This page shows what was measured, who it was measured in, and what that does not settle.
What Arginine Aspartate does in the body
For the temporary relief of minor muscle pain or inflammation, general weakness, muscle fatigue, diminished memory, confusion, or diminished sexual desire or performance.*
Why people take it. For the temporary relief of minor muscle pain or inflammation, general weakness, muscle fatigue, diminished memory, confusion, or diminished sexual desire or performance.*
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
RNAWiki has not recorded a supervision or regulatory status for this substance.
What the registries record it as
The substance registry classes this as chemical.
FDA substance registry · LZB1G2I725 · read 2026-08-29
The supplement label database classes it as non-nutrient/non-botanical, under the name Arginine aspartate.
The use the label states, quoted from it. No plain-language version of this sentence has been written.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 59 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Focus
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer4 registered performance measure of this kind.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved3 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Cholesterol
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved1 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Strength
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer1 registered performance measure of this kind.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Focus
cognitive function go no go task test; cognitive function phychomotor vigilance task test; cognitive function berg washington card sorting task test; cognitive function sternberg task test
Blood sugar
postprandial insulin secretion; index of cell sensitivity to glucose; whole body insulin sensitivity using the matsuda index
Cholesterol
changes in cholesterol metabolism
Strength
strength
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
… Waiting for a reviewer
4 registered performance measure of this kind.
— Not recorded
Harms were not a registered measure for this goal.
△ Only a number moved
3 registered test measure.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Change in Limb Blood Flow
✗ The study did not show it
Who was studied
NCT02966665
How many people
420
Study design
Phase 1
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
WPSSI-III and Nine Hole peg test.
✗ The study did not show it
Who was studied
NCT02331667
How many people
233
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Change of overt HE.
✗ The study did not show it
Who was studied
NCT06483737
How many people
174
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
Change in carotid-femoral pulse wave velocity compared with baseline and SHAM subgroup
✗ The study did not show it
Who was studied
NCT02700958
How many people
160
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
SOFA score
✗ The study did not show it
Who was studied
NCT04513288
How many people
130
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
ratio of arginine to ornithine concentration & ratio of arginine to ADMA
✗ The study did not show it
Who was studied
NCT01718054
How many people
120
Study design
Phase 2/Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route.
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA Drugs@FDA · a recorded source, not a stored snapshot
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
NIH Dietary Supplement Label Database · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.2 registered measures of this kind. No reviewed result.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.5 registered measures of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.5 registered measures of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.1 registered measure of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.11 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Yeast, C. elegans (roundworm), Drosophila (fruit fly), Mouse, Dog. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
quality of life questionnaire
Measured
Things only a test, a scale or a device shows.
measures of liver function ast and alt
measures of liver function pt and ptt
measures of liver function coagulation factors
measures of liver function inr
corpuscular hemoglobin concentration
arterial blood pressure decrease
changes in cholesterol metabolism
postprandial insulin secretion
index of cell sensitivity to glucose
whole body insulin sensitivity using the matsuda index
and 2 more.
Meaningful
Things that change how a life goes, not only a number.
progression free survival
overall survival
cognitive function go no go task test
cognitive function phychomotor vigilance task test
cognitive function berg washington card sorting task test
cognitive function sternberg task test
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (21)
vary by protocol
reduction in liver endotoxin production
maddrey s discriminant function
pancreatic perfusion
net protein balance
gardos channel activity
nitric oxide
pet determined pancreatic islet beta cell mass
fecal calprotectin levels
temperature gradient at 3h post surgery
length of hospital stay
cell function
nitric oxide metabolites
13co2 production
total parenteral opioid use in iv morphine equivalents
reactive hyperemic index
incidence of preeclampsia
severity of preeclampsia
signs and symptoms of neurological disease
reporting adverse events /serious adverse events
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
R-Gene ® 10 is indicated as an intravenous stimulant to the pituitary for the release of human growth hormone in patients where the measurement of pituitary reserve for HGH can be of diagnostic usefulness.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No form or route is recorded.
No source is stored against this line.
Who oversees it
RNAWiki has not recorded a supervision or regulatory status for this substance.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
No register row and no identity class settled the question.
No source is stored against this line.
