This page shows what was measured, who it was measured in, and what that does not settle.
What DEXTROSE, Unspecified Form does in the body
The electrolyte concentrations in the solutions are chosen to restore plasma levels to clinically desired concentrations or maintain plasma levels at the desired concentrations.
From the FDA-approved label: PRISMASOL and PHOXILLUM solutions are pharmacologically inactive. PRISMASOL and PHOXILLUM solutions are used as replacement solution to replace water and electrolytes removed during hemofiltration and hemodiafiltration. Bicarbonate (or precursor lactate) in the solution is used as an alkalinizing buffer to restore acid-base balance to a clinically desirable level.
Why people take it. Dextrose Injection (5% and 10%) is indicated as source of water and calories in adult and pediatric patients, and may also be used as a diluent for reconstitution of a powder or liquid drug product.
What happened in people
RNAWiki has not yet published a reviewed conclusion for this use.
§ A fixed RNAWiki sentence
Where this came from
Wording RNAWiki always uses, not a finding about this substance.
No reviewed claim names a result for any goal on this record.
No source is stored against this line.
The limit that matters most
Not recorded.
Where it acts
Not recorded.
Kind of result
No result is published, so no kind of result applies yet
Supervision
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
What the registries record it as
The substance registry classes this as mixture.
FDA substance registry · IY9XDZ35W2 · read 2026-08-29
The supplement label database classes it as botanical, under the name Dextrose.
A person wrote this explanation into the record, with the studies named in the path below.
The use the label states, quoted from it. It is written for a clinician, not for a reader without medical training.
No statement of the main limit is recorded.
The four opening statements run to 122 words.
Words this page uses
Four words worth knowing first
Chosen from what this page shows, with each one explained before the word it depends on.
Stand-in result
A stand-in result is a number measured because the real result takes too long.
A picture of it, and where the picture fails
It is like judging a journey by the speedometer rather than by arriving.
Where that stops being true. Speed does predict arrival. Many stand-in results do not predict the real one.
What people get wrong. A stand-in result is often reported as the result itself.
A surrogate endpoint substituted for a clinical endpoint, valid only where the substitution has been shown to hold.
Enzyme
An enzyme is a protein that speeds up one chemical change.
A picture of it, and where the picture fails
An enzyme is like a machine on a production line doing one cut.
Where that stops being true. A machine is switched on and off by a person. Enzymes are controlled by the cell.
What people get wrong. Enzymes are thought to be used up. They are not; they work again and again.
A catalytic protein that lowers the activation energy of a specific reaction.
Receptor
A receptor is a part of a cell that a signal fits into.
A picture of it, and where the picture fails
A receptor is like a lock waiting for one key.
Where that stops being true. A lock either opens or does not. A receptor can be half-triggered, or worn out.
What people get wrong. Fitting a receptor is read as causing a benefit. It causes a step, and nothing more.
A protein that binds a specific ligand and converts that binding into a cellular response.
Pathway
A pathway is a chain of steps inside a cell, each one setting off the next.
A picture of it, and where the picture fails
A pathway is like a row of dominoes.
Where that stops being true. Dominoes fall one way. Pathways loop back and can switch themselves off.
What people get wrong. Changing one step is read as changing the outcome. Other steps often absorb it.
An ordered series of molecular interactions producing a defined cellular change.
What happened in people◇Read from sources, not yet reviewed
What was measured, goal by goal
One row for each goal a registered study measured something for. One column for each kind of thing that could be measured.
Registered studies list 40 outcome measures that RNAWiki could read. A registered study says what someone planned to measure. It does not say what they found. 0 of the matched studies tested this substance, and 0 posted a result.
There is no single score. A strong test result and a weak life result are different facts.
Goals down the side, kinds of measurement across the top. Each cell says what kind of thing was registered, not what was found.
Goal
Life outcome
What a body can do
How a person feels
A test result
A step in the body
Harms
How long
Who was studied
Blood sugar
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
△Only a number moved5 registered test measure.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Energy
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer1 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Pain
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
∅Nothing in the sources checkedNo registered study lists a performance measure for this goal.
…Waiting for a reviewer1 registered symptom measure.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Endurance
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer1 registered performance measure of this kind.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Strength
∅Nothing in the sources checkedNo registered study lists a life outcome for this goal.
…Waiting for a reviewer1 registered performance measure of this kind.
∅Nothing in the sources checkedNo registered study lists a symptom measure for this goal.
∅Nothing in the sources checkedNo registered study lists a test result for this goal.
∅Nothing in the sources checkedNo registered study lists a body-step measure for this goal.
—Not recordedHarms were not a registered measure for this goal.
—Not recordedNo finished study window is recorded.
…Waiting for a reviewerWho was studied is listed further down the page.
