Asarum Canadense Root
- Plant preparation
- Varies by country
- Identity checked
- Sources last checked 2026-09-04
This page shows what was measured, who it was measured in, and what that does not settle.
RNAWiki holds very little about this substance. The page shows what there is.
What Asarum Canadense Root does in the body
RNAWiki has not recorded what this substance changes in the body.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
- Where it acts
- Not recorded.
- Kind of result
- No result is published, so no kind of result applies yet
- Supervision
- Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
What the registries record it as
The substance registry classes this as structurallydiverse.
FDA substance registry · E2O4O7TQYK · read 2026-08-29
It is recorded as coming from ASARUM CANADENSE WHOLE. The part recorded is root.
FDA substance registry · E2O4O7TQYK · read 2026-08-29
The organism is Asarum canadense, a species.
NCBI Taxonomy · 28498 · read 2026-08-29
Where each sentence above came from
No plain explanation of what this changes is stored.
No recorded use is stored in reader language.
No statement of the main limit is recorded.
The four opening statements run to 26 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in peopleRead from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
| Goal | Life outcome | What a body can do | How a person feels | A test result | A step in the body | Harms | How long | Who was studied |
|---|---|---|---|---|---|---|---|---|
| Blood sugar | Nothing in the sources checkedNo registered study lists a life outcome for this goal. | Nothing in the sources checkedNo registered study lists a performance measure for this goal. | Nothing in the sources checkedNo registered study lists a symptom measure for this goal. | Only a number moved5 registered test measure. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
| Body weight | Nothing in the sources checkedNo registered study lists a life outcome for this goal. | Nothing in the sources checkedNo registered study lists a performance measure for this goal. | Nothing in the sources checkedNo registered study lists a symptom measure for this goal. | Only a number moved3 registered test measure. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
| Pain | Nothing in the sources checkedNo registered study lists a life outcome for this goal. | Nothing in the sources checkedNo registered study lists a performance measure for this goal. | Waiting for a reviewer3 registered symptom measure. | Nothing in the sources checkedNo registered study lists a test result for this goal. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
| Mood | Nothing in the sources checkedNo registered study lists a life outcome for this goal. | Nothing in the sources checkedNo registered study lists a performance measure for this goal. | Waiting for a reviewer1 registered symptom measure. | Nothing in the sources checkedNo registered study lists a test result for this goal. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
| Healthy ageing | Waiting for a reviewer1 registered study measure of this kind. No reviewed result yet. | Nothing in the sources checkedNo registered study lists a performance measure for this goal. | Nothing in the sources checkedNo registered study lists a symptom measure for this goal. | Nothing in the sources checkedNo registered study lists a test result for this goal. | Nothing in the sources checkedNo registered study lists a body-step measure for this goal. | Not recordedHarms were not a registered measure for this goal. | Not recordedNo finished study window is recorded. | Waiting for a reviewerWho was studied is listed further down the page. |
Which registered measures put each goal on this table
- Blood sugar
- endogenous glucose production; glucose rates of disappearance; hba1c; insulin resistance; fasting glucose
- Body weight
- body fat; body weight; weight change
- Pain
- pain assessment; visual analog scale pain; pain severity
- Mood
- depression; hamilton anxiety rating scale
- Healthy ageing
- all cause mortality
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
- Nothing in the sources checked
- No registered study lists a life outcome for this goal.
- Only a number moved
- 5 registered test measure.
- Not recorded
- Harms were not a registered measure for this goal.
- Waiting for a reviewer
- Who was studied is listed further down the page.
What happened in peopleRead from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
- Living longer, or avoiding a major event Evidence recorded. Death, a heart attack, a stroke, a hospital stay.2 registered measures of this kind. No reviewed result.
- What a body can do day to day Evidence recorded. Walking, dressing, breathing, recovering.1 registered measure of this kind.
- Measured performance Evidence recorded. How much was lifted, how far was run, how fast.1 registered measure of this kind.
- Symptoms and quality of life Evidence recorded. Pain, tiredness, mood, sleep, as the person rated it.4 registered measures of this kind.
- A number that stands in for health Evidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.13 registered measures of this kind.
- A step measured inside a person Evidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
- Animals Evidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Yeast, C. elegans (roundworm), Drosophila (fruit fly), Mouse, Rat, Dog. A result in animals says what to test next. It does not say what happens in people.
- Cells in a dish Evidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
- A guess from software No evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to takeRead from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
- hamilton anxiety rating scale
- pain assessment
- visual analog scale pain
- pain severity
Measured
Things only a test, a scale or a device shows.
- plaque inflammation
- blood pressure
- exercise capacity
- endogenous glucose production
- glucose rates of disappearance
- hba1c
- body fat
- bone mineral density of the lumbar spine
- body weight
- insulin resistance
and 4 more.