What is in the pack
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing is recorded about product quality.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
The exact form studied is not recorded.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
5134 marketed supplement labels list this ingredient, classed as amino acid/protein, mineral, other combinations and single vitamin and mineral.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
This order is fixed in code and does not count clicks or time on the page.
What is not here
7 questions this page could not answer
These sections were prepared and left out because there was nothing to put in them. They are listed rather than hidden, so the gaps in this record are visible.
The path through the body — found nothing in the sources checked.
How long anything takes — found nothing in the sources checked.
What it may clash with — found nothing in the sources checked.
Other ways to the same goal — found nothing in the sources checked.
Claims that go past the evidence — found nothing in the sources checked.
How this medicine reached us — found nothing in the sources checked.
What changed on this page — found nothing in the sources checked.
The record as stored
The full record, for auditing
Everything above is built from what is below. This layer keeps the technical vocabulary, record identifiers and every stored row, so a reader who wants to check the page can.
Recorded evidence blocks (11)
Q1
What did Arginine Aspartate's largest trial (1000 people) and its longest (13 years) measure?
1000 people in Arginine Aspartate's largest registered study, 13 years in its longest registered window, measuring Mean Corpuscular Hemoglobin Concentration. ClinicalTrials.gov · 2026-09-01
16 na, 15 phase2, 7 phase1, 6 phase3, 2 early phase1, 2 na or unstated, 2 phase4; NCT02447874; 2028-01; no ageing endpoint recorded. Last human test completed 2024, NCT05412160.
Interpretation These counts include studies where Arginine Aspartate was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
16
phase2
15
phase1
7
phase3
6
early phase1
2
na or unstated
2
2 more recorded rows
phase4
2
Last recorded human testNCT05412160
2024-12-30
recorded 2026-09-01 · last checked 2026-09-04
Q2
From yeast to human: where has Arginine Aspartate shown lifespan?
terminated; "Explanation provided in detailed descriptiong section of record."
NCT00569465
terminated; "End of the study"
NCT02440061
withdrawn; "This protocol was replaced with a different one and therefore discontinued."
NCT02838030
suspended; "COVID-19 pandemic"
NCT02882373
withdrawn; "Principal Investigator's Request"
2 further recorded trials
NCT05281562
terminated; "Not enough patients meeting eligibility criteria to complete the study. It took months from study initiation to enroll 1 participant in February 2023. Once it was clear it was not possible to enroll another participant, the study was…"
NCT05932979
withdrawn; "the investigation was cancelled because there was no monetary resource to complete it."
recorded 2026-09-01 · last checked 2026-09-04
Q4
Human studies of Arginine Aspartate used Arginine hydrochloride injection 10% — over how long?
More Arginine Aspartate was worse in human: at what point?
Hormetic in human: "Additionally, the metabolism of caffeine, glutamine, arginine and purine was upregulated to induce hormesis in Cd0.5, which enhanced the synthesis of resistant substances such as spermidine, choline, IAA and saponins." Europe PMC · dose-response search · 2026-06-01
5 recorded sentences naming Arginine Aspartate; hormesis, biphasic
Show the evidence
hormesisPMID 38219579
"Additionally, the metabolism of caffeine, glutamine, arginine and purine was upregulated to induce hormesis in Cd0.5, which enhanced the synthesis of resistant substances such as spermidine, choline, IAA and saponins."
biphasic
PMID 42075803
"The superior efficacy of 10 μM L-arginine compared to 50 μM reflected a biphasic concentration-dependent response. <b>Conclusions</b>: L-arginine modulated two critical aspects of doxorubicin efficacy, intestinal absorption and cytotoxic activity."
PMID 42075803
"The biphasic response emphasizes the importance of L-arginine dose optimization."
PMID 41900373
"Results showed that L-arginine and its metabolites regulated hemolytic activity in a concentration-dependent biphasic manner, with agmatine exerting the most potent promoting effect."
"Isoleucine-substituted Dap(MO1)[13,20,24]LL-37 and Dap(MO2)[13,20,24]LL-37 analogs showed significant partial suppression of MPO secretion at both time points (p < 0.001 at 24 h); arginine-substituted analogs exhibited a biphasic phenotype, activating release at 1 h comparably to LL-37 but significantly reducing MPO at 24 h (p < 0.05)."
recorded 2026-06-01 · last checked 2026-09-04
Q6
Which of 13co2 production, arterial blood pressure decrease and cell function did Arginine Aspartate's trials measure?