Which registered measures put each goal on this table
Blood sugar
maximum insulin concentration first phase response; maximum insulin concentration second phase response; insulin area under the curve second phase response; plasma glucose concentration; plasma insulin concentration
Energy
significant reduction in symptoms of pain and fatigue; net energy expenditure at at
Pain
significant reduction in symptoms of pain and fatigue
Endurance
vo2 at at
Strength
strength
Sorted by fixed word lists, version v1. A name the rules do not recognise stays unsorted rather than moving to the nearest column.
What each mark on this table means
∅ Nothing in the sources checked
No registered study lists a life outcome for this goal.
△ Only a number moved
5 registered test measure.
— Not recorded
Harms were not a registered measure for this goal.
… Waiting for a reviewer
Who was studied is listed further down the page.
What happened in people◇Read from sources, not yet reviewed
What happened in people
Each card is one study: the exact question it asked, who was in it, and whether it showed what it set out to show.
Number of Participants with New-onset-DM
✗ The study did not show it
Who was studied
NCT05579626
How many people
4000
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Change in Mean Sitting Systolic Blood Pressure (MSSBP)
✗ The study did not show it
Who was studied
NCT00439738
How many people
412
Study design
Phase 4
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Change from Baseline in Fasting Blood Glucose Concentration
✗ The study did not show it
Who was studied
NCT07045142
How many people
400
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
The change of menstrual cycle pattern.
✗ The study did not show it
Who was studied
NCT04852510
How many people
253
Study design
Phase 2/Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Determination of Liver Fat Content
✗ The study did not show it
Who was studied
NCT06717828
How many people
250
Study design
Not applicable
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
Fever clearance time
✗ The study did not show it
Who was studied
NCT02563704
How many people
238
Study design
Phase 3
Compared against
Not recorded for this study
Kind of result
A number that stands in for health
What was found
Result not recorded on this page
Repeated elsewhere
Unreplicated
What this does not prove. A study that did not show an effect does not show that no effect exists anywhere.
The limits of this study, and where it came from
Main limit. No limitation is recorded for this study.
How far it carries. This study is recorded from the curated record, not from the registry match.
Form and route. Intravenous
Interval reported. Not recorded in this summary
Written into the record, not signed off as a reviewed claim.
openFDA NDC Directory · a recorded source, not a stored snapshot
openFDA SPL label · a recorded source, not a stored snapshot
PubChem PUG-REST · a recorded source, not a stored snapshot
FDA label (openFDA SPL) · a recorded source, not a stored snapshot
What we know
RNAWiki holds 6 written-up human studies for this substance, each with the question it asked.
How we know it
Each card names the study, the number of people and what the study set out to measure.
What this does not prove
These summaries were written by a person and have not been signed off as reviewed claims.
Why it matters
A study that failed is as informative as one that worked, and both are here.
What we still do not know
No reviewed claim exists, so no exact population, effect size or interval is published yet.
What happened in people◇Read from sources, not yet reviewed
How close this is to real life
The top step is something a person would feel or care about. The bottom is a guess from software. Filled steps are where evidence exists for this substance.
■Living longer, or avoiding a major eventEvidence recorded. Death, a heart attack, a stroke, a hospital stay.1 registered measure of this kind. No reviewed result.
■What a body can do day to dayEvidence recorded. Walking, dressing, breathing, recovering.3 registered measures of this kind.
■Measured performanceEvidence recorded. How much was lifted, how far was run, how fast.3 registered measures of this kind.
■Symptoms and quality of lifeEvidence recorded. Pain, tiredness, mood, sleep, as the person rated it.1 registered measure of this kind.
■A number that stands in for healthEvidence recorded. Cholesterol, blood sugar, bone density. A stand-in, not the thing itself.14 registered measures of this kind.
■A step measured inside a personEvidence recorded. Something measured in human tissue or human cells.A human record sits on the stored organism ladder.
■AnimalsEvidence recorded. Mice, rats, dogs. Useful for ideas, not proof about people.Stored records in Mouse, Rat. A result in animals says what to test next. It does not say what happens in people.
■Cells in a dishEvidence recorded. Cells or chemistry on a bench, far from a whole body.Stored mechanism abstracts describe steps measured in cells or tissue.
□A guess from softwareNo evidence recorded. Nobody measured it. RNAWiki never publishes one as a finding.RNAWiki stores no prediction for this record. Software can suggest a link. RNAWiki does not publish one as a finding.
Higher on these steps means closer to something a person would feel. It does not mean better done.
What it would be like to take◇Read from sources, not yet reviewed
Felt, measured, or meaningful
Three different things that get called the same word. Registered studies measured all three, and mixing them is how a blood test becomes a health claim.