Meaningful
Things that change how a life goes, not only a number.
- overall survival
- all cause mortality
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (20)
- depression
- physical activity level
- serious adverse events
- caregiver burden
- time till the first cardiovascular composite endpoint
- bmi z
- balance
- inhaled corticosteroid prescriptions refilled
- relative effect on flow mediated dilatation of radial artery
- falls
- disease activity based on 28 joint count
- troponin t release over the perioperative 72 hour period
- lipids
- incidence of atrial fibrillation
- physical function
- cesarean section
- protocol compliance feasibility and adverse events
- quit rate
- weight
- program feasibility
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclearRead from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
- HOMEOPATHIC INDICATIONS: For temporary relief of symptoms related to chemical toxicity such as sleep disturbances, head discomfort, irregular bowel habits, memory difficulties, pain and weakness, trembling, nausea. **These statements are based upon homeopathic principles.
Who is missing from the studies
- Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
- This is a scope explorer, not a diagnosis engine.
- It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to takeRead from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
- A different form was studied
- The studied form is not the form on the shelf. Nothing in this record points to this reason.
- There was nothing to correct
- Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
- Something else had to happen too
- In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
- The change is too small to feel
- A real change can still sit below what a person notices. Nothing in this record points to this reason.
- Day-to-day swing hides it
- Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
- Not enough time yet
- The studies ran longer than the person has waited. Nothing in this record points to this reason.
- It was not taken as studied
- Missed days change the result, and studies count them. Nothing in this record points to this reason.
- Something else changed at the same time
- Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
- The product may not be what it says
- Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
- No recorded reason
- RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to takeRead from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Varies by country
Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Oral
Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Not usually supervised: sold as a supplement or food ingredient where recorded. That is a legal category, not a safety judgement.
Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
The identity record classes it as a botanical or organism preparation; no register records an approval.
No source is stored against this line.
What is in the pack
Sold as liquid, given by the oral route.
Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to takeNothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclearRead from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Oral
Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
7 products list this as an active ingredient in the United States drug directory. None of them contains it on its own, so nothing on this page can separate it from what it is combined with.
FDA National Drug Code directory · 43742-1416 · read 2026-08-29
They are sold as liquid, taken oral.
FDA National Drug Code directory · 43742-1416 · read 2026-08-29
7 published labels name it as an active ingredient. None of them describes this substance alone, so no label text on this page can be attributed to it rather than to a combination.
US prescribing information · 91f52c95-f36d-4754-8570-f81ed8d36180 · read 2026-08-29
Those labels are classed as human otc drug.
US prescribing information · 91f52c95-f36d-4754-8570-f81ed8d36180 · read 2026-08-29
8010 marketed supplement labels list this ingredient, classed as botanical.
NIH Dietary Supplement Label Database · 200005 · read 2026-08-29
Those labels carry all other and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
NIH Dietary Supplement Label Database · 200005 · read 2026-08-29
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to takeRead from sources, not yet reviewed
What you could measure
Watching one thing carefully can tell you whether it moved. It cannot tell you what moved it.
This is sold without a prescription, so a person can sensibly watch one thing and see whether it moves.
Pick one goal. One goal only. Two at once cannot be told apart afterwards.
Pick one thing to watch. Registered studies measured things like: plaque inflammation; blood pressure; exercise capacity.
Measure before you start. Take the same measurement several times first. One reading is not a starting point.
Know the swing. Write down how much it moves on its own across a normal week.
Change one thing. Change nothing else at the same time, including training and sleep.
Give it the study length. No finished study window is recorded, so no length is suggested here.
Track whether you took it. Missed days are the most common reason a home test shows nothing.
Read the trend. Look at the line across weeks. A single reading tells you almost nothing.
What not to measure
- Anything that swings more day to day than the change you are looking for.
- A wearable estimate of sleep stages, which is an estimate and not a measurement.
- Weight on one morning, which mostly records water.
- A feeling you did not write down before starting, such as: hamilton anxiety rating scale.
When to stop
- Stop if something new and unpleasant starts, and ask a pharmacist or doctor.
- Stop if you cannot keep everything else steady, because the result will not mean anything.
- Stop at the end of the window you set, and read the trend then.
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki does not work out an amount for anyone.
What is missing or unclearRead from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
How fast does the body clear it?
The sources RNAWiki checked hold nothing for this field.
Why it matters. Without this, nothing on this page can say how long anything lasts.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of Asarum Canadense Root are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Mechanism not reviewed
No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in peopleRead from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
Where else this substance is registered
- FDA substance identifier (UNII)
- E2O4O7TQYK
- RxNorm concept
- 1428416
Checks this page had to pass
Passed
Identity resolved
no open identity hold
Passed
No unresolved merge across substance families
no quarantine open
Not passed
Every public sentence names a source
The opening statement carries no source: the record holds neither an explanation nor a recorded use.