13co2 production, arterial blood pressure decrease and cell function lead 40 outcome terms across Arginine Aspartate's trials. ClinicalTrials.gov · 2026-09-01
Interpretation pancreatic perfusion, measures of liver function ast and alt, measures of liver function pt and ptt, measures of liver function coagulation factors, measures of liver function inr and net protein balance follow.
Show the evidence
vary by protocol
1
reduction in liver endotoxin production
1
maddrey s discriminant function
1
pancreatic perfusion
1
measures of liver function ast and alt
1
measures of liver function pt and ptt
1
14 more recorded rows
measures of liver function coagulation factors
1
measures of liver function inr
1
net protein balance
1
gardos channel activity
1
nitric oxide
1
corpuscular hemoglobin concentration
1
arterial blood pressure decrease
1
pet determined pancreatic islet beta cell mass
1
fecal calprotectin levels
1
changes in cholesterol metabolism
1
temperature gradient at 3h post surgery
1
length of hospital stay
1
postprandial insulin secretion
1
index of cell sensitivity to glucose
1
recorded 2026-09-01 · last checked 2026-09-04
Q7
Which of Arginine Aspartate's 7 ongoing trials reports first?
Pharmacokinetics of IV arginine, measured by plasma arginine concentration over time; Gene expression via Illumina RNA sequencing; latest 2029-01
Show the evidence
Trial
NCT02447874
"Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease"; n 21; "Pharmacokinetics of IV arginine, measured by plasma arginine concentration over time"; 2028-01
NCT05306925
"An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponse"; n 48; "Gene expression via Illumina RNA sequencing"; 2026-12-31
NCT05855330
"Arginine Replacement Therapy in COVID-19"; n 21; "Change in mitochondrial function"; 2028-06
NCT06328686
"Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases"; n 10; "Peak plasma L-arginine (arginine) and arginine metabolite concentration"; 2027-12-31
NCT06483737
"Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)"; n 174; "Change of overt HE."; 2027-06-30
NCT07167693
"Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes"; n 60; "Change in endogenous insulin secretion (C-peptide/glucose ratio)"; 2027-12-31
1 further recorded trialNCT07772882
"Study of Supplemental Arginine With Chemotherapy and Immunotherapy in Platinum Resistant Ovarian, Fallopian Tube, and Peritoneal Cancer"; n 24; "Proportion of patients with serious adverse events"; 2029-01
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which 20 trials of Arginine Aspartate posted no result?
Posted no result
20 of 20 completed trials
Registrations
NCT00047983, NCT00029731, NCT00000623, NCT01796678, NCT02844387 and NCT01682889, and 14 more
Completion dates
oldest 2004-04; newest 2024-08-23
Show the evidence
Trial
NCT00047983
2004-04
NCT00029731
2005-07
NCT00000623
2006-07
NCT01796678
2007-06
NCT02844387
2008-12
NCT01682889
2012-01
14 further recorded trials
NCT00497380
2012-02-04
NCT00958997
2012-05
NCT01598649
2013-10
NCT03028285
2017-01-26
NCT03031535
2017-03
NCT02751437
2018-03-31
NCT03580122
2018-09-05
NCT02809170
2019-06
NCT04079010
2019-11-25
NCT04828278
2021-03-01
NCT02499926
2024-01-12
NCT06135792
2024-02-13
NCT04786873
2024-06-13
NCT06216262
2024-08-23
Q9
At the median, Arginine Aspartate's trials enrolled 31 people — anything larger?