Felt
Things a person could notice without a test.
significant reduction in symptoms of pain and fatigue
Measured
Things only a test, a scale or a device shows.
vo2 at at
heart rate to mets at at
strength
maximum insulin concentration first phase response
maximum insulin concentration second phase response
insulin area under the curve second phase response
bone mineral density
plasma fetal growth factor 21 concentration
plasma choline concentration
plasma betaine concentration
and 6 more.
Meaningful
Things that change how a life goes, not only a number.
total functional capacity
stroke scale
A registered study says what someone planned to measure. It does not say what they found. A number moving is not the same as a life going better. The two are shown apart here.
Felt, but not shown to help. A person notices a change. No study showed it leads anywhere good.
Measured, but not felt. A number moves. The person notices nothing. Both can be true.
Measured, but not shown to matter. A number moves in the good direction. Nobody showed that lives went better.
Matters, but takes years. The result that counts may take longer than anyone would keep watching.
Names that fit none of the three (21)
achieving smoking abstinence
glycemic response
post prandial metabolism
usq scores
bsq scores
cpx parameters relative to placebo as measured by
ventilation efficiency slope
oxygen uptake efficiency slope
net energy expenditure at at
population pharmacokinetics v volume
population pharmacokinetics cl clearance
population pharmacokinetics r endogenous infusion rate
population pharmacokinetics k elimination rate
population pharmacokinetics t1/2 half life
sd of residual error
rated tennis elbow evaluation
length of labor
postoperative vomiting between 0 to 2 hours
who experienced an adverse event
pharmacokinetic parameter clearance
These are harms, study-process measures, or names the rules did not recognise. They are shown rather than dropped.
What is missing or unclear◇Read from sources, not yet reviewed
Were people like you studied?
RNAWiki cannot tell whether a study fits you. It can show who was in it, and where the result stops carrying.
Who was studied
People similar to this profile were included.
PRISMASOL and PHOXILLUM solutions are indicated in pediatric and adult patients for use as a replacement solution in Continuous Renal Replacement Therapy (CRRT) to replace plasma volume removed by ultrafiltration and to correct electrolyte and acid-base imbalances. They may also be used in case of drug poisoning when CRRT is used to remove dialyzable substances.
Who is missing from the studies
Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What the label states about particular groups
On pediatric, the label states: “Dextrose Injection (5% and 10%) is indicated in pediatric patients as a source of water and calories, and may also be used as a diluent for reconstitution of a powder or liquid drug product.”
US prescribing information · 3bb406a9-f5cb-403a-b1bb-5c4facbea3d5 · read 2026-08-30
On older people, the label states: “Dextrose Injection (5% and 10%) has not been studied insufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients.”
US prescribing information · 3bb406a9-f5cb-403a-b1bb-5c4facbea3d5 · read 2026-08-30
On people who are pregnant, the label states: “Risk Summary Dextrose Injection (5% and 10%) has been used for decades during labor and delivery.”
US prescribing information · 3bb406a9-f5cb-403a-b1bb-5c4facbea3d5 · read 2026-08-30
On people who are breastfeeding, the label states: “Risk Summary Dextrose Injection (5% and 10%) has been used for decades and is not expected to cause harm to a breastfed infant.”
US prescribing information · 3bb406a9-f5cb-403a-b1bb-5c4facbea3d5 · read 2026-08-30
Where the result stopped carrying
This is a scope explorer, not a diagnosis engine.
It shows who was studied so you can see whether people similar to you were included.
RNAWiki cannot tell whether a study fits you. It can show who was in it.
What it would be like to take◇Read from sources, not yet reviewed
Why it might seem to do nothing
A real effect and a noticed effect are different things. These are the recorded reasons the two come apart.
It was studied for a different goal
The studies measured something else entirely.
On this record: Some registered studies measured things that match no goal on this page.
It was studied in different people
The people in the studies were not much like the reader.
On this record: Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
The evidence may simply be wrong
Small early studies often do not hold up.
On this record: RNAWiki has not yet published a reviewed conclusion for this use.
Other reasons RNAWiki checked and found nothing for (10)
A different form was studied
The studied form is not the form on the shelf. Nothing in this record points to this reason.
There was nothing to correct
Where a level is already normal, topping it up may change nothing. Nothing in this record points to this reason.
Something else had to happen too
In the studies it was paired with training, a diet or another treatment. Nothing in this record points to this reason.
The change is too small to feel
A real change can still sit below what a person notices. Nothing in this record points to this reason.
Day-to-day swing hides it
Sleep, food, stress and time of day move most numbers more than this would. Nothing in this record points to this reason.
Not enough time yet
The studies ran longer than the person has waited. Nothing in this record points to this reason.
It was not taken as studied
Missed days change the result, and studies count them. Nothing in this record points to this reason.
Something else changed at the same time
Two changes at once cannot be told apart afterwards. Nothing in this record points to this reason.