Not passed
Trial roles classified for highlighted evidence
No registered study is classified as testing this substance.
Passed
No internal keys in reader text
enforced by the copy-contract test over the rendered page
Passed
Safety mode resolved
The identity record classes it as a botanical or organism preparation; no register records an approval.
Passed
Canonical metadata present
slug and display name present
What is missing or unclearRead from sources, not yet reviewed
How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
The earliest marketing start date recorded for a listed product is 20190102.
FDA National Drug Code directory · 43742-1416 · read 2026-08-29
What is missing or unclearRead from sources, not yet reviewed
What to learn next
Ordered by what would most change how you read this page, starting with what is easiest to misunderstand.
- Were people like me actually studied?
- How close is this evidence to something I would notice?
- What does nobody know about this yet?
- What is a stand-in result?
This order is fixed in code and does not count clicks or time on the page.
What is not here
7 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
- What happened in people — found nothing in the sources checked.
- The path through the body — found nothing in the sources checked.
- How long anything takes — found nothing in the sources checked.
- What it may clash with — found nothing in the sources checked.
- Other ways to the same goal — found nothing in the sources checked.
- Claims that go past the evidence — found nothing in the sources checked.
- What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (14)
What did Asarum Canadense Root's largest trial (1825937 people) and its longest (24 years) measure?
1825937 people in Asarum Canadense Root's largest registered study, 24 years in its longest registered window, measuring 30-day all-cause mortality. ClinicalTrials.gov · 2026-09-01
2367 na, 250 phase2, 225 phase3, 176 phase4, 113 phase1, 76 na or unstated, 30 early phase1; NCT00131235; 2027-12-31. Last human test completed 2026, NCT07013357.
Interpretation These counts include studies where Asarum Canadense Root was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
- na2367
- phase2250
- phase3225
- phase4176
- phase1113
- na or unstated76
2 more recorded rows
- early phase130
- Last recorded human test NCT070133572026-08-19
recorded 2026-09-01 · last checked 2026-09-04
From yeast to human: where has Asarum Canadense Root shown lifespan?
C. elegans: lifespan, Drosophila: lifespan, yeast: mechanism-only, mouse: lifespan, rat: lifespan, dog: mechanism-only and human: lifespan (3125): the rungs where Asarum Canadense Root has a recorded finding. Europe PMC and ClinicalTrials.gov · organism ladder · 2026-09-01
30-day all-cause mortality. — the recorded outcome words.
Show the evidence
- C. eleganslifespan
- Drosophilalifespan
- yeastmechanism-only
- mouselifespan
- ratlifespan
- dogmechanism-only
1 more recorded row
- human NCT00394303lifespan; 30-day all-cause mortality.; 3125
recorded 2026-09-01 · last checked 2026-09-04
180 of Asarum Canadense Root's trials stopped: safety, futility/efficacy, accrual/recruitment, funding/business, sponsor decision unspecified, other?
safety (5), futility/efficacy (5), accrual/recruitment (51), funding/business (26), sponsor decision unspecified (4) and other (89): Asarum Canadense Root's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"Low probability of positive outcome"; 180 of 3125 registered studies
Show the evidence
Trial
- NCT00089141terminated; "Low probability of positive outcome"
- NCT00146263withdrawn; "Difficulty in enrolling subjects in the proposed crossover study design"
- NCT00212004terminated; "Limited budget to continue this study"
- NCT00218686withdrawn; "In ability to obtain Indian governmental approval from the study from NACO"
- NCT00346983terminated; "Difficulty enrolling eligible subjects"
- NCT00358423terminated; "Difficulty enrolling eligible subjects"
14 further recorded trials
- NCT00374543terminated; "Recruitment goal could not be achieved"
- NCT00394303terminated; "Trial suspended on 26 February, following the publication of a trial with negative results (Ann Intern Med 146(4), 2007). Pending ethics committee re-approval."
- NCT00394589terminated; "Study enrollment was stopped due to insufficient subject accrual."
- NCT00480948terminated; "Study design changes were needed due to change of protocol to a multisite trial and updated set up"
- NCT00487279terminated; "Study terminated early due to inability to enroll."
- NCT00555646terminated; "Change of dose regimen (new protocol)"
- NCT00637494terminated; "DRC recommended stopping study as it had missed its primary endpoint"
- NCT00675714terminated; "At the request of the study site, this study has been closed and access to study-related data is unavailable. We are unable to submit the results-data."