Median enrolment
31
Largest enrolment
1000
Registered trials counted
46
Q10
Was Arginine Aspartate studied with exercise?
exercise is named in Arginine Aspartate's label sentences: "Two-way (supplementation and time) repeated-measures analyses of variance showed that NO, L-arginine, and tetrahydrobiopterin levels in the H<sub>2</sub> inhalation group were significantly higher than those in the placebo group after exercise (D6) and remained higher after 24 h of rest (D7)." openfda-label+europepmc · 2024-12-16
1 recorded statement; exercise
Show the evidence
exercise
Two-way (supplementation and time) repeated-measures analyses of variance showed that NO, L-arginine, and tetrahydrobiopterin levels in the H<sub>2</sub> inhalation group were significantly higher than those in the placebo group after exercise (D6) and remained higher after 24 h of rest (D7).
recorded 2024-12-16 · last checked 2026-09-04
Q11
What is recorded about Arginine Aspartate and NAD+?
"NAD⁺ supplementation blunts Th1 and Th17 inflammation, in part, through arginine metabolism-dependent regulation of mitochondrial energetics, redox balance and signal transduction." — where Arginine Aspartate and NAD+ appear together. Europe PMC · pathway abstract search · 2026-08-01
"NAD⁺ supplementation blunts Th1 and Th17 inflammation, in part, through arginine metabolism-dependent regulation of mitochondrial energetics, redox balance and signal transduction."
sirtuin
"Genetic depletion or pharmacologic inhibition of SIRT5 attenuated NR-mediated increases in arginine and fumarate and abolished the anti-inflammatory -effects of NR on Th1 and Th17 cytokine production."
"Mechanistically, SIRT5 physically interacted with arginosuccinate lyase (ASL), promoted ASL-dependent arginine accumulation, and regulated ASL post-translational acylation, including glutarylation and malonylation."
"Collectively, these findings identify SIRT5 as a critical mediator of NAD⁺ precursor-induced metabolic remodeling that links ASL-dependent arginine metabolism to redox balance and effector function in human CD4⁺ T cells."
NAD+
"Collectively, these findings identify SIRT5 as a critical mediator of NAD⁺ precursor-induced metabolic remodeling that links ASL-dependent arginine metabolism to redox balance and effector function in human CD4⁺ T cells."
mTORPMID 42677610
"In vitro assays confirmed l-arginine alleviated macrophage inflammation through the AMPK-mTOR/NF-κB axis."
AMPK
PMID 42677610
"In vitro assays confirmed l-arginine alleviated macrophage inflammation through the AMPK-mTOR/NF-κB axis."
PMID 42677610
"Collectively, C-LPE3 mitigates colitis through a microbiota-l-arginine-AMPK regulatory axis, supporting its development as a gut-health functional food ingredient."
mTORPMID 42166856
"Together, these findings define an immunometabolic axis-AMPK/mTOR-arginine-TCA cycle coupling-that dictates microglial fate after stroke, and suggests VK as a therapeutic agent capable of concurrently targeting neuroinflammation, mitochondrial dysfunction, and metabolic imbalance."
AMPKPMID 42166856
"Together, these findings define an immunometabolic axis-AMPK/mTOR-arginine-TCA cycle coupling-that dictates microglial fate after stroke, and suggests VK as a therapeutic agent capable of concurrently targeting neuroinflammation, mitochondrial dysfunction, and metabolic imbalance."
mTORPMID 42176791
"Resistant cells also displayed persistent mTORC1 activation and blunted autophagic flux; mTORC1 inhibition restored autophagy and niraparib sensitivity but attenuated the incremental benefit of arginine deprivation, identifying mTORC1-constrained autophagy as a key determinant of this vulnerability."
autophagy
PMID 42176791
"Resistant cells also displayed persistent mTORC1 activation and blunted autophagic flux; mTORC1 inhibition restored autophagy and niraparib sensitivity but attenuated the incremental benefit of arginine deprivation, identifying mTORC1-constrained autophagy as a key determinant of this vulnerability."
PMID 42186568
"The results showed that the imbalance of arginine (deficiency or excess) inhibited the growth of cells and disrupted cell homeostasis by increasing the level of autophagy, ER stress, as well as apoptosis."
PMID 41692973
"We further highlight the therapeutic potential of targeting ferritinophagy and propose future research directions aimed at harnessing this pathway for the treatment of organ injuries.<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACO1/IRP1: aconitase 1; AKI: acute kidney injury; ARDS: acute respiratory distress syndrome; ATG: autophagy related; BECN1: beclin 1; CARM1/PRMT4: coactivator associated…"
recorded 2026-08-01 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
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