGS-based treatment of artificial sweetener wastewater."
dose-response
PMID 35055501
"Studies performed in mice suggest a dose-response relationship between intake of saccharin or aspartame, two artificial sweeteners, and sperm and testis function."
PMID 31108762
"The objective of the current study was to profile and compare the temporal sweetness and qualitative differences of 15 sweeteners to sucrose across nutritive saccharide (sucrose, dextrose, fructose, allulose (D-psicose), palatinose (isomaltulose), sucrose-allulose mixture), nutritive polyol (maltitol, erythritol, mannitol, xylitol, sorbitol) and non-nutritive (acesulfame-k, aspartame, sucralose,…"
dose responsePMID 20067980
"The gamma dose response of free radicals generated in irradiated aspartame tablets and its usability for emergency dosimetry was studied."
recorded 2026-08-26 · last checked 2026-09-04
Q4
Could one person measure Aspartame's effect on performance?
Performance: measured in Aspartame's trials.
Interpretation performance is the recorded endpoint.
Show the evidence
biomarkers
performance; 2026-09-01
glp 1 secretion change sucralose; 2026-09-01
salivary flow from baseline; 2026-09-01
body weight from baseline; 2026-09-01
change oral glucose tolerance; 2026-09-01
blood glucose level; 2026-09-01
3 more recorded rows
biomarkers
brain function; 2026-09-01
biomarkers
disinhibited eating behavior; 2026-09-01
biomarkers
body mass; 2026-09-01
human trials at or under30
3
Not recorded for this substance
a recorded half-life
smallest human trial
12; NCT02934321; NA; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; COMPLETED
Q5
Which of blood glucose level, body mass and body weight from baseline did Aspartame's trials measure?
blood glucose level, body mass and body weight from baseline lead 9 outcome terms across Aspartame's trials. ClinicalTrials.gov · 2026-09-01
Interpretation body weight from baseline, change oral glucose tolerance, blood glucose level, brain function, disinhibited eating behavior and body mass follow.
Show the evidence
performance
1
glp 1 secretion change sucralose
1
salivary flow from baseline
1
body weight from baseline
1
change oral glucose tolerance
1
blood glucose level
1
3 more recorded rows
brain function
1
disinhibited eating behavior
1
body mass
1
recorded 2026-09-01 · last checked 2026-09-04
Q6
What will the one ongoing trial of Aspartame report, and when?
Interpretation P-selectin, a platelet surface marker, assessed as median fluorescence intensity
Show the evidence
TrialNCT05967741
"The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation"; n 24; "P-selectin, a platelet surface marker, assessed as median fluorescence intensity"; 2026-06
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which 9 trials of Aspartame posted no result?
Posted no result
9 of 9 completed trials
Registrations
NCT01799096, NCT00731510, NCT01115088, NCT04804397, NCT01200940 and NCT02999321, and 3 more
Completion dates
oldest 2008-10; newest 2021-01-01
Show the evidence
Trial
NCT01799096
2008-10
NCT00731510
2008-12
NCT01115088
2010-04
NCT04804397
2013-06
NCT01200940
2017-03-30
NCT02999321
2017-05-05
3 further recorded trials
NCT02934321
2019-08-23
NCT02548767
2020-03-13
NCT03708939
2021-01-01
Q8
At the median, Aspartame's trials enrolled 60 people — anything larger?
Median enrolment
60
Largest enrolment
120
Registered trials counted
13
Q9
What do 38 spontaneous reports say about Aspartame — and not say?
These are reports people sent to a regulator. They do not show the medicine caused the reaction. Nobody counted how many people took the medicine and reported nothing. The same event can be reported more than once, and many reports are incomplete. News coverage, lawsuits and new warnings change how often people report. A count is not a rate and not a risk.