- NCT00697606terminated; "lack of funding"
- NCT00789945terminated; "This research was completed before January 18, 2017, and does not meet the ACT requirement to register and report results per the guidance provided in "Clinical Trials Registration and Results Information Submission" dated 09/21/2016."
- NCT00809380terminated; "Study ws terminated because of a too low recruitment rate."
- NCT00815217withdrawn; "due to PI work schedule and no personnel resources"
- NCT01008436terminated; "Lack of product due to industrial changes in the manufacturing process altering the final product."
- NCT01032512withdrawn; "impossibility to include patients in the study"
recorded 2026-09-01 · last checked 2026-09-04
Human studies of Asarum Canadense Root used Injectable control (Sodium Chloride Injection United States Pharmacopeia (USP) (0.9%)) — over how long?
Human studies of Asarum Canadense Root used "Injectable control (Sodium Chloride Injection United States Pharmacopeia (USP) (0.9%))". ClinicalTrials.gov · 2026-09-01
9 recorded entries; human; also "Control, 700 mg Calcium", "Control (109 g white bread)", "The energy content of one single bottle control is also 138kcal and contains 7.6g fat, 11.1g carbohydrates and 3.9g…"
Show the evidence
human
- NCT01903330Injectable control (Sodium Chloride Injection United States Pharmacopeia (USP) (0.9%))
- NCT01909063Control, 700 mg Calcium
- NCT02486978Control (109 g white bread)
- NCT02956369The energy content of one single bottle control is also 138kcal and contains 7.6g fat, 11.1g carbohydrates and 3.9g protein.
- NCT04390503Control (albumin 5%)
- NCT06057675Control (1% lidocaine with 1:100,000 epinephrine)
3 more recorded rows
- human NCT06376916Control (50ml 0.9% NaCl)
- human NCT07439848Control (NaCl 0.9%)
- human NCT07626099Control(Citrizine 10mg)
recorded 2026-09-01 · last checked 2026-09-04
Did Asarum Canadense Root move epigenetic clock, and by how much?
epigenetic clock: "Using a large case-control study of 2189 head and neck squamous cell carcinoma (HNSCC) cases and 2189 age- and sex-matched controls, we investigated the associations between polygenic scores (PGSs) for multiple epigenetic clocks and HNSCC risk, and evaluated their potential causal roles using two-sample Mendelian…" Europe PMC · epigenetic clock search · 2026-07-02
4 recorded sentences; 2026, 2025, 2024; biomarker
Show the evidence
- epigenetic clock PMID 423914452026; "Using a large case-control study of 2189 head and neck squamous cell carcinoma (HNSCC) cases and 2189 age- and sex-matched controls, we investigated the associations between polygenic scores (PGSs) for multiple epigenetic clocks and HNSCC risk, and evaluated their potential causal roles using two-sample Mendelian randomization (MR)."
- epigenetic age PMID 404603542025; "We performed a multicenter case-control analysis of epigenetic age in a prospectively collected set of whole blood DNA samples and clinical data."
- PhenoAge PMID 411957282025; "In a stratified analysis, only the control group showed a modest correlation between TL and PhenoAge clock (<i>r</i> = 0.2, <i>p</i> = 0.06)."
- epigenetic age PMID 387320692024; "Our findings from a prospective population-based-case-control study indicate a direct association between incident CRC and four markers of accelerated baseline epigenetic age."
recorded 2026-07-02 · last checked 2026-09-04
More Asarum Canadense Root was worse in human: at what point?
Hormetic in human: "By contrast, hormesis in natural enemies, such as pathogens, parasitoids and predators, can enhance their biological control performance under specific conditions." Europe PMC · dose-response search · 2026-08-06
5 recorded sentences naming Asarum Canadense Root; hormesis, U-shaped, hormetic
Show the evidence
- hormesis PMID 41261782"By contrast, hormesis in natural enemies, such as pathogens, parasitoids and predators, can enhance their biological control performance under specific conditions."
U-shaped
- PMID 42590765"The results show that the virtual sentinel obstacle strategy prevents entrapment around the tested U-shaped obstacles, while fuzzy control shortens the path and improves smoothness."
- PMID 41814871"Glycemic control exhibits a U-shaped relationship with dietary fat, with an overall optimum at 36.0% of energy."
hormetic
- PMID 37709054"A major feature of the hormetic concept is that low levels of biological, chemical, physical and psychological stress upregulate adaptive responses that not only precondition, repair and restore normal functions to damaged tissues/organs but modestly overcompensate, reducing ongoing background damage, thereby enhancing health beyond that in control groups, lacking the low level "beneficial"…"
- PMID 37709054"The most significant feature of the hormetic dose response is that the limits of biological plasticity for adaptive processes are less than twice that of control group responses, with most, at maximum, being 30-60 % greater than control group values."
recorded 2026-08-06 · last checked 2026-09-04
Could one person measure Asarum Canadense Root's effect on depression?