The product may not be what it says
Contents of a sold product are not always what the label states. Nothing in this record points to this reason.
No recorded reason
RNAWiki has nothing stored that would explain it. Nothing in this record points to this reason.
None of these is a reason to take more. Taking more is not a step this page ever suggests.
What it would be like to take◇Read from sources, not yet reviewed
What taking it involves
The recorded facts about getting hold of it and using it. Nothing here is a suggestion about what you should do.
How it is supplied
Prescription only
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Read from the recorded approval status.
No source is stored against this line.
Form and route
Intravenous
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form and route recorded on this substance.
No source is stored against this line.
Who oversees it
Professional supervision is normally required. A regulator classifies this substance in a way that restricts how it is supplied.
❝ Quoted from a source
Where this came from
Copied from a source RNAWiki stored, with the source named.
Suppression classes recorded: S4.
No source is stored against this line.
What is in the pack
Sold as injection, liquid, given by the intravenous, intrathecal, oral route.
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
Recorded notes on how this is sold and what that means for what is in the pack.
No source is stored against this line.
Where it is registered
Regulatory records are listed in the technical disclosure at the foot of this page.
# Counted from records
Where this came from
A count of rows RNAWiki holds. It describes our records, not your body.
Register entries are stored per jurisdiction and shown with their dates.
No source is stored against this line.
Why people stop
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
No record of why people stopped taking it is stored for this substance.
No source is stored against this line.
What it would be like to take∅Nothing found in the sources checked
What can go wrong
Sorted by where each line came from. A regulator's label and a report somebody sent in are not the same kind of fact.
∅Nothing found in the sources checked
No harm is recorded against this substance in the sources RNAWiki checked. Finding nothing is not the same as showing there is nothing.
The sources listed were searched and held nothing. That is not the same as nothing existing.
Over a long time. No completed tested study window is recorded, so long-term effects are not established by the registry record.
Groups the studies covered thinly. Which groups were under-represented in the studies has not been recorded for this substance. Pregnancy, breastfeeding, children, older adults, and people with liver or kidney conditions are commonly excluded from trials; nothing here says whether they were.
What is missing or unclear◇Read from sources, not yet reviewed
Does the exact form matter?
Evidence belongs to the exact thing that was tested. A different salt, a different mixture or a different preparation is a different question.
The form that was studied
Intravenous
✎ Source-linked record
Where this came from
A person wrote this into the record with the study named beside it. No reviewer has signed it off.
The form used in the studies cited on this page.
No source is stored against this line.
What is sold
Not recorded.
∅ Nothing recorded
Where this came from
RNAWiki holds nothing here and says so rather than guessing.
Nothing further is recorded about which forms are sold.
No source is stored against this line.
What is recorded as being sold
277 products list this as an active ingredient in the United States drug directory. 78 of them contain it and nothing else.
FDA National Drug Code directory · 71872-7102 · read 2026-08-29
They are sold as injection, injection, emulsion, injection, solution, injection, solution, concentrate, liquid and powder, taken extracorporeal, intraperitoneal, intrathecal and intravenous.
FDA National Drug Code directory · 71872-7102 · read 2026-08-29
134 published labels name it as an active ingredient. 43 of them describe this substance alone, which is where its own label text on this page comes from.
US prescribing information · dbed53b7-0109-4561-8342-0178ec8c64b0 · read 2026-08-29
Those labels are classed as human otc drug and human prescription drug.
US prescribing information · dbed53b7-0109-4561-8342-0178ec8c64b0 · read 2026-08-29
987 marketed supplement labels list this ingredient, classed as fiber and other nutrients and non-nutrient/non-botanical.
Those labels carry all other, nutrient and structure/function claims. A claim of that kind is written by the manufacturer and is not assessed by any regulator, so its presence says nothing about whether it is true.
DEXTROSE is intravenous at 3 DOSAGE FORMS AND STRENGTHS Injection: • 5% (5 g/100 mL) (50 mg/mL) of dextrose hydrous a clear, sterile, non-pyrogenic solution in single-dose partial-fill flexible containers: 25 mL, 50 mL, 100 mL, 250 mL, 500 mL, an…, recorded as fda label in effect 2026-06-11 in the United States.
US prescribing information · 3bb406a9-f5cb-403a-b1bb-5c4facbea3d5 · read 2026-08-30
Evidence carries across two names for one substance. It does not carry across a salt, a mirror form or a mixture.
What it would be like to take◇Read from sources, not yet reviewed
What you could measure
This one is decided with a clinician, so this section holds questions to ask rather than a plan to run.
Self-experiment planning is not offered for a prescription or clinician-supervised medicine. The questions below are for a clinician or pharmacist.
Questions worth asking
Which of the trials of DEXTROSE, Unspecified Form studied people like me?
What was measured, and for how long?
Was the result a laboratory value or a health outcome?