Aspartame appears in spontaneous reports to regulators. Across the 1 most-reported reaction term, 38 reaction mentions were counted: drug hypersensitivity 38. open-targets-adr · CHEMBL171679 · 2026-06-24
Show the evidence
drug hypersensitivity
38
recorded 2026-06-24 · last checked 2026-09-04
Q10
Was Aspartame studied with fasting and exercise?
fasting and exercise are named in Aspartame's label sentences: "During the longer visit, participants underwent fasting BG testing before consuming a 500 ml beverage of either a 0.05% aspartame solution, an 11% sucrose solution, or water (with these beverage groups randomized)." openfda-label+europepmc · 2026-01-08
2 recorded statements; fasting, exercise
Show the evidence
fasting
During the longer visit, participants underwent fasting BG testing before consuming a 500 ml beverage of either a 0.05% aspartame solution, an 11% sucrose solution, or water (with these beverage groups randomized).
exercise
Thirty minutes before exercise, participants ingested a drink containing either 250 mg of caffeine + 10 g of glucose + aspartame (CAF), 10 g of glucose + aspartame (GLU), or aspartame alone (ASP).
recorded 2026-01-08 · last checked 2026-09-04
Q11
What is recorded about Aspartame and mTOR?
"Further in vitro experiments demonstrated that aspartame inhibited SIRT1 and the PI3K/AKT/mTOR pathway, increased ROS levels, and promoted apoptosis; these effects were reversed by SIRT1 overexpression." — where Aspartame and mTOR appear together. Europe PMC · pathway abstract search · 2026-08-17
"Further in vitro experiments demonstrated that aspartame inhibited SIRT1 and the PI3K/AKT/mTOR pathway, increased ROS levels, and promoted apoptosis; these effects were reversed by SIRT1 overexpression."
sirtuin
PMID 42604715
"Further in vitro experiments demonstrated that aspartame inhibited SIRT1 and the PI3K/AKT/mTOR pathway, increased ROS levels, and promoted apoptosis; these effects were reversed by SIRT1 overexpression."
PMID 38672209
"In silico and in vitro analyses showed that aspartame could target and reduce the expression of SIRT1 and FOXO3a proteins in neuron cells."
PMID 38672209
"Additionally, aspartame triggered the reduction of autophagy flux by inhibiting the nuclear translocation of SIRT1 in neuronal cells."
autophagy
PMID 38672209
"Additionally, aspartame triggered the reduction of autophagy flux by inhibiting the nuclear translocation of SIRT1 in neuronal cells."
"This study reveals that aspartame can enhance innate immunity, extend lifespan and healthspan, and improve antioxidant capacity in Caenorhabditis elegans by activating the evolutionarily conserved autophagy pathway."
mTORPMID 30373500
"mTOR: mammalian target of rapamycin; SD: Sprague-Dawley; SPF: Specific-pathogen free; ROS: reactive oxygen species; TUNEL: terminal transferase uridyl nick end labelling; DCFH-DA: Dichloro-dihydro-fluorescein diacetate; Fluo-3A: Fluo-3 acetoxymethyl ester; NMDAR: non-competitive N-methyl-D-aspartame glutamate receptor; 4E-BP1: 4E binding protein 1; p70S6K: p70 S6 Kinase; PCR: Polymerase chain…"
NAD+
"The aspartame content in aqueous solutions is determined by enzymatic cleavage into aspartic acid and phenylalanine methyl ester using peptidase, followed by a detection reaction cocatalysed by adenine dinucleotide, wherein either the phenylalanine is, after elimination of the ester group by means of chymotrypsin, converted by phenylalanine dehydrogenase in the presence of NAD< +> into…"
"The aspartame content in aqueous solutions is determined by enzymatic cleavage into aspartic acid and phenylalanine methyl ester using peptidase, followed by a detection reaction cocatalysed by adenine dinucleotide, wherein either the phenylalanine is, after elimination of the ester group by means of chymotrypsin, converted by phenylalanine dehydrogenase in the presence of NAD+ into…"
recorded 2026-08-17 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · Open Targets 26.06 — CC0 · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
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