Depression: measured in Asarum Canadense Root's trials.
Interpretation depression is the recorded endpoint.
Show the evidence
biomarkers
- depression; 2026-09-01
- plaque inflammation; 2026-09-01
- physical activity level; 2026-09-01
- serious adverse events; 2026-09-01
- blood pressure; 2026-09-01
- caregiver burden; 2026-09-01
14 more recorded rows
- biomarkersexercise capacity; 2026-09-01
- biomarkersendogenous glucose production; 2026-09-01
- biomarkersglucose rates of disappearance; 2026-09-01
- biomarkerstime till the first cardiovascular composite endpoint; 2026-09-01
- biomarkershba1c; 2026-09-01
- biomarkersbody fat; 2026-09-01
- biomarkersbmi z; 2026-09-01
- biomarkersbalance; 2026-09-01
- biomarkersinhaled corticosteroid prescriptions refilled; 2026-09-01
- biomarkersrelative effect on flow mediated dilatation of radial artery; 2026-09-01
- biomarkersfalls; 2026-09-01
- biomarkershamilton anxiety rating scale; 2026-09-01
- biomarkersoverall survival; 2026-09-01
- biomarkerspain assessment; 2026-09-01
- human trials at or under30680
- Not recorded for this substancea recorded half-life
- smallest human trial0; NCT00146263; NA; the smallest recorded human enrolment at or below 30; the registry states no direction of its result; WITHDRAWN
Which of all cause mortality, balance and blood pressure did Asarum Canadense Root's trials measure?
all cause mortality, balance and blood pressure lead 40 outcome terms across Asarum Canadense Root's trials. ClinicalTrials.gov · 2026-09-01
Interpretation serious adverse events, blood pressure, caregiver burden, exercise capacity, endogenous glucose production and glucose rates of disappearance follow.
Show the evidence
- depression1
- plaque inflammation1
- physical activity level1
- serious adverse events1
- blood pressure1
- caregiver burden1
14 more recorded rows
- exercise capacity1
- endogenous glucose production1
- glucose rates of disappearance1
- time till the first cardiovascular composite endpoint1
- hba1c1
- body fat1
- bmi z1
- balance1
- inhaled corticosteroid prescriptions refilled1
- relative effect on flow mediated dilatation of radial artery1
- falls1
- hamilton anxiety rating scale1
- overall survival1
- pain assessment1
recorded 2026-09-01 · last checked 2026-09-04
Which of Asarum Canadense Root's 559 ongoing trials reports first?
559 registered trials of Asarum Canadense Root are open; earliest completion 2023-06-30. ClinicalTrials.gov · 2026-09-01
Proportion of preterm births; Total grams of snack food consumed; latest 2045-08-30
Show the evidence
Trial
- NCT00131235"Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth"; n 1320; "Proportion of preterm births"; 2027-12-31
- NCT01725425"The Effect of Portion Sizes on Mood"; n 25; "Total grams of snack food consumed"; 2025-12-31
- NCT01982890"Telomeres and T-cell Receptor Excision Circles (TRECs) From Peripheral Blood in Normal Subjects Over Time"; n 200; "Estimation of variability of multiple measures of the length of telomeres over one year"; 2026-12-31
- NCT02123641"Physical Activity as Intervention Against Age-related Loss of Muscle Mass and Function"; n 451; "Change in leg extensor power"; 2028-06
- NCT02487134"Trial of Routine Abdominal Wall Closure Versus Reinforcement With TIGR Matrix Onlay"; n 200; "Number of patients with incisional hernia one year after surgery"; 2027-06-30
- NCT02653287"Lupus Intervention for Fatigue Trial"; n 200; "Change in Fatigue Severity Scale over time"; 2027-12-31
14 further recorded trials
- NCT03042988"Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension"; n 20; "Systolic blood pressure"; 2026-12-30
- NCT03303586"Effects of Compression Stockings in Asthma Symptoms at Night"; n 40; "Effect of wearing compression stockings on reducing rostral fluid shift during sleep and its effect in airway narrowing"; 2026-08-31
- NCT03367845"Efficacy of Family Programs for Improving Child and Family Health and Development"; n 1005; "Change in Parental Sensitivity"; 2028-06-30
- NCT03499236"Reducing Lung CongestIon Symptoms in Advanced Heart Failure"; n 605; "Safety-Percentage of Treatment patients experiencing major device-related adverse events"; 2027-10-31
- NCT03540758"Regulation of Endogenous Glucose Production by Central KATP Channels"; n 100; "Change in Endogenous glucose production (EGP) rate"; 2027-04
- NCT03607799"A Culturally-tailored Personalized Nutrition Intervention in South Asian Women at Risk of Gestational Diabetes"; n 140; "Glucose area-under-the-curve (glucose AUC)"; 2025-12-31