What would we watch for, and when would we stop?
Tracking can show whether something changed for you. It cannot show what caused it.
RNAWiki records evidence. It does not say whether this substance is right for you.
What is missing or unclear◇Read from sources, not yet reviewed
What nobody knows yet
Open questions, each with why it is open and what would close it.
How fast does the body clear it?
The sources RNAWiki checked hold nothing for this field.
Why it matters. Without this, nothing on this page can say how long anything lasts.
What would answer it
A stored source that records it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing populations
Which groups were under-represented in the studies has not been recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing long-term data
No completed tested study window is recorded.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
No reviewed conclusion
RNAWiki has not yet published a reviewed conclusion for this use.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Missing interaction studies
No interaction was found in the registers checked. Not finding one is not the same as showing there is none.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
Formulation uncertainty
Several salts, forms or products of DEXTROSE, Unspecified Form are recorded. Results from one form may not transfer to another.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
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No reviewed mechanism story exists for this substance.
Why it matters. Recorded by the evidence model as a gap on this record.
What would answer it
A study that measures it, and a reviewer to sign it off.
Last checked 2026-09-04. Searched: The sources listed in the receipts at the foot of this page.
What happened in people◇Read from sources, not yet reviewed
Check any of this yourself
Every line above traced back to the study it came from. This is the technical layer, and the vocabulary changes here.
Where else this substance is registered
FDA substance identifier (UNII)
IY9XDZ35W2
ChEMBL
CHEMBL2109169
ChEBI
42758
RxNorm concept
4850
EMA substance identifier
100000080176
DrugBank
DB09341
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How this medicine reached us
Kept near the foot of the page. A historical event moves up only when it changes something about this substance today.
What the approval register records
153 approved applications cover products containing this substance. The earliest was NDA004589, approved 19460117 to B BRAUN.
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6 questions this page could not answer
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Recorded evidence blocks (12)
Q2
What did DEXTROSE, Unspecified Form's largest trial (1089 people) and its longest (12 years) measure?
1089 people in DEXTROSE, Unspecified Form's largest registered study, 12 years in its longest registered window, measuring Effect of clarithromycin in mortality and risk for death by severe sepsis/shock and multiple organ dysfunction compared with placebo. ClinicalTrials.gov · 2026-09-01
39 na, 15 phase2, 12 phase3, 11 phase1, 10 early phase1, 10 phase4, 2 na or unstated; NCT00085722; 2016-05-01. Last human test completed 2026, NCT06675708.
Interpretation These counts include studies where DEXTROSE, Unspecified Form was a comparison treatment, a background treatment or an exposure in an observational study, and the longest window may be a planned end date. Trial roles have not yet been classified for this record.
Show the evidence
na
39
phase2
15
phase3
12
phase1
11
early phase1
10
phase4
10
2 more recorded rows
na or unstated
2
Last recorded human testNCT06675708
2026-06-30
recorded 2026-09-01 · last checked 2026-09-04
Q3
From mouse to human: where has DEXTROSE, Unspecified Form shown lifespan?
Interpretation Effect of clarithromycin in mortality and risk for death by severe sepsis/shock and multiple organ dysfunction compared with placebo — the recorded outcome words.
Show the evidence
mouse
mechanism-only
rat
lifespan
humanNCT01223690
lifespan; Effect of clarithromycin in mortality and risk for death by severe sepsis/shock and multiple organ dysfunction compared with placebo; 94
futility/efficacy (1), accrual/recruitment (1), funding/business (2) and other (5): DEXTROSE, Unspecified Form's stop wording, clustered. ClinicalTrials.gov · 2026-09-01
"Protocol Under Review"; 9 of 94 registered studies
Show the evidence
Trial
NCT00566514
suspended; "Protocol Under Review"
NCT00712426
terminated; "Results of an interim analysis showed that it was unlikely that creatine was effective in slowing loss of function in early symptomatic Huntington's Disease."
NCT02012608
terminated; "Lack of funding/ PI leaving institution"
15 recorded entries; human; injection; also "Dextrose 5%", "Dextrose 5% in 0,9% Normal Saline", "5% dextrose in half strength saline solution"
Show the evidence
human
NCT01223690
Dextrose 5%
NCT01912807
Dextrose 5% in 0,9% Normal Saline
NCT03139383
5% dextrose in half strength saline solution
NCT03598322
injection; Dextrose 1mL injection
NCT03598322
injection; Dextrose 2mL injection
NCT03598322
injection; Dextrose 4mL injection
9 more recorded rows
humanNCT04680936
Dextrose 5% in water
humanNCT04680936
5% dextrose solution
humanNCT04680936
Dextrose 15 % in Water
humanNCT04731363
dextrose, 30g
humanNCT05029037
Dextrose 500 mL
humanNCT05250271
15 g dextrose
humanNCT05250271
5 g dextrose
humanNCT07548047
50% Dextrose Pleurodesis
humanNCT07564063
dextrose (5%)
recorded 2026-09-01 · last checked 2026-09-04
Q6
More DEXTROSE, Unspecified Form was worse in human: at what point?