- NCT03614962"Warmth and Transcutaneous Electrical Nerve Stimulation (TENS) in Improving Cognitive Functions in People with Dementia"; n 150; "The Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) - Baseline"; 2024-12-02
- NCT03621813"Exercise Rehabilitation in Veteran Cancer Survivors"; n 9; "Pain Visual Analog Scale Change"; 2026-12-30
- NCT03632044"Evaluation of Trigeminal Nerve Blockade"; n 40; "Change in time to oral intake following palatoplasty for cleft palate"; 2027-10-30
- NCT03674697"The Effect of Light Therapy on Post-Surgical Pain"; n 70; "The amount of pain reducing medication used by the active treatment group and the control group."; 2027-12-31
- NCT03706014"Innovative Family Prevention With Latino Siblings in Disadvantaged Settings"; n 270; "Parenting of Siblings Measure"; 2025-12-15
- NCT03822572"ABCSG C08-Exercise II: Trial of Endurance Exercise Following Adjuvant Chemotherapy for Colorectal Cancer"; n 92; "Primary Endpoint - disease free survival (DFS)"; 2028-01
- NCT03824106"Frailty Rehabilitation"; n 324; "Change in Physical Performance"; 2025-12-31
- NCT03900780"Preimplantation Genetic Testing for Aneuploidies in Patients With Recurrent Implantation Failure"; n 100; "OPR"; 2026-12-31
recorded 2026-09-01 · last checked 2026-09-04
Which running trial of Asarum Canadense Root could settle lifespan?
NCT06836856 measures Incidence of In-hospital mortality, reading out 2025-06.
29 open trials; n 100; "Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury"
Show the evidence
Trial
- NCT06836856"Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury"; n 100; "Incidence of In-hospital mortality"; 2025-06
- NCT07042711"Impact of Vitamin D on Therapeutic Respons in NPC Chemoradiated Patients"; n 300; "Effect of Vitamin D Supplementation on therapeutic response in nasopharyngeal cancer (NPC) patients undergoing chemoradiation and its relation with IL-6"; 2025-12-09
- NCT03824106"Frailty Rehabilitation"; n 324; "Change in Physical Performance"; 2025-12-31
- NCT06812286"TrackFrailty Project"; n 45; "Frailty phenotype"; 2026-07
- NCT07130513"Investigating the Feasibility of Krill Oil Intervention to Improve Muscle Function in Adults With Long-term Conditions"; n 30; "Grip strength"; 2026-07-30
- NCT07438002"Analysis of Effects of High-intensity Physical Exercise in Subjects With Dialyzed Chronic Kidney Disease and in Conservative Treatment"; n 50; "Gait speed (6MWT)"; 2026-09
14 further recorded trials
- NCT07747961"Effect of Virtual Reality Mediated Gamified Rehabilitation in Children With Spastic Diplegic Cerebral Palsy"; n 42; "Timed Up and Go Test"; 2026-09-30
- NCT07747974"Effectiveness of Modified Constraint-Induced Movement Therapy Versus Mirror Therapy in Spastic Hemiplegic Cerebral Palsy Children"; n 42; "Grip Strength"; 2026-09-30
- NCT04100200"Berries, Inflammation, and Gut Microbiome"; n 105; "Changes in plasma biomarkers and measures of inflammation concentration: Nrf2/ NF-κB -response between 4 treatments"; 2026-10-01
- NCT07333690"The Effects of Healthy Lifestyle Management Training and Personalized Physical Activity Counseling: A Randomized Controlled Trial"; n 26; "Physical Function"; 2026-10-15
- NCT04135586"Effects of a Physical Exercise Intervention During Neoadjuvant Chemotherapy in Women With Breast Cancer"; n 80; "Cardiorespiratory fitness"; 2026-12-01
- NCT07224659"Exercise and Mortality in Middle-Aged and Older Adults"; n 19000; "Overall survival (all-cause mortality)"; 2026-12-01
- NCT04267705"Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human"; n 103; "Plasma biomarkers and measures of inflammation: Nrf2/ NF-κB"; 2027-01-30
- NCT06620380"Ex Vivo Drug Response Evaluation for Next Generation Care of Brain Metastases"; n 102; "Overall survival"; 2027-06
- NCT06161610"Recurrent High Grade Glioma Treated by LITT"; n 135; "Progression-free survival"; 2027-09-19
- NCT07217275"Rise With Resilience"; n 40; "Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function"; 2027-10
- NCT05585190"Stand up for Your Health With a Sit-stand Desk"; n 198; "Insulin sensitivity (HOMA-IR)"; 2027-12-31
- NCT06882811"Human Umbilical Cord Mesenchymal Stem Cells Treatment in Sepsis"; n 180; "28-day survival rate"; 2027-12-31
- NCT03822572"ABCSG C08-Exercise II: Trial of Endurance Exercise Following Adjuvant Chemotherapy for Colorectal Cancer"; n 92; "Primary Endpoint - disease free survival (DFS)"; 2028-01
- NCT07343206"Early Norepinephrine Administration and Rapid Dose Adjustment"; n 600; "28-day survival"; 2028-03
Which 1335 trials of Asarum Canadense Root posted no result?
- Posted no result
- 1335 of 1335 completed trials
- Registrations
- NCT00000588, NCT00666874, NCT00640783, NCT00227162, NCT00336622 and NCT02806349, and 1329 more
- Completion dates
- oldest 1995-03-31; newest 2024-09-03
Show the evidence
Trial
- NCT000005881995-03-31
- NCT006668742002-02
- NCT006407832004-01
- NCT002271622004-05
- NCT003366222005-03
- NCT028063492005-03
14 further recorded trials
- NCT005653572005-08
- NCT002120562005-12
- NCT013048882005-12
- NCT000422112006-01
- NCT001725362006-02
- NCT001310792006-03
- NCT010281572006-03
- NCT005633292006-07
- NCT005635112006-08
- NCT008018142006-08
- NCT009176182006-09
- NCT007377502006-10
- NCT007380102006-10
- NCT001672712006-11
At the median, Asarum Canadense Root's trials enrolled 70 people — anything larger?
- Median enrolment
- 70
- Largest enrolment
- 1825937
- Registered trials counted
- 3122
Was Asarum Canadense Root studied with fasting, caloric restriction and exercise?
fasting, caloric restriction and exercise are named in Asarum Canadense Root's label sentences: "The ENSATI trial is a randomized, open-label, controlled study with three parallel arms: active dietary counseling control, 25% calorie restriction, and time-restricted eating (14-hour fasting/10-hour eating window) over six months, followed by six months of post-intervention monitoring." openfda-label+europepmc · 2026-06-12
3 recorded statements; fasting, caloric restriction, exercise
Show the evidence
- fastingThe ENSATI trial is a randomized, open-label, controlled study with three parallel arms: active dietary counseling control, 25% calorie restriction, and time-restricted eating (14-hour fasting/10-hour eating window) over six months, followed by six months of post-intervention monitoring.
- caloric restrictionThe ENSATI trial is a randomized, open-label, controlled study with three parallel arms: active dietary counseling control, 25% calorie restriction, and time-restricted eating (14-hour fasting/10-hour eating window) over six months, followed by six months of post-intervention monitoring.
- exerciseIn this 12-month, parallel-group randomised controlled trial, 99 obese adults were randomly assigned to an intervention group (standardised meal kit + exercise) or a control group (standard dietary advice + exercise).
recorded 2026-06-12 · last checked 2026-09-04
What is recorded about Asarum Canadense Root and mTOR?
"Through the AMPK-mTOR axis, AMPK also regulates autophagy and mitophagy, affecting inhibitory control of RIPK1 and autophagic turnover of RIPK3." — where Asarum Canadense Root and mTOR appear together. Europe PMC · pathway abstract search · 2026-08-17
mTOR, AMPK, autophagy, sirtuin, NAD+; PMID 42584540, 42504324, 42534639, 41733736
Show the evidence
- mTOR PMID 42584540"Through the AMPK-mTOR axis, AMPK also regulates autophagy and mitophagy, affecting inhibitory control of RIPK1 and autophagic turnover of RIPK3."
- AMPK PMID 42584540"Through the AMPK-mTOR axis, AMPK also regulates autophagy and mitophagy, affecting inhibitory control of RIPK1 and autophagic turnover of RIPK3."
- autophagy PMID 42584540"Through the AMPK-mTOR axis, AMPK also regulates autophagy and mitophagy, affecting inhibitory control of RIPK1 and autophagic turnover of RIPK3."
- sirtuin PMID 42504324"Sirtuin 1 (SIRT1), an NAD⁺-dependent deacetylase, has emerged as a pivotal regulatory hub that integrates inflammatory signaling, cellular stress responses, metabolic reprogramming, and epigenetic control."
- NAD+ PMID 42504324"Sirtuin 1 (SIRT1), an NAD⁺-dependent deacetylase, has emerged as a pivotal regulatory hub that integrates inflammatory signaling, cellular stress responses, metabolic reprogramming, and epigenetic control."