Hormetic in human: "Studies on virulence stimulations for mycelia treated with fungicide in potato dextrose agar showed that the maximum stimulation for the mixtures occurred at concentrations much lower than the concentration of carbendazim alone, indicating a dose-additive interaction when compared with carbendazim hormesis." Europe PMC · dose-response search · 2019-03-12
5 recorded sentences naming DEXTROSE, Unspecified Form; hormesis, dose-response, biphasic
Show the evidence
hormesisPMID 30398945
"Studies on virulence stimulations for mycelia treated with fungicide in potato dextrose agar showed that the maximum stimulation for the mixtures occurred at concentrations much lower than the concentration of carbendazim alone, indicating a dose-additive interaction when compared with carbendazim hormesis."
dose-responsePMID 31108762
"The objective of the current study was to profile and compare the temporal sweetness and qualitative differences of 15 sweeteners to sucrose across nutritive saccharide (sucrose, dextrose, fructose, allulose (D-psicose), palatinose (isomaltulose), sucrose-allulose mixture), nutritive polyol (maltitol, erythritol, mannitol, xylitol, sorbitol) and non-nutritive (acesulfame-k, aspartame, sucralose,…"
biphasicPMID 28967446
"Two liquid culture media of casamino acids and peptone as nitrogen sources and glucose as carbon source for both media cultures were respectively used in the production of blastospores, while for the production of conidia, the fungi were grown in potato dextrose agar; from these cultures, solutions of conidia to a concentration of 1×10<sup>6</sup> per milliliter were prepared to inoculate flasks…"
dose-response
PMID 27799816
"Dextrose injections decreased pain in osteoarthritis patients but did not exhibit a positive dose-response relationship following serial injections."
PMID 23695173
"The antiallodynic SN50 dose-response curves of CPIP rats in the fed/insulin/dextrose, fed/dextrose, and fed conditions exhibited a rightward shift compared with the fed/insulin group."
recorded 2019-03-12 · last checked 2026-09-04
Q7
Which of achieving smoking abstinence, bone mineral density and bsq scores did DEXTROSE, Unspecified Form's trials measure?
achieving smoking abstinence, bone mineral density and bsq scores lead 40 outcome terms across DEXTROSE, Unspecified Form's trials. ClinicalTrials.gov · 2026-09-01
post prandial metabolism, total functional capacity, usq scores, bsq scores, cpx parameters relative to placebo as measured by and vo2 at at follow.
Show the evidence
significant reduction in symptoms of pain and fatigue
1
achieving smoking abstinence
1
glycemic response
1
post prandial metabolism
1
total functional capacity
1
usq scores
1
14 more recorded rows
bsq scores
1
cpx parameters relative to placebo as measured by
1
vo2 at at
1
ventilation efficiency slope
1
oxygen uptake efficiency slope
1
heart rate to mets at at
1
net energy expenditure at at
1
population pharmacokinetics v volume
1
population pharmacokinetics cl clearance
1
population pharmacokinetics r endogenous infusion rate
1
population pharmacokinetics k elimination rate
1
population pharmacokinetics t1/2 half life
1
sd of residual error
1
strength
1
recorded 2026-09-01 · last checked 2026-09-04
Q8
Which of DEXTROSE, Unspecified Form's 17 ongoing trials reports first?