- AMPK PMID 42534639"Empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has demonstrated pleiotropic metabolic effects extending beyond glycemic control, including modulation of AMPK signaling, attenuation of oxidative stress, and suppression of inflammatory activation."
3 more recorded rows
- sirtuin PMID 41733736"The SIRT1 inhibitor alone did not alter axon numbers significantly compared with the control group."
- AMPK PMID 42193899"Mechanistically, HISPRO was associated with activation of the SIRT1-PGC1α-AMPK signaling axis compared with the control group, as evidenced by increased <i>Nampt</i> and <i>Nmnat1</i> expression, an elevated NAD<sup>+</sup>/NADH ratio, and enhanced AMPK phosphorylation."
- sirtuin PMID 42193899"Mechanistically, HISPRO was associated with activation of the SIRT1-PGC1α-AMPK signaling axis compared with the control group, as evidenced by increased <i>Nampt</i> and <i>Nmnat1</i> expression, an elevated NAD<sup>+</sup>/NADH ratio, and enhanced AMPK phosphorylation."
NAD+
- PMID 42193899"Mechanistically, HISPRO was associated with activation of the SIRT1-PGC1α-AMPK signaling axis compared with the control group, as evidenced by increased <i>Nampt</i> and <i>Nmnat1</i> expression, an elevated NAD<sup>+</sup>/NADH ratio, and enhanced AMPK phosphorylation."
- PMID 41977220"Sirtuin 1 (SIRT1), a NAD<sup>+</sup>-dependent deacetylase, has emerged as a central metabolic sensor linking energy availability to transcriptional control of inflammation, oxidative stress, mitochondrial biogenesis and cellular senescence."
- mTOR PMID 42121908"At the molecular level, AMPK coordinates signaling networks that include mTOR, SIRT1, PGC-1α, and FOXO to modulate mitochondrial function, oxidative stress, and autophagy-related quality control."
- autophagy PMID 42121908"At the molecular level, AMPK coordinates signaling networks that include mTOR, SIRT1, PGC-1α, and FOXO to modulate mitochondrial function, oxidative stress, and autophagy-related quality control."
- mTOR PMID 42607934"Experimental and clinical evidence indicates that phytochemicals engage conserved ageing hubs spanning insulin-IGF signaling, AMPK-mTOR nutrient sensing, redox regulation, and mitochondrial quality control - exemplified by berberine via AMPK, curcumin via NF-κB, and resveratrol via SIRT1."
- autophagy"Two stress-adaptive programs sit at the center of such pathological transition: autophagy, the homeostatic engine responsible for lysosomal recycling and organelle quality control, and cellular senescence, a tissue repair system that becomes deleterious when persistent, driving dysfunction through stable growth arrest and senescence-associated secretory phenotype (SASP)-associated inflammatory…"
recorded 2026-08-17 · last checked 2026-09-04
Where it is registered
Identifiers, relations and other names
The exact record
- UNII
- E2O4O7TQYK
- RxCUI
- 1428416
- Trade name
- Ear Ring, Dizzy, Chemdetox, Chemtox, Control, Ear Ring / Dizzy / Chemdetox / Chemtox / Control
- Also called
- ASARUM ACUMINATUM ROOT, ASARUM CANADENSE, ASARUM CANADENSE ROOT EXTRACT, ASARUM CANADENSE [HPUS], ASARUM REFLEXUM ROOT, ASARUM RUBROCINCTUM ROOT, Asarum canadense [WHO-DD], CANADIAN SNAKEROOT, CANADIAN WILD GINGER ROOT, CANADIAN WILDGINGER ROOT
- Development code
- FEMA NO. 3023
Sources (9)
Sources
- ClinicalTrials.gov clinicaltrials.gov ·
- ClinicalTrials.gov ClinicalTrials.gov API v2 snapshot 2026-09-01T09:00:05 ·
- this record's own fields 2,3,5 ·
- Europe PMC dose-response search ·
- Europe PMC epigenetic clock search ·
- Europe PMC pathway abstract search ·
3 more sources
- Europe PMC search ·
- Europe PMC and ClinicalTrials.gov organism ladder ·
- openfda-label+europepmc K1:E2O4O7TQYK ·
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · openFDA / DailyMed — US Government work
How these records are assembled · Which registers were checked
Index-quality checks
- identity passed: no open identity hold
- required summary fields resolved: 4 required field(s) not terminal: Why people use it, Best-supported result, Biggest unanswered question, Human evidence
- public claims reviewed: 0 reviewed claim(s); drafts are never rendered
- source coverage passed: 9 source rows
- no critical contamination: no quarantine open
- canonical metadata passed: slug and display name present
- no raw internal fields: enforced by the copy-contract test over the rendered page
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