17 registered trials of DEXTROSE, Unspecified Form are open; earliest completion 2025-03-01. ClinicalTrials.gov · 2026-09-01
Change in LH Pulse Amplitude Before and After Acute or Chronic FFA Administration; Epinephrine; latest 2030-09-26
Show the evidence
Trial
NCT02653092
"Reprometabolic Syndrome Mediates Subfertility in Obesity"; n 84; "Change in LH Pulse Amplitude Before and After Acute or Chronic FFA Administration"; 2026-12-11
NCT03241706
"Liver Glycogen and Hypoglycemia in Humans"; n 40; "Epinephrine"; 2028-05-31
NCT04736953
"Sirolimus Treatment Of Patients With SLE"; n 220; "Therapeutic Benefit"; 2029-01-01
NCT04895358
"Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)"; n 342; "Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1) by Blinded Independent Central Review (BICR) in Participants With Combined Positive Score (CPS) ≥1"; 2027-12-18
NCT05264727
"Glucagon Suppression by Hyperglycemia in the Presence and Absence of Amino Acid Infusion"; n 30; "Change in Glucagon Suppression (G50) caused by amino acids vs. saline"; 2026-12-31
NCT05895747
"5-HTP and Creatine for Depression R33 Phase"; n 106; "17-Item Hamilton Depression Rating Scale"; 2027-09-30
11 further recorded trials
NCT05933577
"A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)"; n 1089; "Recurrence-Free Survival (RFS)"; 2030-09-26
NCT06357234
"Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery"; n 100; "Anti-Nausea Rescue Medication"; 2027-09
NCT06427694
"Low-Dose IL-2 For The Reduction Of Vascular Inflammation In ACS -Clinical Outcomes & Follow-up Study"; n 60; "Major adverse cardiovascular outcomes"; 2030-02-11
NCT06635174
"Efficacy of 50% Oral Dextrose As Pain Relief in Newborns Before Bladder Catheterization"; n 90; "change in blood pressure"; 2025-03-01
NCT06799715
"Assessments of Metabolic Responses to Acute Oral Administration of Sucrose, Glucose, and Fructose"; n 20; "Effect of sucrose, glucose, fructose, and water on the GI hormone response - GLP-1"; 2026-09
NCT07224282
"The Effects of Ketone Supplements With Carbohydrates on Cycling Performance Above Lactate Threshold"; n 15; "Time to fatigue"; 2026-05-03
NCT07473128
"Effect of Trilaciclib in the Prevention of Myelosupression in Subjects With Limited-stage Small Cell Lung Cancer"; n 120; "To Compare trilaciclib to placebo on prevention of myelosuppression"; 2027-06
NCT07494084
"Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance"; n 48; "Insulin resistance-Minimal Model (Si)"; 2029-07
NCT07548047
"Effectiveness of Dextrose Pleurodesis for the Management of Post-Operative Air Leak"; n 80; "Time to air leak resolution"; 2029-06-30
NCT07564063
"Enhanced Recovery After Surgery in Hysterectomy Patients"; n 78; "length of hospital stay (LOS)"; 2027-01-01
NCT07681804
"Betamethasone vs Dextrose Injections in Trigger Finger"; n 42; "Change in pain intensity assessed by Numeric Rating Scale (NRS)"; 2027-05
recorded 2026-09-01 · last checked 2026-09-04
Q9
Which running trial of DEXTROSE, Unspecified Form could settle lifespan?
NCT04895358 measures Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1) by Blinded Independent Central Review (BICR) in Participants With Combined Positive Score (CPS) ≥1, reading out 2027-12-18.
3 open trials; n 342; "Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)"
Show the evidence
Trial
NCT04895358
"Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)"; n 342; "Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1) by Blinded Independent Central Review (BICR) in Participants With Combined Positive Score (CPS) ≥1"; 2027-12-18
NCT07494084
"Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance"; n 48; "Insulin resistance-Minimal Model (Si)"; 2029-07
NCT05933577
"A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)"; n 1089; "Recurrence-Free Survival (RFS)"; 2030-09-26
Q10
Which 37 trials of DEXTROSE, Unspecified Form posted no result?
Posted no result
37 of 37 completed trials
Registrations
NCT00676767, NCT00616876, NCT00687960, NCT00821067, NCT01300754 and NCT01326611, and 31 more
Completion dates
oldest 2006-11; newest 2024-04-21
Show the evidence
Trial
NCT00676767
2006-11
NCT00616876
2007-01
NCT00687960
2007-12
NCT00821067
2009-05
NCT01300754
2010-09
NCT01326611
2010-12
14 further recorded trials
NCT01223690
2011-04
NCT01213719
2011-07
NCT02305069
2012-09
NCT01904617
2014-04
NCT02118142
2014-07
NCT00765557
2014-07-22
NCT02984098
2015-06
NCT03333369
2015-08-13
NCT03139383
2015-10-31
NCT01547364
2015-11
NCT01476605
2015-12-01
NCT02471690
2016-04
NCT00085722
2016-05-01
NCT02269735
2016-07-29
Q11
At the median, DEXTROSE, Unspecified Form's trials enrolled 49 people — anything larger?
Median enrolment
49
Largest enrolment
1089
Registered trials counted
94
Q12
Was DEXTROSE, Unspecified Form studied with fasting and exercise?
fasting and exercise are named in DEXTROSE, Unspecified Form's label sentences: "In this randomized controlled trial, 70 patients scheduled for elective hip or lower extremity surgery were randomized into two groups: a fasting group (8 to 10 hours) and a dextrose group (200 mL of oral dextrose administered 2 to 3 hours preoperatively)." openfda-label+europepmc · 2026-06-09
2 recorded statements; fasting, exercise
Show the evidence
fasting
In this randomized controlled trial, 70 patients scheduled for elective hip or lower extremity surgery were randomized into two groups: a fasting group (8 to 10 hours) and a dextrose group (200 mL of oral dextrose administered 2 to 3 hours preoperatively).
exercise
To test whether pre-exercise galactose and lactose reduce glycaemic excursions during exercise compared with dextrose while maintaining protection against hypoglycaemia compared with placebo in adults with Type 1 diabetes METHODS: In a randomised, double-blind, 4-condition crossover trial, 14 adults with Type 1 diabetes completed four 60-min cycling sessions.
recorded 2026-06-09 · last checked 2026-09-04
Q13
What is recorded about DEXTROSE, Unspecified Form and mTOR?
"In summary, the yeast essential protein conditional degradation library we constructed will serve as a valuable resource for systematically investigating the roles of essential genes in autophagy and other biological functions.<b>Abbreviation:</b> AID: auxin-inducible degron; ALP: alkaline phosphatase; ATG: autophagy related; CSG:…" — where DEXTROSE, Unspecified Form and mTOR appear together. Europe PMC · pathway abstract search · 2025-03-04
"In summary, the yeast essential protein conditional degradation library we constructed will serve as a valuable resource for systematically investigating the roles of essential genes in autophagy and other biological functions.<b>Abbreviation:</b> AID: auxin-inducible degron; ALP: alkaline phosphatase; ATG: autophagy related; CSG: constitutive slow growth; DAmP: Decreased Abundance by mRNA…"
autophagy
PMID 39988731
"In summary, the yeast essential protein conditional degradation library we constructed will serve as a valuable resource for systematically investigating the roles of essential genes in autophagy and other biological functions.<b>Abbreviation:</b> AID: auxin-inducible degron; ALP: alkaline phosphatase; ATG: autophagy related; CSG: constitutive slow growth; DAmP: Decreased Abundance by mRNA…"
PMID 40395315
"Our findings provide insight into the molecular mechanisms of selective autophagy including pexophagy in filamentous fungi. <b>Abbreviations:</b> AIM, Atg8-family interacting motifs; Atg8, autophagy-related 8; EGFP, enhanced green fluorescent protein; GABARAP, Gamma aminobutyric acid A receptor associated protein; LC3, Microtubule-associated protein light chain 3; MTS, microbody targeting signal;…"
mTORPMID 34092182
"Taken together, our data unveil a dual-functional bacterial effector that tightly regulates host autophagy flux to benefit pathogen intracellular survival.<b>Abbreviations:</b> AKT: AKT serine/threonine kinase; ATG5: autophagy related 5; BMDMs: bone marrow-derived macrophages; DTT: dithiothreitol; FBS: fetal calf serum; GAP: GTPase-activating protein; MOI: multiplicity of infection; Mtb:…"
autophagyPMID 34092182
"Taken together, our data unveil a dual-functional bacterial effector that tightly regulates host autophagy flux to benefit pathogen intracellular survival.<b>Abbreviations:</b> AKT: AKT serine/threonine kinase; ATG5: autophagy related 5; BMDMs: bone marrow-derived macrophages; DTT: dithiothreitol; FBS: fetal calf serum; GAP: GTPase-activating protein; MOI: multiplicity of infection; Mtb:…"
AMPKPMID 31525119
"AMPK: AMP-activated protein kinase; ATP5F1A: ATP synthase F1 subunit alpha; CALCOCO2/NDP52: calcium binding and coiled-coil domain 2; CCCP: chlorophenylhydrazone; DFP: chelator deferiprone; GFP: green fluorescent protein; H2B-Ub1: H2B monoubiquitination; HSPD1/HSP60: heat shock protein family D (Hsp60) member 1; KD: kinase dead; OPTN, optineurin; Paf1: polymerase-associated factor 1; PINK1: PTEN…"
IGF-1PMID 23552376
"The dextrose plus starch-diets enhanced the postprandial insulin response in a dose-dependent manner (e.g. at day 2 insulin area under the curve was 4516 μU/444 min for CON, 8197 μU/444 min for INS-L and 10 894 μU/444 min for INS-H; s.e.m. = 694; P < 0.001), but did not affect plasma IGF-1 concentrations during the first 3 days of WEI."
recorded 2025-03-04 · last checked 2026-09-04
Where it is registeredIdentifiers, relations and other names
ClinicalTrials.gov — US Government work · Europe PMC — metadata only, under the recorded legal gate · derived from this page's own recorded fields; no external licence · mixed register set; per-register licences in docs/specs/corpus-20k-sources.md · openFDA / DailyMed — US Government work
✗ required summary fields resolved: 4 required field(s) not terminal: Why people use it, Best-supported result, Biggest unanswered question, Human evidence
✓ public claims reviewed: 0 reviewed claim(s); drafts are never rendered
✓ source coverage passed: 8 source rows
✓ no critical contamination: no quarantine open
✓ canonical metadata passed: slug and display name present
✓ no raw internal fields: enforced by the copy-contract test over the rendered page
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